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Protein

Peroxisomal membrane protein 11B

Gene

PEX11B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in peroxisomal proliferation (PubMed:9792670). May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane (PubMed:12618434). Promotes membrane protrusion and elongation on the peroxisomal surface (PubMed:20826455).3 Publications

Caution

PubMed:9792670 states that both the N- and the C-terminus are located in the cytoplasm.Curated

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processPeroxisome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein 11B
Alternative name(s):
Peroxin-11B
Peroxisomal biogenesis factor 11B
Protein PEX11 homolog beta
Short name:
PEX11-beta
Gene namesi
Name:PEX11B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000131779.10
HGNCiHGNC:8853 PEX11B
MIMi603867 gene
neXtProtiNX_O96011

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei233 – 255HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane, Peroxisome

Pathology & Biotechi

Involvement in diseasei

Peroxisome biogenesis disorder 14B (PBD14B)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive peroxisome biogenesis disorder characterized clinically by mild intellectual disability, congenital cataracts, progressive hearing loss, and polyneuropathy. Additionally, recurrent migraine-like episodes following mental stress or physical exertion, not a common feature in peroxisome disorders, are observed.
See also OMIM:614920

Keywords - Diseasei

Peroxisome biogenesis disorder

Organism-specific databases

DisGeNETi8799
MalaCardsiPEX11B
MIMi614920 phenotype
OpenTargetsiENSG00000131779
Orphaneti772 Infantile Refsum disease
44 Neonatal adrenoleukodystrophy
912 Zellweger syndrome
PharmGKBiPA33195

Polymorphism and mutation databases

BioMutaiPEX11B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001059671 – 259Peroxisomal membrane protein 11BAdd BLAST259

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei43N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO96011
MaxQBiO96011
PaxDbiO96011
PeptideAtlasiO96011
PRIDEiO96011
ProteomicsDBi51190
51191 [O96011-2]

PTM databases

iPTMnetiO96011
PhosphoSitePlusiO96011
SwissPalmiO96011

Expressioni

Gene expression databases

BgeeiENSG00000131779 Expressed in 221 organ(s), highest expression level in amniotic fluid
CleanExiHS_PEX11B
ExpressionAtlasiO96011 baseline and differential
GenevisibleiO96011 HS

Organism-specific databases

HPAiHPA050104

Interactioni

Subunit structurei

Homodimer (PubMed:20826455). Heterodimer with PEX11G (PubMed:20826455). Interacts with PEX19 (PubMed:10704444). Interacts with FIS1 (PubMed:20826455).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PEX19P4085512EBI-594824,EBI-594747

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114327, 13 interactors
IntActiO96011, 4 interactors
MINTiO96011
STRINGi9606.ENSP00000358312

Structurei

3D structure databases

ProteinModelPortaliO96011
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni211 – 259Interaction with PEX19, PEX11G and FIS1 and peroxisome targeting2 PublicationsAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi159 – 182Gly-richAdd BLAST24

Sequence similaritiesi

Belongs to the peroxin-11 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4186 Eukaryota
ENOG4111NS6 LUCA
GeneTreeiENSGT00390000014273
HOGENOMiHOG000251589
HOVERGENiHBG053771
InParanoidiO96011
KOiK13352
OMAiCDFFIPL
OrthoDBiEOG091G0H6Y
PhylomeDBiO96011
TreeFamiTF325704

Family and domain databases

InterProiView protein in InterPro
IPR008733 PEX11
PfamiView protein in Pfam
PF05648 PEX11, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O96011-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDAWVRFSAQ SQARERLCRA AQYACSLLGH ALQRHGASPE LQKQIRQLES
60 70 80 90 100
HLSLGRKLLR LGNSADALES AKRAVHLSDV VLRFCITVSH LNRALYFACD
110 120 130 140 150
NVLWAGKSGL APRVDQEKWA QRSFRYYLFS LIMNLSRDAY EIRLLMEQES
160 170 180 190 200
SACSRRLKGS GGGVPGGSET GGLGGPGTPG GGLPQLALKL RLQVLLLARV
210 220 230 240 250
LRGHPPLLLD VVRNACDLFI PLDKLGLWRC GPGIVGLCGL VSSILSILTL

IYPWLRLKP
Length:259
Mass (Da):28,431
Last modified:May 1, 1999 - v1
Checksum:iDC26CE30021C7B8D
GO
Isoform 2 (identifier: O96011-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MDAWVRFSAQSQARERLC → MGKL

Note: No experimental confirmation available.
Show »
Length:245
Mass (Da):26,724
Checksum:i48F9E9DDDA9F4447
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C3V6H7C3V6_HUMAN
Peroxisomal membrane protein 11B
PEX11B
81Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti98A → V in AAH11963 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0428601 – 18MDAWV…RERLC → MGKL in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018080 mRNA Translation: BAA34812.1
AF093670 mRNA Translation: AAC78660.1
CR542047 mRNA Translation: CAG46844.1
AK023991 mRNA Translation: BAG51247.1
AK301983 mRNA Translation: BAG63391.1
AL160282 Genomic DNA No translation available.
CH471244 Genomic DNA Translation: EAW71422.1
BC011963 mRNA Translation: AAH11963.1
CCDSiCCDS72870.1 [O96011-2]
CCDS72871.1 [O96011-1]
PIRiJE0326
RefSeqiNP_001171724.1, NM_001184795.1 [O96011-2]
NP_003837.1, NM_003846.2 [O96011-1]
UniGeneiHs.714608

Genome annotation databases

EnsembliENST00000369306; ENSP00000358312; ENSG00000131779 [O96011-1]
ENST00000537888; ENSP00000437510; ENSG00000131779 [O96011-2]
GeneIDi8799
KEGGihsa:8799
UCSCiuc001eny.3 human [O96011-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018080 mRNA Translation: BAA34812.1
AF093670 mRNA Translation: AAC78660.1
CR542047 mRNA Translation: CAG46844.1
AK023991 mRNA Translation: BAG51247.1
AK301983 mRNA Translation: BAG63391.1
AL160282 Genomic DNA No translation available.
CH471244 Genomic DNA Translation: EAW71422.1
BC011963 mRNA Translation: AAH11963.1
CCDSiCCDS72870.1 [O96011-2]
CCDS72871.1 [O96011-1]
PIRiJE0326
RefSeqiNP_001171724.1, NM_001184795.1 [O96011-2]
NP_003837.1, NM_003846.2 [O96011-1]
UniGeneiHs.714608

3D structure databases

ProteinModelPortaliO96011
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114327, 13 interactors
IntActiO96011, 4 interactors
MINTiO96011
STRINGi9606.ENSP00000358312

PTM databases

iPTMnetiO96011
PhosphoSitePlusiO96011
SwissPalmiO96011

Polymorphism and mutation databases

BioMutaiPEX11B

Proteomic databases

EPDiO96011
MaxQBiO96011
PaxDbiO96011
PeptideAtlasiO96011
PRIDEiO96011
ProteomicsDBi51190
51191 [O96011-2]

Protocols and materials databases

DNASUi8799
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369306; ENSP00000358312; ENSG00000131779 [O96011-1]
ENST00000537888; ENSP00000437510; ENSG00000131779 [O96011-2]
GeneIDi8799
KEGGihsa:8799
UCSCiuc001eny.3 human [O96011-1]

Organism-specific databases

CTDi8799
DisGeNETi8799
EuPathDBiHostDB:ENSG00000131779.10
GeneCardsiPEX11B
HGNCiHGNC:8853 PEX11B
HPAiHPA050104
MalaCardsiPEX11B
MIMi603867 gene
614920 phenotype
neXtProtiNX_O96011
OpenTargetsiENSG00000131779
Orphaneti772 Infantile Refsum disease
44 Neonatal adrenoleukodystrophy
912 Zellweger syndrome
PharmGKBiPA33195
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4186 Eukaryota
ENOG4111NS6 LUCA
GeneTreeiENSGT00390000014273
HOGENOMiHOG000251589
HOVERGENiHBG053771
InParanoidiO96011
KOiK13352
OMAiCDFFIPL
OrthoDBiEOG091G0H6Y
PhylomeDBiO96011
TreeFamiTF325704

Miscellaneous databases

ChiTaRSiPEX11B human
GeneWikiiPEX11B
GenomeRNAii8799
PROiPR:O96011
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131779 Expressed in 221 organ(s), highest expression level in amniotic fluid
CleanExiHS_PEX11B
ExpressionAtlasiO96011 baseline and differential
GenevisibleiO96011 HS

Family and domain databases

InterProiView protein in InterPro
IPR008733 PEX11
PfamiView protein in Pfam
PF05648 PEX11, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPX11B_HUMAN
AccessioniPrimary (citable) accession number: O96011
Secondary accession number(s): B3KN85, B4DXH9, Q96ET2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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