UniProtKB - O96008 (TOM40_HUMAN)

BLAST

>sp|O96008|TOM40_HUMAN Mitochondrial import receptor subunit TOM40 homolog OS=Homo sapiens OX=9606 GN=TOMM40 PE=1 SV=1
MGNVLAASSPPAGPPPPPAPALVGLPPPPPSPPGFTLPPLGGSLGAGTSTSRSSERTPGA
ATASASGAAEDGACGCLPNPGTFEECHRKCKELFPIQMEGVKLTVNKGLSNHFQVNHTVA
LSTIGESNYHFGVTYVGTKQLSPTEAFPVLVGDMDNSGSLNAQVIHQLGPGLRSKMAIQT
QQSKFVNWQVDGEYRGSDFTAAVTLGNPDVLVGSGILVAHYLQSITPCLALGGELVYHRR
PGEEGTVMSLAGKYTLNNWLATVTLGQAGMHATYYHKASDQLQVGVEFEASTRMQDTSVS
FGYQLDLPKANLLFKGSVDSNWIVGATLEKKLPPLPLTLALGAFLNHRKNKFQCGFGLTI
G

Align

Format
Add to basket Added to basket
History
Entry version 156 (07 Nov 2018)
Sequence version 1 (01 May 1999)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

Mitochondrial import receptor subunit TOM40 homolog

Gene

TOMM40

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Channel-forming protein essential for import of protein precursors into mitochondria.1 Publication

GO - Molecular functionⁱ

porin activity Source: UniProtKB-KW
protein transmembrane transporter activity Source: BHF-UCL

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

ion transport Source: UniProtKB-KW
protein import into mitochondrial matrix
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein targeting to mitochondrion
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15644312

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Porin
Biological process	Ion transport, Protein transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1268020 Mitochondrial protein import R-HSA-5205685 Pink/Parkin Mediated Mitophagy

Reactomeⁱ

R-HSA-1268020 Mitochondrial protein import
R-HSA-5205685 Pink/Parkin Mediated Mitophagy

Protein family/group databases

TCDBⁱ	1.B.8.2.5 the mitochondrial and plastid porin (mpp) family

TCDBⁱ

1.B.8.2.5 the mitochondrial and plastid porin (mpp) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mitochondrial import receptor subunit TOM40 homolog Alternative name(s): Protein Haymaker Translocase of outer membrane 40 kDa subunit homolog p38.5
Gene namesⁱ	Name:TOMM40 Synonyms:C19orf1, PEREC1, TOM40
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000130204.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18001 TOMM40
MIMⁱ	608061 gene
neXtProtⁱ	NX_O96008

Keywords - Cellular componentⁱ

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10452
MalaCards human disease database More...MalaCardsⁱ	TOMM40
Open Targets More...OpenTargetsⁱ	ENSG00000130204
Orphanetⁱ	1020 Early-onset autosomal dominant Alzheimer disease
PharmGKBⁱ	PA38274

Polymorphism and mutation databases

BioMutaⁱ	TOMM40

BioMutaⁱ

TOMM40

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000051523	1 – 361	Mitochondrial import receptor subunit TOM40 homologAdd BLAST		361

Proteomic databases

EPDⁱ	O96008
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O96008
PaxDbⁱ	O96008
PeptideAtlas More...PeptideAtlasⁱ	O96008
PRIDEⁱ	O96008
ProteomicsDBⁱ	51187 51188 [O96008-2]
TopDownProteomicsⁱ	O96008-1 [O96008-1]

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00014053

REPRODUCTION-2DPAGEⁱ

IPI00014053

PTM databases

iPTMnetⁱ	O96008
PhosphoSitePlusⁱ	O96008
SwissPalmⁱ	O96008

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000130204 Expressed in 240 organ(s), highest expression level in dorsal plus ventral thalamus
CleanExⁱ	HS_TOMM40
ExpressionAtlasⁱ	O96008 baseline and differential
Genevisibleⁱ	O96008 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA036231 HPA036232

HPAⁱ

HPA036231
HPA036232

Interactionⁱ

Subunit structureⁱ

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with mitochondrial targeting sequences. Interacts with TIMM29; linking the TIM22 complex to the TOM complex (PubMed:27554484).4 Publications

Protein-protein interaction databases

BioGridⁱ	115716, 126 interactors
CORUMⁱ	O96008
IntActⁱ	O96008, 38 interactors
Molecular INTeraction database More...MINTⁱ	O96008
STRINGⁱ	9606.ENSP00000252487

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O96008
SMRⁱ	O96008
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	10 – 39	Pro-richAdd BLAST		30

Sequence similaritiesⁱ

Belongs to the Tom40 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGⁱ	KOG3296 Eukaryota ENOG410XS2U LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003308
HOGENOMⁱ	HOG000007440
HOVERGENⁱ	HBG054707
InParanoidⁱ	O96008
KEGG Orthology (KO) More...KOⁱ	K11518
OMAⁱ	DFRMSTF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MNA
PhylomeDBⁱ	O96008
TreeFamⁱ	TF106204

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07305 Porin3_Tom40, 1 hit
Gene3Dⁱ	2.40.160.10, 1 hit
InterProⁱ	View protein in InterPro IPR023614 Porin_dom_sf IPR027246 Porin_Euk/Tom40 IPR037930 Tom40
PANTHERⁱ	PTHR10802 PTHR10802, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01459 Porin_3, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O96008-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNVLAASSP PAGPPPPPAP ALVGLPPPPP SPPGFTLPPL GGSLGAGTST 
        60         70         80         90        100
SRSSERTPGA ATASASGAAE DGACGCLPNP GTFEECHRKC KELFPIQMEG 
       110        120        130        140        150
VKLTVNKGLS NHFQVNHTVA LSTIGESNYH FGVTYVGTKQ LSPTEAFPVL 
       160        170        180        190        200
VGDMDNSGSL NAQVIHQLGP GLRSKMAIQT QQSKFVNWQV DGEYRGSDFT 
       210        220        230        240        250
AAVTLGNPDV LVGSGILVAH YLQSITPCLA LGGELVYHRR PGEEGTVMSL 
       260        270        280        290        300
AGKYTLNNWL ATVTLGQAGM HATYYHKASD QLQVGVEFEA STRMQDTSVS 
       310        320        330        340        350
FGYQLDLPKA NLLFKGSVDS NWIVGATLEK KLPPLPLTLA LGAFLNHRKN 
       360 
KFQCGFGLTI G

Length:361

Mass (Da):37,893

Last modified:May 1, 1999 - v1

Checksum:ⁱCFE55E01F8003D32

Isoform 2 (identifier: O96008-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
317-329: SVDSNWIVGATLE → KGLGSPTRETGRR
330-361: Missing.

« Hide

        10         20         30         40         50
MGNVLAASSP PAGPPPPPAP ALVGLPPPPP SPPGFTLPPL GGSLGAGTST 
        60         70         80         90        100
SRSSERTPGA ATASASGAAE DGACGCLPNP GTFEECHRKC KELFPIQMEG 
       110        120        130        140        150
VKLTVNKGLS NHFQVNHTVA LSTIGESNYH FGVTYVGTKQ LSPTEAFPVL 
       160        170        180        190        200
VGDMDNSGSL NAQVIHQLGP GLRSKMAIQT QQSKFVNWQV DGEYRGSDFT 
       210        220        230        240        250
AAVTLGNPDV LVGSGILVAH YLQSITPCLA LGGELVYHRR PGEEGTVMSL 
       260        270        280        290        300
AGKYTLNNWL ATVTLGQAGM HATYYHKASD QLQVGVEFEA STRMQDTSVS 
       310        320 
FGYQLDLPKA NLLFKGKGLG SPTRETGRR

Note: No experimental confirmation available.

Show »

Length:329

Mass (Da):34,441

Checksum:ⁱADE7536E9A9ECDCF

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

K7EJ57	K7EJ57_HUMAN	Mitochondrial import receptor subun... Mitochondrial import receptor subunit TOM40 homolog	TOMM40	214	Annotation score:
K7EKG4	K7EKG4_HUMAN	Mitochondrial import receptor subun... Mitochondrial import receptor subunit TOM40 homolog	TOMM40	168	Annotation score:
K7EKG6	K7EKG6_HUMAN	Mitochondrial import receptor subun... Mitochondrial import receptor subunit TOM40 homolog	TOMM40	36	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	49	S → R in AAH06413 (PubMed:15489334).Curated	1
Sequence conflictⁱ	219	A → S in AAL46625 (PubMed:11745481).Curated	1
Sequence conflictⁱ	220	H → R in AAL46624 (PubMed:11745481).Curated	1
Sequence conflictⁱ	258	N → S in AAL46626 (PubMed:11745481).Curated	1
Sequence conflictⁱ	297	T → A in AAL46626 (PubMed:11745481).Curated	1
Sequence conflictⁱ	313	L → F in AAL46624 (PubMed:11745481).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_008589	317 – 329	SVDSN…GATLE → KGLGSPTRETGRR in isoform 2. 1 PublicationAdd BLAST		13
Alternative sequenceⁱVSP_008590	330 – 361	Missing in isoform 2. 1 PublicationAdd BLAST		32

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF050154 Genomic DNA Translation: AAD02504.1 AF043250 mRNA Translation: AAC82342.1 AF043253, AF043251, AF043252 Genomic DNA Translation: AAC82343.1 AF316398 mRNA Translation: AAL46624.1 AF316399 mRNA Translation: AAL46625.1 AF316401 mRNA Translation: AAL46626.1 AF316402 mRNA Translation: AAL46627.1 CH471126 Genomic DNA Translation: EAW57302.1 CH471126 Genomic DNA Translation: EAW57304.1 CH471126 Genomic DNA Translation: EAW57305.1 BC001779 mRNA Translation: AAH01779.1 BC006413 mRNA Translation: AAH06413.1 BC012134 mRNA Translation: AAH12134.1 BC017224 mRNA Translation: AAH17224.1 BC047528 mRNA Translation: AAH47528.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12646.1 [O96008-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001122388.1, NM_001128916.1 [O96008-1] NP_001122389.1, NM_001128917.1 [O96008-1] NP_006105.1, NM_006114.2 [O96008-1]
UniGeneⁱ	Hs.655909

Genome annotation databases

Ensemblⁱ	ENST00000252487; ENSP00000252487; ENSG00000130204 [O96008-1] ENST00000405636; ENSP00000385184; ENSG00000130204 [O96008-1] ENST00000426677; ENSP00000410339; ENSG00000130204 [O96008-1] ENST00000592434; ENSP00000466084; ENSG00000130204 [O96008-2]
GeneIDⁱ	10452
KEGGⁱ	hsa:10452
UCSC genome browser More...UCSCⁱ	uc002ozx.4 human [O96008-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O96008	Mitochondrial import receptor subunit TOM40 homolog (Fragment)		HUMAN		214	UniRef100_O96008

Protein	Similar proteins		Species	Score	Length	Source
O96008	Mitochondrial import receptor subunit TOM40 homolog		BOVIN		361	UniRef90_O96008
Mitochondrial import receptor subunit TOM40 homolog (Fragment)		HUMAN		214
Putative translocase of outer mitochondrial membrane complex subunit tom40 (Fragment)		DESRO		427
Uncharacterized protein		SHEEP		363
mitochondrial import receptor subunit TOM40 homolog		Florida manatee		362
+67
O96008-2	Mitochondrial import receptor subunit TOM40 homolog		MOUSE		361	UniRef90_O96008-2
Mitochondrial import receptor subunit TOM40 homolog		RAT		361
TOMM40 (Fragment)		CEREH		379
Mitochondrial translocase of outer membrane protein		PIG		361
Mitochondrial import receptor subunit TOM40 homolog (Fragment)		NEOVI		207
+35

Protein	Similar proteins		Species	Score	Length	Source
O96008	Mitochondrial import receptor subunit TOM40 homolog		BOVIN		361	UniRef50_O96008
Mitochondrial import receptor subunit TOM40 homolog		MOUSE		361
Mitochondrial import receptor subunit TOM40 homolog		RAT		361
Mitochondrial import receptor subunit TOM40 homolog (Fragment)		HUMAN		214
Putative translocase of outer mitochondrial membrane complex subunit tom40 (Fragment)		DESRO		427
+145

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF050154 Genomic DNA Translation: AAD02504.1 AF043250 mRNA Translation: AAC82342.1 AF043253, AF043251, AF043252 Genomic DNA Translation: AAC82343.1 AF316398 mRNA Translation: AAL46624.1 AF316399 mRNA Translation: AAL46625.1 AF316401 mRNA Translation: AAL46626.1 AF316402 mRNA Translation: AAL46627.1 CH471126 Genomic DNA Translation: EAW57302.1 CH471126 Genomic DNA Translation: EAW57304.1 CH471126 Genomic DNA Translation: EAW57305.1 BC001779 mRNA Translation: AAH01779.1 BC006413 mRNA Translation: AAH06413.1 BC012134 mRNA Translation: AAH12134.1 BC017224 mRNA Translation: AAH17224.1 BC047528 mRNA Translation: AAH47528.1
CCDSⁱ	CCDS12646.1 [O96008-1]
RefSeqⁱ	NP_001122388.1, NM_001128916.1 [O96008-1] NP_001122389.1, NM_001128917.1 [O96008-1] NP_006105.1, NM_006114.2 [O96008-1]
UniGeneⁱ	Hs.655909

3D structure databases

ProteinModelPortalⁱ	O96008
SMRⁱ	O96008
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115716, 126 interactors
CORUMⁱ	O96008
IntActⁱ	O96008, 38 interactors
MINTⁱ	O96008
STRINGⁱ	9606.ENSP00000252487

Protein family/group databases

TCDBⁱ	1.B.8.2.5 the mitochondrial and plastid porin (mpp) family

TCDBⁱ

1.B.8.2.5 the mitochondrial and plastid porin (mpp) family

PTM databases

iPTMnetⁱ	O96008
PhosphoSitePlusⁱ	O96008
SwissPalmⁱ	O96008

Polymorphism and mutation databases

BioMutaⁱ	TOMM40

BioMutaⁱ

TOMM40

2D gel databases

REPRODUCTION-2DPAGEⁱ	IPI00014053

REPRODUCTION-2DPAGEⁱ

IPI00014053

Proteomic databases

EPDⁱ	O96008
MaxQBⁱ	O96008
PaxDbⁱ	O96008
PeptideAtlasⁱ	O96008
PRIDEⁱ	O96008
ProteomicsDBⁱ	51187 51188 [O96008-2]
TopDownProteomicsⁱ	O96008-1 [O96008-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10452
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000252487; ENSP00000252487; ENSG00000130204 [O96008-1] ENST00000405636; ENSP00000385184; ENSG00000130204 [O96008-1] ENST00000426677; ENSP00000410339; ENSG00000130204 [O96008-1] ENST00000592434; ENSP00000466084; ENSG00000130204 [O96008-2]
GeneIDⁱ	10452
KEGGⁱ	hsa:10452
UCSCⁱ	uc002ozx.4 human [O96008-1]

Organism-specific databases

CTDⁱ	10452
DisGeNETⁱ	10452
EuPathDBⁱ	HostDB:ENSG00000130204.12
GeneCardsⁱ	TOMM40
H-InvDBⁱ	HIX0041357
HGNCⁱ	HGNC:18001 TOMM40
HPAⁱ	HPA036231 HPA036232
MalaCardsⁱ	TOMM40
MIMⁱ	608061 gene
neXtProtⁱ	NX_O96008
OpenTargetsⁱ	ENSG00000130204
Orphanetⁱ	1020 Early-onset autosomal dominant Alzheimer disease
PharmGKBⁱ	PA38274
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3296 Eukaryota ENOG410XS2U LUCA
GeneTreeⁱ	ENSGT00390000003308
HOGENOMⁱ	HOG000007440
HOVERGENⁱ	HBG054707
InParanoidⁱ	O96008
KOⁱ	K11518
OMAⁱ	DFRMSTF
OrthoDBⁱ	EOG091G0MNA
PhylomeDBⁱ	O96008
TreeFamⁱ	TF106204

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1268020 Mitochondrial protein import R-HSA-5205685 Pink/Parkin Mediated Mitophagy

Reactomeⁱ

R-HSA-1268020 Mitochondrial protein import
R-HSA-5205685 Pink/Parkin Mediated Mitophagy

Miscellaneous databases

ChiTaRSⁱ	TOMM40 human
GeneWikiⁱ	TOMM40
GenomeRNAiⁱ	10452
Protein Ontology More...PROⁱ	PR:O96008
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000130204 Expressed in 240 organ(s), highest expression level in dorsal plus ventral thalamus
CleanExⁱ	HS_TOMM40
ExpressionAtlasⁱ	O96008 baseline and differential
Genevisibleⁱ	O96008 HS

Family and domain databases

CDDⁱ	cd07305 Porin3_Tom40, 1 hit
Gene3Dⁱ	2.40.160.10, 1 hit
InterProⁱ	View protein in InterPro IPR023614 Porin_dom_sf IPR027246 Porin_Euk/Tom40 IPR037930 Tom40
PANTHERⁱ	PTHR10802 PTHR10802, 1 hit
Pfamⁱ	View protein in Pfam PF01459 Porin_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TOM40_HUMAN
Accessionⁱ	O96008Primary (citable) accession number: O96008 Secondary accession number(s): A0A024R0P9 , Q86VW4, Q8WY09, Q8WY10, Q8WY11, Q9BR95
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
	Last sequence update:	May 1, 1999
	Last modified:	November 7, 2018
	This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O96008 (TOM40_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Mitochondrial import receptor subunit TOM40 homolog

TOMM40

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Cytosol

Mitochondrion

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ