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UniProtKB - O96008 (TOM40_HUMAN)

Entry version 176 (02 Jun 2021)
Sequence version 1 (01 May 1999)
Previous versions | rss
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Protein

Mitochondrial import receptor subunit TOM40 homolog

Gene

TOMM40

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Channel-forming protein essential for import of protein precursors into mitochondria (PubMed:15644312, PubMed:31206022).

Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by forming a complex with BCAP31 and mediating the translocation of Complex I components from the cytosol to the mitochondria (PubMed:31206022).

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionPorin
Biological processIon transport, Protein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O96008

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1268020, Mitochondrial protein import
R-HSA-5205685, PINK1-PRKN Mediated Mitophagy

Protein family/group databases

Transport Classification Database

More...TCDBi		1.B.8.2.5, the mitochondrial and plastid porin (mpp) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM40 homolog
Alternative name(s):
Protein Haymaker
Translocase of outer membrane 40 kDa subunit homolog
p38.5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TOMM40
Synonyms:C19orf1, PEREC1, TOM40
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18001, TOMM40

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608061, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O96008

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000130204.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		10452

MalaCards human disease database

More...MalaCardsi		TOMM40

Open Targets

More...OpenTargetsi		ENSG00000130204

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		1020, Early-onset autosomal dominant Alzheimer disease

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38274

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O96008, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4523158

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TOMM40

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000515231 – 361Mitochondrial import receptor subunit TOM40 homologAdd BLAST361

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O96008

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O96008

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O96008

MaxQB - The MaxQuant DataBase

More...MaxQBi		O96008

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O96008

PeptideAtlas

More...PeptideAtlasi		O96008

PRoteomics IDEntifications database

More...PRIDEi		O96008

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51187 [O96008-1]
51188 [O96008-2]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		O96008-1 [O96008-1]

2D gel databases

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		IPI00014053

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O96008

MetOSite database of methionine sulfoxide sites

More...MetOSitei		O96008

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O96008

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O96008

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000130204, Expressed in dorsal plus ventral thalamus and 253 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O96008, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O96008, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000130204, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70).

Interacts with mitochondrial targeting sequences (PubMed:12198123, PubMed:15644312, PubMed:18331822).

Interacts with TIMM29; linking the TIM22 complex to the TOM complex (PubMed:27554484).

Forms a complex with BCAP31 (via C-terminus) which mediates the translocation of components of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) from the cytosol to the mitochondria (PubMed:31206022).

Interacts (via N-terminus) with CYP1A1 (via mitochondrial targeting signal); this interaction is required for CYP1A1 translocation across the mitochondrial outer membrane (By similarity).

By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115716, 241 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-6121, TOM40 mitochondrial outer membrane translocase complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O96008

Protein interaction database and analysis system

More...IntActi		O96008, 54 interactors

Molecular INTeraction database

More...MINTi		O96008

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000410339

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O96008, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1361
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O96008

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 71DisorderedSequence analysisAdd BLAST71

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi9 – 37Pro residuesSequence analysisAdd BLAST29
Compositional biasi43 – 61Polar residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Tom40 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3296, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000003308

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_054399_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O96008

Identification of Orthologs from Complete Genome Data

More...OMAi		DFRMSTF

Database of Orthologous Groups

More...OrthoDBi		1346842at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O96008

TreeFam database of animal gene trees

More...TreeFami		TF106204

Family and domain databases

Conserved Domains Database

More...CDDi		cd07305, Porin3_Tom40, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.160.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR023614, Porin_dom_sf
IPR027246, Porin_Euk/Tom40
IPR037930, Tom40

The PANTHER Classification System

More...PANTHERi		PTHR10802, PTHR10802, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01459, Porin_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O96008-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGNVLAASSP PAGPPPPPAP ALVGLPPPPP SPPGFTLPPL GGSLGAGTST 
        60         70         80         90        100
SRSSERTPGA ATASASGAAE DGACGCLPNP GTFEECHRKC KELFPIQMEG 
       110        120        130        140        150
VKLTVNKGLS NHFQVNHTVA LSTIGESNYH FGVTYVGTKQ LSPTEAFPVL 
       160        170        180        190        200
VGDMDNSGSL NAQVIHQLGP GLRSKMAIQT QQSKFVNWQV DGEYRGSDFT 
       210        220        230        240        250
AAVTLGNPDV LVGSGILVAH YLQSITPCLA LGGELVYHRR PGEEGTVMSL 
       260        270        280        290        300
AGKYTLNNWL ATVTLGQAGM HATYYHKASD QLQVGVEFEA STRMQDTSVS 
       310        320        330        340        350
FGYQLDLPKA NLLFKGSVDS NWIVGATLEK KLPPLPLTLA LGAFLNHRKN 
       360 
KFQCGFGLTI G
Length:361
Mass (Da):37,893
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCFE55E01F8003D32
GO
Isoform 2 (identifier: O96008-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     317-329: SVDSNWIVGATLE → KGLGSPTRETGRR
     330-361: Missing.

Show »
Length:329
Mass (Da):34,441
Checksum:iADE7536E9A9ECDCF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EJ57K7EJ57_HUMAN
Mitochondrial import receptor subun...
TOMM40
214Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKG4K7EKG4_HUMAN
Mitochondrial import receptor subun...
TOMM40
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKG6K7EKG6_HUMAN
Mitochondrial import receptor subun...
TOMM40
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti49S → R in AAH06413 (PubMed:15489334).Curated1
Sequence conflicti219A → S in AAL46625 (PubMed:11745481).Curated1
Sequence conflicti220H → R in AAL46624 (PubMed:11745481).Curated1
Sequence conflicti258N → S in AAL46626 (PubMed:11745481).Curated1
Sequence conflicti297T → A in AAL46626 (PubMed:11745481).Curated1
Sequence conflicti313L → F in AAL46624 (PubMed:11745481).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_008589317 – 329SVDSN…GATLE → KGLGSPTRETGRR in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_008590330 – 361Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF050154 Genomic DNA Translation: AAD02504.1
AF043250 mRNA Translation: AAC82342.1
AF043253, AF043251, AF043252 Genomic DNA Translation: AAC82343.1
AF316398 mRNA Translation: AAL46624.1
AF316399 mRNA Translation: AAL46625.1
AF316401 mRNA Translation: AAL46626.1
AF316402 mRNA Translation: AAL46627.1
CH471126 Genomic DNA Translation: EAW57302.1
CH471126 Genomic DNA Translation: EAW57304.1
CH471126 Genomic DNA Translation: EAW57305.1
BC001779 mRNA Translation: AAH01779.1
BC006413 mRNA Translation: AAH06413.1
BC012134 mRNA Translation: AAH12134.1
BC017224 mRNA Translation: AAH17224.1
BC047528 mRNA Translation: AAH47528.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12646.1 [O96008-1]

NCBI Reference Sequences

More...RefSeqi		NP_001122388.1, NM_001128916.1 [O96008-1]
NP_001122389.1, NM_001128917.1 [O96008-1]
NP_006105.1, NM_006114.2 [O96008-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000252487; ENSP00000252487; ENSG00000130204 [O96008-1]
ENST00000405636; ENSP00000385184; ENSG00000130204 [O96008-1]
ENST00000426677; ENSP00000410339; ENSG00000130204 [O96008-1]
ENST00000592434; ENSP00000466084; ENSG00000130204 [O96008-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10452

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10452

UCSC genome browser

More...UCSCi		uc002ozx.4, human [O96008-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF050154 Genomic DNA Translation: AAD02504.1
AF043250 mRNA Translation: AAC82342.1
AF043253, AF043251, AF043252 Genomic DNA Translation: AAC82343.1
AF316398 mRNA Translation: AAL46624.1
AF316399 mRNA Translation: AAL46625.1
AF316401 mRNA Translation: AAL46626.1
AF316402 mRNA Translation: AAL46627.1
CH471126 Genomic DNA Translation: EAW57302.1
CH471126 Genomic DNA Translation: EAW57304.1
CH471126 Genomic DNA Translation: EAW57305.1
BC001779 mRNA Translation: AAH01779.1
BC006413 mRNA Translation: AAH06413.1
BC012134 mRNA Translation: AAH12134.1
BC017224 mRNA Translation: AAH17224.1
BC047528 mRNA Translation: AAH47528.1
CCDSiCCDS12646.1 [O96008-1]
RefSeqiNP_001122388.1, NM_001128916.1 [O96008-1]
NP_001122389.1, NM_001128917.1 [O96008-1]
NP_006105.1, NM_006114.2 [O96008-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
7CK6electron microscopy3.40A/B1-361[»]
SMRiO96008
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115716, 241 interactors
ComplexPortaliCPX-6121, TOM40 mitochondrial outer membrane translocase complex
CORUMiO96008
IntActiO96008, 54 interactors
MINTiO96008
STRINGi9606.ENSP00000410339

Chemistry databases

ChEMBLiCHEMBL4523158

Protein family/group databases

TCDBi1.B.8.2.5, the mitochondrial and plastid porin (mpp) family

PTM databases

iPTMnetiO96008
MetOSiteiO96008
PhosphoSitePlusiO96008
SwissPalmiO96008

Genetic variation databases

BioMutaiTOMM40

2D gel databases

REPRODUCTION-2DPAGEiIPI00014053

Proteomic databases

EPDiO96008
jPOSTiO96008
MassIVEiO96008
MaxQBiO96008
PaxDbiO96008
PeptideAtlasiO96008
PRIDEiO96008
ProteomicsDBi51187 [O96008-1]
51188 [O96008-2]
TopDownProteomicsiO96008-1 [O96008-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3972, 148 antibodies

The DNASU plasmid repository

More...DNASUi		10452

Genome annotation databases

EnsembliENST00000252487; ENSP00000252487; ENSG00000130204 [O96008-1]
ENST00000405636; ENSP00000385184; ENSG00000130204 [O96008-1]
ENST00000426677; ENSP00000410339; ENSG00000130204 [O96008-1]
ENST00000592434; ENSP00000466084; ENSG00000130204 [O96008-2]
GeneIDi10452
KEGGihsa:10452
UCSCiuc002ozx.4, human [O96008-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10452
DisGeNETi10452

GeneCards: human genes, protein and diseases

More...GeneCardsi		TOMM40
HGNCiHGNC:18001, TOMM40
HPAiENSG00000130204, Low tissue specificity
MalaCardsiTOMM40
MIMi608061, gene
neXtProtiNX_O96008
OpenTargetsiENSG00000130204
Orphaneti1020, Early-onset autosomal dominant Alzheimer disease
PharmGKBiPA38274
VEuPathDBiHostDB:ENSG00000130204.12

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3296, Eukaryota
GeneTreeiENSGT00390000003308
HOGENOMiCLU_054399_0_0_1
InParanoidiO96008
OMAiDFRMSTF
OrthoDBi1346842at2759
PhylomeDBiO96008
TreeFamiTF106204

Enzyme and pathway databases

PathwayCommonsiO96008
ReactomeiR-HSA-1268020, Mitochondrial protein import
R-HSA-5205685, PINK1-PRKN Mediated Mitophagy

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10452, 733 hits in 1003 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TOMM40, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TOMM40

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10452
PharosiO96008, Tbio

Protein Ontology

More...PROi		PR:O96008
RNActiO96008, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000130204, Expressed in dorsal plus ventral thalamus and 253 other tissues
ExpressionAtlasiO96008, baseline and differential
GenevisibleiO96008, HS

Family and domain databases

CDDicd07305, Porin3_Tom40, 1 hit
Gene3Di2.40.160.10, 1 hit
InterProiView protein in InterPro
IPR023614, Porin_dom_sf
IPR027246, Porin_Euk/Tom40
IPR037930, Tom40
PANTHERiPTHR10802, PTHR10802, 1 hit
PfamiView protein in Pfam
PF01459, Porin_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTOM40_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O96008
Secondary accession number(s): A0A024R0P9
, Q86VW4, Q8WY09, Q8WY10, Q8WY11, Q9BR95
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: June 2, 2021
This is version 176 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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