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Protein

Molybdopterin synthase catalytic subunit

Gene

MOCS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.UniRule annotation2 Publications

Miscellaneous

This protein is produced by a bicistronic gene which also produces the small subunit (MOCS2A) from an overlapping reading frame. Expression of these 2 proteins are related since a mutation that removes the start codon of the small subunit (MOCS2A) also impairs expression of the large subunit (MOCS2B).

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: molybdopterin biosynthesis

This protein is involved in the pathway molybdopterin biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway molybdopterin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei159SubstrateUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • molybdopterin synthase activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processMolybdenum cofactor biosynthesis

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS09033-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.8.1.12 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-947581 Molybdenum cofactor biosynthesis

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00344

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Molybdopterin synthase catalytic subunitUniRule annotation (EC:2.8.1.12UniRule annotation)
Alternative name(s):
MOCO1-B
Molybdenum cofactor synthesis protein 2 large subunitUniRule annotation
Molybdenum cofactor synthesis protein 2BUniRule annotation
Short name:
MOCS2BUniRule annotation
Molybdopterin-synthase large subunit
Short name:
MPT synthase large subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MOCS2UniRule annotation
Synonyms:MCBPE, MOCO1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000164172.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7193 MOCS2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603708 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O96007

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Molybdenum cofactor deficiency, complementation group B (MOCODB)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive metabolic disorder characterized by neonatal onset of intractable seizures, opisthotonus, and facial dysmorphism associated with hypouricemia and elevated urinary sulfite levels. Affected individuals show severe neurologic damage and often die in early childhood.
See also OMIM:252160
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_012765168E → K in MOCODB. 1 PublicationCorresponds to variant dbSNP:rs121908605EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
4338

MalaCards human disease database

More...
MalaCardsi
MOCS2
MIMi252160 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000164172

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
308393 Sulfite oxidase deficiency due to molybdenum cofactor deficiency type B

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30903

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MOCS2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001631111 – 188Molybdopterin synthase catalytic subunitAdd BLAST188

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei20PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O96007

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O96007

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O96007

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O96007

PeptideAtlas

More...
PeptideAtlasi
O96007

PRoteomics IDEntifications database

More...
PRIDEi
O96007

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51186

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O96007

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O96007

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest levels are found in heart and skeletal muscle. Lower levels are present in brain, kidney and pancreas. Very low levels are found in lung and peripheral blood leukocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164172 Expressed in 219 organ(s), highest expression level in caudate nucleus

CleanEx database of gene expression profiles

More...
CleanExi
HS_MOCS2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O96007 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O96007 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA037679
HPA037680

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.UniRule annotation

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110481, 5 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
O96007

Protein interaction database and analysis system

More...
IntActi
O96007, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000380157

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1188
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AP8X-ray2.78A/B/C/D38-172[»]
5MPOX-ray2.43C/D27-179[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O96007

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O96007

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni143 – 144Substrate bindingUniRule annotation2
Regioni166 – 168Substrate bindingUniRule annotation3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MoaE family. MOCS2B subfamily.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3307 Eukaryota
COG0314 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000047669

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000280991

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O96007

KEGG Orthology (KO)

More...
KOi
K03635

Identification of Orthologs from Complete Genome Data

More...
OMAi
WKKEMYE

Database of Orthologous Groups

More...
OrthoDBi
1419096at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O96007

TreeFam database of animal gene trees

More...
TreeFami
TF314334

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00756 MoaE, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.1170.40, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_03052 MOC2B, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036563 MoaE_sf
IPR028888 MOCS2B_euk
IPR003448 Mopterin_biosynth_MoaE

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02391 MoaE, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54690 SSF54690, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O96007-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSLEISSSC FSLETKLPLS PPLVEDSAFE PSRKDMDEVE EKSKDVINFT
60 70 80 90 100
AEKLSVDEVS QLVISPLCGA ISLFVGTTRN NFEGKKVISL EYEAYLPMAE
110 120 130 140 150
NEVRKICSDI RQKWPVKHIA VFHRLGLVPV SEASIIIAVS SAHRAASLEA
160 170 180
VSYAIDTLKA KVPIWKKEIY EESSTWKGNK ECFWASNS
Length:188
Mass (Da):20,944
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF405256D85621146
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O96033MOC2A_HUMAN
Molybdopterin synthase sulfur carri...
MOCS2 MOCO1
88Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PKT9E9PKT9_HUMAN
Molybdopterin synthase sulfur carri...
MOCS2
83Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05009150T → A. Corresponds to variant dbSNP:rs2233213Ensembl.1
Natural variantiVAR_05009277T → A. Corresponds to variant dbSNP:rs2233215Ensembl.1
Natural variantiVAR_050093123H → Y. Corresponds to variant dbSNP:rs2233218EnsemblClinVar.1
Natural variantiVAR_012765168E → K in MOCODB. 1 PublicationCorresponds to variant dbSNP:rs121908605EnsemblClinVar.1
Natural variantiVAR_050094187N → S. Corresponds to variant dbSNP:rs2233221Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF091871 mRNA Translation: AAD14599.1
AF117815 mRNA Translation: AAD13297.1
AF155659 mRNA Translation: AAF67478.1
AK312887 mRNA Translation: BAG35735.1
CR457172 mRNA Translation: CAG33453.1
CH471123 Genomic DNA Translation: EAW54874.1
BC046097 mRNA Translation: AAH46097.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3958.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B59370

NCBI Reference Sequences

More...
RefSeqi
NP_004522.1, NM_004531.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.163645
Hs.594335

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000396954; ENSP00000380157; ENSG00000164172

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4338

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4338

UCSC genome browser

More...
UCSCi
uc003joz.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF091871 mRNA Translation: AAD14599.1
AF117815 mRNA Translation: AAD13297.1
AF155659 mRNA Translation: AAF67478.1
AK312887 mRNA Translation: BAG35735.1
CR457172 mRNA Translation: CAG33453.1
CH471123 Genomic DNA Translation: EAW54874.1
BC046097 mRNA Translation: AAH46097.1
CCDSiCCDS3958.1
PIRiB59370
RefSeqiNP_004522.1, NM_004531.4
UniGeneiHs.163645
Hs.594335

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AP8X-ray2.78A/B/C/D38-172[»]
5MPOX-ray2.43C/D27-179[»]
ProteinModelPortaliO96007
SMRiO96007
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110481, 5 interactors
CORUMiO96007
IntActiO96007, 5 interactors
STRINGi9606.ENSP00000380157

PTM databases

iPTMnetiO96007
PhosphoSitePlusiO96007

Polymorphism and mutation databases

BioMutaiMOCS2

Proteomic databases

EPDiO96007
jPOSTiO96007
MaxQBiO96007
PaxDbiO96007
PeptideAtlasiO96007
PRIDEiO96007
ProteomicsDBi51186

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396954; ENSP00000380157; ENSG00000164172
GeneIDi4338
KEGGihsa:4338
UCSCiuc003joz.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4338
DisGeNETi4338
EuPathDBiHostDB:ENSG00000164172.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MOCS2
HGNCiHGNC:7193 MOCS2
HPAiHPA037679
HPA037680
MalaCardsiMOCS2
MIMi252160 phenotype
603708 gene
neXtProtiNX_O96007
OpenTargetsiENSG00000164172
Orphaneti308393 Sulfite oxidase deficiency due to molybdenum cofactor deficiency type B
PharmGKBiPA30903

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3307 Eukaryota
COG0314 LUCA
GeneTreeiENSGT00510000047669
HOGENOMiHOG000280991
InParanoidiO96007
KOiK03635
OMAiWKKEMYE
OrthoDBi1419096at2759
PhylomeDBiO96007
TreeFamiTF314334

Enzyme and pathway databases

UniPathwayi
UPA00344

BioCyciMetaCyc:HS09033-MONOMER
BRENDAi2.8.1.12 2681
ReactomeiR-HSA-947581 Molybdenum cofactor biosynthesis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MOCS2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MOCS2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4338

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000164172 Expressed in 219 organ(s), highest expression level in caudate nucleus
CleanExiHS_MOCS2
ExpressionAtlasiO96007 baseline and differential
GenevisibleiO96007 HS

Family and domain databases

CDDicd00756 MoaE, 1 hit
Gene3Di3.90.1170.40, 1 hit
HAMAPiMF_03052 MOC2B, 1 hit
InterProiView protein in InterPro
IPR036563 MoaE_sf
IPR028888 MOCS2B_euk
IPR003448 Mopterin_biosynth_MoaE
PfamiView protein in Pfam
PF02391 MoaE, 1 hit
SUPFAMiSSF54690 SSF54690, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMOC2B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O96007
Secondary accession number(s): Q6IAI3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: May 1, 1999
Last modified: January 16, 2019
This is version 150 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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