UniProtKB - O96001 (PPR17_HUMAN)
Protein
Protein phosphatase 1 regulatory subunit 17
Gene
PPP1R17
Organism
Homo sapiens (Human)
Status
Functioni
Inhibits phosphatase activities of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) complexes.By similarity
GO - Molecular functioni
- protein serine/threonine phosphatase inhibitor activity Source: GO_Central
GO - Biological processi
- central nervous system development Source: UniProtKB
- intracellular signal transduction Source: UniProtKB
- regulation of phosphatase activity Source: UniProtKB
Keywordsi
Molecular function | Protein phosphatase inhibitor |
Enzyme and pathway databases
PathwayCommonsi | O96001 |
SignaLinki | O96001 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein phosphatase 1 regulatory subunit 17Alternative name(s): G-substrate |
Gene namesi | Name:PPP1R17 Synonyms:C7orf16, GSBS |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000106341.10 |
HGNCi | HGNC:16973, PPP1R17 |
MIMi | 604088, gene |
neXtProti | NX_O96001 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 10842 |
MalaCardsi | PPP1R17 |
OpenTargetsi | ENSG00000106341 |
PharmGKBi | PA134908901 |
Miscellaneous databases
Pharosi | O96001, Tbio |
Polymorphism and mutation databases
BioMutai | PPP1R17 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000083869 | 1 – 155 | Protein phosphatase 1 regulatory subunit 17Add BLAST | 155 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 68 | Phosphothreonine; by PKG/PRKG11 Publication | 1 | |
Modified residuei | 119 | Phosphothreonine; by PKG/PRKG11 Publication | 1 |
Post-translational modificationi
Substrate for cGMP-dependent protein kinase. Phosphorylated by PRKG1 isoform alpha. Phosphorylation of Thr-68 and Thr-119 is required for its phosphatase activity (By similarity).By similarity
Substrate for cGMP-dependent protein kinase.
Keywords - PTMi
PhosphoproteinProteomic databases
MassIVEi | O96001 |
PaxDbi | O96001 |
PeptideAtlasi | O96001 |
PRIDEi | O96001 |
ProteomicsDBi | 51180 [O96001-1] 51181 [O96001-2] |
PTM databases
iPTMneti | O96001 |
PhosphoSitePlusi | O96001 |
Expressioni
Tissue specificityi
Highly expressed in cerebellum.
Gene expression databases
Bgeei | ENSG00000106341, Expressed in subventricular zone (inner) (primate) and 91 other tissues |
ExpressionAtlasi | O96001, baseline and differential |
Genevisiblei | O96001, HS |
Organism-specific databases
HPAi | ENSG00000106341, Group enriched (adrenal gland, blood, brain) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 116054, 3 interactors |
STRINGi | 9606.ENSP00000340125 |
Miscellaneous databases
RNActi | O96001, protein |
Family & Domainsi
Phylogenomic databases
eggNOGi | ENOG502S50G, Eukaryota |
GeneTreei | ENSGT00390000005586 |
HOGENOMi | CLU_113768_0_0_1 |
InParanoidi | O96001 |
OMAi | PGVISEH |
OrthoDBi | 904682at2759 |
PhylomeDBi | O96001 |
TreeFami | TF335928 |
Family and domain databases
InterProi | View protein in InterPro IPR033242, PPP1R17 |
PANTHERi | PTHR15387, PTHR15387, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: O96001-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMSTEQMQPL ELSEDRLDKL DPRCSHLDDL SDQFIKDCDL KKKPRKGKNV
60 70 80 90 100
QATLNVESDQ KKPRRKDTPA LHIPPFIPGV FSEHLIKRYD VQERHPKGKM
110 120 130 140 150
IPVLHNTDLE QKKPRRKDTP ALHMSPFAAG VTLLRDERPK AIVEDDEKDG
DKIAI
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051025 | 10 | L → R. Corresponds to variant dbSNP:rs36047130EnsemblClinVar. | 1 | |
Natural variantiVAR_027838 | 12 | L → V3 PublicationsCorresponds to variant dbSNP:rs3735422Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042736 | 28 – 78 | Missing in isoform 2. 1 PublicationAdd BLAST | 51 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF071789 mRNA Translation: AAD12588.1 AF097730 mRNA Translation: AAD13030.1 AK293478 mRNA Translation: BAG56969.1 AC006325 Genomic DNA Translation: AAF03537.1 BC028094 mRNA Translation: AAH28094.1 |
CCDSi | CCDS47570.1 [O96001-2] CCDS5436.1 [O96001-1] |
RefSeqi | NP_001138595.1, NM_001145123.2 [O96001-2] NP_006649.2, NM_006658.4 [O96001-1] XP_011513396.1, XM_011515094.1 [O96001-1] |
Genome annotation databases
Ensembli | ENST00000342032; ENSP00000340125; ENSG00000106341 [O96001-1] ENST00000409146; ENSP00000386459; ENSG00000106341 [O96001-2] |
GeneIDi | 10842 |
KEGGi | hsa:10842 |
UCSCi | uc003tcl.4, human [O96001-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF071789 mRNA Translation: AAD12588.1 AF097730 mRNA Translation: AAD13030.1 AK293478 mRNA Translation: BAG56969.1 AC006325 Genomic DNA Translation: AAF03537.1 BC028094 mRNA Translation: AAH28094.1 |
CCDSi | CCDS47570.1 [O96001-2] CCDS5436.1 [O96001-1] |
RefSeqi | NP_001138595.1, NM_001145123.2 [O96001-2] NP_006649.2, NM_006658.4 [O96001-1] XP_011513396.1, XM_011515094.1 [O96001-1] |
3D structure databases
SMRi | O96001 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116054, 3 interactors |
STRINGi | 9606.ENSP00000340125 |
PTM databases
iPTMneti | O96001 |
PhosphoSitePlusi | O96001 |
Polymorphism and mutation databases
BioMutai | PPP1R17 |
Proteomic databases
MassIVEi | O96001 |
PaxDbi | O96001 |
PeptideAtlasi | O96001 |
PRIDEi | O96001 |
ProteomicsDBi | 51180 [O96001-1] 51181 [O96001-2] |
Protocols and materials databases
Antibodypediai | 26306, 143 antibodies |
Genome annotation databases
Ensembli | ENST00000342032; ENSP00000340125; ENSG00000106341 [O96001-1] ENST00000409146; ENSP00000386459; ENSG00000106341 [O96001-2] |
GeneIDi | 10842 |
KEGGi | hsa:10842 |
UCSCi | uc003tcl.4, human [O96001-1] |
Organism-specific databases
CTDi | 10842 |
DisGeNETi | 10842 |
EuPathDBi | HostDB:ENSG00000106341.10 |
GeneCardsi | PPP1R17 |
HGNCi | HGNC:16973, PPP1R17 |
HPAi | ENSG00000106341, Group enriched (adrenal gland, blood, brain) |
MalaCardsi | PPP1R17 |
MIMi | 604088, gene |
neXtProti | NX_O96001 |
OpenTargetsi | ENSG00000106341 |
PharmGKBi | PA134908901 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S50G, Eukaryota |
GeneTreei | ENSGT00390000005586 |
HOGENOMi | CLU_113768_0_0_1 |
InParanoidi | O96001 |
OMAi | PGVISEH |
OrthoDBi | 904682at2759 |
PhylomeDBi | O96001 |
TreeFami | TF335928 |
Enzyme and pathway databases
PathwayCommonsi | O96001 |
SignaLinki | O96001 |
Miscellaneous databases
BioGRID-ORCSi | 10842, 0 hits in 842 CRISPR screens |
GeneWikii | C7orf16 |
GenomeRNAii | 10842 |
Pharosi | O96001, Tbio |
PROi | PR:O96001 |
RNActi | O96001, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000106341, Expressed in subventricular zone (inner) (primate) and 91 other tissues |
ExpressionAtlasi | O96001, baseline and differential |
Genevisiblei | O96001, HS |
Family and domain databases
InterProi | View protein in InterPro IPR033242, PPP1R17 |
PANTHERi | PTHR15387, PTHR15387, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PPR17_HUMAN | |
Accessioni | O96001Primary (citable) accession number: O96001 Secondary accession number(s): B4DE58, Q9UDQ0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | January 11, 2011 | |
Last modified: | December 2, 2020 | |
This is version 139 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations