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Protein

Protein phosphatase 1 regulatory subunit 17

Gene

PPP1R17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits phosphatase activities of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) complexes.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtein phosphatase inhibitor

Enzyme and pathway databases

SignaLinkiO96001

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 17
Alternative name(s):
G-substrate
Gene namesi
Name:PPP1R17
Synonyms:C7orf16, GSBS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000106341.10
HGNCiHGNC:16973 PPP1R17
MIMi604088 gene
neXtProtiNX_O96001

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi10842
MalaCardsiPPP1R17
OpenTargetsiENSG00000106341
PharmGKBiPA134908901

Polymorphism and mutation databases

BioMutaiPPP1R17

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000838691 – 155Protein phosphatase 1 regulatory subunit 17Add BLAST155

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei68Phosphothreonine; by PKG/PRKG11 Publication1
Modified residuei119Phosphothreonine; by PKG/PRKG11 Publication1

Post-translational modificationi

Substrate for cGMP-dependent protein kinase. Phosphorylated by PRKG1 isoform alpha. Phosphorylation of Thr-68 and Thr-119 is required for its phosphatase activity (By similarity).By similarity
Substrate for cGMP-dependent protein kinase.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO96001
PeptideAtlasiO96001
PRIDEiO96001
ProteomicsDBi51180
51181 [O96001-2]

PTM databases

iPTMnetiO96001
PhosphoSitePlusiO96001

Expressioni

Tissue specificityi

Highly expressed in cerebellum.

Gene expression databases

BgeeiENSG00000106341 Expressed in 64 organ(s), highest expression level in cerebellum
CleanExiHS_C7orf16
ExpressionAtlasiO96001 baseline and differential
GenevisibleiO96001 HS

Organism-specific databases

HPAiHPA047819
HPA073123

Interactioni

Protein-protein interaction databases

BioGridi116054, 1 interactor
STRINGi9606.ENSP00000340125

Structurei

3D structure databases

ProteinModelPortaliO96001
SMRiO96001
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IMZI Eukaryota
ENOG410Y65X LUCA
GeneTreeiENSGT00390000005586
HOGENOMiHOG000069880
HOVERGENiHBG005927
InParanoidiO96001
KOiK08067
OMAiPGVISEH
OrthoDBiEOG091G0OSZ
PhylomeDBiO96001
TreeFamiTF335928

Family and domain databases

InterProiView protein in InterPro
IPR033242 PPP1R17
PANTHERiPTHR15387 PTHR15387, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O96001-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMSTEQMQPL ELSEDRLDKL DPRCSHLDDL SDQFIKDCDL KKKPRKGKNV
60 70 80 90 100
QATLNVESDQ KKPRRKDTPA LHIPPFIPGV FSEHLIKRYD VQERHPKGKM
110 120 130 140 150
IPVLHNTDLE QKKPRRKDTP ALHMSPFAAG VTLLRDERPK AIVEDDEKDG

DKIAI
Length:155
Mass (Da):17,866
Last modified:January 11, 2011 - v2
Checksum:i20D86A3B7F41AB0F
GO
Isoform 2 (identifier: O96001-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-78: Missing.

Note: No experimental confirmation available.
Show »
Length:104
Mass (Da):12,013
Checksum:i8A7B1692608775F2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05102510L → R. Corresponds to variant dbSNP:rs36047130EnsemblClinVar.1
Natural variantiVAR_02783812L → V3 PublicationsCorresponds to variant dbSNP:rs3735422Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04273628 – 78Missing in isoform 2. 1 PublicationAdd BLAST51

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071789 mRNA Translation: AAD12588.1
AF097730 mRNA Translation: AAD13030.1
AK293478 mRNA Translation: BAG56969.1
AC006325 Genomic DNA Translation: AAF03537.1
BC028094 mRNA Translation: AAH28094.1
CCDSiCCDS47570.1 [O96001-2]
CCDS5436.1 [O96001-1]
RefSeqiNP_001138595.1, NM_001145123.2 [O96001-2]
NP_006649.2, NM_006658.4 [O96001-1]
XP_011513396.1, XM_011515094.1 [O96001-1]
UniGeneiHs.227011

Genome annotation databases

EnsembliENST00000342032; ENSP00000340125; ENSG00000106341 [O96001-1]
ENST00000409146; ENSP00000386459; ENSG00000106341 [O96001-2]
GeneIDi10842
KEGGihsa:10842
UCSCiuc003tcl.4 human [O96001-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071789 mRNA Translation: AAD12588.1
AF097730 mRNA Translation: AAD13030.1
AK293478 mRNA Translation: BAG56969.1
AC006325 Genomic DNA Translation: AAF03537.1
BC028094 mRNA Translation: AAH28094.1
CCDSiCCDS47570.1 [O96001-2]
CCDS5436.1 [O96001-1]
RefSeqiNP_001138595.1, NM_001145123.2 [O96001-2]
NP_006649.2, NM_006658.4 [O96001-1]
XP_011513396.1, XM_011515094.1 [O96001-1]
UniGeneiHs.227011

3D structure databases

ProteinModelPortaliO96001
SMRiO96001
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116054, 1 interactor
STRINGi9606.ENSP00000340125

PTM databases

iPTMnetiO96001
PhosphoSitePlusiO96001

Polymorphism and mutation databases

BioMutaiPPP1R17

Proteomic databases

PaxDbiO96001
PeptideAtlasiO96001
PRIDEiO96001
ProteomicsDBi51180
51181 [O96001-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342032; ENSP00000340125; ENSG00000106341 [O96001-1]
ENST00000409146; ENSP00000386459; ENSG00000106341 [O96001-2]
GeneIDi10842
KEGGihsa:10842
UCSCiuc003tcl.4 human [O96001-1]

Organism-specific databases

CTDi10842
DisGeNETi10842
EuPathDBiHostDB:ENSG00000106341.10
GeneCardsiPPP1R17
H-InvDBiHIX0006577
HGNCiHGNC:16973 PPP1R17
HPAiHPA047819
HPA073123
MalaCardsiPPP1R17
MIMi604088 gene
neXtProtiNX_O96001
OpenTargetsiENSG00000106341
PharmGKBiPA134908901
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMZI Eukaryota
ENOG410Y65X LUCA
GeneTreeiENSGT00390000005586
HOGENOMiHOG000069880
HOVERGENiHBG005927
InParanoidiO96001
KOiK08067
OMAiPGVISEH
OrthoDBiEOG091G0OSZ
PhylomeDBiO96001
TreeFamiTF335928

Enzyme and pathway databases

SignaLinkiO96001

Miscellaneous databases

GeneWikiiC7orf16
GenomeRNAii10842
PROiPR:O96001
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106341 Expressed in 64 organ(s), highest expression level in cerebellum
CleanExiHS_C7orf16
ExpressionAtlasiO96001 baseline and differential
GenevisibleiO96001 HS

Family and domain databases

InterProiView protein in InterPro
IPR033242 PPP1R17
PANTHERiPTHR15387 PTHR15387, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPPR17_HUMAN
AccessioniPrimary (citable) accession number: O96001
Secondary accession number(s): B4DE58, Q9UDQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 11, 2011
Last modified: November 7, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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