PPP1R17

Protein namesⁱ	Recommended name: Protein phosphatase 1 regulatory subunit 17 Alternative name(s): G-substrate
Gene namesⁱ	Name:PPP1R17 Synonyms:C7orf16, GSBS
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000106341.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16973 PPP1R17
MIMⁱ	604088 gene
neXtProtⁱ	NX_O96001

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10842
MalaCards human disease database More...MalaCardsⁱ	PPP1R17
Open Targets More...OpenTargetsⁱ	ENSG00000106341
PharmGKBⁱ	PA134908901

Polymorphism and mutation databases

BioMutaⁱ	PPP1R17

BioMutaⁱ

PPP1R17

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000083869	1 – 155	Protein phosphatase 1 regulatory subunit 17Add BLAST		155

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	68	Phosphothreonine; by PKG/PRKG11 Publication		1
Modified residueⁱ	119	Phosphothreonine; by PKG/PRKG11 Publication		1

Post-translational modificationⁱ

Substrate for cGMP-dependent protein kinase. Phosphorylated by PRKG1 isoform alpha. Phosphorylation of Thr-68 and Thr-119 is required for its phosphatase activity (By similarity).By similarity

Substrate for cGMP-dependent protein kinase.

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	O96001
PeptideAtlas More...PeptideAtlasⁱ	O96001
PRIDEⁱ	O96001
ProteomicsDBⁱ	51180 51181 [O96001-2]

PTM databases

iPTMnetⁱ	O96001
PhosphoSitePlusⁱ	O96001

Expressionⁱ

Tissue specificityⁱ

Highly expressed in cerebellum.

Gene expression databases

Bgeeⁱ	ENSG00000106341 Expressed in 64 organ(s), highest expression level in cerebellum
CleanExⁱ	HS_C7orf16
ExpressionAtlasⁱ	O96001 baseline and differential
Genevisibleⁱ	O96001 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA047819 HPA073123

HPAⁱ

HPA047819
HPA073123

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	116054, 1 interactor
STRINGⁱ	9606.ENSP00000340125

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O96001
SMRⁱ	O96001
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Phylogenomic databases

eggNOGⁱ	ENOG410IMZI Eukaryota ENOG410Y65X LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000005586
HOGENOMⁱ	HOG000069880
HOVERGENⁱ	HBG005927
InParanoidⁱ	O96001
KEGG Orthology (KO) More...KOⁱ	K08067
OMAⁱ	PGVISEH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0OSZ
PhylomeDBⁱ	O96001
TreeFamⁱ	TF335928

Family and domain databases

InterProⁱ	View protein in InterPro IPR033242 PPP1R17
PANTHERⁱ	PTHR15387 PTHR15387, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: O96001-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMSTEQMQPL ELSEDRLDKL DPRCSHLDDL SDQFIKDCDL KKKPRKGKNV 
        60         70         80         90        100
QATLNVESDQ KKPRRKDTPA LHIPPFIPGV FSEHLIKRYD VQERHPKGKM 
       110        120        130        140        150
IPVLHNTDLE QKKPRRKDTP ALHMSPFAAG VTLLRDERPK AIVEDDEKDG 

DKIAI

Length:155

Mass (Da):17,866

Last modified:January 11, 2011 - v2

Checksum:ⁱ20D86A3B7F41AB0F

GO

Isoform 2 (identifier: O96001-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
28-78: Missing.

« Hide

        10         20         30         40         50
MMSTEQMQPL ELSEDRLDKL DPRCSHLGVF SEHLIKRYDV QERHPKGKMI 
        60         70         80         90        100
PVLHNTDLEQ KKPRRKDTPA LHMSPFAAGV TLLRDERPKA IVEDDEKDGD 

KIAI

Note: No experimental confirmation available.

Show »

Length:104

Mass (Da):12,013

Checksum:ⁱ8A7B1692608775F2

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_051025	10	L → R. Corresponds to variant dbSNP:rs36047130EnsemblClinVar.		1
Natural variantⁱVAR_027838	12	L → V3 PublicationsCorresponds to variant dbSNP:rs3735422Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_042736	28 – 78	Missing in isoform 2. 1 PublicationAdd BLAST		51

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF071789 mRNA Translation: AAD12588.1 AF097730 mRNA Translation: AAD13030.1 AK293478 mRNA Translation: BAG56969.1 AC006325 Genomic DNA Translation: AAF03537.1 BC028094 mRNA Translation: AAH28094.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS47570.1 [O96001-2] CCDS5436.1 [O96001-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001138595.1, NM_001145123.2 [O96001-2] NP_006649.2, NM_006658.4 [O96001-1] XP_011513396.1, XM_011515094.1 [O96001-1]
UniGeneⁱ	Hs.227011

Genome annotation databases

Ensemblⁱ	ENST00000342032; ENSP00000340125; ENSG00000106341 [O96001-1] ENST00000409146; ENSP00000386459; ENSG00000106341 [O96001-2]
GeneIDⁱ	10842
KEGGⁱ	hsa:10842
UCSC genome browser More...UCSCⁱ	uc003tcl.4 human [O96001-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
O96001	Chromosome 7 open reading frame 16		HUMAN		155	UniRef100_O96001
PPP1R17 isoform 1		PANTR		155
Uncharacterized protein		PANPA		155
Protein phosphatase 1 regulatory subunit 17		GORGO		155
O96001-2	PPP1R17 isoform 3		PANTR		104	UniRef100_A0A2I3SYD6
Uncharacterized protein		PANPA		104
Protein phosphatase 1 regulatory subunit 17		GORGO		104

Protein	Similar proteins		Species	Score	Length	Source
O96001	Chromosome 7 open reading frame 16		HUMAN		155	UniRef90_O96001
PPP1R17 isoform 1		PANTR		155
Uncharacterized protein		PANPA		155
Protein phosphatase 1 regulatory subunit 17		GORGO		155
Protein phosphatase 1 regulatory subunit 17		AILME		160
+37
O96001-2	PPP1R17 isoform 3		PANTR		104	UniRef90_A0A2I3SYD6
Uncharacterized protein		PANPA		104
Protein phosphatase 1 regulatory subunit 17		GORGO		104
Protein phosphatase 1 regulatory subunit 17		AOTNA		104
Protein phosphatase 1 regulatory subunit 17		SAIBB		104
+17

Protein	Similar proteins		Species	Score	Length	Source
O96001	Chromosome 7 open reading frame 16		HUMAN		155	UniRef50_O96001
PPP1R17 isoform 1		PANTR		155
Uncharacterized protein		PANPA		155
Protein phosphatase 1 regulatory subunit 17		GORGO		155
Protein phosphatase 1 regulatory subunit 17		AILME		160
+111
O96001-2	PPP1R17 isoform 3		PANTR		104	UniRef50_A0A2I3SYD6
Uncharacterized protein		PANPA		104
Protein phosphatase 1 regulatory subunit 17		GORGO		104
Uncharacterized protein		COLAP		104
Uncharacterized protein		PAPAN		104
+25

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF071789 mRNA Translation: AAD12588.1 AF097730 mRNA Translation: AAD13030.1 AK293478 mRNA Translation: BAG56969.1 AC006325 Genomic DNA Translation: AAF03537.1 BC028094 mRNA Translation: AAH28094.1
CCDSⁱ	CCDS47570.1 [O96001-2] CCDS5436.1 [O96001-1]
RefSeqⁱ	NP_001138595.1, NM_001145123.2 [O96001-2] NP_006649.2, NM_006658.4 [O96001-1] XP_011513396.1, XM_011515094.1 [O96001-1]
UniGeneⁱ	Hs.227011

3D structure databases

ProteinModelPortalⁱ	O96001
SMRⁱ	O96001
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116054, 1 interactor
STRINGⁱ	9606.ENSP00000340125

PTM databases

iPTMnetⁱ	O96001
PhosphoSitePlusⁱ	O96001

Polymorphism and mutation databases

BioMutaⁱ	PPP1R17

BioMutaⁱ

PPP1R17

Proteomic databases

PaxDbⁱ	O96001
PeptideAtlasⁱ	O96001
PRIDEⁱ	O96001
ProteomicsDBⁱ	51180 51181 [O96001-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000342032; ENSP00000340125; ENSG00000106341 [O96001-1] ENST00000409146; ENSP00000386459; ENSG00000106341 [O96001-2]
GeneIDⁱ	10842
KEGGⁱ	hsa:10842
UCSCⁱ	uc003tcl.4 human [O96001-1]

Organism-specific databases

CTDⁱ	10842
DisGeNETⁱ	10842
EuPathDBⁱ	HostDB:ENSG00000106341.10
GeneCardsⁱ	PPP1R17
H-InvDBⁱ	HIX0006577
HGNCⁱ	HGNC:16973 PPP1R17
HPAⁱ	HPA047819 HPA073123
MalaCardsⁱ	PPP1R17
MIMⁱ	604088 gene
neXtProtⁱ	NX_O96001
OpenTargetsⁱ	ENSG00000106341
PharmGKBⁱ	PA134908901
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IMZI Eukaryota ENOG410Y65X LUCA
GeneTreeⁱ	ENSGT00390000005586
HOGENOMⁱ	HOG000069880
HOVERGENⁱ	HBG005927
InParanoidⁱ	O96001
KOⁱ	K08067
OMAⁱ	PGVISEH
OrthoDBⁱ	EOG091G0OSZ
PhylomeDBⁱ	O96001
TreeFamⁱ	TF335928

Enzyme and pathway databases

SignaLinkⁱ	O96001

SignaLinkⁱ

O96001

Miscellaneous databases

GeneWikiⁱ	C7orf16
GenomeRNAiⁱ	10842
Protein Ontology More...PROⁱ	PR:O96001
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000106341 Expressed in 64 organ(s), highest expression level in cerebellum
CleanExⁱ	HS_C7orf16
ExpressionAtlasⁱ	O96001 baseline and differential
Genevisibleⁱ	O96001 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR033242 PPP1R17
PANTHERⁱ	PTHR15387 PTHR15387, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PPR17_HUMAN
Accessionⁱ	O96001Primary (citable) accession number: O96001 Secondary accession number(s): B4DE58, Q9UDQ0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	January 11, 2011
	Last modified:	November 7, 2018
	This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM

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UniProtKB - O96001 (PPR17_HUMAN)

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Protein phosphatase 1 regulatory subunit 17

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ