UniProtKB - O96000 (NDUBA_HUMAN)
Protein
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
Gene
NDUFB10
Organism
Homo sapiens (Human)
Status
Functioni
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.1 Publication
GO - Molecular functioni
- NADH dehydrogenase (ubiquinone) activity Source: UniProtKB
GO - Biological processi
- mitochondrial electron transport, NADH to ubiquinone Source: Reactome
- mitochondrial respiratory chain complex I assembly Source: UniProtKB
Keywordsi
Biological process | Electron transport, Respiratory chain, Transport |
Enzyme and pathway databases
BioCyci | MetaCyc:HS06786-MONOMER |
PathwayCommonsi | O96000 |
Reactomei | R-HSA-611105, Respiratory electron transport R-HSA-6799198, Complex I biogenesis |
Names & Taxonomyi
Protein namesi | Recommended name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10Alternative name(s): Complex I-PDSW Short name: CI-PDSW NADH-ubiquinone oxidoreductase PDSW subunit |
Gene namesi | Name:NDUFB10 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000140990.14 |
HGNCi | HGNC:7696, NDUFB10 |
MIMi | 603843, gene |
neXtProti | NX_O96000 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane 1 Publication; Peripheral membrane protein Curated; Matrix side Curated
Mitochondrion
- mitochondrial inner membrane Source: Reactome
- mitochondrial respiratory chain complex I Source: UniProtKB
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePathology & Biotechi
Organism-specific databases
DisGeNETi | 4716 |
MalaCardsi | NDUFB10 |
OpenTargetsi | ENSG00000140990 |
Orphaneti | 2609, Isolated complex I deficiency |
PharmGKBi | PA31502 |
Miscellaneous databases
Pharosi | O96000, Tclin |
Chemistry databases
ChEMBLi | CHEMBL2363065 |
DrugBanki | DB00157, NADH |
DrugCentrali | O96000 |
Polymorphism and mutation databases
BioMutai | NDUFB10 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000118830 | 1 – 172 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10Add BLAST | 172 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 145 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | O96000 |
jPOSTi | O96000 |
MassIVEi | O96000 |
MaxQBi | O96000 |
PaxDbi | O96000 |
PeptideAtlasi | O96000 |
PRIDEi | O96000 |
ProteomicsDBi | 51179 [O96000-1] 76829 |
TopDownProteomicsi | O96000-1 [O96000-1] |
2D gel databases
UCD-2DPAGEi | O96000 |
PTM databases
iPTMneti | O96000 |
PhosphoSitePlusi | O96000 |
SwissPalmi | O96000 |
Expressioni
Gene expression databases
Bgeei | ENSG00000140990, Expressed in left ventricle myocardium and 212 other tissues |
ExpressionAtlasi | O96000, baseline and differential |
Genevisiblei | O96000, HS |
Organism-specific databases
HPAi | ENSG00000140990, Tissue enhanced (skeletal) |
Interactioni
Subunit structurei
Complex I is composed of 45 different subunits.
2 PublicationsBinary interactionsi
Hide detailsO96000
With | #Exp. | IntAct |
---|---|---|
FAM9B [Q8IZU0] | 6 | EBI-1246371,EBI-10175124 |
HGS [O14964] | 3 | EBI-1246371,EBI-740220 |
POLR1C [O15160] | 3 | EBI-1246371,EBI-1055079 |
Protein-protein interaction databases
BioGRIDi | 110796, 90 interactors |
ComplexPortali | CPX-577, Mitochondrial respiratory chain complex I |
CORUMi | O96000 |
DIPi | DIP-38298N |
IntActi | O96000, 30 interactors |
MINTi | O96000 |
STRINGi | 9606.ENSP00000268668 |
Miscellaneous databases
RNActi | O96000, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the complex I NDUFB10 subunit family.Curated
Phylogenomic databases
eggNOGi | KOG4009, Eukaryota |
GeneTreei | ENSGT00390000006348 |
HOGENOMi | CLU_112615_1_0_1 |
InParanoidi | O96000 |
OMAi | ITWFRET |
PhylomeDBi | O96000 |
TreeFami | TF105792 |
Family and domain databases
InterProi | View protein in InterPro IPR019377, NADH_UbQ_OxRdtase_su10 IPR039993, NDUFB10 |
PANTHERi | PTHR13094, PTHR13094, 1 hit |
Pfami | View protein in Pfam PF10249, NDUFB10, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O96000-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPDSWDKDVY PEPPRRTPVQ PNPIVYMMKA FDLIVDRPVT LVREFIERQH
60 70 80 90 100
AKNRYYYYHR QYRRVPDITE CKEEDIMCMY EAEMQWKRDY KVDQEIINIM
110 120 130 140 150
QDRLKACQQR EGQNYQQNCI KEVEQFTQVA KAYQDRYQDL GAYSSARKCL
160 170
AKQRQRMLQE RKAAKEAAAA TS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BPJ9 | H3BPJ9_HUMAN | Complex I-PDSW | NDUFB10 | 161 | Annotation score: | ||
H3BV16 | H3BV16_HUMAN | Complex I-PDSW | NDUFB10 | 142 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056555 | 137 – 172 | YQDLG…AAATS → CACPTHPQPPTILLRPGGQN HCKSSLPSLVLT in isoform 2. 1 PublicationAdd BLAST | 36 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF044954 mRNA Translation: AAD05419.1 AF088995 , AF088992, AF088993, AF088994 Genomic DNA Translation: AAD16091.1 AF088991 mRNA Translation: AAD08677.1 AF067169 mRNA Translation: AAD32453.1 AC005363 Genomic DNA No translation available. CH471112 Genomic DNA Translation: EAW85597.1 BC007509 mRNA Translation: AAH07509.1 BC005829 mRNA Translation: AAH05829.1 |
CCDSi | CCDS10451.1 [O96000-1] |
PIRi | JE0381 |
RefSeqi | NP_004539.1, NM_004548.2 [O96000-1] |
Genome annotation databases
Ensembli | ENST00000268668; ENSP00000268668; ENSG00000140990 [O96000-1] ENST00000543683; ENSP00000445086; ENSG00000140990 [O96000-2] |
GeneIDi | 4716 |
KEGGi | hsa:4716 |
UCSCi | uc002cni.3, human [O96000-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF044954 mRNA Translation: AAD05419.1 AF088995 , AF088992, AF088993, AF088994 Genomic DNA Translation: AAD16091.1 AF088991 mRNA Translation: AAD08677.1 AF067169 mRNA Translation: AAD32453.1 AC005363 Genomic DNA No translation available. CH471112 Genomic DNA Translation: EAW85597.1 BC007509 mRNA Translation: AAH07509.1 BC005829 mRNA Translation: AAH05829.1 |
CCDSi | CCDS10451.1 [O96000-1] |
PIRi | JE0381 |
RefSeqi | NP_004539.1, NM_004548.2 [O96000-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5XTC | electron microscopy | 3.70 | d | 1-171 | [»] | |
5XTD | electron microscopy | 3.70 | d | 1-171 | [»] | |
5XTH | electron microscopy | 3.90 | d | 1-171 | [»] | |
5XTI | electron microscopy | 17.40 | Bd/d | 1-171 | [»] | |
SMRi | O96000 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110796, 90 interactors |
ComplexPortali | CPX-577, Mitochondrial respiratory chain complex I |
CORUMi | O96000 |
DIPi | DIP-38298N |
IntActi | O96000, 30 interactors |
MINTi | O96000 |
STRINGi | 9606.ENSP00000268668 |
Chemistry databases
ChEMBLi | CHEMBL2363065 |
DrugBanki | DB00157, NADH |
DrugCentrali | O96000 |
PTM databases
iPTMneti | O96000 |
PhosphoSitePlusi | O96000 |
SwissPalmi | O96000 |
Polymorphism and mutation databases
BioMutai | NDUFB10 |
2D gel databases
UCD-2DPAGEi | O96000 |
Proteomic databases
EPDi | O96000 |
jPOSTi | O96000 |
MassIVEi | O96000 |
MaxQBi | O96000 |
PaxDbi | O96000 |
PeptideAtlasi | O96000 |
PRIDEi | O96000 |
ProteomicsDBi | 51179 [O96000-1] 76829 |
TopDownProteomicsi | O96000-1 [O96000-1] |
Protocols and materials databases
Antibodypediai | 23340, 314 antibodies |
DNASUi | 4716 |
Genome annotation databases
Ensembli | ENST00000268668; ENSP00000268668; ENSG00000140990 [O96000-1] ENST00000543683; ENSP00000445086; ENSG00000140990 [O96000-2] |
GeneIDi | 4716 |
KEGGi | hsa:4716 |
UCSCi | uc002cni.3, human [O96000-1] |
Organism-specific databases
CTDi | 4716 |
DisGeNETi | 4716 |
EuPathDBi | HostDB:ENSG00000140990.14 |
GeneCardsi | NDUFB10 |
HGNCi | HGNC:7696, NDUFB10 |
HPAi | ENSG00000140990, Tissue enhanced (skeletal) |
MalaCardsi | NDUFB10 |
MIMi | 603843, gene |
neXtProti | NX_O96000 |
OpenTargetsi | ENSG00000140990 |
Orphaneti | 2609, Isolated complex I deficiency |
PharmGKBi | PA31502 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4009, Eukaryota |
GeneTreei | ENSGT00390000006348 |
HOGENOMi | CLU_112615_1_0_1 |
InParanoidi | O96000 |
OMAi | ITWFRET |
PhylomeDBi | O96000 |
TreeFami | TF105792 |
Enzyme and pathway databases
BioCyci | MetaCyc:HS06786-MONOMER |
PathwayCommonsi | O96000 |
Reactomei | R-HSA-611105, Respiratory electron transport R-HSA-6799198, Complex I biogenesis |
Miscellaneous databases
BioGRID-ORCSi | 4716, 321 hits in 848 CRISPR screens |
ChiTaRSi | NDUFB10, human |
GeneWikii | NDUFB10 |
GenomeRNAii | 4716 |
Pharosi | O96000, Tclin |
PROi | PR:O96000 |
RNActi | O96000, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000140990, Expressed in left ventricle myocardium and 212 other tissues |
ExpressionAtlasi | O96000, baseline and differential |
Genevisiblei | O96000, HS |
Family and domain databases
InterProi | View protein in InterPro IPR019377, NADH_UbQ_OxRdtase_su10 IPR039993, NDUFB10 |
PANTHERi | PTHR13094, PTHR13094, 1 hit |
Pfami | View protein in Pfam PF10249, NDUFB10, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NDUBA_HUMAN | |
Accessioni | O96000Primary (citable) accession number: O96000 Secondary accession number(s): Q96II6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 176 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM