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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

Gene

NDUFB10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.1 Publication

GO - Molecular functioni

  • NADH dehydrogenase (ubiquinone) activity Source: UniProtKB

GO - Biological processi

  • mitochondrial electron transport, NADH to ubiquinone Source: UniProtKB
  • mitochondrial respiratory chain complex I assembly Source: UniProtKB

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-HSA-611105 Respiratory electron transport
R-HSA-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
Alternative name(s):
Complex I-PDSW
Short name:
CI-PDSW
NADH-ubiquinone oxidoreductase PDSW subunit
Gene namesi
Name:NDUFB10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000140990.14
HGNCiHGNC:7696 NDUFB10
MIMi603843 gene
neXtProtiNX_O96000

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000140990
Orphaneti2609 Isolated complex I deficiency
PharmGKBiPA31502

Chemistry databases

ChEMBLiCHEMBL2363065
DrugBankiDB00157 NADH

Polymorphism and mutation databases

BioMutaiNDUFB10

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001188301 – 172NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10Add BLAST172

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei145PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO96000
MaxQBiO96000
PaxDbiO96000
PeptideAtlasiO96000
PRIDEiO96000
ProteomicsDBi51179
TopDownProteomicsiO96000-1 [O96000-1]

2D gel databases

UCD-2DPAGEiO96000

PTM databases

iPTMnetiO96000
PhosphoSitePlusiO96000
SwissPalmiO96000

Expressioni

Gene expression databases

BgeeiENSG00000140990 Expressed in 197 organ(s), highest expression level in left ventricle myocardium
CleanExiHS_NDUFB10
ExpressionAtlasiO96000 baseline and differential
GenevisibleiO96000 HS

Organism-specific databases

HPAiHPA073189

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FAM9BQ8IZU05EBI-1246371,EBI-10175124

Protein-protein interaction databases

BioGridi110796, 42 interactors
ComplexPortaliCPX-577 Mitochondrial respiratory chain complex I
CORUMiO96000
DIPiDIP-38298N
IntActiO96000, 25 interactors
MINTiO96000
STRINGi9606.ENSP00000268668

Structurei

3D structure databases

ProteinModelPortaliO96000
SMRiO96000
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFB10 subunit family.Curated

Phylogenomic databases

eggNOGiKOG4009 Eukaryota
ENOG4111MMM LUCA
GeneTreeiENSGT00390000006348
HOGENOMiHOG000090968
HOVERGENiHBG003196
InParanoidiO96000
KOiK03966
OMAiYYSARKC
OrthoDBiEOG091G1BQN
PhylomeDBiO96000
TreeFamiTF105792

Family and domain databases

InterProiView protein in InterPro
IPR019377 NADH_UbQ_OxRdtase_su10
IPR039993 NDUFB10
PANTHERiPTHR13094 PTHR13094, 1 hit
PfamiView protein in Pfam
PF10249 NDUFB10, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O96000-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPDSWDKDVY PEPPRRTPVQ PNPIVYMMKA FDLIVDRPVT LVREFIERQH
60 70 80 90 100
AKNRYYYYHR QYRRVPDITE CKEEDIMCMY EAEMQWKRDY KVDQEIINIM
110 120 130 140 150
QDRLKACQQR EGQNYQQNCI KEVEQFTQVA KAYQDRYQDL GAYSSARKCL
160 170
AKQRQRMLQE RKAAKEAAAA TS
Length:172
Mass (Da):20,777
Last modified:January 23, 2007 - v3
Checksum:iA5E6561402F4486A
GO
Isoform 2 (identifier: O96000-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     137-172: YQDLGAYSSARKCLAKQRQRMLQERKAAKEAAAATS → CACPTHPQPPTILLRPGGQNHCKSSLPSLVLT

Note: No experimental confirmation available.
Show »
Length:168
Mass (Da):20,143
Checksum:i0233CEC9A1DDF5D0
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BPJ9H3BPJ9_HUMAN
NADH dehydrogenase [ubiquinone] 1 b...
NDUFB10
161Annotation score:
H3BV16H3BV16_HUMAN
NADH dehydrogenase [ubiquinone] 1 b...
NDUFB10
142Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056555137 – 172YQDLG…AAATS → CACPTHPQPPTILLRPGGQN HCKSSLPSLVLT in isoform 2. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044954 mRNA Translation: AAD05419.1
AF088995
, AF088992, AF088993, AF088994 Genomic DNA Translation: AAD16091.1
AF088991 mRNA Translation: AAD08677.1
AF067169 mRNA Translation: AAD32453.1
AC005363 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85597.1
BC007509 mRNA Translation: AAH07509.1
BC005829 mRNA Translation: AAH05829.1
CCDSiCCDS10451.1 [O96000-1]
PIRiJE0381
RefSeqiNP_004539.1, NM_004548.2 [O96000-1]
UniGeneiHs.513266

Genome annotation databases

EnsembliENST00000268668; ENSP00000268668; ENSG00000140990 [O96000-1]
ENST00000543683; ENSP00000445086; ENSG00000140990 [O96000-2]
GeneIDi4716
KEGGihsa:4716
UCSCiuc002cni.3 human [O96000-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044954 mRNA Translation: AAD05419.1
AF088995
, AF088992, AF088993, AF088994 Genomic DNA Translation: AAD16091.1
AF088991 mRNA Translation: AAD08677.1
AF067169 mRNA Translation: AAD32453.1
AC005363 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85597.1
BC007509 mRNA Translation: AAH07509.1
BC005829 mRNA Translation: AAH05829.1
CCDSiCCDS10451.1 [O96000-1]
PIRiJE0381
RefSeqiNP_004539.1, NM_004548.2 [O96000-1]
UniGeneiHs.513266

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XTCelectron microscopy3.70d1-171[»]
5XTDelectron microscopy3.70d1-171[»]
5XTHelectron microscopy3.90d1-171[»]
5XTIelectron microscopy17.40Bd/d1-171[»]
ProteinModelPortaliO96000
SMRiO96000
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110796, 42 interactors
ComplexPortaliCPX-577 Mitochondrial respiratory chain complex I
CORUMiO96000
DIPiDIP-38298N
IntActiO96000, 25 interactors
MINTiO96000
STRINGi9606.ENSP00000268668

Chemistry databases

ChEMBLiCHEMBL2363065
DrugBankiDB00157 NADH

PTM databases

iPTMnetiO96000
PhosphoSitePlusiO96000
SwissPalmiO96000

Polymorphism and mutation databases

BioMutaiNDUFB10

2D gel databases

UCD-2DPAGEiO96000

Proteomic databases

EPDiO96000
MaxQBiO96000
PaxDbiO96000
PeptideAtlasiO96000
PRIDEiO96000
ProteomicsDBi51179
TopDownProteomicsiO96000-1 [O96000-1]

Protocols and materials databases

DNASUi4716
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268668; ENSP00000268668; ENSG00000140990 [O96000-1]
ENST00000543683; ENSP00000445086; ENSG00000140990 [O96000-2]
GeneIDi4716
KEGGihsa:4716
UCSCiuc002cni.3 human [O96000-1]

Organism-specific databases

CTDi4716
EuPathDBiHostDB:ENSG00000140990.14
GeneCardsiNDUFB10
HGNCiHGNC:7696 NDUFB10
HPAiHPA073189
MIMi603843 gene
neXtProtiNX_O96000
OpenTargetsiENSG00000140990
Orphaneti2609 Isolated complex I deficiency
PharmGKBiPA31502
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4009 Eukaryota
ENOG4111MMM LUCA
GeneTreeiENSGT00390000006348
HOGENOMiHOG000090968
HOVERGENiHBG003196
InParanoidiO96000
KOiK03966
OMAiYYSARKC
OrthoDBiEOG091G1BQN
PhylomeDBiO96000
TreeFamiTF105792

Enzyme and pathway databases

ReactomeiR-HSA-611105 Respiratory electron transport
R-HSA-6799198 Complex I biogenesis

Miscellaneous databases

ChiTaRSiNDUFB10 human
GeneWikiiNDUFB10
GenomeRNAii4716
PROiPR:O96000
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140990 Expressed in 197 organ(s), highest expression level in left ventricle myocardium
CleanExiHS_NDUFB10
ExpressionAtlasiO96000 baseline and differential
GenevisibleiO96000 HS

Family and domain databases

InterProiView protein in InterPro
IPR019377 NADH_UbQ_OxRdtase_su10
IPR039993 NDUFB10
PANTHERiPTHR13094 PTHR13094, 1 hit
PfamiView protein in Pfam
PF10249 NDUFB10, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNDUBA_HUMAN
AccessioniPrimary (citable) accession number: O96000
Secondary accession number(s): Q96II6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 162 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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