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UniProtKB - O96000 (NDUBA_HUMAN)

Entry version 180 (29 Sep 2021)
Sequence version 3 (23 Jan 2007)
Previous versions | rss
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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

Gene

NDUFB10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain.

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS06786-MONOMER

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O96000

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-611105, Respiratory electron transport
R-HSA-6799198, Complex I biogenesis

SIGNOR Signaling Network Open Resource

More...SIGNORi		O96000

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
Alternative name(s):
Complex I-PDSW
Short name:
CI-PDSW
NADH-ubiquinone oxidoreductase PDSW subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NDUFB10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7696, NDUFB10

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603843, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O96000

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000140990

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mitochondrial complex I deficiency, nuclear type 35 (MC1DN35)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of mitochondrial complex I deficiency, the most common biochemical signature of mitochondrial disorders, a group of highly heterogeneous conditions characterized by defective oxidative phosphorylation, which collectively affects 1 in 5-10000 live births. Clinical disorders have variable severity, ranging from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease. MC1DN35 transmission pattern is consistent with autosomal recessive inheritance.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_084767107C → S in MC1DN35; decreased protein abundance; decreased CHCHD4-mediated oxidation; loss of mitochondrial localization; retained in the cytosol; loss of function in mitochondrial respiratory chain complex I assembly. 1 Publication1

Keywords - Diseasei

Disease variant, Primary mitochondrial disease

Organism-specific databases

DisGeNET

More...DisGeNETi		4716

MalaCards human disease database

More...MalaCardsi		NDUFB10
MIMi619003, phenotype

Open Targets

More...OpenTargetsi		ENSG00000140990

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		2609, Isolated complex I deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31502

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O96000, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2363065

Drug and drug target database

More...DrugBanki		DB00157, NADH

DrugCentral

More...DrugCentrali		O96000

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NDUFB10

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001188301 – 172NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10Add BLAST172

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei145PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The formation of intramolecular disulfide bonds is assisted by CHCHD4 and ensures folding, import into the mitochondrion and is required for the function in mitochondrial respiratory chain complex I assembly.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O96000

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O96000

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O96000

MaxQB - The MaxQuant DataBase

More...MaxQBi		O96000

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O96000

PeptideAtlas

More...PeptideAtlasi		O96000

PRoteomics IDEntifications database

More...PRIDEi		O96000

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51179 [O96000-1]
76829

Consortium for Top Down Proteomics

More...TopDownProteomicsi		O96000-1 [O96000-1]

2D gel databases

University College Dublin 2-DE Proteome Database

More...UCD-2DPAGEi		O96000

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O96000, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O96000

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O96000

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O96000

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000140990, Expressed in left ventricle myocardium and 213 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O96000, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O96000, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000140990, Tissue enhanced (skeletal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Complex I is composed of 45 different subunits (PubMed:12611891, PubMed:27626371, PubMed:28040730).

Interacts with CHCHD4; assists NDUFB10 oxidation, folding and import into mitochondrion (PubMed:28040730).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110796, 113 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-577, Mitochondrial respiratory chain complex I

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O96000

Database of interacting proteins

More...DIPi		DIP-38298N

Protein interaction database and analysis system

More...IntActi		O96000, 37 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000268668

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		O96000

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O96000, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O96000

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the complex I NDUFB10 subunit family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4009, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000006348

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_112615_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O96000

Identification of Orthologs from Complete Genome Data

More...OMAi		ERMKACQ

Database for complete collections of gene phylogenies

More...PhylomeDBi		O96000

TreeFam database of animal gene trees

More...TreeFami		TF105792

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR019377, NADH_UbQ_OxRdtase_su10
IPR039993, NDUFB10

The PANTHER Classification System

More...PANTHERi		PTHR13094, PTHR13094, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10249, NDUFB10, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O96000-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPDSWDKDVY PEPPRRTPVQ PNPIVYMMKA FDLIVDRPVT LVREFIERQH 
        60         70         80         90        100
AKNRYYYYHR QYRRVPDITE CKEEDIMCMY EAEMQWKRDY KVDQEIINIM 
       110        120        130        140        150
QDRLKACQQR EGQNYQQNCI KEVEQFTQVA KAYQDRYQDL GAYSSARKCL 
       160        170 
AKQRQRMLQE RKAAKEAAAA TS
Length:172
Mass (Da):20,777
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA5E6561402F4486A
GO
Isoform 2 (identifier: O96000-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     137-172: YQDLGAYSSARKCLAKQRQRMLQERKAAKEAAAATS → CACPTHPQPPTILLRPGGQNHCKSSLPSLVLT

Show »
Length:168
Mass (Da):20,143
Checksum:i0233CEC9A1DDF5D0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BPJ9H3BPJ9_HUMAN
Complex I-PDSW
NDUFB10
161Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BV16H3BV16_HUMAN
Complex I-PDSW
NDUFB10
142Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_084767107C → S in MC1DN35; decreased protein abundance; decreased CHCHD4-mediated oxidation; loss of mitochondrial localization; retained in the cytosol; loss of function in mitochondrial respiratory chain complex I assembly. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_056555137 – 172YQDLG…AAATS → CACPTHPQPPTILLRPGGQN HCKSSLPSLVLT in isoform 2. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF044954 mRNA Translation: AAD05419.1
AF088995 AF088994 Genomic DNA Translation: AAD16091.1
AF088991 mRNA Translation: AAD08677.1
AF067169 mRNA Translation: AAD32453.1
AC005363 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85597.1
BC007509 mRNA Translation: AAH07509.1
BC005829 mRNA Translation: AAH05829.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10451.1 [O96000-1]

Protein sequence database of the Protein Information Resource

More...PIRi		JE0381

NCBI Reference Sequences

More...RefSeqi		NP_004539.1, NM_004548.2 [O96000-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000268668; ENSP00000268668; ENSG00000140990 [O96000-1]
ENST00000543683; ENSP00000445086; ENSG00000140990 [O96000-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4716

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4716

UCSC genome browser

More...UCSCi		uc002cni.3, human [O96000-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044954 mRNA Translation: AAD05419.1
AF088995 AF088994 Genomic DNA Translation: AAD16091.1
AF088991 mRNA Translation: AAD08677.1
AF067169 mRNA Translation: AAD32453.1
AC005363 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85597.1
BC007509 mRNA Translation: AAH07509.1
BC005829 mRNA Translation: AAH05829.1
CCDSiCCDS10451.1 [O96000-1]
PIRiJE0381
RefSeqiNP_004539.1, NM_004548.2 [O96000-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XTCelectron microscopy3.70d1-171[»]
5XTDelectron microscopy3.70d1-171[»]
5XTHelectron microscopy3.90d1-171[»]
5XTIelectron microscopy17.40Bd/d1-171[»]
SMRiO96000
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110796, 113 interactors
ComplexPortaliCPX-577, Mitochondrial respiratory chain complex I
CORUMiO96000
DIPiDIP-38298N
IntActiO96000, 37 interactors
STRINGi9606.ENSP00000268668

Chemistry databases

BindingDBiO96000
ChEMBLiCHEMBL2363065
DrugBankiDB00157, NADH
DrugCentraliO96000

PTM databases

GlyGeniO96000, 1 site, 1 O-linked glycan (1 site)
iPTMnetiO96000
PhosphoSitePlusiO96000
SwissPalmiO96000

Genetic variation databases

BioMutaiNDUFB10

2D gel databases

UCD-2DPAGEiO96000

Proteomic databases

EPDiO96000
jPOSTiO96000
MassIVEiO96000
MaxQBiO96000
PaxDbiO96000
PeptideAtlasiO96000
PRIDEiO96000
ProteomicsDBi51179 [O96000-1]
76829
TopDownProteomicsiO96000-1 [O96000-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23340, 328 antibodies

The DNASU plasmid repository

More...DNASUi		4716

Genome annotation databases

EnsembliENST00000268668; ENSP00000268668; ENSG00000140990 [O96000-1]
ENST00000543683; ENSP00000445086; ENSG00000140990 [O96000-2]
GeneIDi4716
KEGGihsa:4716
UCSCiuc002cni.3, human [O96000-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4716
DisGeNETi4716

GeneCards: human genes, protein and diseases

More...GeneCardsi		NDUFB10
HGNCiHGNC:7696, NDUFB10
HPAiENSG00000140990, Tissue enhanced (skeletal)
MalaCardsiNDUFB10
MIMi603843, gene
619003, phenotype
neXtProtiNX_O96000
OpenTargetsiENSG00000140990
Orphaneti2609, Isolated complex I deficiency
PharmGKBiPA31502
VEuPathDBiHostDB:ENSG00000140990

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4009, Eukaryota
GeneTreeiENSGT00390000006348
HOGENOMiCLU_112615_1_0_1
InParanoidiO96000
OMAiERMKACQ
PhylomeDBiO96000
TreeFamiTF105792

Enzyme and pathway databases

BioCyciMetaCyc:HS06786-MONOMER
PathwayCommonsiO96000
ReactomeiR-HSA-611105, Respiratory electron transport
R-HSA-6799198, Complex I biogenesis
SIGNORiO96000

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4716, 345 hits in 1028 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NDUFB10, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		NDUFB10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4716
PharosiO96000, Tclin

Protein Ontology

More...PROi		PR:O96000
RNActiO96000, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000140990, Expressed in left ventricle myocardium and 213 other tissues
ExpressionAtlasiO96000, baseline and differential
GenevisibleiO96000, HS

Family and domain databases

InterProiView protein in InterPro
IPR019377, NADH_UbQ_OxRdtase_su10
IPR039993, NDUFB10
PANTHERiPTHR13094, PTHR13094, 1 hit
PfamiView protein in Pfam
PF10249, NDUFB10, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNDUBA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O96000
Secondary accession number(s): Q96II6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 23, 2007
Last modified: September 29, 2021
This is version 180 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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