NDUFB10

Functionⁱ

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.1 Publication

GO - Molecular functionⁱ

NADH dehydrogenase (ubiquinone) activity
Source: UniProtKB
Non-traceable author statementⁱ
- 9878551

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mitochondrial electron transport, NADH to ubiquinone
Source: UniProtKB
Non-traceable author statementⁱ
- 9878551
mitochondrial respiratory chain complex I assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 27626371

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Electron transport, Respiratory chain, Transport

Biological process

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-611105 Respiratory electron transport R-HSA-6799198 Complex I biogenesis

Reactomeⁱ

R-HSA-611105 Respiratory electron transport
R-HSA-6799198 Complex I biogenesis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 Alternative name(s): Complex I-PDSW Short name: CI-PDSW NADH-ubiquinone oxidoreductase PDSW subunit
Gene namesⁱ	Name:NDUFB10
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000140990.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7696 NDUFB10
MIMⁱ	603843 gene
neXtProtⁱ	NX_O96000

Keywords - Cellular componentⁱ

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000140990
Orphanetⁱ	2609 Isolated complex I deficiency
PharmGKBⁱ	PA31502

Chemistry databases

ChEMBLⁱ	CHEMBL2363065
Drug and drug target database More...DrugBankⁱ	DB00157 NADH

Polymorphism and mutation databases

BioMutaⁱ	NDUFB10

BioMutaⁱ

NDUFB10

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000118830	1 – 172	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10Add BLAST		172

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	145	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	O96000
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O96000
PaxDbⁱ	O96000
PeptideAtlas More...PeptideAtlasⁱ	O96000
PRIDEⁱ	O96000
ProteomicsDBⁱ	51179
TopDownProteomicsⁱ	O96000-1 [O96000-1]

2D gel databases

UCD-2DPAGEⁱ	O96000

UCD-2DPAGEⁱ

O96000

PTM databases

iPTMnetⁱ	O96000
PhosphoSitePlusⁱ	O96000
SwissPalmⁱ	O96000

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000140990 Expressed in 197 organ(s), highest expression level in left ventricle myocardium
CleanExⁱ	HS_NDUFB10
ExpressionAtlasⁱ	O96000 baseline and differential
Genevisibleⁱ	O96000 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA073189

HPAⁱ

HPA073189

Interactionⁱ

Subunit structureⁱ

Complex I is composed of 45 different subunits.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
FAM9B	Q8IZU0	5	EBI-1246371,EBI-10175124

With

Entry

#Exp.

IntAct

Notes

FAM9B

Q8IZU0

5

EBI-1246371,EBI-10175124

Protein-protein interaction databases

BioGridⁱ	110796, 42 interactors
ComplexPortalⁱ	CPX-577 Mitochondrial respiratory chain complex I
CORUMⁱ	O96000
Database of interacting proteins More...DIPⁱ	DIP-38298N
IntActⁱ	O96000, 25 interactors
Molecular INTeraction database More...MINTⁱ	O96000
STRINGⁱ	9606.ENSP00000268668

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O96000
SMRⁱ	O96000
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the complex I NDUFB10 subunit family.Curated

Phylogenomic databases

eggNOGⁱ	KOG4009 Eukaryota ENOG4111MMM LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000006348
HOGENOMⁱ	HOG000090968
HOVERGENⁱ	HBG003196
InParanoidⁱ	O96000
KEGG Orthology (KO) More...KOⁱ	K03966
OMAⁱ	YYSARKC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G1BQN
PhylomeDBⁱ	O96000
TreeFamⁱ	TF105792

Family and domain databases

InterProⁱ	View protein in InterPro IPR019377 NADH_UbQ_OxRdtase_su10 IPR039993 NDUFB10
PANTHERⁱ	PTHR13094 PTHR13094, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10249 NDUFB10, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O96000-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPDSWDKDVY PEPPRRTPVQ PNPIVYMMKA FDLIVDRPVT LVREFIERQH 
        60         70         80         90        100
AKNRYYYYHR QYRRVPDITE CKEEDIMCMY EAEMQWKRDY KVDQEIINIM 
       110        120        130        140        150
QDRLKACQQR EGQNYQQNCI KEVEQFTQVA KAYQDRYQDL GAYSSARKCL 
       160        170 
AKQRQRMLQE RKAAKEAAAA TS

Length:172

Mass (Da):20,777

Last modified:January 23, 2007 - v3

Checksum:ⁱA5E6561402F4486A

GO

Isoform 2 (identifier: O96000-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
137-172: YQDLGAYSSARKCLAKQRQRMLQERKAAKEAAAATS → CACPTHPQPPTILLRPGGQNHCKSSLPSLVLT

« Hide

        10         20         30         40         50
MPDSWDKDVY PEPPRRTPVQ PNPIVYMMKA FDLIVDRPVT LVREFIERQH 
        60         70         80         90        100
AKNRYYYYHR QYRRVPDITE CKEEDIMCMY EAEMQWKRDY KVDQEIINIM 
       110        120        130        140        150
QDRLKACQQR EGQNYQQNCI KEVEQFTQVA KAYQDRCACP THPQPPTILL 
       160 
RPGGQNHCKS SLPSLVLT

Note: No experimental confirmation available.

Show »

Length:168

Mass (Da):20,143

Checksum:ⁱ0233CEC9A1DDF5D0

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H3BPJ9	H3BPJ9_HUMAN	NADH dehydrogenase [ubiquinone] 1 b... NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	NDUFB10	161	Annotation score:
H3BV16	H3BV16_HUMAN	NADH dehydrogenase [ubiquinone] 1 b... NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	NDUFB10	142	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056555	137 – 172	YQDLG…AAATS → CACPTHPQPPTILLRPGGQN HCKSSLPSLVLT in isoform 2. 1 PublicationAdd BLAST		36

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF044954 mRNA Translation: AAD05419.1 AF088995 , AF088992, AF088993, AF088994 Genomic DNA Translation: AAD16091.1 AF088991 mRNA Translation: AAD08677.1 AF067169 mRNA Translation: AAD32453.1 AC005363 Genomic DNA No translation available. CH471112 Genomic DNA Translation: EAW85597.1 BC007509 mRNA Translation: AAH07509.1 BC005829 mRNA Translation: AAH05829.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10451.1 [O96000-1]
PIRⁱ	JE0381
NCBI Reference Sequences More...RefSeqⁱ	NP_004539.1, NM_004548.2 [O96000-1]
UniGeneⁱ	Hs.513266

Genome annotation databases

Ensemblⁱ	ENST00000268668; ENSP00000268668; ENSG00000140990 [O96000-1] ENST00000543683; ENSP00000445086; ENSG00000140990 [O96000-2]
GeneIDⁱ	4716
KEGGⁱ	hsa:4716
UCSC genome browser More...UCSCⁱ	uc002cni.3 human [O96000-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O96000	NADH dehydrogenase (Ubiquinone) 1 beta subcomplex, 10, 22kDa, isoform CRA_b		HUMAN		172	UniRef100_O96000
NADH ubiquinone oxidoreductase PDSW subunit (RH 16p13.3) (Fragment)		HUMAN		43
UPI000BA4E5EC		HUMAN		171

Protein	Similar proteins		Species	Score	Length	Source
O96000	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10		GORGO		172	UniRef90_O96000
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10		PONPY		172
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10		PANTR		172
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10		PONAB		172
NADH dehydrogenase (Ubiquinone) 1 beta subcomplex, 10, 22kDa, isoform CRA_b		HUMAN		172
+10
O96000-2	NDUFB10 isoform 3		PANTR		168	UniRef90_O96000-2
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10		GORGO		168
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 (Fragment)		HUMAN		142
NDUFB10 isoform 5 (Fragment)		PANTR		143

Protein	Similar proteins		Species	Score	Length	Source
O96000	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10		PONAB		172	UniRef50_O96000
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10		PANTR		172
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10		GORGO		172
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10		PONPY		172
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	)	BOVIN		176
+202

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF044954 mRNA Translation: AAD05419.1 AF088995 , AF088992, AF088993, AF088994 Genomic DNA Translation: AAD16091.1 AF088991 mRNA Translation: AAD08677.1 AF067169 mRNA Translation: AAD32453.1 AC005363 Genomic DNA No translation available. CH471112 Genomic DNA Translation: EAW85597.1 BC007509 mRNA Translation: AAH07509.1 BC005829 mRNA Translation: AAH05829.1
CCDSⁱ	CCDS10451.1 [O96000-1]
PIRⁱ	JE0381
RefSeqⁱ	NP_004539.1, NM_004548.2 [O96000-1]
UniGeneⁱ	Hs.513266

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5XTC	electron microscopy	3.70	d	1-171	[»]
	5XTD	electron microscopy	3.70	d	1-171	[»]
	5XTH	electron microscopy	3.90	d	1-171	[»]
	5XTI	electron microscopy	17.40	Bd/d	1-171	[»]
ProteinModelPortalⁱ	O96000
SMRⁱ	O96000
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110796, 42 interactors
ComplexPortalⁱ	CPX-577 Mitochondrial respiratory chain complex I
CORUMⁱ	O96000
DIPⁱ	DIP-38298N
IntActⁱ	O96000, 25 interactors
MINTⁱ	O96000
STRINGⁱ	9606.ENSP00000268668

Chemistry databases

ChEMBLⁱ	CHEMBL2363065
DrugBankⁱ	DB00157 NADH

PTM databases

iPTMnetⁱ	O96000
PhosphoSitePlusⁱ	O96000
SwissPalmⁱ	O96000

Polymorphism and mutation databases

BioMutaⁱ	NDUFB10

BioMutaⁱ

NDUFB10

2D gel databases

UCD-2DPAGEⁱ	O96000

UCD-2DPAGEⁱ

O96000

Proteomic databases

EPDⁱ	O96000
MaxQBⁱ	O96000
PaxDbⁱ	O96000
PeptideAtlasⁱ	O96000
PRIDEⁱ	O96000
ProteomicsDBⁱ	51179
TopDownProteomicsⁱ	O96000-1 [O96000-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	4716
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000268668; ENSP00000268668; ENSG00000140990 [O96000-1] ENST00000543683; ENSP00000445086; ENSG00000140990 [O96000-2]
GeneIDⁱ	4716
KEGGⁱ	hsa:4716
UCSCⁱ	uc002cni.3 human [O96000-1]

Organism-specific databases

CTDⁱ	4716
EuPathDBⁱ	HostDB:ENSG00000140990.14
GeneCardsⁱ	NDUFB10
HGNCⁱ	HGNC:7696 NDUFB10
HPAⁱ	HPA073189
MIMⁱ	603843 gene
neXtProtⁱ	NX_O96000
OpenTargetsⁱ	ENSG00000140990
Orphanetⁱ	2609 Isolated complex I deficiency
PharmGKBⁱ	PA31502
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4009 Eukaryota ENOG4111MMM LUCA
GeneTreeⁱ	ENSGT00390000006348
HOGENOMⁱ	HOG000090968
HOVERGENⁱ	HBG003196
InParanoidⁱ	O96000
KOⁱ	K03966
OMAⁱ	YYSARKC
OrthoDBⁱ	EOG091G1BQN
PhylomeDBⁱ	O96000
TreeFamⁱ	TF105792

Enzyme and pathway databases

Reactomeⁱ	R-HSA-611105 Respiratory electron transport R-HSA-6799198 Complex I biogenesis

Reactomeⁱ

R-HSA-611105 Respiratory electron transport
R-HSA-6799198 Complex I biogenesis

Miscellaneous databases

ChiTaRSⁱ	NDUFB10 human
GeneWikiⁱ	NDUFB10
GenomeRNAiⁱ	4716
Protein Ontology More...PROⁱ	PR:O96000
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000140990 Expressed in 197 organ(s), highest expression level in left ventricle myocardium
CleanExⁱ	HS_NDUFB10
ExpressionAtlasⁱ	O96000 baseline and differential
Genevisibleⁱ	O96000 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR019377 NADH_UbQ_OxRdtase_su10 IPR039993 NDUFB10
PANTHERⁱ	PTHR13094 PTHR13094, 1 hit
Pfamⁱ	View protein in Pfam PF10249 NDUFB10, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NDUBA_HUMAN
Accessionⁱ	O96000Primary (citable) accession number: O96000 Secondary accession number(s): Q96II6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 162 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - O96000 (NDUBA_HUMAN)

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NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ