B-cell lymphoma/leukemia 10

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• CARD domain binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation."
    Gaide O., Favier B., Legler D.F., Bonnet D., Brissoni B., Valitutti S., Bron C., Tschopp J., Thome M.
    Nat Immunol 3:836-843(2002) [PubMed] [Europe PMC] [Abstract]
• enzyme binding Source: UniProtKBInferred from physical interactionⁱ
  • "Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO."
    Zhou H., Wertz I., O'Rourke K., Ultsch M., Seshagiri S., Eby M., Xiao W., Dixit V.M.
    Nature 427:167-171(2004) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: IntActInferred from physical interactionⁱ
  • Ref.3

    "Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase."
    Thome M., Martinon F., Hofmann K., Rubio V., Steiner V., Schneider P., Mattmann C., Tschopp J.
    J. Biol. Chem. 274:9962-9968(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  • "A proteome-scale map of the human interactome network."
    Rolland T., Tasan M., Charloteaux B., Pevzner S.J., Zhong Q., Sahni N., Yi S., Lemmens I., Fontanillo C., Mosca R., Kamburov A., Ghiassian S.D., Yang X., Ghamsari L., Balcha D., Begg B.E., Braun P., Brehme M.

    , Broly M.P., Carvunis A.R., Convery-Zupan D., Corominas R., Coulombe-Huntington J., Dann E., Dreze M., Dricot A., Fan C., Franzosa E., Gebreab F., Gutierrez B.J., Hardy M.F., Jin M., Kang S., Kiros R., Lin G.N., Luck K., MacWilliams A., Menche J., Murray R.R., Palagi A., Poulin M.M., Rambout X., Rasla J., Reichert P., Romero V., Ruyssinck E., Sahalie J.M., Scholz A., Shah A.A., Sharma A., Shen Y., Spirohn K., Tam S., Tejeda A.O., Trigg S.A., Twizere J.C., Vega K., Walsh J., Cusick M.E., Xia Y., Barabasi A.L., Iakoucheva L.M., Aloy P., De Las Rivas J., Tavernier J., Calderwood M.A., Hill D.E., Hao T., Roth F.P., Vidal M.
    Cell 159:1212-1226(2014) [PubMed] [Europe PMC] [Abstract]
  • "A reference map of the human binary protein interactome."
    Luck K., Kim D.K., Lambourne L., Spirohn K., Begg B.E., Bian W., Brignall R., Cafarelli T., Campos-Laborie F.J., Charloteaux B., Choi D., Cote A.G., Daley M., Deimling S., Desbuleux A., Dricot A., Gebbia M., Hardy M.F.

    , Kishore N., Knapp J.J., Kovacs I.A., Lemmens I., Mee M.W., Mellor J.C., Pollis C., Pons C., Richardson A.D., Schlabach S., Teeking B., Yadav A., Babor M., Balcha D., Basha O., Bowman-Colin C., Chin S.F., Choi S.G., Colabella C., Coppin G., D'Amata C., De Ridder D., De Rouck S., Duran-Frigola M., Ennajdaoui H., Goebels F., Goehring L., Gopal A., Haddad G., Hatchi E., Helmy M., Jacob Y., Kassa Y., Landini S., Li R., van Lieshout N., MacWilliams A., Markey D., Paulson J.N., Rangarajan S., Rasla J., Rayhan A., Rolland T., San-Miguel A., Shen Y., Sheykhkarimli D., Sheynkman G.M., Simonovsky E., Tasan M., Tejeda A., Tropepe V., Twizere J.C., Wang Y., Weatheritt R.J., Weile J., Xia Y., Yang X., Yeger-Lotem E., Zhong Q., Aloy P., Bader G.D., De Las Rivas J., Gaudet S., Hao T., Rak J., Tavernier J., Hill D.E., Vidal M., Roth F.P., Calderwood M.A.
    Nature 580:402-408(2020) [PubMed] [Europe PMC] [Abstract]
• kinase binding Source: UniProtKBInferred from physical interactionⁱ
  • "The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4."
    Dong W., Liu Y., Peng J., Chen L., Zou T., Xiao H., Liu Z., Li W., Bu Y., Qi Y.
    J Biol Chem 281:26029-26040(2006) [PubMed] [Europe PMC] [Abstract]
  • "Bcl10 is phosphorylated on Ser138 by Ca2+/calmodulin-dependent protein kinase II."
    Ishiguro K., Ando T., Goto H., Xavier R.
    Mol Immunol 44:2095-2100(2007) [PubMed] [Europe PMC] [Abstract]
• NF-kappaB binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "A pathway for tumor necrosis factor-alpha-induced Bcl10 nuclear translocation. Bcl10 is up-regulated by NF-kappaB and phosphorylated by Akt1 and then complexes with Bcl3 to enter the nucleus."
    Yeh P.Y., Kuo S.H., Yeh K.H., Chuang S.E., Hsu C.H., Chang W.C., Lin H.I., Gao M., Cheng A.L.
    J Biol Chem 281:167-175(2006) [PubMed] [Europe PMC] [Abstract]
• protease binding Source: BHF-UCLInferred from physical interactionⁱ
  • "T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20."
    Coornaert B., Baens M., Heyninck K., Bekaert T., Haegman M., Staal J., Sun L., Chen Z.J., Marynen P., Beyaert R.
    Nat. Immunol. 9:263-271(2008) [PubMed] [Europe PMC] [Abstract]
• protein-containing complex binding Source: Ensembl
• protein C-terminus binding Source: UniProtKBInferred from physical interactionⁱ
  • "CARD9 is a novel caspase recruitment domain-containing protein that interacts with Bcl10/CLAP and activates NF-kappa B."
    Bertin J., Guo Y., Wang L., Srinivasula S.M., Jacobson M.D., Poyet J.-L., Merriam S., Du M.-Q., Dyer M.J.S., Robison K.E., DiStefano P.S., Alnemri E.S.
    J. Biol. Chem. 275:41082-41086(2000) [PubMed] [Europe PMC] [Abstract]
• protein kinase B binding Source: UniProtKBInferred from physical interactionⁱ
  • "A pathway for tumor necrosis factor-alpha-induced Bcl10 nuclear translocation. Bcl10 is up-regulated by NF-kappaB and phosphorylated by Akt1 and then complexes with Bcl3 to enter the nucleus."
    Yeh P.Y., Kuo S.H., Yeh K.H., Chuang S.E., Hsu C.H., Chang W.C., Lin H.I., Gao M., Cheng A.L.
    J Biol Chem 281:167-175(2006) [PubMed] [Europe PMC] [Abstract]
• protein kinase binding Source: UniProtKBInferred from direct assayⁱ
  • "Bcl10 is phosphorylated on Ser138 by Ca2+/calmodulin-dependent protein kinase II."
    Ishiguro K., Ando T., Goto H., Xavier R.
    Mol Immunol 44:2095-2100(2007) [PubMed] [Europe PMC] [Abstract]
• protein self-association Source: UniProtKBInferred from physical interactionⁱ
  • "The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes."
    Sun L., Deng L., Ea C.-K., Xia Z.-P., Chen Z.J.
    Mol. Cell 14:289-301(2004) [PubMed] [Europe PMC] [Abstract]
• transcription coactivator activity Source: UniProtKBInferred from direct assayⁱ
  • "Characterization of Bcl10 as a potential transcriptional activator that interacts with general transcription factor TFIIB."
    Liu Y., Dong W., Chen L., Zhang P., Qi Y.
    Biochem Biophys Res Commun 320:1-6(2004) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: UniProtKBInferred from physical interactionⁱ
  • "Characterization of Bcl10 as a potential transcriptional activator that interacts with general transcription factor TFIIB."
    Liu Y., Dong W., Chen L., Zhang P., Qi Y.
    Biochem Biophys Res Commun 320:1-6(2004) [PubMed] [Europe PMC] [Abstract]
• ubiquitin protein ligase binding Source: UniProtKBInferred from physical interactionⁱ
  • "cIAP2 is a ubiquitin protein ligase for BCL10 and is dysregulated in mucosa-associated lymphoid tissue lymphomas."
    Hu S., Du M.Q., Park S.M., Alcivar A., Qu L., Gupta S., Tang J., Baens M., Ye H., Lee T.H., Marynen P., Riley J.L., Yang X.
    J Clin Invest 116:174-181(2006) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• adaptive immune response Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.19

    "Inherited BCL10 deficiency impairs hematopoietic and nonhematopoietic immunity."
    Torres J.M., Martinez-Barricarte R., Garcia-Gomez S., Mazariegos M.S., Itan Y., Boisson B., Rholvarez R., Jimenez-Reinoso A., Del Pino L., Rodriguez-Pena R., Ferreira A., Hernandez-Jimenez E., Toledano V., Cubillos-Zapata C., Diaz-Almiron M., Lopez-Collazo E., Unzueta-Roch J.L., Sanchez-Ramon S.

    , Regueiro J.R., Lopez-Granados E., Casanova J.L., Perez de Diego R.
    J. Clin. Invest. 124:5239-5248(2014) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INVOLVEMENT IN IMD37.
• B cell apoptotic process Source: Ensembl
• cell death Source: UniProtKBInferred from direct assayⁱ
  • Ref.6

    "c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB."
    Costanzo A., Guiet C., Vito P.
    J. Biol. Chem. 274:20127-20132(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• cellular defense response Source: Ensembl
• cellular response to lipopolysaccharide Source: UniProtKB <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4."
    Dong W., Liu Y., Peng J., Chen L., Zou T., Xiao H., Liu Z., Li W., Bu Y., Qi Y.
    J Biol Chem 281:26029-26040(2006) [PubMed] [Europe PMC] [Abstract]
• cellular response to mechanical stimulus Source: UniProtKBInferred from expression patternⁱ
  • "Expression of the Bcl-2 protein BAD promotes prostate cancer growth."
    Smith A.J., Karpova Y., D'Agostino R. Jr., Willingham M., Kulik G.
    PLoS One 4:e6224-e6224(2009) [PubMed] [Europe PMC] [Abstract]
• Fc-epsilon receptor signaling pathway Source: Reactome
• I-kappaB kinase/NF-kappaB signaling Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• immunoglobulin mediated immune response Source: Ensembl
• innate immune response Source: UniProtKBInferred from expression patternⁱ
  • "The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4."
    Dong W., Liu Y., Peng J., Chen L., Zou T., Xiao H., Liu Z., Li W., Bu Y., Qi Y.
    J Biol Chem 281:26029-26040(2006) [PubMed] [Europe PMC] [Abstract]
• lipopolysaccharide-mediated signaling pathway Source: UniProtKBInferred from direct assayⁱ
  • "The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4."
    Dong W., Liu Y., Peng J., Chen L., Zou T., Xiao H., Liu Z., Li W., Bu Y., Qi Y.
    J Biol Chem 281:26029-26040(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of mature B cell apoptotic process Source: UniProtKBInferred from direct assayⁱ
  • "Bcl10 can promote survival of antigen-stimulated B lymphocytes."
    Tian M.T., Gonzalez G., Scheer B., DeFranco A.L.
    Blood 106:2105-2112(2005) [PubMed] [Europe PMC] [Abstract]
• neural tube closure Source: UniProtKB <p>Inferred from Sequence or Structural Similarity<br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • "Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure."
    Ruland J., Duncan G.S., Elia A., del Barco Barrantes I., Nguyen L., Plyte S., Millar D.G., Bouchard D., Wakeham A., Ohashi P.S., Mak T.W.
    Cell 104:33-42(2001) [PubMed] [Europe PMC] [Abstract]
• positive regulation of apoptotic process Source: UniProtKBInferred from direct assayⁱ
  • "CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis."
    Razmara M., Srinivasula S.M., Wang L., Poyet J.-L., Geddes B.J., DiStefano P.S., Bertin J., Alnemri E.S.
    J. Biol. Chem. 277:13952-13958(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1beta via a noncanonical caspase-8 inflammasome."
    Gringhuis S.I., Kaptein T.M., Wevers B.A., Theelen B., van der Vlist M., Boekhout T., Geijtenbeek T.B.
    Nat Immunol 13:246-254(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of extrinsic apoptotic signaling pathway Source: UniProtKBInferred from direct assayⁱ
  • Ref.12

    "Interchangeable binding of Bcl10 to TRAF2 and cIAPs regulates apoptosis signaling."
    Yui D., Yoneda T., Oono K., Katayama T., Imaizumi K., Tohyama M.
    Oncogene 20:4317-4323(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: PHOSPHORYLATION.
• positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKBInferred from expression patternⁱ
  • "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."
    Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y., Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., Sugano S.
    Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of interleukin-6 production Source: GO_Central <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • "Adaptors discriminate mast-cell cytokine production from eicosanoid production and degranulation."
    Rivera J.
    Trends Immunol 27:251-253(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of interleukin-8 production Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Carrageenan induces interleukin-8 production through distinct Bcl10 pathway in normal human colonic epithelial cells."
    Borthakur A., Bhattacharyya S., Dudeja P.K., Tobacman J.K.
    Am J Physiol Gastrointest Liver Physiol 292:G829-38(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of kinase activity Source: GOC
• positive regulation of lymphotoxin A production Source: GO_CentralNon-traceable author statementⁱ
  • "Adaptors discriminate mast-cell cytokine production from eicosanoid production and degranulation."
    Rivera J.
    Trends Immunol 27:251-253(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of mast cell cytokine production Source: GO_CentralNon-traceable author statementⁱ
  • "Adaptors discriminate mast-cell cytokine production from eicosanoid production and degranulation."
    Rivera J.
    Trends Immunol 27:251-253(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of NF-kappaB transcription factor activity Source: UniProtKBInferred from direct assayⁱ
  • Ref.6

    "c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB."
    Costanzo A., Guiet C., Vito P.
    J. Biol. Chem. 274:20127-20132(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  • "Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO."
    Zhou H., Wertz I., O'Rourke K., Ultsch M., Seshagiri S., Eby M., Xiao W., Dixit V.M.
    Nature 427:167-171(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of phosphorylation Source: UniProtKBInferred from direct assayⁱ
  • "The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes."
    Sun L., Deng L., Ea C.-K., Xia Z.-P., Chen Z.J.
    Mol. Cell 14:289-301(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein ubiquitination Source: UniProtKBInferred from direct assayⁱ
  • "Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO."
    Zhou H., Wertz I., O'Rourke K., Ultsch M., Seshagiri S., Eby M., Xiao W., Dixit V.M.
    Nature 427:167-171(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of T cell activation Source: Ensembl
• positive regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • "Characterization of Bcl10 as a potential transcriptional activator that interacts with general transcription factor TFIIB."
    Liu Y., Dong W., Chen L., Zhang P., Qi Y.
    Biochem Biophys Res Commun 320:1-6(2004) [PubMed] [Europe PMC] [Abstract]
• protein ubiquitination Source: Reactome
• regulation of T cell receptor signaling pathway Source: Ensembl
• response to food Source: UniProtKBInferred from direct assayⁱ
  • "Carrageenan induces interleukin-8 production through distinct Bcl10 pathway in normal human colonic epithelial cells."
    Borthakur A., Bhattacharyya S., Dudeja P.K., Tobacman J.K.
    Am J Physiol Gastrointest Liver Physiol 292:G829-38(2007) [PubMed] [Europe PMC] [Abstract]
• response to fungus Source: Ensembl
• stimulatory C-type lectin receptor signaling pathway Source: Reactome
• T cell apoptotic process Source: Ensembl
• T cell receptor signaling pathway Source: UniProtKBInferred from direct assayⁱ
  • "The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes."
    Sun L., Deng L., Ea C.-K., Xia Z.-P., Chen Z.J.
    Mol. Cell 14:289-301(2004) [PubMed] [Europe PMC] [Abstract]
• toll-like receptor signaling pathway Source: UniProtKBInferred from direct assayⁱ
  • "The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4."
    Dong W., Liu Y., Peng J., Chen L., Zou T., Xiao H., Liu Z., Li W., Bu Y., Qi Y.
    J Biol Chem 281:26029-26040(2006) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

Mutagenesis

Keywords - Diseaseⁱ

Organism-specific databases

Miscellaneous databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• CARD domain binding Source: UniProtKBInferred from physical interactionⁱ
  • "CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation."
    Gaide O., Favier B., Legler D.F., Bonnet D., Brissoni B., Valitutti S., Bron C., Tschopp J., Thome M.
    Nat Immunol 3:836-843(2002) [PubMed] [Europe PMC] [Abstract]
• enzyme binding Source: UniProtKBInferred from physical interactionⁱ
  • "Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO."
    Zhou H., Wertz I., O'Rourke K., Ultsch M., Seshagiri S., Eby M., Xiao W., Dixit V.M.
    Nature 427:167-171(2004) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: IntActInferred from physical interactionⁱ
  • Ref.3

    "Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase."
    Thome M., Martinon F., Hofmann K., Rubio V., Steiner V., Schneider P., Mattmann C., Tschopp J.
    J. Biol. Chem. 274:9962-9968(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  • "A proteome-scale map of the human interactome network."
    Rolland T., Tasan M., Charloteaux B., Pevzner S.J., Zhong Q., Sahni N., Yi S., Lemmens I., Fontanillo C., Mosca R., Kamburov A., Ghiassian S.D., Yang X., Ghamsari L., Balcha D., Begg B.E., Braun P., Brehme M.

    , Broly M.P., Carvunis A.R., Convery-Zupan D., Corominas R., Coulombe-Huntington J., Dann E., Dreze M., Dricot A., Fan C., Franzosa E., Gebreab F., Gutierrez B.J., Hardy M.F., Jin M., Kang S., Kiros R., Lin G.N., Luck K., MacWilliams A., Menche J., Murray R.R., Palagi A., Poulin M.M., Rambout X., Rasla J., Reichert P., Romero V., Ruyssinck E., Sahalie J.M., Scholz A., Shah A.A., Sharma A., Shen Y., Spirohn K., Tam S., Tejeda A.O., Trigg S.A., Twizere J.C., Vega K., Walsh J., Cusick M.E., Xia Y., Barabasi A.L., Iakoucheva L.M., Aloy P., De Las Rivas J., Tavernier J., Calderwood M.A., Hill D.E., Hao T., Roth F.P., Vidal M.
    Cell 159:1212-1226(2014) [PubMed] [Europe PMC] [Abstract]
  • "A reference map of the human binary protein interactome."
    Luck K., Kim D.K., Lambourne L., Spirohn K., Begg B.E., Bian W., Brignall R., Cafarelli T., Campos-Laborie F.J., Charloteaux B., Choi D., Cote A.G., Daley M., Deimling S., Desbuleux A., Dricot A., Gebbia M., Hardy M.F.

    , Kishore N., Knapp J.J., Kovacs I.A., Lemmens I., Mee M.W., Mellor J.C., Pollis C., Pons C., Richardson A.D., Schlabach S., Teeking B., Yadav A., Babor M., Balcha D., Basha O., Bowman-Colin C., Chin S.F., Choi S.G., Colabella C., Coppin G., D'Amata C., De Ridder D., De Rouck S., Duran-Frigola M., Ennajdaoui H., Goebels F., Goehring L., Gopal A., Haddad G., Hatchi E., Helmy M., Jacob Y., Kassa Y., Landini S., Li R., van Lieshout N., MacWilliams A., Markey D., Paulson J.N., Rangarajan S., Rasla J., Rayhan A., Rolland T., San-Miguel A., Shen Y., Sheykhkarimli D., Sheynkman G.M., Simonovsky E., Tasan M., Tejeda A., Tropepe V., Twizere J.C., Wang Y., Weatheritt R.J., Weile J., Xia Y., Yang X., Yeger-Lotem E., Zhong Q., Aloy P., Bader G.D., De Las Rivas J., Gaudet S., Hao T., Rak J., Tavernier J., Hill D.E., Vidal M., Roth F.P., Calderwood M.A.
    Nature 580:402-408(2020) [PubMed] [Europe PMC] [Abstract]
• kinase binding Source: UniProtKBInferred from physical interactionⁱ
  • "The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4."
    Dong W., Liu Y., Peng J., Chen L., Zou T., Xiao H., Liu Z., Li W., Bu Y., Qi Y.
    J Biol Chem 281:26029-26040(2006) [PubMed] [Europe PMC] [Abstract]
  • "Bcl10 is phosphorylated on Ser138 by Ca2+/calmodulin-dependent protein kinase II."
    Ishiguro K., Ando T., Goto H., Xavier R.
    Mol Immunol 44:2095-2100(2007) [PubMed] [Europe PMC] [Abstract]
• NF-kappaB binding Source: UniProtKBInferred from direct assayⁱ
  • "A pathway for tumor necrosis factor-alpha-induced Bcl10 nuclear translocation. Bcl10 is up-regulated by NF-kappaB and phosphorylated by Akt1 and then complexes with Bcl3 to enter the nucleus."
    Yeh P.Y., Kuo S.H., Yeh K.H., Chuang S.E., Hsu C.H., Chang W.C., Lin H.I., Gao M., Cheng A.L.
    J Biol Chem 281:167-175(2006) [PubMed] [Europe PMC] [Abstract]
• protease binding Source: BHF-UCLInferred from physical interactionⁱ
  • "T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20."
    Coornaert B., Baens M., Heyninck K., Bekaert T., Haegman M., Staal J., Sun L., Chen Z.J., Marynen P., Beyaert R.
    Nat. Immunol. 9:263-271(2008) [PubMed] [Europe PMC] [Abstract]
• protein C-terminus binding Source: UniProtKBInferred from physical interactionⁱ
  • "CARD9 is a novel caspase recruitment domain-containing protein that interacts with Bcl10/CLAP and activates NF-kappa B."
    Bertin J., Guo Y., Wang L., Srinivasula S.M., Jacobson M.D., Poyet J.-L., Merriam S., Du M.-Q., Dyer M.J.S., Robison K.E., DiStefano P.S., Alnemri E.S.
    J. Biol. Chem. 275:41082-41086(2000) [PubMed] [Europe PMC] [Abstract]
• protein kinase B binding Source: UniProtKBInferred from physical interactionⁱ
  • "A pathway for tumor necrosis factor-alpha-induced Bcl10 nuclear translocation. Bcl10 is up-regulated by NF-kappaB and phosphorylated by Akt1 and then complexes with Bcl3 to enter the nucleus."
    Yeh P.Y., Kuo S.H., Yeh K.H., Chuang S.E., Hsu C.H., Chang W.C., Lin H.I., Gao M., Cheng A.L.
    J Biol Chem 281:167-175(2006) [PubMed] [Europe PMC] [Abstract]
• protein kinase binding Source: UniProtKBInferred from direct assayⁱ
  • "Bcl10 is phosphorylated on Ser138 by Ca2+/calmodulin-dependent protein kinase II."
    Ishiguro K., Ando T., Goto H., Xavier R.
    Mol Immunol 44:2095-2100(2007) [PubMed] [Europe PMC] [Abstract]
• protein self-association Source: UniProtKBInferred from physical interactionⁱ
  • "The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes."
    Sun L., Deng L., Ea C.-K., Xia Z.-P., Chen Z.J.
    Mol. Cell 14:289-301(2004) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: UniProtKBInferred from physical interactionⁱ
  • "Characterization of Bcl10 as a potential transcriptional activator that interacts with general transcription factor TFIIB."
    Liu Y., Dong W., Chen L., Zhang P., Qi Y.
    Biochem Biophys Res Commun 320:1-6(2004) [PubMed] [Europe PMC] [Abstract]
• ubiquitin protein ligase binding Source: UniProtKBInferred from physical interactionⁱ
  • "cIAP2 is a ubiquitin protein ligase for BCL10 and is dysregulated in mucosa-associated lymphoid tissue lymphomas."
    Hu S., Du M.Q., Park S.M., Alcivar A., Qu L., Gupta S., Tang J., Baens M., Ye H., Lee T.H., Marynen P., Riley J.L., Yang X.
    J Clin Invest 116:174-181(2006) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MEPTAPSLTE EDLTEVKKDA LENLRVYLCE KIIAERHFDH LRAKKILSRE 
        60         70         80         90        100
DTEEISCRTS SRKRAGKLLD YLQENPKGLD TLVESIRREK TQNFLIQKIT 
       110        120        130        140        150
DEVLKLRNIK LEHLKGLKCS SCEPFPDGAT NNLSRSNSDE SNFSEKLRAS 
       160        170        180        190        200
TVMYHPEGES STTPFFSTNS SLNLPVLEVG RTENTIFSST TLPRPGDPGA 
       210        220        230 
PPLPPDLQLE EEGTCANSSE MFLPLRSRTV SRQ                   

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 1
   Human chromosome 1: entries, gene names and cross-references to MIM
2. Human entries with genetic variants
   List of human entries with genetic variants
3. Human variants curated from literature reports
   Index of human variants curated from literature reports
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
5. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references