UniProtKB - O95999 (BCL10_HUMAN)
B-cell lymphoma/leukemia 10
BCL10
Functioni
GO - Molecular functioni
- CARD domain binding Source: UniProtKB
- enzyme binding Source: UniProtKB
- identical protein binding Source: IntAct
- kinase binding Source: UniProtKB
- NF-kappaB binding Source: UniProtKB
- protease binding Source: BHF-UCL
- protein-containing complex binding Source: Ensembl
- protein C-terminus binding Source: UniProtKB
- protein kinase B binding Source: UniProtKB
- protein kinase binding Source: UniProtKB
- protein self-association Source: UniProtKB
- transcription coactivator activity Source: UniProtKB
- transcription factor binding Source: UniProtKB
- ubiquitin protein ligase binding Source: UniProtKB
GO - Biological processi
- adaptive immune response Source: UniProtKB
- B cell apoptotic process Source: Ensembl
- cell death Source: UniProtKB
- cellular defense response Source: Ensembl
- cellular response to lipopolysaccharide Source: UniProtKB
- cellular response to mechanical stimulus Source: UniProtKB
- Fc-epsilon receptor signaling pathway Source: Reactome
- I-kappaB kinase/NF-kappaB signaling Source: GO_Central
- immunoglobulin mediated immune response Source: Ensembl
- innate immune response Source: UniProtKB
- lipopolysaccharide-mediated signaling pathway Source: UniProtKB
- negative regulation of mature B cell apoptotic process Source: UniProtKB
- neural tube closure Source: UniProtKB
- positive regulation of apoptotic process Source: UniProtKB
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: ARUK-UCL
- positive regulation of extrinsic apoptotic signaling pathway Source: UniProtKB
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- positive regulation of interleukin-6 production Source: GO_Central
- positive regulation of interleukin-8 production Source: UniProtKB
- positive regulation of kinase activity Source: GOC
- positive regulation of lymphotoxin A production Source: GO_Central
- positive regulation of mast cell cytokine production Source: GO_Central
- positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
- positive regulation of phosphorylation Source: UniProtKB
- positive regulation of protein ubiquitination Source: UniProtKB
- positive regulation of T cell activation Source: Ensembl
- positive regulation of transcription, DNA-templated Source: UniProtKB
- protein ubiquitination Source: Reactome
- regulation of T cell receptor signaling pathway Source: Ensembl
- response to food Source: UniProtKB
- response to fungus Source: Ensembl
- stimulatory C-type lectin receptor signaling pathway Source: Reactome
- T cell apoptotic process Source: Ensembl
- T cell receptor signaling pathway Source: UniProtKB
- toll-like receptor signaling pathway Source: UniProtKB
Keywordsi
Biological process | Apoptosis, Immunity |
Enzyme and pathway databases
PathwayCommonsi | O95999 |
Reactomei | R-HSA-1169091, Activation of NF-kappaB in B cells R-HSA-202424, Downstream TCR signaling R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-8866654, E3 ubiquitin ligases ubiquitinate target proteins |
SignaLinki | O95999 |
SIGNORi | O95999 |
Names & Taxonomyi
Protein namesi | Recommended name: B-cell lymphoma/leukemia 10Alternative name(s): B-cell CLL/lymphoma 10 Short name: Bcl-10 CARD-containing molecule enhancing NF-kappa-B CARD-like apoptotic protein Short name: hCLAP CED-3/ICH-1 prodomain homologous E10-like regulator Short name: CIPER Cellular homolog of vCARMEN Short name: cCARMEN Cellular-E10 Short name: c-E10 Mammalian CARD-containing adapter molecule E10 Short name: mE10 |
Gene namesi | Name:BCL10 Synonyms:CIPER, CLAP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:989, BCL10 |
MIMi | 603517, gene |
neXtProti | NX_O95999 |
VEuPathDBi | HostDB:ENSG00000142867.12 |
Subcellular locationi
Other locations
- perinuclear region 1 Publication
- Membrane raft 1 Publication
Note: Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts.
Cytoskeleton
- cytoplasmic microtubule Source: UniProtKB
Cytosol
- cytosol Source: UniProtKB
Lysosome
- lysosome Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- immunological synapse Source: Ensembl
Other locations
- CBM complex Source: UniProtKB
- cytoplasm Source: UniProtKB
- membrane raft Source: UniProtKB-SubCell
- perinuclear region of cytoplasm Source: UniProtKB
- polkadots Source: Ensembl
- protein-containing complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, MembranePathology & Biotechi
Involvement in diseasei
Immunodeficiency 37 (IMD37)1 Publication
Lymphoma, mucosa-associated lymphoid type (MALTOMA)1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 28 | L → A: Abolishes cell death-inducing capability. 1 Publication | 1 | |
Mutagenesisi | 41 | L → A: Abolishes cell death-inducing capability. 2 Publications | 1 | |
Mutagenesisi | 41 | L → Q: Abolishes NF-kappa-B activation and homo/heterodimerization. 2 Publications | 1 | |
Mutagenesisi | 46 | I → A: Abolishes cell death-inducing capability. 1 Publication | 1 | |
Mutagenesisi | 47 | L → A: Abolishes cell death-inducing capability. 1 Publication | 1 | |
Mutagenesisi | 53 | E → A: Abolishes cell death-inducing capability. 1 Publication | 1 | |
Mutagenesisi | 55 | I → A: Abolishes cell death-inducing capability. 1 Publication | 1 | |
Mutagenesisi | 78 | G → R: Abolishes NF-kappa-B activation. 1 Publication | 1 | |
Mutagenesisi | 81 – 85 | TLVES → ALVEA: Complete loss of IKBKB/IKKB-mediated phosphorylation. 1 Publication | 5 | |
Mutagenesisi | 228 | R → G: Abolishes MALT1-mediated cleavage. 1 Publication | 1 | |
Mutagenesisi | 231 | S → A: Promotes NF-kappa-B activation. | 1 |
Keywords - Diseasei
Disease variant, Tumor suppressorOrganism-specific databases
DisGeNETi | 8915 |
MalaCardsi | BCL10 |
MIMi | 137245, phenotype 616098, phenotype |
OpenTargetsi | ENSG00000142867 |
Orphaneti | 52417, MALT lymphoma |
PharmGKBi | PA25299 |
Miscellaneous databases
Pharosi | O95999, Tbio |
Genetic variation databases
BioMutai | BCL10 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000144074 | 1 – 233 | B-cell lymphoma/leukemia 10Add BLAST | 233 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 138 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | O95999 |
jPOSTi | O95999 |
MassIVEi | O95999 |
PaxDbi | O95999 |
PeptideAtlasi | O95999 |
PRIDEi | O95999 |
ProteomicsDBi | 51178 |
PTM databases
iPTMneti | O95999 |
PhosphoSitePlusi | O95999 |
SwissPalmi | O95999 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000142867, Expressed in epithelial cell of pancreas and 234 other tissues |
ExpressionAtlasi | O95999, baseline and differential |
Genevisiblei | O95999, HS |
Organism-specific databases
HPAi | ENSG00000142867, Low tissue specificity |
Interactioni
Subunit structurei
Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. Self-associates by CARD-CARD interaction and forms a tight complex with MALT1.
Interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14.
Forms a complex with CARD14 and MALT1; resulting in the formation of a CBM (CARD14-BCL10-MALT1) complex (PubMed:27113748). Binds caspase-9 with its C-terminal domain.
Interacts with TRAF2 and BIRC2/c-IAP2.
Interacts with PELI2 and SOCS3; these interactions may be mutually exclusive (By similarity).
Interacts with CARD11 and MALT1; as part of a CBM (CARD11-BCL10-MALT1) complex involved in NF-kappa-B activation.
By similarity1 PublicationBinary interactionsi
Hide detailsO95999
GO - Molecular functioni
- CARD domain binding Source: UniProtKB
- enzyme binding Source: UniProtKB
- identical protein binding Source: IntAct
- kinase binding Source: UniProtKB
- NF-kappaB binding Source: UniProtKB
- protease binding Source: BHF-UCL
- protein C-terminus binding Source: UniProtKB
- protein kinase B binding Source: UniProtKB
- protein kinase binding Source: UniProtKB
- protein self-association Source: UniProtKB
- transcription factor binding Source: UniProtKB
- ubiquitin protein ligase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 114429, 80 interactors |
CORUMi | O95999 |
DIPi | DIP-29740N |
IntActi | O95999, 40 interactors |
MINTi | O95999 |
STRINGi | 9606.ENSP00000359612 |
Miscellaneous databases
RNActi | O95999, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | O95999 |
SMRi | O95999 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 13 – 101 | CARDPROSITE-ProRule annotationAdd BLAST | 89 |
Phylogenomic databases
eggNOGi | ENOG502RXGH, Eukaryota |
GeneTreei | ENSGT00490000043442 |
HOGENOMi | CLU_103803_0_0_1 |
InParanoidi | O95999 |
OMAi | MRPYLCD |
OrthoDBi | 1472514at2759 |
PhylomeDBi | O95999 |
TreeFami | TF328636 |
Family and domain databases
CDDi | cd08810, CARD_BCL10, 1 hit |
InterProi | View protein in InterPro IPR033238, BCL10/E10 IPR001315, CARD IPR042143, CARD_BCL10 IPR011029, DEATH-like_dom_sf |
PANTHERi | PTHR34920, PTHR34920, 1 hit |
Pfami | View protein in Pfam PF00619, CARD, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit |
PROSITEi | View protein in PROSITE PS50209, CARD, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MEPTAPSLTE EDLTEVKKDA LENLRVYLCE KIIAERHFDH LRAKKILSRE
60 70 80 90 100
DTEEISCRTS SRKRAGKLLD YLQENPKGLD TLVESIRREK TQNFLIQKIT
110 120 130 140 150
DEVLKLRNIK LEHLKGLKCS SCEPFPDGAT NNLSRSNSDE SNFSEKLRAS
160 170 180 190 200
TVMYHPEGES STTPFFSTNS SLNLPVLEVG RTENTIFSST TLPRPGDPGA
210 220 230
PPLPPDLQLE EEGTCANSSE MFLPLRSRTV SRQ
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WWW9 | A0A087WWW9_HUMAN | B-cell lymphoma/leukemia 10 | BCL10 | 222 | Annotation score: | ||
A0A3B3ISX2 | A0A3B3ISX2_HUMAN | B-cell lymphoma/leukemia 10 | BCL10 | 80 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_013208 | 5 | A → S Found in a MALT lymphoma sample; unknown pathological significance. 3 PublicationsCorresponds to variant dbSNP:rs12037217EnsemblClinVar. | 1 | |
Natural variantiVAR_013209 | 16 | V → E Found in a MALT lymphoma sample; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_013210 | 31 | K → E Found in a MALT lymphoma sample; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_013211 | 45 | K → Q1 Publication | 1 | |
Natural variantiVAR_013212 | 52 | T → I Found in a mesothelioma sample; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_013213 | 57 | C → R Found in a MALT lymphoma sample; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_013214 | 58 | R → G Found in a germ cell tumor sample; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs121918314EnsemblClinVar. | 1 | |
Natural variantiVAR_013215 | 58 | R → Q1 Publication | 1 | |
Natural variantiVAR_013216 | 64 | R → K Found in a MALT lymphoma sample; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_013217 | 93 | N → S1 Publication | 1 | |
Natural variantiVAR_013218 | 101 | D → E Found in a MALT lymphoma sample; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_013219 | 134 | S → P Found in a MALT lymphoma sample; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_013220 | 153 | M → V1 Publication | 1 | |
Natural variantiVAR_077898 | 162 | T → M Found in a testicular teratoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs200837308Ensembl. | 1 | |
Natural variantiVAR_013221 | 168 | T → A Found in a MALT lymphoma sample; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1384278393Ensembl. | 1 | |
Natural variantiVAR_013222 | 174 | L → S Found in a MALT lymphoma sample; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_013223 | 210 | Missing Found in a follicular lymphoma sample; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_013224 | 213 | G → E Found in a MALT lymphoma sample; unknown pathological significance. 3 PublicationsCorresponds to variant dbSNP:rs3768235EnsemblClinVar. | 1 | |
Natural variantiVAR_013225 | 218 | S → F Found in a germ cell tumor and other cancer cell lines; unknown pathological significance. 2 Publications | 1 | |
Natural variantiVAR_013226 | 230 | V → I Found in a MALT lymphoma sample; unknown pathological significance. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ006288 mRNA Translation: CAA06955.1 AF057700 mRNA Translation: AAD15800.1 AF100338 mRNA Translation: AAD16428.1 AF127386 mRNA Translation: AAD32597.1 AF134395 mRNA Translation: AAD39147.1 AF105066 mRNA Translation: AAF06894.1 AF082283 mRNA Translation: AAC99767.1 AF097732 Genomic DNA Translation: AAD24918.1 AK291346 mRNA Translation: BAF84035.1 AL590113 Genomic DNA No translation available. CH471097 Genomic DNA Translation: EAW73208.1 BC053617 mRNA Translation: AAH53617.1 |
CCDSi | CCDS704.1 |
RefSeqi | NP_003912.1, NM_003921.4 |
Genome annotation databases
Ensembli | ENST00000648566; ENSP00000498104; ENSG00000142867 |
GeneIDi | 8915 |
KEGGi | hsa:8915 |
UCSCi | uc021opd.3, human |
Keywords - Coding sequence diversityi
Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ006288 mRNA Translation: CAA06955.1 AF057700 mRNA Translation: AAD15800.1 AF100338 mRNA Translation: AAD16428.1 AF127386 mRNA Translation: AAD32597.1 AF134395 mRNA Translation: AAD39147.1 AF105066 mRNA Translation: AAF06894.1 AF082283 mRNA Translation: AAC99767.1 AF097732 Genomic DNA Translation: AAD24918.1 AK291346 mRNA Translation: BAF84035.1 AL590113 Genomic DNA No translation available. CH471097 Genomic DNA Translation: EAW73208.1 BC053617 mRNA Translation: AAH53617.1 |
CCDSi | CCDS704.1 |
RefSeqi | NP_003912.1, NM_003921.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2MB9 | NMR | - | A | 1-115 | [»] | |
6BZE | electron microscopy | 4.00 | A/B/C/D/E/F/G/H | 10-115 | [»] | |
6GK2 | electron microscopy | 4.90 | H | 10-115 | [»] | |
BMRBi | O95999 | |||||
SMRi | O95999 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114429, 80 interactors |
CORUMi | O95999 |
DIPi | DIP-29740N |
IntActi | O95999, 40 interactors |
MINTi | O95999 |
STRINGi | 9606.ENSP00000359612 |
PTM databases
iPTMneti | O95999 |
PhosphoSitePlusi | O95999 |
SwissPalmi | O95999 |
Genetic variation databases
BioMutai | BCL10 |
Proteomic databases
EPDi | O95999 |
jPOSTi | O95999 |
MassIVEi | O95999 |
PaxDbi | O95999 |
PeptideAtlasi | O95999 |
PRIDEi | O95999 |
ProteomicsDBi | 51178 |
Protocols and materials databases
Antibodypediai | 4526, 1260 antibodies |
CPTCi | O95999, 1 antibody |
DNASUi | 8915 |
Genome annotation databases
Ensembli | ENST00000648566; ENSP00000498104; ENSG00000142867 |
GeneIDi | 8915 |
KEGGi | hsa:8915 |
UCSCi | uc021opd.3, human |
Organism-specific databases
CTDi | 8915 |
DisGeNETi | 8915 |
GeneCardsi | BCL10 |
HGNCi | HGNC:989, BCL10 |
HPAi | ENSG00000142867, Low tissue specificity |
MalaCardsi | BCL10 |
MIMi | 137245, phenotype 603517, gene 616098, phenotype |
neXtProti | NX_O95999 |
OpenTargetsi | ENSG00000142867 |
Orphaneti | 52417, MALT lymphoma |
PharmGKBi | PA25299 |
VEuPathDBi | HostDB:ENSG00000142867.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RXGH, Eukaryota |
GeneTreei | ENSGT00490000043442 |
HOGENOMi | CLU_103803_0_0_1 |
InParanoidi | O95999 |
OMAi | MRPYLCD |
OrthoDBi | 1472514at2759 |
PhylomeDBi | O95999 |
TreeFami | TF328636 |
Enzyme and pathway databases
PathwayCommonsi | O95999 |
Reactomei | R-HSA-1169091, Activation of NF-kappaB in B cells R-HSA-202424, Downstream TCR signaling R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-8866654, E3 ubiquitin ligases ubiquitinate target proteins |
SignaLinki | O95999 |
SIGNORi | O95999 |
Miscellaneous databases
BioGRID-ORCSi | 8915, 17 hits in 1007 CRISPR screens |
ChiTaRSi | BCL10, human |
GeneWikii | BCL10 |
GenomeRNAii | 8915 |
Pharosi | O95999, Tbio |
PROi | PR:O95999 |
RNActi | O95999, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000142867, Expressed in epithelial cell of pancreas and 234 other tissues |
ExpressionAtlasi | O95999, baseline and differential |
Genevisiblei | O95999, HS |
Family and domain databases
CDDi | cd08810, CARD_BCL10, 1 hit |
InterProi | View protein in InterPro IPR033238, BCL10/E10 IPR001315, CARD IPR042143, CARD_BCL10 IPR011029, DEATH-like_dom_sf |
PANTHERi | PTHR34920, PTHR34920, 1 hit |
Pfami | View protein in Pfam PF00619, CARD, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit |
PROSITEi | View protein in PROSITE PS50209, CARD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BCL10_HUMAN | |
Accessioni | O95999Primary (citable) accession number: O95999 Secondary accession number(s): Q5VUF1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2002 |
Last sequence update: | May 1, 1999 | |
Last modified: | April 7, 2021 | |
This is version 188 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references