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UniProtKB - O95999 (BCL10_HUMAN)

Entry version 190 (29 Sep 2021)
Sequence version 1 (01 May 1999)
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Protein

B-cell lymphoma/leukemia 10

Gene

BCL10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation (PubMed:10187770, PubMed:10364242, PubMed:10400625, PubMed:25365219, PubMed:24074955).

Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing proteins CARD9, CARD11 and CARD14 to activate NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:24074955).

Recruited by activated CARD domain-containing proteins: homooligomerized CARD domain-containing proteins form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10, subsequent recruitment of MALT1 and formation of a CBM complex (PubMed:24074955).

This leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:18287044, PubMed:27777308, PubMed:24074955).

Activated by CARD9 downstream of C-type lectin receptors; CARD9-mediated signals are essential for antifungal immunity (PubMed:26488816).

Activated by CARD11 downstream of T-cell receptor (TCR) and B-cell receptor (BCR) (PubMed:18264101, PubMed:18287044, PubMed:27777308, PubMed:24074955).

Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK (PubMed:10187815).

10 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAdaptive immunity, Apoptosis, Immunity, Innate immunity

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O95999

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1169091, Activation of NF-kappaB in B cells
R-HSA-202424, Downstream TCR signaling
R-HSA-2871837, FCERI mediated NF-kB activation
R-HSA-5607764, CLEC7A (Dectin-1) signaling
R-HSA-8866654, E3 ubiquitin ligases ubiquitinate target proteins

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O95999

SIGNOR Signaling Network Open Resource

More...SIGNORi		O95999

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
B-cell lymphoma/leukemia 10
Alternative name(s):
B-cell CLL/lymphoma 101 Publication
Short name:
Bcl-101 Publication
CARD-containing molecule enhancing NF-kappa-B
CARD-like apoptotic protein1 Publication
Short name:
hCLAP1 Publication
CED-3/ICH-1 prodomain homologous E10-like regulator1 Publication
Short name:
CIPER1 Publication
Cellular homolog of vCARMEN
Short name:
cCARMEN
Cellular-E101 Publication
Short name:
c-E101 Publication
Mammalian CARD-containing adapter molecule E101 Publication
Short name:
mE101 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BCL101 PublicationImported
Synonyms:CIPER1 Publication, CLAP1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:989, BCL10

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603517, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O95999

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000142867

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving BCL10 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(1;14)(p22;q32). Although the BCL10/IgH translocation leaves the coding region of BCL10 intact, frequent BCL10 mutations could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.1 Publication
Immunodeficiency 37 (IMD37)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of primary combined immunodeficiency, a group of disorders characterized by severe recurrent infections, with normal numbers or an absence of T and B lymphocytes, and impaired cellular and humoral immunity. IMD37 is characterized by hypogammaglobulinemia without lymphopenia, but with profoundly reduced memory B cells and memory T cells, and increased numbers of circulating naive lymphocytes. Inheritance is autosomal recessive.
Related information in OMIM
Lymphoma, mucosa-associated lymphoid type (MALTOMA)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA subtype of non-Hodgkin lymphoma, originating in mucosa-associated lymphoid tissue. MALT lymphomas occur most commonly in the gastro-intestinal tract but have been described in a variety of extranodal sites including the ocular adnexa, salivary gland, thyroid, lung, thymus, and breast. Histologically, they are characterized by an infiltrate of small to medium-sized lymphocytes with abundant cytoplasm and irregularly shaped nuclei. Scattered transformed blasts (large cells) also are present. Non-malignant reactive follicles are observed frequently. A pivotal feature is the presence of lymphoepithelial lesions, with invasion and partial destruction of mucosal glands and crypts by aggregates of tumor cells.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi17K → R: Decreased linear ubiquitination and impaired ability to activate NF-kappa-B; when associated with R-31 and R-63. 1 Publication1
Mutagenesisi28L → A: Abolishes cell death-inducing capability. 1 Publication1
Mutagenesisi31K → R: Decreased ubiquitination and ability to bind NEMO; when associated with 63-R--R-67. Decreased ubiquitination and ability to bind NEMO, impaired ability to activate NF-kappa-B; when associated with R-63. Decreased linear ubiquitination and impaired ability to activate NF-kappa-B; when associated with R-17 and R-63. 2 Publications1
Mutagenesisi36R → E: Abolished homomultimerization and formation of a CBM complex, abolished ability to activate NF-kappa-B. 1 Publication1
Mutagenesisi41L → A: Abolishes cell death-inducing capability. 2 Publications1
Mutagenesisi41L → Q: Abolishes NF-kappa-B activation and homo/heterodimerization. 2 Publications1
Mutagenesisi46I → A: Abolishes cell death-inducing capability. 1 Publication1
Mutagenesisi47L → A: Abolishes cell death-inducing capability. 1 Publication1
Mutagenesisi50 – 51ED → RR: Abolished homomultimerization and formation of a CBM complex. 1 Publication2
Mutagenesisi50E → R: Abolished homomultimerization and formation of a CBM complex, abolished ability to activate NF-kappa-B. 1 Publication1
Mutagenesisi53E → A: Abolishes cell death-inducing capability. 1 Publication1
Mutagenesisi53E → R: Abolished homomultimerization and formation of a CBM complex, abolished ability to activate NF-kappa-B. 1 Publication1
Mutagenesisi55I → A: Abolishes cell death-inducing capability. 1 Publication1
Mutagenesisi63 – 67KRAGK → RRAGR: Decreased ubiquitination and ability to bind NEMO; when associated with R-31. 1 Publication5
Mutagenesisi63K → R: Decreased ubiquitination and ability to bind NEMO, impaired ability to activate NF-kappa-B; when associated with R-31. Decreased linear ubiquitination and impaired ability to activate NF-kappa-B; when associated with R-17 and R-31. 2 Publications1
Mutagenesisi78G → R: Abolishes NF-kappa-B activation. 1 Publication1
Mutagenesisi81 – 85TLVES → ALVEA: Complete loss of IKBKB/IKKB-mediated phosphorylation. 1 Publication5
Mutagenesisi105 – 115KLRNIKLEHLK → RLRNIRLEHLR: Does not affect ubiquitination and ability to bind NEMO. 1 PublicationAdd BLAST11
Mutagenesisi228R → G: Abolishes MALT1-mediated cleavage. 1 Publication1
Mutagenesisi231S → A: Promotes NF-kappa-B activation. 1

Keywords - Diseasei

Disease variant, Tumor suppressor

Organism-specific databases

DisGeNET

More...DisGeNETi		8915

MalaCards human disease database

More...MalaCardsi		BCL10
MIMi137245, phenotype
616098, phenotype

Open Targets

More...OpenTargetsi		ENSG00000142867

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		52417, MALT lymphoma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25299

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O95999, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		BCL10

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001440741 – 233B-cell lymphoma/leukemia 10Add BLAST233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki17Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki31Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications
Cross-linki63Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications
Modified residuei138PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. Phosphorylation results in dissociation from TRAF2 and binding to BIRC2/c-IAP2 (PubMed:11466612). Phosphorylated by IKBKB/IKKB (PubMed:17213322).2 Publications
Ubiquitinated via both 'Lys-63'-linked and linear ('Met-1'-linked) polyubiquitin chains in response to T-cell receptor (TCR) activation (PubMed:18287044, PubMed:27777308). Ubiquitination is recognized by IKBKG/NEMO, the regulatory subunit of I-kappa-B kinase (IKK), and is required for TCR-induced NF-kappa-B activation (PubMed:18287044, PubMed:27777308). Linear ubiquitination at Lys-17, Lys-31 and Lys-63 is mediated by RNF31/HOIP; linear ubiquitination is recognized with much higher affinity than 'Lys-63'-linked ubiquitin by IKBKG/NEMO (PubMed:27777308). CARD11 is required for linear ubiquitination by HOIP by promoting the targeting of BCL10 to RNF31/HOIP (PubMed:27777308).2 Publications
Proteolytically cleaved by MALT1; required for T-cell activation.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei228 – 229Cleavage; by MALT11 Publication2

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O95999

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O95999

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O95999

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O95999

PeptideAtlas

More...PeptideAtlasi		O95999

PRoteomics IDEntifications database

More...PRIDEi		O95999

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51178

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O95999, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O95999

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O95999

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O95999

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000142867, Expressed in epithelial cell of pancreas and 235 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O95999, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O95999, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000142867, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homomultimer; homooligomerized following recruitment by CARD domain-containing proteins that form a nucleating helical template that recruits BCL10 via CARD-CARD interaction (PubMed:24074955). Self-associates by CARD-CARD interaction and interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14 (PubMed:26488816, PubMed:27113748, PubMed:27777308, PubMed:28628108, PubMed:31296852, PubMed:24074955).

Forms a complex with CARD14 and MALT1; resulting in the formation of a CBM (CARD14-BCL10-MALT1) complex (PubMed:27113748).

Forms a complex with CARD11 and MALT1; resulting in the formation of a CBM (CARD11-BCL10-MALT1) complex (PubMed:28628108, PubMed:24074955).

Forms a complex with CARD9 and MALT1; resulting in the formation of a CBM (CARD9-BCL10-MALT1) complex (By similarity).

Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB (PubMed:17287217). Binds caspase-9 with its C-terminal domain (PubMed:10187815).

Interacts with TRAF2 and BIRC2/c-IAP2 (PubMed:11466612).

Interacts with PELI2 and SOCS3; these interactions may be mutually exclusive (By similarity).

By similarity9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114429, 80 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O95999

Database of interacting proteins

More...DIPi		DIP-29740N

Protein interaction database and analysis system

More...IntActi		O95999, 40 interactors

Molecular INTeraction database

More...MINTi		O95999

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000359612

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O95999, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1233
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		O95999

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O95999

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini13 – 101CARDPROSITE-ProRule annotationAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni187 – 233DisorderedSequence analysisAdd BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi212 – 233Polar residuesSequence analysisAdd BLAST22

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RXGH, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00490000043442

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_103803_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O95999

Identification of Orthologs from Complete Genome Data

More...OMAi		YGGTNNL

Database of Orthologous Groups

More...OrthoDBi		1472514at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O95999

TreeFam database of animal gene trees

More...TreeFami		TF328636

Family and domain databases

Conserved Domains Database

More...CDDi		cd08810, CARD_BCL10, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.533.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR033238, BCL10/E10
IPR001315, CARD
IPR042143, CARD_BCL10
IPR011029, DEATH-like_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR34920, PTHR34920, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00619, CARD, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47986, SSF47986, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50209, CARD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O95999-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPTAPSLTE EDLTEVKKDA LENLRVYLCE KIIAERHFDH LRAKKILSRE 
        60         70         80         90        100
DTEEISCRTS SRKRAGKLLD YLQENPKGLD TLVESIRREK TQNFLIQKIT 
       110        120        130        140        150
DEVLKLRNIK LEHLKGLKCS SCEPFPDGAT NNLSRSNSDE SNFSEKLRAS 
       160        170        180        190        200
TVMYHPEGES STTPFFSTNS SLNLPVLEVG RTENTIFSST TLPRPGDPGA 
       210        220        230 
PPLPPDLQLE EEGTCANSSE MFLPLRSRTV SRQ
Length:233
Mass (Da):26,252
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF87C97F2B784BA4B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WWW9A0A087WWW9_HUMAN
B-cell lymphoma/leukemia 10
BCL10
222Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ISX2A0A3B3ISX2_HUMAN
B-cell lymphoma/leukemia 10
BCL10
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0132085A → S Found in a MALT lymphoma sample; unknown pathological significance. 3 PublicationsCorresponds to variant dbSNP:rs12037217EnsemblClinVar.1
Natural variantiVAR_01320916V → E Found in a MALT lymphoma sample; unknown pathological significance. 1 Publication1
Natural variantiVAR_01321031K → E Found in a MALT lymphoma sample; unknown pathological significance. 1 Publication1
Natural variantiVAR_01321145K → Q1 Publication1
Natural variantiVAR_01321252T → I Found in a mesothelioma sample; unknown pathological significance. 1 Publication1
Natural variantiVAR_01321357C → R Found in a MALT lymphoma sample; unknown pathological significance. 1 Publication1
Natural variantiVAR_01321458R → G Found in a germ cell tumor sample; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs121918314EnsemblClinVar.1
Natural variantiVAR_01321558R → Q1 Publication1
Natural variantiVAR_01321664R → K Found in a MALT lymphoma sample; unknown pathological significance. 1 Publication1
Natural variantiVAR_01321793N → S1 Publication1
Natural variantiVAR_013218101D → E Found in a MALT lymphoma sample; unknown pathological significance. 1 Publication1
Natural variantiVAR_013219134S → P Found in a MALT lymphoma sample; unknown pathological significance. 1 Publication1
Natural variantiVAR_013220153M → V1 Publication1
Natural variantiVAR_077898162T → M Found in a testicular teratoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs200837308Ensembl.1
Natural variantiVAR_013221168T → A Found in a MALT lymphoma sample; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1384278393Ensembl.1
Natural variantiVAR_013222174L → S Found in a MALT lymphoma sample; unknown pathological significance. 1 Publication1
Natural variantiVAR_013223210Missing Found in a follicular lymphoma sample; unknown pathological significance. 1 Publication1
Natural variantiVAR_013224213G → E Found in a MALT lymphoma sample; unknown pathological significance. 3 PublicationsCorresponds to variant dbSNP:rs3768235EnsemblClinVar.1
Natural variantiVAR_013225218S → F Found in a germ cell tumor and other cancer cell lines; unknown pathological significance. 2 Publications1
Natural variantiVAR_013226230V → I Found in a MALT lymphoma sample; unknown pathological significance. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ006288 mRNA Translation: CAA06955.1
AF057700 mRNA Translation: AAD15800.1
AF100338 mRNA Translation: AAD16428.1
AF127386 mRNA Translation: AAD32597.1
AF134395 mRNA Translation: AAD39147.1
AF105066 mRNA Translation: AAF06894.1
AF082283 mRNA Translation: AAC99767.1
AF097732 Genomic DNA Translation: AAD24918.1
AK291346 mRNA Translation: BAF84035.1
AL590113 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73208.1
BC053617 mRNA Translation: AAH53617.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS704.1

NCBI Reference Sequences

More...RefSeqi		NP_003912.1, NM_003921.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000648566; ENSP00000498104; ENSG00000142867

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8915

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8915

UCSC genome browser

More...UCSCi		uc021opd.3, human

Keywords - Coding sequence diversityi

Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006288 mRNA Translation: CAA06955.1
AF057700 mRNA Translation: AAD15800.1
AF100338 mRNA Translation: AAD16428.1
AF127386 mRNA Translation: AAD32597.1
AF134395 mRNA Translation: AAD39147.1
AF105066 mRNA Translation: AAF06894.1
AF082283 mRNA Translation: AAC99767.1
AF097732 Genomic DNA Translation: AAD24918.1
AK291346 mRNA Translation: BAF84035.1
AL590113 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73208.1
BC053617 mRNA Translation: AAH53617.1
CCDSiCCDS704.1
RefSeqiNP_003912.1, NM_003921.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MB9NMR-A1-115[»]
6BZEelectron microscopy4.00A/B/C/D/E/F/G/H10-115[»]
6GK2electron microscopy4.90H10-115[»]
BMRBiO95999
SMRiO95999
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114429, 80 interactors
CORUMiO95999
DIPiDIP-29740N
IntActiO95999, 40 interactors
MINTiO95999
STRINGi9606.ENSP00000359612

PTM databases

GlyGeniO95999, 1 site, 1 O-linked glycan (1 site)
iPTMnetiO95999
PhosphoSitePlusiO95999
SwissPalmiO95999

Genetic variation databases

BioMutaiBCL10

Proteomic databases

EPDiO95999
jPOSTiO95999
MassIVEiO95999
PaxDbiO95999
PeptideAtlasiO95999
PRIDEiO95999
ProteomicsDBi51178

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4526, 1273 antibodies

The CPTC Antibody Portal

More...CPTCi		O95999, 1 antibody

The DNASU plasmid repository

More...DNASUi		8915

Genome annotation databases

EnsembliENST00000648566; ENSP00000498104; ENSG00000142867
GeneIDi8915
KEGGihsa:8915
UCSCiuc021opd.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8915
DisGeNETi8915

GeneCards: human genes, protein and diseases

More...GeneCardsi		BCL10
HGNCiHGNC:989, BCL10
HPAiENSG00000142867, Low tissue specificity
MalaCardsiBCL10
MIMi137245, phenotype
603517, gene
616098, phenotype
neXtProtiNX_O95999
OpenTargetsiENSG00000142867
Orphaneti52417, MALT lymphoma
PharmGKBiPA25299
VEuPathDBiHostDB:ENSG00000142867

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RXGH, Eukaryota
GeneTreeiENSGT00490000043442
HOGENOMiCLU_103803_0_0_1
InParanoidiO95999
OMAiYGGTNNL
OrthoDBi1472514at2759
PhylomeDBiO95999
TreeFamiTF328636

Enzyme and pathway databases

PathwayCommonsiO95999
ReactomeiR-HSA-1169091, Activation of NF-kappaB in B cells
R-HSA-202424, Downstream TCR signaling
R-HSA-2871837, FCERI mediated NF-kB activation
R-HSA-5607764, CLEC7A (Dectin-1) signaling
R-HSA-8866654, E3 ubiquitin ligases ubiquitinate target proteins
SignaLinkiO95999
SIGNORiO95999

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8915, 17 hits in 1030 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		BCL10, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		BCL10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8915
PharosiO95999, Tbio

Protein Ontology

More...PROi		PR:O95999
RNActiO95999, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000142867, Expressed in epithelial cell of pancreas and 235 other tissues
ExpressionAtlasiO95999, baseline and differential
GenevisibleiO95999, HS

Family and domain databases

CDDicd08810, CARD_BCL10, 1 hit
Gene3Di1.10.533.10, 1 hit
InterProiView protein in InterPro
IPR033238, BCL10/E10
IPR001315, CARD
IPR042143, CARD_BCL10
IPR011029, DEATH-like_dom_sf
PANTHERiPTHR34920, PTHR34920, 1 hit
PfamiView protein in Pfam
PF00619, CARD, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50209, CARD, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBCL10_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95999
Secondary accession number(s): Q5VUF1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 1, 1999
Last modified: September 29, 2021
This is version 190 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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