BCL10

Functionⁱ

Involved in adaptive immune response (PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 (PubMed:18264101).2 Publications

GO - Molecular functionⁱ

CARD domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12154360
enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 14695475
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 10187771
- 25416956
kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16831874
- 17052756
NF-kappaB binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16280327
protease binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 18223652
protein C-terminus binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11053425
protein kinase B binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16280327
protein kinase binding
Source: UniProtKB
Inferred from direct assayⁱ
- 17052756
protein self-association
Source: UniProtKB
Inferred from physical interactionⁱ
- 15125833
transcription coactivator activity
Source: UniProtKB
Inferred from direct assayⁱ
- 15207693
transcription factor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 15207693
ubiquitin protein ligase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16395405

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adaptive immune response
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25365219
B cell apoptotic process Source: Ensembl
cell death
Source: UniProtKB
Inferred from direct assayⁱ
- 10400625
cellular defense response Source: Ensembl
cellular response to mechanical stimulus
Source: UniProtKB
Inferred from expression patternⁱ
- 19593445
Fc-epsilon receptor signaling pathway Source: Reactome
I-kappaB kinase/NF-kappaB signaling
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
immunoglobulin mediated immune response Source: Ensembl
innate immune response
Source: UniProtKB
Inferred from expression patternⁱ
- 16831874
interleukin-6 biosynthetic process
Source: UniProtKB
Non-traceable author statementⁱ
- 16647297
lipopolysaccharide-mediated signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 16831874
lymphotoxin A biosynthetic process
Source: UniProtKB
Non-traceable author statementⁱ
- 16647297
negative regulation of mature B cell apoptotic process
Source: UniProtKB
Inferred from direct assayⁱ
- 15878976
neural tube closure
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 11163238
positive regulation of apoptotic process
Source: UniProtKB
Inferred from direct assayⁱ
- 11821383
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
positive regulation of extrinsic apoptotic signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 11466612
positive regulation of I-kappaB kinase/NF-kappaB signaling
Source: UniProtKB
Inferred from expression patternⁱ
- 12761501
positive regulation of interleukin-8 biosynthetic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17095757
positive regulation of kinase activity Source: GOC
positive regulation of mast cell cytokine production
Source: UniProtKB
Non-traceable author statementⁱ
- 16647297
positive regulation of NF-kappaB transcription factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 10400625
- 14695475
positive regulation of phosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 15125833
positive regulation of protein ubiquitination
Source: UniProtKB
Inferred from direct assayⁱ
- 14695475
positive regulation of T cell activation Source: Ensembl
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 15207693
protein complex oligomerization
Source: UniProtKB
Inferred from physical interactionⁱ
- 14695475
protein heterooligomerization Source: Ensembl
protein homooligomerization
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 16831874
protein ubiquitination Source: Reactome
regulation of T cell receptor signaling pathway Source: Ensembl
response to food
Source: UniProtKB
Inferred from direct assayⁱ
- 17095757
response to fungus Source: Ensembl
response to molecule of bacterial origin
Source: UniProtKB
Inferred from expression patternⁱ
- 16831874
stimulatory C-type lectin receptor signaling pathway Source: Reactome
T cell apoptotic process Source: Ensembl
T cell receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 15125833
toll-like receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 16831874

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Apoptosis, Immunity

Biological process

Apoptosis, Immunity

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1169091 Activation of NF-kappaB in B cells R-HSA-202424 Downstream TCR signaling R-HSA-2871837 FCERI mediated NF-kB activation R-HSA-5607764 CLEC7A (Dectin-1) signaling R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins
SignaLinkⁱ	O95999
SIGNORⁱ	O95999

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: B-cell lymphoma/leukemia 10 Alternative name(s): B-cell CLL/lymphoma 10 Short name: Bcl-10 CARD-containing molecule enhancing NF-kappa-B CARD-like apoptotic protein Short name: hCLAP CED-3/ICH-1 prodomain homologous E10-like regulator Short name: CIPER Cellular homolog of vCARMEN Short name: cCARMEN Cellular-E10 Short name: c-E10 Mammalian CARD-containing adapter molecule E10 Short name: mE10
Gene namesⁱ	Name:BCL10 Synonyms:CIPER, CLAP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000142867.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:989 BCL10
MIMⁱ	603517 gene
neXtProtⁱ	NX_O95999

Keywords - Cellular componentⁱ

Cytoplasm, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

A chromosomal aberration involving BCL10 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(1;14)(p22;q32). Although the BCL10/IgH translocation leaves the coding region of BCL10 intact, frequent BCL10 mutations could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.

Immunodeficiency 37 (IMD37)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of primary combined immunodeficiency, a group of disorders characterized by severe recurrent infections, with normal numbers or an absence of T and B lymphocytes, and impaired cellular and humoral immunity. IMD37 is characterized by hypogammaglobulinemia without lymphopenia, but with profoundly reduced memory B cells and memory T cells, and increased numbers of circulating naive lymphocytes. Inheritance is autosomal recessive.

Lymphoma, mucosa-associated lymphoid type (MALTOMA)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA subtype of non-Hodgkin lymphoma, originating in mucosa-associated lymphoid tissue. MALT lymphomas occur most commonly in the gastro-intestinal tract but have been described in a variety of extranodal sites including the ocular adnexa, salivary gland, thyroid, lung, thymus, and breast. Histologically, they are characterized by an infiltrate of small to medium-sized lymphocytes with abundant cytoplasm and irregularly shaped nuclei. Scattered transformed blasts (large cells) also are present. Non-malignant reactive follicles are observed frequently. A pivotal feature is the presence of lymphoepithelial lesions, with invasion and partial destruction of mucosal glands and crypts by aggregates of tumor cells.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	28	L → A: Abolishes cell death-inducing capability. 1 Publication	1
Mutagenesisⁱ	41	L → A: Abolishes cell death-inducing capability. 2 Publications	1
Mutagenesisⁱ	41	L → Q: Abolishes NF-kappa-B activation and homo/hetero-dimerization. 2 Publications	1
Mutagenesisⁱ	46	I → A: Abolishes cell death-inducing capability. 1 Publication	1
Mutagenesisⁱ	47	L → A: Abolishes cell death-inducing capability. 1 Publication	1
Mutagenesisⁱ	53	E → A: Abolishes cell death-inducing capability. 1 Publication	1
Mutagenesisⁱ	55	I → A: Abolishes cell death-inducing capability. 1 Publication	1
Mutagenesisⁱ	78	G → R: Abolishes NF-kappa-B activation. 1 Publication	1
Mutagenesisⁱ	81 – 85	TLVES → ALVEA: Complete loss of IKBKB/IKKB-mediated phosphorylation. 1 Publication	5
Mutagenesisⁱ	228	R → G: Abolishes MALT1-mediated cleavage. 1 Publication	1
Mutagenesisⁱ	231	S → A: Promotes NF-kappa-B activation.	1

Keywords - Diseaseⁱ

Disease mutation, Tumor suppressor

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8915
MalaCards human disease database More...MalaCardsⁱ	BCL10
MIMⁱ	137245 phenotype 616098 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000142867
Orphanetⁱ	52417 MALT lymphoma
PharmGKBⁱ	PA25299

Polymorphism and mutation databases

BioMutaⁱ	BCL10

BioMutaⁱ

BCL10

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000144074	1 – 233	B-cell lymphoma/leukemia 10Add BLAST		233

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources		1
Modified residueⁱ	138	PhosphoserineCombined sources		1

Post-translational modificationⁱ

Phosphorylated. Phosphorylation results in dissociation from TRAF2 and binding to BIRC2/c-IAP2. Phosphorylated by IKBKB/IKKB.2 Publications

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	O95999
PaxDbⁱ	O95999
PeptideAtlas More...PeptideAtlasⁱ	O95999
PRIDEⁱ	O95999
ProteomicsDBⁱ	51178

PTM databases

iPTMnetⁱ	O95999
PhosphoSitePlusⁱ	O95999

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.

Gene expression databases

Bgeeⁱ	ENSG00000142867 Expressed in 224 organ(s), highest expression level in epithelial cell of pancreas
CleanExⁱ	HS_BCL10
ExpressionAtlasⁱ	O95999 baseline and differential
Genevisibleⁱ	O95999 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB001944 HPA017925

HPAⁱ

CAB001944
HPA017925

Interactionⁱ

Subunit structureⁱ

Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. Self-associates by CARD-CARD interaction and forms a tight complex with MALT1. Interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. Forms a complex with CARD14 and MALT1; resulting in the formation of a CBM (CARD14-BCL10-MALT1) complex (PubMed:27113748). Binds caspase-9 with its C-terminal domain. Interacts with TRAF2 and BIRC2/c-IAP2. Interacts with PELI2 and SOCS3; these interactions may be mutually exclusive (By similarity). Interacts with CARD11 and MALT1; as part of a CBM (CARD11-BCL10-MALT1) complex involved in NF-kappa-B activation.By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		4	EBI-958922,EBI-958922
AKT1	P31749	5	EBI-958922,EBI-296087
BCL3	P20749	3	EBI-958922,EBI-958997
CARD11	Q9BXL7	7	EBI-958922,EBI-7006141
CARD9	Q9H257	6	EBI-958922,EBI-751319
COG6	Q9Y2V7	4	EBI-958922,EBI-3866319
E10	Q66677	2	EBI-958922,EBI-11709474	From Equine herpesvirus 2 (strain 86/87).
IKBKG	Q9Y6K9	7	EBI-958922,EBI-81279
MALT1	Q9UDY8	18	EBI-958922,EBI-1047372
PRKCZ	Q05513	3	EBI-958922,EBI-295351
TRAF2	Q12933	8	EBI-958922,EBI-355744

GO - Molecular functionⁱ

CARD domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12154360
enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 14695475
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 10187771
- 25416956
kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16831874
- 17052756
NF-kappaB binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16280327
protease binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 18223652
protein C-terminus binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11053425
protein kinase B binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16280327
protein kinase binding
Source: UniProtKB
Inferred from direct assayⁱ
- 17052756
protein self-association
Source: UniProtKB
Inferred from physical interactionⁱ
- 15125833
transcription factor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 15207693
ubiquitin protein ligase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16395405

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114429, 65 interactors
CORUMⁱ	O95999
Database of interacting proteins More...DIPⁱ	DIP-29740N
IntActⁱ	O95999, 39 interactors
Molecular INTeraction database More...MINTⁱ	O95999
STRINGⁱ	9606.ENSP00000271015

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	11 – 14	Combined sources	4
Helixⁱ	17 – 28	Combined sources	12
Turnⁱ	29 – 31	Combined sources	3
Beta strandⁱ	32 – 38	Combined sources	7
Helixⁱ	39 – 42	Combined sources	4
Helixⁱ	49 – 53	Combined sources	5
Turnⁱ	54 – 57	Combined sources	4
Helixⁱ	61 – 72	Combined sources	12
Turnⁱ	76 – 79	Combined sources	4
Helixⁱ	80 – 86	Combined sources	7
Beta strandⁱ	89 – 92	Combined sources	4
Helixⁱ	94 – 105	Combined sources	12
Helixⁱ	107 – 113	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	O95999
SMRⁱ	O95999
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	13 – 101	CARDPROSITE-ProRule annotationAdd BLAST		89

Phylogenomic databases

eggNOGⁱ	ENOG410IVMM Eukaryota ENOG4111JRA LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00490000043442
HOGENOMⁱ	HOG000008671
HOVERGENⁱ	HBG050680
InParanoidⁱ	O95999
KEGG Orthology (KO) More...KOⁱ	K07368
OMAⁱ	RHYLCDK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0UTQ
PhylomeDBⁱ	O95999
TreeFamⁱ	TF328636

Family and domain databases

InterProⁱ	View protein in InterPro IPR033238 BCL10/E10 IPR001315 CARD IPR011029 DEATH-like_dom_sf
PANTHERⁱ	PTHR34920 PTHR34920, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00619 CARD, 1 hit
SUPFAMⁱ	SSF47986 SSF47986, 1 hit
PROSITEⁱ	View protein in PROSITE PS50209 CARD, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

O95999-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEPTAPSLTE EDLTEVKKDA LENLRVYLCE KIIAERHFDH LRAKKILSRE 
        60         70         80         90        100
DTEEISCRTS SRKRAGKLLD YLQENPKGLD TLVESIRREK TQNFLIQKIT 
       110        120        130        140        150
DEVLKLRNIK LEHLKGLKCS SCEPFPDGAT NNLSRSNSDE SNFSEKLRAS 
       160        170        180        190        200
TVMYHPEGES STTPFFSTNS SLNLPVLEVG RTENTIFSST TLPRPGDPGA 
       210        220        230 
PPLPPDLQLE EEGTCANSSE MFLPLRSRTV SRQ

Length:233

Mass (Da):26,252

Last modified:May 1, 1999 - v1

Checksum:ⁱF87C97F2B784BA4B

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A087WWW9	A0A087WWW9_HUMAN		B-cell lymphoma/leukemia 10 B-cell lymphoma/leukemia 10	BCL10	156	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_013208	5	A → S Found in a MALT lymphoma sample; unknown pathological significance. 3 PublicationsCorresponds to variant dbSNP:rs12037217EnsemblClinVar.	1
Natural variantⁱVAR_013209	16	V → E Found in a MALT lymphoma sample; unknown pathological significance. 1 Publication	1
Natural variantⁱVAR_013210	31	K → E Found in a MALT lymphoma sample; unknown pathological significance. 1 Publication	1
Natural variantⁱVAR_013211	45	K → Q1 Publication	1
Natural variantⁱVAR_013212	52	T → I Found in a mesothelioma sample; unknown pathological significance. 1 Publication	1
Natural variantⁱVAR_013213	57	C → R Found in a MALT lymphoma sample; unknown pathological significance. 1 Publication	1
Natural variantⁱVAR_013214	58	R → G Found in a germ cell tumor sample; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs121918314EnsemblClinVar.	1
Natural variantⁱVAR_013215	58	R → Q1 Publication	1
Natural variantⁱVAR_013216	64	R → K Found in a MALT lymphoma sample; unknown pathological significance. 1 Publication	1
Natural variantⁱVAR_013217	93	N → S1 Publication	1
Natural variantⁱVAR_013218	101	D → E Found in a MALT lymphoma sample; unknown pathological significance. 1 Publication	1
Natural variantⁱVAR_013219	134	S → P Found in a MALT lymphoma sample; unknown pathological significance. 1 Publication	1
Natural variantⁱVAR_013220	153	M → V1 Publication	1
Natural variantⁱVAR_077898	162	T → M Found in a testicular teratoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs200837308Ensembl.	1
Natural variantⁱVAR_013221	168	T → A Found in a MALT lymphoma sample; unknown pathological significance. 1 Publication	1
Natural variantⁱVAR_013222	174	L → S Found in a MALT lymphoma sample; unknown pathological significance. 1 Publication	1
Natural variantⁱVAR_013223	210	Missing Found in a follicular lymphoma sample; unknown pathological significance. 1 Publication	1
Natural variantⁱVAR_013224	213	G → E Found in a MALT lymphoma sample; unknown pathological significance. 3 PublicationsCorresponds to variant dbSNP:rs3768235EnsemblClinVar.	1
Natural variantⁱVAR_013225	218	S → F Found in a germ cell tumor and other cancer cell lines; unknown pathological significance. 2 Publications	1
Natural variantⁱVAR_013226	230	V → I Found in a MALT lymphoma sample; unknown pathological significance. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ006288 mRNA Translation: CAA06955.1 AF057700 mRNA Translation: AAD15800.1 AF100338 mRNA Translation: AAD16428.1 AF127386 mRNA Translation: AAD32597.1 AF134395 mRNA Translation: AAD39147.1 AF105066 mRNA Translation: AAF06894.1 AF082283 mRNA Translation: AAC99767.1 AF097732 Genomic DNA Translation: AAD24918.1 AK291346 mRNA Translation: BAF84035.1 AL590113 Genomic DNA No translation available. CH471097 Genomic DNA Translation: EAW73208.1 BC053617 mRNA Translation: AAH53617.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS704.1
NCBI Reference Sequences More...RefSeqⁱ	NP_003912.1, NM_003921.4
UniGeneⁱ	Hs.193516

Genome annotation databases

Ensemblⁱ	ENST00000370580; ENSP00000359612; ENSG00000142867
GeneIDⁱ	8915
KEGGⁱ	hsa:8915
UCSC genome browser More...UCSCⁱ	uc021opd.3 human

Keywords - Coding sequence diversityⁱ

Chromosomal rearrangement

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O95999	B-cell CLL/lymphoma 10		PANTR		317	UniRef100_O95999
B cell CLL/lymphoma 10		PANTR		316
B-cell CLL/lymphoma 10		PANTR		233

Protein	Similar proteins		Species	Score	Length	Source
O95999	B-cell CLL/lymphoma 10		PANTR		317	UniRef90_O95999
Uncharacterized protein		GORGO		316
Uncharacterized protein		PANPA		316
Uncharacterized protein		CHLSB		233
Uncharacterized protein		CERAT		233
+12

Protein	Similar proteins		Species	Score	Length	Source
O95999	B-cell CLL/lymphoma 10		PANTR		317	UniRef50_O95999
Uncharacterized protein		PANPA		316
Uncharacterized protein		GORGO		316
B-cell lymphoma/leukemia 10		MACMU		233
Uncharacterized protein		RHIRO		316
+27

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ006288 mRNA Translation: CAA06955.1 AF057700 mRNA Translation: AAD15800.1 AF100338 mRNA Translation: AAD16428.1 AF127386 mRNA Translation: AAD32597.1 AF134395 mRNA Translation: AAD39147.1 AF105066 mRNA Translation: AAF06894.1 AF082283 mRNA Translation: AAC99767.1 AF097732 Genomic DNA Translation: AAD24918.1 AK291346 mRNA Translation: BAF84035.1 AL590113 Genomic DNA No translation available. CH471097 Genomic DNA Translation: EAW73208.1 BC053617 mRNA Translation: AAH53617.1
CCDSⁱ	CCDS704.1
RefSeqⁱ	NP_003912.1, NM_003921.4
UniGeneⁱ	Hs.193516

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2MB9	NMR	-	A	1-115	[»]
	6BZE	electron microscopy	4.00	A/B/C/D/E/F/G/H	10-115	[»]
ProteinModelPortalⁱ	O95999
SMRⁱ	O95999
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114429, 65 interactors
CORUMⁱ	O95999
DIPⁱ	DIP-29740N
IntActⁱ	O95999, 39 interactors
MINTⁱ	O95999
STRINGⁱ	9606.ENSP00000271015

PTM databases

iPTMnetⁱ	O95999
PhosphoSitePlusⁱ	O95999

Polymorphism and mutation databases

BioMutaⁱ	BCL10

BioMutaⁱ

BCL10

Proteomic databases

EPDⁱ	O95999
PaxDbⁱ	O95999
PeptideAtlasⁱ	O95999
PRIDEⁱ	O95999
ProteomicsDBⁱ	51178

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	8915
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000370580; ENSP00000359612; ENSG00000142867
GeneIDⁱ	8915
KEGGⁱ	hsa:8915
UCSCⁱ	uc021opd.3 human

Organism-specific databases

CTDⁱ	8915
DisGeNETⁱ	8915
EuPathDBⁱ	HostDB:ENSG00000142867.12
GeneCardsⁱ	BCL10
HGNCⁱ	HGNC:989 BCL10
HPAⁱ	CAB001944 HPA017925
MalaCardsⁱ	BCL10
MIMⁱ	137245 phenotype 603517 gene 616098 phenotype
neXtProtⁱ	NX_O95999
OpenTargetsⁱ	ENSG00000142867
Orphanetⁱ	52417 MALT lymphoma
PharmGKBⁱ	PA25299
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IVMM Eukaryota ENOG4111JRA LUCA
GeneTreeⁱ	ENSGT00490000043442
HOGENOMⁱ	HOG000008671
HOVERGENⁱ	HBG050680
InParanoidⁱ	O95999
KOⁱ	K07368
OMAⁱ	RHYLCDK
OrthoDBⁱ	EOG091G0UTQ
PhylomeDBⁱ	O95999
TreeFamⁱ	TF328636

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1169091 Activation of NF-kappaB in B cells R-HSA-202424 Downstream TCR signaling R-HSA-2871837 FCERI mediated NF-kB activation R-HSA-5607764 CLEC7A (Dectin-1) signaling R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins
SignaLinkⁱ	O95999
SIGNORⁱ	O95999

Miscellaneous databases

ChiTaRSⁱ	BCL10 human
GeneWikiⁱ	BCL10
GenomeRNAiⁱ	8915
Protein Ontology More...PROⁱ	PR:O95999
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000142867 Expressed in 224 organ(s), highest expression level in epithelial cell of pancreas
CleanExⁱ	HS_BCL10
ExpressionAtlasⁱ	O95999 baseline and differential
Genevisibleⁱ	O95999 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR033238 BCL10/E10 IPR001315 CARD IPR011029 DEATH-like_dom_sf
PANTHERⁱ	PTHR34920 PTHR34920, 1 hit
Pfamⁱ	View protein in Pfam PF00619 CARD, 1 hit
SUPFAMⁱ	SSF47986 SSF47986, 1 hit
PROSITEⁱ	View protein in PROSITE PS50209 CARD, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BCL10_HUMAN
Accessionⁱ	O95999Primary (citable) accession number: O95999 Secondary accession number(s): Q5VUF1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
	Last sequence update:	May 1, 1999
	Last modified:	November 7, 2018
	This is version 170 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - O95999 (BCL10_HUMAN)

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B-cell lymphoma/leukemia 10

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

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Organism-specific databases

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Organism-specific databases

Polymorphism and mutation databases

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Proteomic databases

PTM databases

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Gene expression databases

Organism-specific databases

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Protein-protein interaction databases

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Secondary structure

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Keywords - Coding sequence diversityi

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Sequence databases

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Gene expression databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ