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Entry version 150 (08 May 2019)
Sequence version 1 (01 May 1999)
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Protein

Adenomatous polyposis coli protein 2

Gene

APC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases (PubMed:25753423). May also function in Wnt signaling by promoting the rapid degradation of CTNNB1 (PubMed:10021369, PubMed:11691822, PubMed:9823329).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • beta-catenin binding Source: MGI
  • gamma-catenin binding Source: GO_Central
  • microtubule binding Source: InterPro

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processWnt signaling pathway

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
O95996

SIGNOR Signaling Network Open Resource

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SIGNORi
O95996

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adenomatous polyposis coli protein 2
Alternative name(s):
Adenomatous polyposis coli protein-like
Short name:
APC-like
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:APC2
Synonyms:APCL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:24036 APC2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
612034 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_O95996

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Sotos syndrome 3 (SOTOS3)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Sotos syndrome, a childhood overgrowth syndrome characterized by prenatal and postnatal overgrowth, developmental delay, mental retardation, advanced bone age, and abnormal craniofacial morphology. SOTOS3 patients do not have advanced bone age, hypotonia, seizures, or autism. SOTOS3 transmission pattern is consistent with autosomal recessive inheritance.
See also OMIM:617169

Organism-specific databases

DisGeNET

More...
DisGeNETi
10297

MalaCards human disease database

More...
MalaCardsi
APC2
MIMi617169 phenotype

Open Targets

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OpenTargetsi
ENSG00000115266

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
821 Sotos syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134906843

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
APC2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003136861 – 2303Adenomatous polyposis coli protein 2Add BLAST2303

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1585PhosphoserineBy similarity1
Modified residuei1587PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O95996

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O95996

PeptideAtlas

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PeptideAtlasi
O95996

PRoteomics IDEntifications database

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PRIDEi
O95996

ProteomicsDB human proteome resource

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ProteomicsDBi
51171
51172 [O95996-2]
51173 [O95996-3]

PTM databases

CarbonylDB database of protein carbonylation sites

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CarbonylDBi
O95996

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O95996

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O95996

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed (at protein level). Specifically expressed in the CNS.3 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in fetal brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000115266 Expressed in 173 organ(s), highest expression level in paraflocculus

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O95996 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O95996 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA078002

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PSRC1 (By similarity). Interacts with APC, CTNNB1, MAPRE1, MAPRE3, TP53BP2 and possibly with AXIN2.By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115585, 6 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-440 Beta-catenin destruction core complex, variant 4
CPX-442 Beta-catenin destruction core complex, variant 6
CPX-443 Beta-catenin destruction core complex, variant 8
CPX-99 Beta-catenin destruction core complex, variant 2

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
O95996

Protein interaction database and analysis system

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IntActi
O95996, 5 interactors

Molecular INTeraction database

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MINTi
O95996

STRING: functional protein association networks

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STRINGi
9606.ENSP00000442954

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O95996

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati302 – 341ARM 1Add BLAST40
Repeati479 – 518ARM 2Add BLAST40
Repeati522 – 562ARM 3Add BLAST41
Repeati566 – 609ARM 4Add BLAST44
Repeati615 – 654ARM 5Add BLAST40
Repeati657 – 696ARM 6Add BLAST40
Repeati1058 – 10771Add BLAST20
Repeati1150 – 11692Add BLAST20
Repeati1263 – 12823Add BLAST20
Repeati1391 – 14104Add BLAST20
Repeati1568 – 15875Add BLAST20

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1058 – 15875 X 20 AA approximate repeat of F-X-V-E-X-T-P-X-C-F-S-R-X-S-S-L-S-S-L-SAdd BLAST530
Regioni1058 – 1587Interaction with CTNNB11 PublicationAdd BLAST530
Regioni1821 – 1900Required for localization to microtubules and function in microtubule stabilization1 PublicationAdd BLAST80
Regioni2067 – 2144Interaction with MAPRE1 and MAPRE31 PublicationAdd BLAST78

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili8 – 59Sequence analysisAdd BLAST52
Coiled coili840 – 864Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1145 – 1196Ser-richAdd BLAST52
Compositional biasi1518 – 1622Pro-richAdd BLAST105
Compositional biasi1765 – 1953Pro-richAdd BLAST189

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2122 Eukaryota
ENOG410XR2V LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00530000063749

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O95996

KEGG Orthology (KO)

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KOi
K02085

Identification of Orthologs from Complete Genome Data

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OMAi
VETQFSM

Database of Orthologous Groups

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OrthoDBi
31524at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O95996

TreeFam database of animal gene trees

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TreeFami
TF106496

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR026837 APC2
IPR009234 APC_basic_dom
IPR026831 APC_dom
IPR026818 Apc_fam
IPR032038 APC_N
IPR036149 APC_N_sf
IPR041257 APC_rep
IPR009223 APC_rpt
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR009224 SAMP

The PANTHER Classification System

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PANTHERi
PTHR12607 PTHR12607, 1 hit
PTHR12607:SF3 PTHR12607:SF3, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF05956 APC_basic, 1 hit
PF16689 APC_N_CC, 1 hit
PF05923 APC_r, 4 hits
PF18797 APC_rep, 1 hit
PF00514 Arm, 1 hit
PF05924 SAMP, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00185 ARM, 6 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48371 SSF48371, 1 hit
SSF58050 SSF58050, 1 hit
SSF82931 SSF82931, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95996-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASSVAPYEQ LVRQVEALKA ENSHLRQELR DNSSHLSKLE TETSGMKEVL
60 70 80 90 100
KHLQGKLEQE ARVLVSSGQT EVLEQLKALQ MDITSLYNLK FQPPTLGPEP
110 120 130 140 150
AARTPEGSPV HGSGPSKDSF GELSRATIRL LEELDRERCF LLNEIEKEEK
160 170 180 190 200
EKLWYYSQLQ GLSKRLDELP HVETQFSMQM DLIRQQLEFE AQHIRSLMEE
210 220 230 240 250
RFGTSDEMVQ RAQIRASRLE QIDKELLEAQ DRVQQTEPQA LLAVKSVPVD
260 270 280 290 300
EDPETEVPTH PEDGTPQPGN SKVEVVFWLL SMLATRDQED TARTLLAMSS
310 320 330 340 350
SPESCVAMRR SGCLPLLLQI LHGTEAAAGG RAGAPGAPGA KDARMRANAA
360 370 380 390 400
LHNIVFSQPD QGLARKEMRV LHVLEQIRAY CETCWDWLQA RDGGPEGGGA
410 420 430 440 450
GSAPIPIEPQ ICQATCAVMK LSFDEEYRRA MNELGGLQAV AELLQVDYEM
460 470 480 490 500
HKMTRDPLNL ALRRYAGMTL TNLTFGDVAN KATLCARRGC MEAIVAQLAS
510 520 530 540 550
DSEELHQVVS SILRNLSWRA DINSKKVLRE AGSVTALVQC VLRATKESTL
560 570 580 590 600
KSVLSALWNL SAHSTENKAA ICQVDGALGF LVSTLTYKCQ SNSLAIIESG
610 620 630 640 650
GGILRNVSSL VATREDYRQV LRDHNCLQTL LQHLTSHSLT IVSNACGTLW
660 670 680 690 700
NLSARSARDQ ELLWDLGAVG MLRNLVHSKH KMIAMGSAAA LRNLLAHRPA
710 720 730 740 750
KHQAAATAVS PGSCVPSLYV RKQRALEAEL DARHLAQALE HLEKQGPPAA
760 770 780 790 800
EAATKKPLPP LRHLDGLAQD YASDSGCFDD DDAPSSLAAA AATGEPASPA
810 820 830 840 850
ALSLFLGSPF LQGQALARTP PTRRGGKEAE KDTSGEAAVA AKAKAKLALA
860 870 880 890 900
VARIDQLVED ISALHTSSDD SFSLSSGDPG QEAPREGRAQ SCSPCRGPEG
910 920 930 940 950
GRREAGSRAH PLLRLKAAHA SLSNDSLNSG SASDGYCPRE HMLPCPLAAL
960 970 980 990 1000
ASRREDPRCG QPRPSRLDLD LPGCQAEPPA REATSADARV RTIKLSPTYQ
1010 1020 1030 1040 1050
HVPLLEGASR AGAEPLAGPG ISPGARKQAW LPADHLSKVP EKLAAAPLSV
1060 1070 1080 1090 1100
ASKALQKLAA QEGPLSLSRC SSLSSLSSAG RPGPSEGGDL DDSDSSLEGL
1110 1120 1130 1140 1150
EEAGPSEAEL DSTWRAPGAT SLPVAIPAPR RNRGRGLGVE DATPSSSSEN
1160 1170 1180 1190 1200
YVQETPLVLS RCSSVSSLGS FESPSIASSI PSEPCSGQGS GTISPSELPD
1210 1220 1230 1240 1250
SPGQTMPPSR SKTPPLAPAP QGPPEATQFS LQWESYVKRF LDIADCRERC
1260 1270 1280 1290 1300
RLPSELDAGS VRFTVEKPDE NFSCASSLSA LALHEHYVQQ DVELRLLPSA
1310 1320 1330 1340 1350
CPERGGGAGG AGLHFAGHRR REEGPAPTGS RPRGAADQEL ELLRECLGAA
1360 1370 1380 1390 1400
VPARLRKVAS ALVPGRRALP VPVYMLVPAP APAQEDDSCT DSAEGTPVNF
1410 1420 1430 1440 1450
SSAASLSDET LQGPPRDQPG GPAGRQRPTG RPTSARQAMG HRHKAGGAGR
1460 1470 1480 1490 1500
SAEQSRGAGK NRAGLELPLG RPPSAPADKD GSKPGRTRGD GALQSLCLTT
1510 1520 1530 1540 1550
PTEEAVYCFY GNDSDEEPPA AAPTPTHRRT SAIPRAFTRE RPQGRKEAPA
1560 1570 1580 1590 1600
PSKAAPAAPP PARTQPSLIA DETPPCYSLS SSASSLSEPE PSEPPAVHPR
1610 1620 1630 1640 1650
GREPAVTKDP GPGGGRDSSP SPRAAEELLQ RCISSALPRR RPPVSGLRRR
1660 1670 1680 1690 1700
KPRATRLDER PAEGSRERGE EAAGSDRASD LDSVEWRAIQ EGANSIVTWL
1710 1720 1730 1740 1750
HQAAAATREA SSESDSILSF VSGLSVGSTL QPPKHRKGRQ AEGEMGSARR
1760 1770 1780 1790 1800
PEKRGAASVK TSGSPRSPAG PEKPRGTQKT TPGVPAVLRG RTVIYVPSPA
1810 1820 1830 1840 1850
PRAQPKGTPG PRATPRKVAP PCLAQPAAPA KVPSPGQQRS RSLHRPAKTS
1860 1870 1880 1890 1900
ELATLSQPPR SATPPARLAK TPSSSSSQTS PASQPLPRKR PPVTQAAGAL
1910 1920 1930 1940 1950
PGPGASPVPK TPARTLLAKQ HKTQRSPVRI PFMQRPARRG PPPLARAVPE
1960 1970 1980 1990 2000
PGPRGRAGTE AGPGARGGRL GLVRVASALS SGSESSDRSG FRRQLTFIKE
2010 2020 2030 2040 2050
SPGLRRRRSE LSSAESAASA PQGASPRRGR PALPAVFLCS SRCEELRAAP
2060 2070 2080 2090 2100
RQGPAPARQR PPAARPSPGE RPARRTTSES PSRLPVRAPA ARPETVKRYA
2110 2120 2130 2140 2150
SLPHISVARR PDGAVPAAPA SADAARRSSD GEPRPLPRVA APGTTWRRIR
2160 2170 2180 2190 2200
DEDVPHILRS TLPATALPLR GSTPEDAPAG PPPRKTSDAV VQTEEVAAPK
2210 2220 2230 2240 2250
TNSSTSPSLE TREPPGAPAG GQLSLLGSDV DGPSLAKAPI SAPFVHEGLG
2260 2270 2280 2290 2300
VAVGGFPASR HGSPSRSARV PPFNYVPSPM VVAATTDSAA EKAPATASAT

LLE
Length:2,303
Mass (Da):243,949
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7BF940183ACD643D
GO
Isoform 2 (identifier: O95996-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     168-441: Missing.

Show »
Length:2,029
Mass (Da):213,799
Checksum:iF509BD1F39C43FFF
GO
Isoform 3 (identifier: O95996-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     175-175: Missing.

Show »
Length:2,302
Mass (Da):243,821
Checksum:iBD396DB4248091F4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B5MDS5B5MDS5_HUMAN
Adenomatous polyposis coli protein ...
APC2
730Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGQ0A0A0C4DGQ0_HUMAN
Adenomatous polyposis coli protein ...
APC2
702Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EN62K7EN62_HUMAN
Adenomatous polyposis coli protein ...
APC2
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ELQ3K7ELQ3_HUMAN
Adenomatous polyposis coli protein ...
APC2
193Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ERC5K7ERC5_HUMAN
Adenomatous polyposis coli protein ...
APC2
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD28183 differs from that shown. Reason: Frameshift at positions 1322 and 1338.Curated
The sequence AAF01784 differs from that shown. Contaminating sequence.Curated
The sequence CAA10317 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB61207 differs from that shown. Contaminating sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti463Missing in AAD28183 (Ref. 4) Curated1
Sequence conflicti526 – 527KV → NL in AAD28183 (Ref. 4) Curated2
Sequence conflicti526 – 527KV → NL in AAD29274 (Ref. 4) Curated2
Sequence conflicti566E → A in AAF01784 (PubMed:10021369).Curated1
Sequence conflicti566E → A in CAB61207 (PubMed:10021369).Curated1
Sequence conflicti816L → Q in AAD28183 (Ref. 4) Curated1
Sequence conflicti971L → P in AAD28183 (Ref. 4) Curated1
Sequence conflicti1106S → I in AAD28183 (Ref. 4) Curated1
Sequence conflicti1140E → G in CAA10317 (PubMed:10021369).Curated1
Sequence conflicti1188Q → H in AAD28183 (Ref. 4) Curated1
Sequence conflicti1361A → G in AAD28183 (Ref. 4) Curated1
Sequence conflicti1456R → P in AAD28183 (Ref. 4) Curated1
Sequence conflicti1515D → V in AAD28183 (Ref. 4) Curated1
Sequence conflicti2219A → V in CAA10317 (PubMed:10021369).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037703562A → S in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0812241921H → N1 Publication1
Natural variantiVAR_0377042003G → S in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1288757495Ensembl.1
Natural variantiVAR_0377052241S → A. Corresponds to variant dbSNP:rs265277Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_030106168 – 441Missing in isoform 2. 1 PublicationAdd BLAST274
Alternative sequenceiVSP_030107175Missing in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB012162 mRNA Translation: BAA34611.1
AB022529 Genomic DNA Translation: BAA75469.1
CH471139 Genomic DNA Translation: EAW69498.1
AF110334 mRNA Translation: AAD28183.1 Frameshift.
AF110335 Genomic DNA Translation: AAD29273.1
AF110337, AF110336 Genomic DNA Translation: AAD29274.1
AF128222 mRNA Translation: AAF01784.1 Sequence problems.
AJ012652 mRNA Translation: CAB61207.1 Sequence problems.
AJ131187 Genomic DNA Translation: CAA10317.1 Different initiation.
BC032573 mRNA Translation: AAH32573.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12068.1 [O95996-1]

NCBI Reference Sequences

More...
RefSeqi
NP_005874.1, NM_005883.2 [O95996-1]
XP_006722672.1, XM_006722609.3 [O95996-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000233607; ENSP00000233607; ENSG00000115266 [O95996-1]
ENST00000535453; ENSP00000442954; ENSG00000115266 [O95996-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10297

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10297

UCSC genome browser

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UCSCi
uc002lsr.1 human [O95996-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012162 mRNA Translation: BAA34611.1
AB022529 Genomic DNA Translation: BAA75469.1
CH471139 Genomic DNA Translation: EAW69498.1
AF110334 mRNA Translation: AAD28183.1 Frameshift.
AF110335 Genomic DNA Translation: AAD29273.1
AF110337, AF110336 Genomic DNA Translation: AAD29274.1
AF128222 mRNA Translation: AAF01784.1 Sequence problems.
AJ012652 mRNA Translation: CAB61207.1 Sequence problems.
AJ131187 Genomic DNA Translation: CAA10317.1 Different initiation.
BC032573 mRNA Translation: AAH32573.1
CCDSiCCDS12068.1 [O95996-1]
RefSeqiNP_005874.1, NM_005883.2 [O95996-1]
XP_006722672.1, XM_006722609.3 [O95996-1]

3D structure databases

SMRiO95996
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115585, 6 interactors
ComplexPortaliCPX-440 Beta-catenin destruction core complex, variant 4
CPX-442 Beta-catenin destruction core complex, variant 6
CPX-443 Beta-catenin destruction core complex, variant 8
CPX-99 Beta-catenin destruction core complex, variant 2
ELMiO95996
IntActiO95996, 5 interactors
MINTiO95996
STRINGi9606.ENSP00000442954

PTM databases

CarbonylDBiO95996
iPTMnetiO95996
PhosphoSitePlusiO95996

Polymorphism and mutation databases

BioMutaiAPC2

Proteomic databases

jPOSTiO95996
PaxDbiO95996
PeptideAtlasiO95996
PRIDEiO95996
ProteomicsDBi51171
51172 [O95996-2]
51173 [O95996-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233607; ENSP00000233607; ENSG00000115266 [O95996-1]
ENST00000535453; ENSP00000442954; ENSG00000115266 [O95996-1]
GeneIDi10297
KEGGihsa:10297
UCSCiuc002lsr.1 human [O95996-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10297
DisGeNETi10297

GeneCards: human genes, protein and diseases

More...
GeneCardsi
APC2

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0039920
HGNCiHGNC:24036 APC2
HPAiHPA078002
MalaCardsiAPC2
MIMi612034 gene
617169 phenotype
neXtProtiNX_O95996
OpenTargetsiENSG00000115266
Orphaneti821 Sotos syndrome
PharmGKBiPA134906843

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2122 Eukaryota
ENOG410XR2V LUCA
GeneTreeiENSGT00530000063749
InParanoidiO95996
KOiK02085
OMAiVETQFSM
OrthoDBi31524at2759
PhylomeDBiO95996
TreeFamiTF106496

Enzyme and pathway databases

SignaLinkiO95996
SIGNORiO95996

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10297

Protein Ontology

More...
PROi
PR:O95996

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000115266 Expressed in 173 organ(s), highest expression level in paraflocculus
ExpressionAtlasiO95996 baseline and differential
GenevisibleiO95996 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR026837 APC2
IPR009234 APC_basic_dom
IPR026831 APC_dom
IPR026818 Apc_fam
IPR032038 APC_N
IPR036149 APC_N_sf
IPR041257 APC_rep
IPR009223 APC_rpt
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR009224 SAMP
PANTHERiPTHR12607 PTHR12607, 1 hit
PTHR12607:SF3 PTHR12607:SF3, 1 hit
PfamiView protein in Pfam
PF05956 APC_basic, 1 hit
PF16689 APC_N_CC, 1 hit
PF05923 APC_r, 4 hits
PF18797 APC_rep, 1 hit
PF00514 Arm, 1 hit
PF05924 SAMP, 2 hits
SMARTiView protein in SMART
SM00185 ARM, 6 hits
SUPFAMiSSF48371 SSF48371, 1 hit
SSF58050 SSF58050, 1 hit
SSF82931 SSF82931, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAPCL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95996
Secondary accession number(s): Q05BW4
, Q9UBZ1, Q9UEM8, Q9UQJ8, Q9UQJ9, Q9Y632
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 1999
Last modified: May 8, 2019
This is version 150 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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