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Entry version 150 (07 Oct 2020)
Sequence version 1 (01 May 1999)
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Protein

Anterior gradient protein 2 homolog

Gene

AGR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion (PubMed:23274113).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
O95994

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Anterior gradient protein 2 homolog
Short name:
AG-2
Short name:
hAG-2
Alternative name(s):
HPC8
Secreted cement gland protein XAG-2 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AGR2
Synonyms:AG2
ORF Names:UNQ515/PRO1030
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000106541.11

Human Gene Nomenclature Database

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HGNCi
HGNC:328, AGR2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
606358, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95994

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endoplasmic reticulum, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi60E → A: Monomer only, and reduced cell adhesion efficiency. 1 Publication1
Mutagenesisi63Y → A: Disrupted dimerization. 1 Publication1
Mutagenesisi64K → A: Disrupted dimerization. 1 Publication1
Mutagenesisi81C → S: Loss of interaction with MUC2. 1 Publication1

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...
DisGeNETi
10551

Open Targets

More...
OpenTargetsi
ENSG00000106541

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24625

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O95994, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AGR2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 201 PublicationAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000103721 – 175Anterior gradient protein 2 homologAdd BLAST155

Keywords - PTMi

Disulfide bond

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-1293
CPTAC-456

Encyclopedia of Proteome Dynamics

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EPDi
O95994

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O95994

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
O95994

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O95994

PeptideAtlas

More...
PeptideAtlasi
O95994

PRoteomics IDEntifications database

More...
PRIDEi
O95994

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
51169

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
O95994

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O95994

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O95994

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell lines.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000106541, Expressed in mucosa of sigmoid colon and 174 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O95994, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O95994, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000106541, Tissue enhanced (ductus deferens, gallbladder, seminal vesicle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and homodimer (PubMed:23274113).

Interacts with LYPD3 and DAG1 (alphaDAG1).

Interacts with MUC2; disulfide-linked.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

O95994
With#Exp.IntAct
ANKRD11 [X5D778]3EBI-712648,EBI-17183751
APOBEC3B - isoform 2 [Q9UH17-2]3EBI-712648,EBI-17624977
ASPH - isoform 6 [Q12797-6]3EBI-712648,EBI-12092171
BORCS8 [Q96FH0]3EBI-712648,EBI-744076
C3 [P01024]3EBI-712648,EBI-905851
CAMLG [P49069]3EBI-712648,EBI-1748958
CATSPER1 [Q8NEC5]6EBI-712648,EBI-744545
CD34 [P28906]3EBI-712648,EBI-2836676
CD68 [P34810]3EBI-712648,EBI-2826276
CDKN2AIPNL [Q96HQ2]3EBI-712648,EBI-10038935
CETN3 [O15182]3EBI-712648,EBI-712959
CLIC3 [O95833]3EBI-712648,EBI-10192241
CNNM3 [Q8NE01]3EBI-712648,EBI-741032
CPNE6 - isoform 2 [O95741-2]5EBI-712648,EBI-13312079
CRCP - isoform 2 [O75575-2]3EBI-712648,EBI-12880830
CREB1 [P16220]3EBI-712648,EBI-711855
CRYGA [Q24JT5]3EBI-712648,EBI-10239205
CYB5R2 - isoform 2 [Q6BCY4-2]3EBI-712648,EBI-12102608
DCAF11 [Q8TEB1]3EBI-712648,EBI-2213388
EIF3F [O00303]3EBI-712648,EBI-711990
EPHB6 - isoform 2 [O15197-2]3EBI-712648,EBI-10182490
FABP2 [P12104]6EBI-712648,EBI-3905109
FAM110A [Q9BQ89]5EBI-712648,EBI-1752811
FAM117B [Q6P1L5]3EBI-712648,EBI-3893327
FTCD [O95954]3EBI-712648,EBI-10192648
GABPB1 [Q06547]3EBI-712648,EBI-618165
GET3 [O43681]7EBI-712648,EBI-2515857
GRB2 [P62993]5EBI-712648,EBI-401755
GTF2H5 [Q6ZYL4]3EBI-712648,EBI-6380438
GTPBP3 [Q969Y2]3EBI-712648,EBI-740290
GUCA1A [P43080]3EBI-712648,EBI-6873005
hCG_2042749 [A0A024R4Z4]3EBI-712648,EBI-14231181
HCK - isoform 2 [P08631-2]3EBI-712648,EBI-9834454
HMG20A [Q9NP66]3EBI-712648,EBI-740641
HSD3B7 [Q9H2F3]3EBI-712648,EBI-3918847
IL36RN [Q9UBH0]3EBI-712648,EBI-465156
IMPDH2 [P12268]3EBI-712648,EBI-353389
KLHL38 [Q2WGJ6]3EBI-712648,EBI-6426443
KRT31 [Q15323]6EBI-712648,EBI-948001
LGALS14 [Q8TCE9]3EBI-712648,EBI-10274069
LSM1 [O15116]3EBI-712648,EBI-347619
MBD3 - isoform 2 [O95983-2]3EBI-712648,EBI-11978579
MUC2 [Q02817]2EBI-712648,EBI-2105803
MYL6 [P60660]3EBI-712648,EBI-300817
NRF1 - isoform 4 [Q16656-4]5EBI-712648,EBI-11742836
NSD1 - isoform 2 [Q96L73-2]3EBI-712648,EBI-11110981
NTAQ1 [Q96HA8]3EBI-712648,EBI-741158
NUP54 [Q7Z3B4]3EBI-712648,EBI-741048
NUP58 [Q9BVL2]5EBI-712648,EBI-2811583
NUP62CL [Q9H1M0]6EBI-712648,EBI-751933
PHC3 - isoform 7 [Q8NDX5-7]5EBI-712648,EBI-12910528
POGZ [Q7Z3K3]3EBI-712648,EBI-1389308
POLR2L [P62875]3EBI-712648,EBI-359527
POM121 [Q96HA1]4EBI-712648,EBI-739990
POM121 - isoform 2 [Q96HA1-2]3EBI-712648,EBI-11956563
POU6F2 [P78424]3EBI-712648,EBI-12029004
PRPF18 [Q99633]3EBI-712648,EBI-2798416
PSMA1 [P25786]3EBI-712648,EBI-359352
PSMB1 [P20618]3EBI-712648,EBI-372273
PSORS1C2 [Q9UIG4]3EBI-712648,EBI-11974061
PTTG2 - isoform 2 [Q9NZH5-2]3EBI-712648,EBI-17630019
RBFOX1 - isoform 5 [Q9NWB1-5]3EBI-712648,EBI-12123390
RBP5 [P82980]3EBI-712648,EBI-3941274
RTL4 [Q6ZR62]3EBI-712648,EBI-18292412
SDC3 [A0A0S2Z4U3]3EBI-712648,EBI-10204280
SGTA [O43765]3EBI-712648,EBI-347996
SGTB [Q96EQ0]6EBI-712648,EBI-744081
SH2D1B [O14796]3EBI-712648,EBI-3923013
STK16 [O75716]3EBI-712648,EBI-749295
TCEA2 [Q15560]3EBI-712648,EBI-710310
TFAP2D [Q7Z6R9]3EBI-712648,EBI-11952651
THOC1 [Q96FV9]3EBI-712648,EBI-1765605
TLE5 - isoform 2 [Q08117-2]3EBI-712648,EBI-11741437
TRAF2 [Q12933]3EBI-712648,EBI-355744
TSTD2 [Q5T7W7]3EBI-712648,EBI-8994397
TYK2 [P29597]5EBI-712648,EBI-1383454
UBE2I [Q7KZS0]3EBI-712648,EBI-10180829
UBQLN1 [Q9UMX0]9EBI-712648,EBI-741480
UBQLN1 - isoform 2 [Q9UMX0-2]3EBI-712648,EBI-10173939
UBQLN2 [Q9UHD9]5EBI-712648,EBI-947187
USP20 [A0A024R8A9]3EBI-712648,EBI-14096082
VEZF1 [Q14119]5EBI-712648,EBI-11980193
WUGSC:H_DJ0726N20.gs.b [Q9Y6T4]5EBI-712648,EBI-12369705
ZDHHC24 [Q6UX98]3EBI-712648,EBI-10254561
ZNF410 - isoform 3 [Q86VK4-3]3EBI-712648,EBI-11741890

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
115802, 903 interactors

Database of interacting proteins

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DIPi
DIP-48825N

Protein interaction database and analysis system

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IntActi
O95994, 99 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000391490

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O95994, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1175
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
O95994

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O95994

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni21 – 40Required to promote cell adhesion1 PublicationAdd BLAST20

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi45 – 54Homodimer stabilization; interchainCombined sources1 Publication10
Motifi60 – 67Homodimer stabilization; interchainCombined sources1 Publication8

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AGR family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RYQ8, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063273

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_088048_1_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O95994

KEGG Orthology (KO)

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KOi
K20356

Database of Orthologous Groups

More...
OrthoDBi
1382017at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O95994

TreeFam database of animal gene trees

More...
TreeFami
TF321449

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.30.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036249, Thioredoxin-like_sf

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52833, SSF52833, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O95994-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKIPVSAFL LLVALSYTLA RDTTVKPGAK KDTKDSRPKL PQTLSRGWGD
60 70 80 90 100
QLIWTQTYEE ALYKSKTSNK PLMIIHHLDE CPHSQALKKV FAENKEIQKL
110 120 130 140 150
AEQFVLLNLV YETTDKHLSP DGQYVPRIMF VDPSLTVRAD ITGRYSNRLY
160 170
AYEPADTALL LDNMKKALKL LKTEL
Length:175
Mass (Da):19,979
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF271B1BD377BEE11
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B5MC07B5MC07_HUMAN
Anterior gradient protein 2 homolog
AGR2
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J3E2C9J3E2_HUMAN
Anterior gradient protein 2 homolog
AGR2
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3Z9H7C3Z9_HUMAN
Anterior gradient protein 2 homolog
AGR2
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF007791 mRNA Translation: AAC77358.1
AF038451 mRNA Translation: AAC82614.1
AF088867 mRNA Translation: AAF22484.1
AF115926 mRNA Translation: AAL54870.1
AF087879 mRNA Translation: AAP97179.1
AY359009 mRNA Translation: AAQ89368.1
BT007048 mRNA Translation: AAP35697.1
AC073333 Genomic DNA Translation: AAP22354.1
BC015503 mRNA Translation: AAH15503.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS5364.1

Protein sequence database of the Protein Information Resource

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PIRi
JE0350

NCBI Reference Sequences

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RefSeqi
NP_006399.1, NM_006408.3
XP_005249638.1, XM_005249581.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000419304; ENSP00000391490; ENSG00000106541

Database of genes from NCBI RefSeq genomes

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GeneIDi
10551

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10551

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007791 mRNA Translation: AAC77358.1
AF038451 mRNA Translation: AAC82614.1
AF088867 mRNA Translation: AAF22484.1
AF115926 mRNA Translation: AAL54870.1
AF087879 mRNA Translation: AAP97179.1
AY359009 mRNA Translation: AAQ89368.1
BT007048 mRNA Translation: AAP35697.1
AC073333 Genomic DNA Translation: AAP22354.1
BC015503 mRNA Translation: AAH15503.1
CCDSiCCDS5364.1
PIRiJE0350
RefSeqiNP_006399.1, NM_006408.3
XP_005249638.1, XM_005249581.4

3D structure databases

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Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LNSNMR-A/B41-175[»]
2LNTNMR-A41-175[»]
BMRBiO95994
SMRiO95994
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115802, 903 interactors
DIPiDIP-48825N
IntActiO95994, 99 interactors
STRINGi9606.ENSP00000391490

PTM databases

iPTMnetiO95994
PhosphoSitePlusiO95994

Polymorphism and mutation databases

BioMutaiAGR2

Proteomic databases

CPTACiCPTAC-1293
CPTAC-456
EPDiO95994
jPOSTiO95994
MassIVEiO95994
PaxDbiO95994
PeptideAtlasiO95994
PRIDEiO95994
ProteomicsDBi51169
TopDownProteomicsiO95994

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
1524, 860 antibodies

The DNASU plasmid repository

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DNASUi
10551

Genome annotation databases

EnsembliENST00000419304; ENSP00000391490; ENSG00000106541
GeneIDi10551
KEGGihsa:10551

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10551
DisGeNETi10551
EuPathDBiHostDB:ENSG00000106541.11

GeneCards: human genes, protein and diseases

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GeneCardsi
AGR2
HGNCiHGNC:328, AGR2
HPAiENSG00000106541, Tissue enhanced (ductus deferens, gallbladder, seminal vesicle)
MIMi606358, gene
neXtProtiNX_O95994
OpenTargetsiENSG00000106541
PharmGKBiPA24625

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502RYQ8, Eukaryota
GeneTreeiENSGT00530000063273
HOGENOMiCLU_088048_1_1_1
InParanoidiO95994
KOiK20356
OrthoDBi1382017at2759
PhylomeDBiO95994
TreeFamiTF321449

Enzyme and pathway databases

PathwayCommonsiO95994

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
10551, 16 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
AGR2, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
AGR2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10551
PharosiO95994, Tbio

Protein Ontology

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PROi
PR:O95994
RNActiO95994, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000106541, Expressed in mucosa of sigmoid colon and 174 other tissues
ExpressionAtlasiO95994, baseline and differential
GenevisibleiO95994, HS

Family and domain databases

Gene3Di3.40.30.10, 1 hit
InterProiView protein in InterPro
IPR036249, Thioredoxin-like_sf
SUPFAMiSSF52833, SSF52833, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAGR2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95994
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 1, 1999
Last modified: October 7, 2020
This is version 150 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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