AGR2

Functionⁱ

Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion (PubMed:23274113).By similarity2 Publications

GO - Molecular functionⁱ

dystroglycan binding
Source: UniProtKB
Inferred from direct assayⁱ
- 12592373
epidermal growth factor receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 25666625
protein homodimerization activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23220234
- 23274113

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

digestive tract morphogenesis Source: UniProtKB
lung goblet cell differentiation Source: Ensembl
mucus secretion Source: UniProtKB
negative regulation of cell death
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23220234
positive regulation of cell-substrate adhesion
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23274113
positive regulation of developmental growth Source: UniProtKB
positive regulation of epidermal growth factor receptor signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25666625
positive regulation of gene expression
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22184114
positive regulation of IRE1-mediated unfolded protein response
Source: UniProtKB
Inferred from direct assayⁱ
- 23220234
positive regulation of PERK-mediated unfolded protein response
Source: UniProtKB
Inferred from direct assayⁱ
- 23220234
positive regulation of protein localization to plasma membrane
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25666625

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Anterior gradient protein 2 homolog Short name: AG-2 Short name: hAG-2 Alternative name(s): HPC8 Secreted cement gland protein XAG-2 homolog
Gene namesⁱ	Name:AGR2 Synonyms:AG2 ORF Names:UNQ515/PRO1030
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000106541.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:328 AGR2
MIMⁱ	606358 gene
neXtProtⁱ	NX_O95994

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Secreted

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	60	E → A: Monomer only, and reduced cell adhesion efficiency. 1 Publication	1
Mutagenesisⁱ	63	Y → A: Disrupted dimerization. 1 Publication	1
Mutagenesisⁱ	64	K → A: Disrupted dimerization. 1 Publication	1
Mutagenesisⁱ	81	C → S: Loss of interaction with MUC2. 1 Publication	1

Keywords - Diseaseⁱ

Proto-oncogene

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10551
Open Targets More...OpenTargetsⁱ	ENSG00000106541
PharmGKBⁱ	PA24625

Polymorphism and mutation databases

BioMutaⁱ	AGR2

BioMutaⁱ

AGR2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 20	1 PublicationAdd BLAST		20
ChainⁱPRO_0000001037	21 – 175	Anterior gradient protein 2 homologAdd BLAST		155

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

EPDⁱ	O95994
PaxDbⁱ	O95994
PeptideAtlas More...PeptideAtlasⁱ	O95994
PRIDEⁱ	O95994
ProteomicsDBⁱ	51169
TopDownProteomicsⁱ	O95994

PTM databases

iPTMnetⁱ	O95994
PhosphoSitePlusⁱ	O95994

Expressionⁱ

Tissue specificityⁱ

Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell lines.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000106541 Expressed in 156 organ(s), highest expression level in mucosa of sigmoid colon
CleanExⁱ	HS_AGR2
ExpressionAtlasⁱ	O95994 baseline and differential
Genevisibleⁱ	O95994 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA007912

HPAⁱ

HPA007912

Interactionⁱ

Subunit structureⁱ

Monomer and homodimer (PubMed:23274113). Interacts with LYPD3 and DAG1 (alphaDAG1). Interacts with MUC2; disulfide-linked.3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CATSPER1	Q8NEC5	5	EBI-712648,EBI-744545
FABP2	P12104	6	EBI-712648,EBI-3905109
KRT31	Q15323	5	EBI-712648,EBI-948001
MUC2	Q02817	2	EBI-712648,EBI-2105803
NUP62CL	Q9H1M0	5	EBI-712648,EBI-751933
POM121	Q96HA1	4	EBI-712648,EBI-739990
SGTB	Q96EQ0	4	EBI-712648,EBI-744081
UBQLN1	Q9UMX0	7	EBI-712648,EBI-741480
UBQLN1	Q9UMX0-2	3	EBI-712648,EBI-10173939
UBQLN2	Q9UHD9	4	EBI-712648,EBI-947187

GO - Molecular functionⁱ

dystroglycan binding
Source: UniProtKB
Inferred from direct assayⁱ
- 12592373
epidermal growth factor receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 25666625
protein homodimerization activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23220234
- 23274113

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115802, 27 interactors
Database of interacting proteins More...DIPⁱ	DIP-48825N
IntActⁱ	O95994, 74 interactors
STRINGⁱ	9606.ENSP00000391490

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	48 – 51	Combined sources	4
Helixⁱ	58 – 66	Combined sources	9
Turnⁱ	67 – 69	Combined sources	3
Beta strandⁱ	72 – 77	Combined sources	6
Beta strandⁱ	79 – 81	Combined sources	3
Helixⁱ	82 – 91	Combined sources	10
Helixⁱ	95 – 102	Combined sources	8
Beta strandⁱ	103 – 105	Combined sources	3
Beta strandⁱ	109 – 111	Combined sources	3
Turnⁱ	116 – 118	Combined sources	3
Beta strandⁱ	127 – 132	Combined sources	6
Turnⁱ	133 – 135	Combined sources	3
Turnⁱ	146 – 150	Combined sources	5
Turnⁱ	154 – 156	Combined sources	3
Helixⁱ	157 – 167	Combined sources	11
Beta strandⁱ	171 – 173	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	O95994
SMRⁱ	O95994
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	21 – 40	Required to promote cell adhesion1 PublicationAdd BLAST		20

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	45 – 54	Homodimer stabilization; interchainCombined sources1 Publication		10
Motifⁱ	60 – 67	Homodimer stabilization; interchainCombined sources1 Publication		8

Sequence similaritiesⁱ

Belongs to the AGR family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IVR8 Eukaryota ENOG4111K70 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063273
HOGENOMⁱ	HOG000231100
HOVERGENⁱ	HBG006516
InParanoidⁱ	O95994
KEGG Orthology (KO) More...KOⁱ	K20356
PhylomeDBⁱ	O95994
TreeFamⁱ	TF321449

Family and domain databases

InterProⁱ	View protein in InterPro IPR036249 Thioredoxin-like_sf
SUPFAMⁱ	SSF52833 SSF52833, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

O95994-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEKIPVSAFL LLVALSYTLA RDTTVKPGAK KDTKDSRPKL PQTLSRGWGD 
        60         70         80         90        100
QLIWTQTYEE ALYKSKTSNK PLMIIHHLDE CPHSQALKKV FAENKEIQKL 
       110        120        130        140        150
AEQFVLLNLV YETTDKHLSP DGQYVPRIMF VDPSLTVRAD ITGRYSNRLY 
       160        170 
AYEPADTALL LDNMKKALKL LKTEL

Length:175

Mass (Da):19,979

Last modified:May 1, 1999 - v1

Checksum:ⁱF271B1BD377BEE11

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B5MC07	B5MC07_HUMAN	Anterior gradient protein 2 homolog Anterior gradient protein 2 homolog	AGR2	188	Annotation score:
C9J3E2	C9J3E2_HUMAN	Anterior gradient protein 2 homolog Anterior gradient protein 2 homolog	AGR2	131	Annotation score:
H7C3Z9	H7C3Z9_HUMAN	Anterior gradient protein 2 homolog Anterior gradient protein 2 homolog	AGR2	119	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF007791 mRNA Translation: AAC77358.1 AF038451 mRNA Translation: AAC82614.1 AF088867 mRNA Translation: AAF22484.1 AF115926 mRNA Translation: AAL54870.1 AF087879 mRNA Translation: AAP97179.1 AY359009 mRNA Translation: AAQ89368.1 BT007048 mRNA Translation: AAP35697.1 AC073333 Genomic DNA Translation: AAP22354.1 BC015503 mRNA Translation: AAH15503.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5364.1
PIRⁱ	JE0350
NCBI Reference Sequences More...RefSeqⁱ	NP_006399.1, NM_006408.3 XP_005249638.1, XM_005249581.4
UniGeneⁱ	Hs.530009

Genome annotation databases

Ensemblⁱ	ENST00000419304; ENSP00000391490; ENSG00000106541
GeneIDⁱ	10551
KEGGⁱ	hsa:10551

Protein	Similar proteins		Species	Score	Length	Source
O95994	AGR2		HUMAN		195	UniRef100_O95994
AGR2		HUMAN		175
Anterior gradient protein 2 homolog (Fragment)		HUMAN		131

Protein	Similar proteins		Species	Score	Length	Source
O95994	AGR2		HUMAN		195	UniRef90_O95994
Uncharacterized protein		AOTNA		189
AGR2		HUMAN		175
Anterior gradient protein 2 homolog (Fragment)		HUMAN		131
Uncharacterized protein		AOTNA		175

Protein	Similar proteins		Species	Score	Length	Source
O95994	Anterior gradient protein 2 homolog		PONAB		175	UniRef50_O95994
Anterior gradient protein 2 homolog		MOUSE		175
AGR2		HUMAN		195
Uncharacterized protein		AOTNA		189
Uncharacterized protein		PIG		193
+192

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF007791 mRNA Translation: AAC77358.1 AF038451 mRNA Translation: AAC82614.1 AF088867 mRNA Translation: AAF22484.1 AF115926 mRNA Translation: AAL54870.1 AF087879 mRNA Translation: AAP97179.1 AY359009 mRNA Translation: AAQ89368.1 BT007048 mRNA Translation: AAP35697.1 AC073333 Genomic DNA Translation: AAP22354.1 BC015503 mRNA Translation: AAH15503.1
CCDSⁱ	CCDS5364.1
PIRⁱ	JE0350
RefSeqⁱ	NP_006399.1, NM_006408.3 XP_005249638.1, XM_005249581.4
UniGeneⁱ	Hs.530009

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2LNS	NMR	-	A/B	41-175	[»]
	2LNT	NMR	-	A	41-175	[»]
ProteinModelPortalⁱ	O95994
SMRⁱ	O95994
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115802, 27 interactors
DIPⁱ	DIP-48825N
IntActⁱ	O95994, 74 interactors
STRINGⁱ	9606.ENSP00000391490

PTM databases

iPTMnetⁱ	O95994
PhosphoSitePlusⁱ	O95994

Polymorphism and mutation databases

BioMutaⁱ	AGR2

BioMutaⁱ

AGR2

Proteomic databases

EPDⁱ	O95994
PaxDbⁱ	O95994
PeptideAtlasⁱ	O95994
PRIDEⁱ	O95994
ProteomicsDBⁱ	51169
TopDownProteomicsⁱ	O95994

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10551
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000419304; ENSP00000391490; ENSG00000106541
GeneIDⁱ	10551
KEGGⁱ	hsa:10551

Organism-specific databases

CTDⁱ	10551
DisGeNETⁱ	10551
EuPathDBⁱ	HostDB:ENSG00000106541.11
GeneCardsⁱ	AGR2
HGNCⁱ	HGNC:328 AGR2
HPAⁱ	HPA007912
MIMⁱ	606358 gene
neXtProtⁱ	NX_O95994
OpenTargetsⁱ	ENSG00000106541
PharmGKBⁱ	PA24625
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IVR8 Eukaryota ENOG4111K70 LUCA
GeneTreeⁱ	ENSGT00530000063273
HOGENOMⁱ	HOG000231100
HOVERGENⁱ	HBG006516
InParanoidⁱ	O95994
KOⁱ	K20356
PhylomeDBⁱ	O95994
TreeFamⁱ	TF321449

Miscellaneous databases

ChiTaRSⁱ	AGR2 human
GeneWikiⁱ	AGR2
GenomeRNAiⁱ	10551
Protein Ontology More...PROⁱ	PR:O95994
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000106541 Expressed in 156 organ(s), highest expression level in mucosa of sigmoid colon
CleanExⁱ	HS_AGR2
ExpressionAtlasⁱ	O95994 baseline and differential
Genevisibleⁱ	O95994 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR036249 Thioredoxin-like_sf
SUPFAMⁱ	SSF52833 SSF52833, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AGR2_HUMAN
Accessionⁱ	O95994Primary (citable) accession number: O95994
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
	Last sequence update:	May 1, 1999
	Last modified:	November 7, 2018
	This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM

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Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O95994 (AGR2_HUMAN)

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Anterior gradient protein 2 homolog

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Endoplasmic reticulum

Endoplasmic reticulum

Extracellular region or secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ