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Protein

Anterior gradient protein 2 homolog

Gene

AGR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion (PubMed:23274113).By similarity2 Publications

GO - Molecular functioni

  • dystroglycan binding Source: UniProtKB
  • epidermal growth factor receptor binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Anterior gradient protein 2 homolog
Short name:
AG-2
Short name:
hAG-2
Alternative name(s):
HPC8
Secreted cement gland protein XAG-2 homolog
Gene namesi
Name:AGR2
Synonyms:AG2
ORF Names:UNQ515/PRO1030
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000106541.11
HGNCiHGNC:328 AGR2
MIMi606358 gene
neXtProtiNX_O95994

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi60E → A: Monomer only, and reduced cell adhesion efficiency. 1 Publication1
Mutagenesisi63Y → A: Disrupted dimerization. 1 Publication1
Mutagenesisi64K → A: Disrupted dimerization. 1 Publication1
Mutagenesisi81C → S: Loss of interaction with MUC2. 1 Publication1

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi10551
OpenTargetsiENSG00000106541
PharmGKBiPA24625

Polymorphism and mutation databases

BioMutaiAGR2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000000103721 – 175Anterior gradient protein 2 homologAdd BLAST155

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiO95994
PaxDbiO95994
PeptideAtlasiO95994
PRIDEiO95994
ProteomicsDBi51169
TopDownProteomicsiO95994

PTM databases

iPTMnetiO95994
PhosphoSitePlusiO95994

Expressioni

Tissue specificityi

Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell lines.1 Publication

Gene expression databases

BgeeiENSG00000106541 Expressed in 156 organ(s), highest expression level in mucosa of sigmoid colon
CleanExiHS_AGR2
ExpressionAtlasiO95994 baseline and differential
GenevisibleiO95994 HS

Organism-specific databases

HPAiHPA007912

Interactioni

Subunit structurei

Monomer and homodimer (PubMed:23274113). Interacts with LYPD3 and DAG1 (alphaDAG1). Interacts with MUC2; disulfide-linked.3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115802, 27 interactors
DIPiDIP-48825N
IntActiO95994, 74 interactors
STRINGi9606.ENSP00000391490

Structurei

Secondary structure

1175
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO95994
SMRiO95994
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 40Required to promote cell adhesion1 PublicationAdd BLAST20

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi45 – 54Homodimer stabilization; interchainCombined sources1 Publication10
Motifi60 – 67Homodimer stabilization; interchainCombined sources1 Publication8

Sequence similaritiesi

Belongs to the AGR family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IVR8 Eukaryota
ENOG4111K70 LUCA
GeneTreeiENSGT00530000063273
HOGENOMiHOG000231100
HOVERGENiHBG006516
InParanoidiO95994
KOiK20356
PhylomeDBiO95994
TreeFamiTF321449

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
SUPFAMiSSF52833 SSF52833, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O95994-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKIPVSAFL LLVALSYTLA RDTTVKPGAK KDTKDSRPKL PQTLSRGWGD
60 70 80 90 100
QLIWTQTYEE ALYKSKTSNK PLMIIHHLDE CPHSQALKKV FAENKEIQKL
110 120 130 140 150
AEQFVLLNLV YETTDKHLSP DGQYVPRIMF VDPSLTVRAD ITGRYSNRLY
160 170
AYEPADTALL LDNMKKALKL LKTEL
Length:175
Mass (Da):19,979
Last modified:May 1, 1999 - v1
Checksum:iF271B1BD377BEE11
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B5MC07B5MC07_HUMAN
Anterior gradient protein 2 homolog
AGR2
188Annotation score:
C9J3E2C9J3E2_HUMAN
Anterior gradient protein 2 homolog
AGR2
131Annotation score:
H7C3Z9H7C3Z9_HUMAN
Anterior gradient protein 2 homolog
AGR2
119Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007791 mRNA Translation: AAC77358.1
AF038451 mRNA Translation: AAC82614.1
AF088867 mRNA Translation: AAF22484.1
AF115926 mRNA Translation: AAL54870.1
AF087879 mRNA Translation: AAP97179.1
AY359009 mRNA Translation: AAQ89368.1
BT007048 mRNA Translation: AAP35697.1
AC073333 Genomic DNA Translation: AAP22354.1
BC015503 mRNA Translation: AAH15503.1
CCDSiCCDS5364.1
PIRiJE0350
RefSeqiNP_006399.1, NM_006408.3
XP_005249638.1, XM_005249581.4
UniGeneiHs.530009

Genome annotation databases

EnsembliENST00000419304; ENSP00000391490; ENSG00000106541
GeneIDi10551
KEGGihsa:10551

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007791 mRNA Translation: AAC77358.1
AF038451 mRNA Translation: AAC82614.1
AF088867 mRNA Translation: AAF22484.1
AF115926 mRNA Translation: AAL54870.1
AF087879 mRNA Translation: AAP97179.1
AY359009 mRNA Translation: AAQ89368.1
BT007048 mRNA Translation: AAP35697.1
AC073333 Genomic DNA Translation: AAP22354.1
BC015503 mRNA Translation: AAH15503.1
CCDSiCCDS5364.1
PIRiJE0350
RefSeqiNP_006399.1, NM_006408.3
XP_005249638.1, XM_005249581.4
UniGeneiHs.530009

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LNSNMR-A/B41-175[»]
2LNTNMR-A41-175[»]
ProteinModelPortaliO95994
SMRiO95994
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115802, 27 interactors
DIPiDIP-48825N
IntActiO95994, 74 interactors
STRINGi9606.ENSP00000391490

PTM databases

iPTMnetiO95994
PhosphoSitePlusiO95994

Polymorphism and mutation databases

BioMutaiAGR2

Proteomic databases

EPDiO95994
PaxDbiO95994
PeptideAtlasiO95994
PRIDEiO95994
ProteomicsDBi51169
TopDownProteomicsiO95994

Protocols and materials databases

DNASUi10551
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000419304; ENSP00000391490; ENSG00000106541
GeneIDi10551
KEGGihsa:10551

Organism-specific databases

CTDi10551
DisGeNETi10551
EuPathDBiHostDB:ENSG00000106541.11
GeneCardsiAGR2
HGNCiHGNC:328 AGR2
HPAiHPA007912
MIMi606358 gene
neXtProtiNX_O95994
OpenTargetsiENSG00000106541
PharmGKBiPA24625
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVR8 Eukaryota
ENOG4111K70 LUCA
GeneTreeiENSGT00530000063273
HOGENOMiHOG000231100
HOVERGENiHBG006516
InParanoidiO95994
KOiK20356
PhylomeDBiO95994
TreeFamiTF321449

Miscellaneous databases

ChiTaRSiAGR2 human
GeneWikiiAGR2
GenomeRNAii10551
PROiPR:O95994
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106541 Expressed in 156 organ(s), highest expression level in mucosa of sigmoid colon
CleanExiHS_AGR2
ExpressionAtlasiO95994 baseline and differential
GenevisibleiO95994 HS

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
SUPFAMiSSF52833 SSF52833, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAGR2_HUMAN
AccessioniPrimary (citable) accession number: O95994
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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