UniProtKB - O95994 (AGR2_HUMAN)
Protein
Anterior gradient protein 2 homolog
Gene
AGR2
Organism
Homo sapiens (Human)
Status
Functioni
Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion (PubMed:23274113).By similarity2 Publications
GO - Molecular functioni
- dystroglycan binding Source: UniProtKB
- epidermal growth factor receptor binding Source: UniProtKB
- identical protein binding Source: UniProtKB
GO - Biological processi
- digestive tract morphogenesis Source: UniProtKB
- mucus secretion Source: UniProtKB
- negative regulation of cell death Source: UniProtKB
- positive regulation of cell-substrate adhesion Source: UniProtKB
- positive regulation of developmental growth Source: UniProtKB
- positive regulation of epidermal growth factor receptor signaling pathway Source: UniProtKB
- positive regulation of gene expression Source: UniProtKB
- positive regulation of IRE1-mediated unfolded protein response Source: UniProtKB
- positive regulation of PERK-mediated unfolded protein response Source: UniProtKB
- positive regulation of protein localization to plasma membrane Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | O95994 |
Names & Taxonomyi
Protein namesi | Recommended name: Anterior gradient protein 2 homologShort name: AG-2 Short name: hAG-2 Alternative name(s): HPC8 Secreted cement gland protein XAG-2 homolog |
Gene namesi | Name:AGR2 Synonyms:AG2 ORF Names:UNQ515/PRO1030 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:328, AGR2 |
MIMi | 606358, gene |
neXtProti | NX_O95994 |
VEuPathDBi | HostDB:ENSG00000106541.11 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum By similarity
Extracellular region or secreted
- Secreted 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
Extracellular region or secreted
- extracellular space Source: UniProtKB
Keywords - Cellular componenti
Endoplasmic reticulum, SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 60 | E → A: Monomer only, and reduced cell adhesion efficiency. 1 Publication | 1 | |
Mutagenesisi | 63 | Y → A: Disrupted dimerization. 1 Publication | 1 | |
Mutagenesisi | 64 | K → A: Disrupted dimerization. 1 Publication | 1 | |
Mutagenesisi | 81 | C → S: Loss of interaction with MUC2. 1 Publication | 1 |
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 10551 |
OpenTargetsi | ENSG00000106541 |
PharmGKBi | PA24625 |
Miscellaneous databases
Pharosi | O95994, Tbio |
Genetic variation databases
BioMutai | AGR2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | 1 PublicationAdd BLAST | 20 | |
ChainiPRO_0000001037 | 21 – 175 | Anterior gradient protein 2 homologAdd BLAST | 155 |
Keywords - PTMi
Disulfide bondProteomic databases
CPTACi | CPTAC-1293 CPTAC-456 |
EPDi | O95994 |
jPOSTi | O95994 |
MassIVEi | O95994 |
PaxDbi | O95994 |
PeptideAtlasi | O95994 |
PRIDEi | O95994 |
ProteomicsDBi | 51169 |
TopDownProteomicsi | O95994 |
PTM databases
iPTMneti | O95994 |
PhosphoSitePlusi | O95994 |
Expressioni
Tissue specificityi
Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell lines.1 Publication
Gene expression databases
Bgeei | ENSG00000106541, Expressed in mucosa of sigmoid colon and 174 other tissues |
ExpressionAtlasi | O95994, baseline and differential |
Genevisiblei | O95994, HS |
Organism-specific databases
HPAi | ENSG00000106541, Tissue enhanced (ductus deferens, gallbladder, seminal vesicle) |
Interactioni
Subunit structurei
Monomer and homodimer (PubMed:23274113).
Interacts with LYPD3 and DAG1 (alphaDAG1).
Interacts with MUC2; disulfide-linked.
3 PublicationsBinary interactionsi
O95994
GO - Molecular functioni
- dystroglycan binding Source: UniProtKB
- epidermal growth factor receptor binding Source: UniProtKB
- identical protein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 115802, 928 interactors |
DIPi | DIP-48825N |
IntActi | O95994, 100 interactors |
STRINGi | 9606.ENSP00000391490 |
Miscellaneous databases
RNActi | O95994, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | O95994 |
SMRi | O95994 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 21 – 40 | Required to promote cell adhesion1 PublicationAdd BLAST | 20 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 45 – 54 | Homodimer stabilization; interchainCombined sources1 Publication | 10 | |
Motifi | 60 – 67 | Homodimer stabilization; interchainCombined sources1 Publication | 8 |
Sequence similaritiesi
Belongs to the AGR family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502RYQ8, Eukaryota |
GeneTreei | ENSGT00530000063273 |
HOGENOMi | CLU_088048_1_1_1 |
InParanoidi | O95994 |
OMAi | VFAEHKD |
OrthoDBi | 1382017at2759 |
PhylomeDBi | O95994 |
TreeFami | TF321449 |
Family and domain databases
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR036249, Thioredoxin-like_sf |
SUPFAMi | SSF52833, SSF52833, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
O95994-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEKIPVSAFL LLVALSYTLA RDTTVKPGAK KDTKDSRPKL PQTLSRGWGD
60 70 80 90 100
QLIWTQTYEE ALYKSKTSNK PLMIIHHLDE CPHSQALKKV FAENKEIQKL
110 120 130 140 150
AEQFVLLNLV YETTDKHLSP DGQYVPRIMF VDPSLTVRAD ITGRYSNRLY
160 170
AYEPADTALL LDNMKKALKL LKTEL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB5MC07 | B5MC07_HUMAN | Anterior gradient protein 2 homolog | AGR2 | 188 | Annotation score: | ||
C9J3E2 | C9J3E2_HUMAN | Anterior gradient protein 2 homolog | AGR2 | 131 | Annotation score: | ||
H7C3Z9 | H7C3Z9_HUMAN | Anterior gradient protein 2 homolog | AGR2 | 119 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF007791 mRNA Translation: AAC77358.1 AF038451 mRNA Translation: AAC82614.1 AF088867 mRNA Translation: AAF22484.1 AF115926 mRNA Translation: AAL54870.1 AF087879 mRNA Translation: AAP97179.1 AY359009 mRNA Translation: AAQ89368.1 BT007048 mRNA Translation: AAP35697.1 AC073333 Genomic DNA Translation: AAP22354.1 BC015503 mRNA Translation: AAH15503.1 |
CCDSi | CCDS5364.1 |
PIRi | JE0350 |
RefSeqi | NP_006399.1, NM_006408.3 XP_005249638.1, XM_005249581.4 |
Genome annotation databases
Ensembli | ENST00000419304; ENSP00000391490; ENSG00000106541 |
GeneIDi | 10551 |
KEGGi | hsa:10551 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF007791 mRNA Translation: AAC77358.1 AF038451 mRNA Translation: AAC82614.1 AF088867 mRNA Translation: AAF22484.1 AF115926 mRNA Translation: AAL54870.1 AF087879 mRNA Translation: AAP97179.1 AY359009 mRNA Translation: AAQ89368.1 BT007048 mRNA Translation: AAP35697.1 AC073333 Genomic DNA Translation: AAP22354.1 BC015503 mRNA Translation: AAH15503.1 |
CCDSi | CCDS5364.1 |
PIRi | JE0350 |
RefSeqi | NP_006399.1, NM_006408.3 XP_005249638.1, XM_005249581.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2LNS | NMR | - | A/B | 41-175 | [»] | |
2LNT | NMR | - | A | 41-175 | [»] | |
BMRBi | O95994 | |||||
SMRi | O95994 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115802, 928 interactors |
DIPi | DIP-48825N |
IntActi | O95994, 100 interactors |
STRINGi | 9606.ENSP00000391490 |
PTM databases
iPTMneti | O95994 |
PhosphoSitePlusi | O95994 |
Genetic variation databases
BioMutai | AGR2 |
Proteomic databases
CPTACi | CPTAC-1293 CPTAC-456 |
EPDi | O95994 |
jPOSTi | O95994 |
MassIVEi | O95994 |
PaxDbi | O95994 |
PeptideAtlasi | O95994 |
PRIDEi | O95994 |
ProteomicsDBi | 51169 |
TopDownProteomicsi | O95994 |
Protocols and materials databases
Antibodypediai | 1524, 872 antibodies |
DNASUi | 10551 |
Genome annotation databases
Ensembli | ENST00000419304; ENSP00000391490; ENSG00000106541 |
GeneIDi | 10551 |
KEGGi | hsa:10551 |
Organism-specific databases
CTDi | 10551 |
DisGeNETi | 10551 |
GeneCardsi | AGR2 |
HGNCi | HGNC:328, AGR2 |
HPAi | ENSG00000106541, Tissue enhanced (ductus deferens, gallbladder, seminal vesicle) |
MIMi | 606358, gene |
neXtProti | NX_O95994 |
OpenTargetsi | ENSG00000106541 |
PharmGKBi | PA24625 |
VEuPathDBi | HostDB:ENSG00000106541.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RYQ8, Eukaryota |
GeneTreei | ENSGT00530000063273 |
HOGENOMi | CLU_088048_1_1_1 |
InParanoidi | O95994 |
OMAi | VFAEHKD |
OrthoDBi | 1382017at2759 |
PhylomeDBi | O95994 |
TreeFami | TF321449 |
Enzyme and pathway databases
PathwayCommonsi | O95994 |
Miscellaneous databases
BioGRID-ORCSi | 10551, 18 hits in 988 CRISPR screens |
ChiTaRSi | AGR2, human |
GeneWikii | AGR2 |
GenomeRNAii | 10551 |
Pharosi | O95994, Tbio |
PROi | PR:O95994 |
RNActi | O95994, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000106541, Expressed in mucosa of sigmoid colon and 174 other tissues |
ExpressionAtlasi | O95994, baseline and differential |
Genevisiblei | O95994, HS |
Family and domain databases
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR036249, Thioredoxin-like_sf |
SUPFAMi | SSF52833, SSF52833, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AGR2_HUMAN | |
Accessioni | O95994Primary (citable) accession number: O95994 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2005 |
Last sequence update: | May 1, 1999 | |
Last modified: | April 7, 2021 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families