UniProtKB - O95990 (F107A_HUMAN)
Protein
Actin-associated protein FAM107A
Gene
FAM107A
Organism
Homo sapiens (Human)
Status
Functioni
Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F-actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (By similarity). Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner (PubMed:20543869). Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner (PubMed:10564580, PubMed:28604741). May play a role in tumor development (PubMed:10564580).By similarity3 Publications
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
GO - Biological processi
- actin filament bundle assembly Source: UniProtKB
- actin filament polymerization Source: UniProtKB
- cell cycle Source: UniProtKB-KW
- cellular response to glucocorticoid stimulus Source: UniProtKB
- cellular response to nutrient levels Source: UniProtKB
- cognition Source: UniProtKB
- negative regulation of focal adhesion assembly Source: UniProtKB
- negative regulation of G1/S transition of mitotic cell cycle Source: UniProtKB
- negative regulation of long-term synaptic potentiation Source: UniProtKB
- positive regulation of cell migration Source: UniProtKB
- positive regulation of protein ubiquitination Source: UniProtKB
- regulation of actin cytoskeleton organization Source: UniProtKB
- regulation of cell growth Source: UniProtKB
- regulation of microtubule cytoskeleton organization Source: UniProtKB
- regulation of protein stability Source: UniProtKB
Keywordsi
Molecular function | Actin-binding |
Biological process | Cell cycle, Growth regulation, Stress response |
Enzyme and pathway databases
PathwayCommonsi | O95990 |
SIGNORi | O95990 |
Names & Taxonomyi
Protein namesi | Recommended name: Actin-associated protein FAM107ACuratedAlternative name(s): Down-regulated in renal cell carcinoma 11 Publication Protein TU3A1 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000168309.16 |
HGNCi | HGNC:30827, FAM107A |
MIMi | 608295, gene |
neXtProti | NX_O95990 |
Subcellular locationi
Plasma membrane
- ruffle membrane 1 Publication
Cytoskeleton
- stress fiber 2 Publications
Nucleus
- Nucleus 4 Publications
Other locations
- focal adhesion 1 Publication
- synapse By similarity
Note: Colocalizes with F-actin and COMMD1 in the nucleus (PubMed:28604741). Colocalizes with MAP1A along actin stress fibers and membrane ruffles (PubMed:20543869).2 Publications
Cytoskeleton
- actin cytoskeleton Source: UniProtKB
- stress fiber Source: UniProtKB
Nucleus
- nuclear speck Source: HPA
- nucleus Source: UniProtKB
Plasma Membrane
- ruffle membrane Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- focal adhesion Source: UniProtKB
- neuron projection Source: UniProtKB
- synapse Source: UniProtKB
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Nucleus, SynapsePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 48 – 50 | Missing : Increases nuclear and diffused cytoplasm localization, decreases interaction with MAP1A, alters actin cytoskeleton organization and decreases focal adhesion (FA) disassembly and cell migration. 1 Publication | 3 | |
Mutagenesisi | 65 – 66 | PE → AA: Increases diffused cytoplasm localization, loss of interaction with ACTB and colocalization with nuclear F-actin, decreases COMMD1 protein stability and ubiquitination of NF-kappa-B subunit RELA and decreases focal adhesion (FA) disassembly and cell migration; when associated with 122-A-A-123. 1 Publication | 2 | |
Mutagenesisi | 74 – 76 | RRR → AAA: Decreases nuclear localization and ubiquitination of NF-kappa-B subunit RELA. 1 Publication | 3 | |
Mutagenesisi | 81 – 84 | KKKK → AAAA: Decreases nuclear localization. 1 Publication | 4 | |
Mutagenesisi | 122 – 123 | PE → AA: Increases diffused cytoplasm localization, loss of interaction with ACTB and colocalization with nuclear F-actin, decreases COMMD1 protein stability and ubiquitination of NF-kappa-B subunit RELA and decreases focal adhesion (FA) disassembly and cell migration; when associated with 65-A-A-66. 1 Publication | 2 |
Organism-specific databases
DisGeNETi | 11170 |
OpenTargetsi | ENSG00000168309 |
PharmGKBi | PA143485464 |
Miscellaneous databases
Pharosi | O95990, Tbio |
Polymorphism and mutation databases
BioMutai | FAM107A |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080014 | 1 – 144 | Actin-associated protein FAM107AAdd BLAST | 144 |
Proteomic databases
MassIVEi | O95990 |
PaxDbi | O95990 |
PeptideAtlasi | O95990 |
PRIDEi | O95990 |
ProteomicsDBi | 51166 [O95990-1] 51167 [O95990-2] |
PTM databases
iPTMneti | O95990 |
Expressioni
Tissue specificityi
Widely expressed (PubMed:10564580). Expressed in neurons (PubMed:20543869). Expressed in malignant glial tumors (PubMed:20543869). Expression is reduced or absent in a number of cancer cell lines (PubMed:10564580).2 Publications
Gene expression databases
Bgeei | ENSG00000168309, Expressed in entorhinal cortex and 234 other tissues |
ExpressionAtlasi | O95990, baseline and differential |
Genevisiblei | O95990, HS |
Organism-specific databases
HPAi | ENSG00000168309, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsIsoform 3 [O95990-3]
Isoform 4 [O95990-4]
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
Protein-protein interaction databases
BioGRIDi | 116341, 61 interactors |
IntActi | O95990, 33 interactors |
STRINGi | 9606.ENSP00000419124 |
Miscellaneous databases
RNActi | O95990, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 66 – 112 | Sequence analysisAdd BLAST | 47 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 74 – 84 | Nuclear localization signal1 PublicationAdd BLAST | 11 |
Sequence similaritiesi
Belongs to the FAM107 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502RZJK, Eukaryota |
GeneTreei | ENSGT00390000011228 |
InParanoidi | O95990 |
OMAi | QEDHAPE |
PhylomeDBi | O95990 |
TreeFami | TF325943 |
Family and domain databases
InterProi | View protein in InterPro IPR009533, FAM107 |
PANTHERi | PTHR16768, PTHR16768, 1 hit |
Pfami | View protein in Pfam PF06625, DUF1151, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: O95990-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MYSEIQRERA DIGGLMARPE YREWNPELIK PKKLLNPVKA SRSHQELHRE
60 70 80 90 100
LLMNHRRGLG VDSKPELQRV LEHRRRNQLI KKKKEELEAK RLQCPFEQEL
110 120 130 140
LRRQQRLNQL EKPPEKEEDH APEFIKVREN LRRIATLTSE EREL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9JAU5 | C9JAU5_HUMAN | Actin-associated protein FAM107A | FAM107A | 105 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Isoform 4 (identifier: O95990-4) | |||||
Sequence conflicti | 26 | R → Q in BAG51416 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_017238 | 15 | L → M in ovarian cancer and renal cell carcinoma cell lines. 1 Publication | 1 | |
Natural variantiVAR_017239 | 19 | P → L in renal cell carcinoma cell line. 1 Publication | 1 | |
Natural variantiVAR_049016 | 89 | A → S. Corresponds to variant dbSNP:rs1043942Ensembl. | 1 | |
Natural variantiVAR_049017 | 141 | E → Q. Corresponds to variant dbSNP:rs11539086Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054803 | 1 | M → MAQRLGEWARGPSDATGLYR AVLLRSAAM in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_054804 | 1 | M → MGAAQGKKKTYSPQARFHSE NEKQRRNGSAAM in isoform 4. 1 Publication | 1 | |
Alternative sequenceiVSP_009232 | 110 – 144 | LEKPP…EEREL → VGDGHPAGTTHPPGLSSREE LCCGHS in isoform 2. 1 PublicationAdd BLAST | 35 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF089854 mRNA Translation: AAD16094.1 AF089853 mRNA Translation: AAD16093.1 AB023810 Genomic DNA Translation: BAA83072.1 AB023811 mRNA Translation: BAA82845.1 AL050264 mRNA Translation: CAB43366.1 AK054720 mRNA Translation: BAG51416.1 AK055443 mRNA Translation: BAB70924.1 AK316450 mRNA Translation: BAH14821.1 AC116036 Genomic DNA No translation available. AC119424 Genomic DNA No translation available. CH471055 Genomic DNA Translation: EAW65380.1 BC010561 mRNA Translation: AAH10561.1 |
CCDSi | CCDS2892.1 [O95990-1] CCDS63672.1 [O95990-3] CCDS63673.1 [O95990-4] |
PIRi | T08666 |
RefSeqi | NP_001070246.1, NM_001076778.2 [O95990-1] NP_001269642.1, NM_001282713.1 [O95990-3] NP_001269643.1, NM_001282714.1 [O95990-4] NP_009108.1, NM_007177.3 [O95990-1] |
Genome annotation databases
Ensembli | ENST00000360997; ENSP00000354270; ENSG00000168309 [O95990-1] ENST00000394481; ENSP00000377991; ENSG00000168309 [O95990-1] ENST00000447756; ENSP00000400858; ENSG00000168309 [O95990-3] ENST00000464064; ENSP00000419529; ENSG00000168309 [O95990-2] ENST00000474531; ENSP00000419124; ENSG00000168309 [O95990-4] ENST00000649301; ENSP00000497152; ENSG00000168309 [O95990-1] |
GeneIDi | 11170 |
KEGGi | hsa:11170 |
UCSCi | uc003dko.5, human [O95990-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF089854 mRNA Translation: AAD16094.1 AF089853 mRNA Translation: AAD16093.1 AB023810 Genomic DNA Translation: BAA83072.1 AB023811 mRNA Translation: BAA82845.1 AL050264 mRNA Translation: CAB43366.1 AK054720 mRNA Translation: BAG51416.1 AK055443 mRNA Translation: BAB70924.1 AK316450 mRNA Translation: BAH14821.1 AC116036 Genomic DNA No translation available. AC119424 Genomic DNA No translation available. CH471055 Genomic DNA Translation: EAW65380.1 BC010561 mRNA Translation: AAH10561.1 |
CCDSi | CCDS2892.1 [O95990-1] CCDS63672.1 [O95990-3] CCDS63673.1 [O95990-4] |
PIRi | T08666 |
RefSeqi | NP_001070246.1, NM_001076778.2 [O95990-1] NP_001269642.1, NM_001282713.1 [O95990-3] NP_001269643.1, NM_001282714.1 [O95990-4] NP_009108.1, NM_007177.3 [O95990-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 116341, 61 interactors |
IntActi | O95990, 33 interactors |
STRINGi | 9606.ENSP00000419124 |
PTM databases
iPTMneti | O95990 |
Polymorphism and mutation databases
BioMutai | FAM107A |
Proteomic databases
MassIVEi | O95990 |
PaxDbi | O95990 |
PeptideAtlasi | O95990 |
PRIDEi | O95990 |
ProteomicsDBi | 51166 [O95990-1] 51167 [O95990-2] |
Protocols and materials databases
Antibodypediai | 31675, 119 antibodies |
DNASUi | 11170 |
Genome annotation databases
Ensembli | ENST00000360997; ENSP00000354270; ENSG00000168309 [O95990-1] ENST00000394481; ENSP00000377991; ENSG00000168309 [O95990-1] ENST00000447756; ENSP00000400858; ENSG00000168309 [O95990-3] ENST00000464064; ENSP00000419529; ENSG00000168309 [O95990-2] ENST00000474531; ENSP00000419124; ENSG00000168309 [O95990-4] ENST00000649301; ENSP00000497152; ENSG00000168309 [O95990-1] |
GeneIDi | 11170 |
KEGGi | hsa:11170 |
UCSCi | uc003dko.5, human [O95990-1] |
Organism-specific databases
CTDi | 11170 |
DisGeNETi | 11170 |
EuPathDBi | HostDB:ENSG00000168309.16 |
GeneCardsi | FAM107A |
HGNCi | HGNC:30827, FAM107A |
HPAi | ENSG00000168309, Tissue enhanced (brain) |
MIMi | 608295, gene |
neXtProti | NX_O95990 |
OpenTargetsi | ENSG00000168309 |
PharmGKBi | PA143485464 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RZJK, Eukaryota |
GeneTreei | ENSGT00390000011228 |
InParanoidi | O95990 |
OMAi | QEDHAPE |
PhylomeDBi | O95990 |
TreeFami | TF325943 |
Enzyme and pathway databases
PathwayCommonsi | O95990 |
SIGNORi | O95990 |
Miscellaneous databases
BioGRID-ORCSi | 11170, 7 hits in 842 CRISPR screens |
ChiTaRSi | FAM107A, human |
GeneWikii | FAM107A |
GenomeRNAii | 11170 |
Pharosi | O95990, Tbio |
PROi | PR:O95990 |
RNActi | O95990, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000168309, Expressed in entorhinal cortex and 234 other tissues |
ExpressionAtlasi | O95990, baseline and differential |
Genevisiblei | O95990, HS |
Family and domain databases
InterProi | View protein in InterPro IPR009533, FAM107 |
PANTHERi | PTHR16768, PTHR16768, 1 hit |
Pfami | View protein in Pfam PF06625, DUF1151, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F107A_HUMAN | |
Accessioni | O95990Primary (citable) accession number: O95990 Secondary accession number(s): B3KNQ4 Q96NH4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | May 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations