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Protein

T-cell leukemia/lymphoma protein 1B

Gene

TCL1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enhances the phosphorylation and activation of AKT1 and AKT2.1 Publication

Miscellaneous

Activated in chronic T-cell leukemias (T-CLL) carrying rearrangements of the 14q32.1 region.

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB
  • protein serine/threonine kinase activator activity Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

SIGNORiO95988

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell leukemia/lymphoma protein 1B
Alternative name(s):
Oncogene TCL-1B
Short name:
Oncogene TCL1B
SYN-1
Syncytiotrophoblast-specific protein
TCL1/MTCP1-like protein 1
Gene namesi
Name:TCL1B
Synonyms:TCL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000213231.12
HGNCiHGNC:11649 TCL1B
MIMi603769 gene
neXtProtiNX_O95988

Subcellular locationi

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi9623
OpenTargetsiENSG00000213231
PharmGKBiPA36401

Polymorphism and mutation databases

BioMutaiTCL1B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001844901 – 128T-cell leukemia/lymphoma protein 1BAdd BLAST128

Proteomic databases

PaxDbiO95988
PeptideAtlasiO95988
PRIDEiO95988
ProteomicsDBi51164

PTM databases

iPTMnetiO95988
PhosphoSitePlusiO95988

Expressioni

Tissue specificityi

Expressed in a variety of tissues including placenta and testis.2 Publications

Gene expression databases

BgeeiENSG00000213231 Expressed in 18 organ(s), highest expression level in testis
CleanExiHS_TCL1B
ExpressionAtlasiO95988 baseline and differential
GenevisibleiO95988 HS

Organism-specific databases

HPAiHPA053163

Interactioni

Subunit structurei

Interacts with AKT1 and AKT2 (via PH domain). Does not interact with AKT3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MKRN3Q130644EBI-727338,EBI-2340269

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114983, 32 interactors
IntActiO95988, 10 interactors
STRINGi9606.ENSP00000343223

Structurei

3D structure databases

ProteinModelPortaliO95988
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCL1 family.Curated

Phylogenomic databases

eggNOGiENOG410JEJH Eukaryota
ENOG41114XX LUCA
GeneTreeiENSGT00390000006885
HOGENOMiHOG000037945
InParanoidiO95988
KOiK16836
OMAiEWARASN
OrthoDBiEOG091G0SNX
PhylomeDBiO95988
TreeFamiTF340217

Family and domain databases

Gene3Di2.40.15.10, 1 hit
InterProiView protein in InterPro
IPR004832 TCL1_MTCP1
IPR036672 TCL1_MTCP1_sf
PANTHERiPTHR14060 PTHR14060, 1 hit
PfamiView protein in Pfam
PF01840 TCL1_MTCP1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD015575 TCL1_MTCP1, 1 hit
SUPFAMiSSF50904 SSF50904, 1 hit

Sequencei

Sequence statusi: Complete.

O95988-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASEASVRLG VPPGRLWIQR PGIYEDEEGR TWVTVVVRFN PSRREWARAS
60 70 80 90 100
QGSRYEPSIT VHLWQMAVHT RELLSSGQMP FSQLPAVWQL YPGRKYRAAD
110 120
SSFWEIADHG QIDSMEQLVL TYQPERKD
Length:128
Mass (Da):14,846
Last modified:May 1, 1999 - v1
Checksum:i6BA2CF3F40F78B4D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02046793G → R2 PublicationsCorresponds to variant dbSNP:rs1064017Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018563 mRNA Translation: BAA76712.1
AB025274 Genomic DNA Translation: BAA82476.1
AF110465 Genomic DNA Translation: AAD16996.1
AF110466 mRNA Translation: AAD16997.1
AF137027 mRNA Translation: AAD30130.1
CR457087 mRNA Translation: CAG33368.1
AL133467 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81619.1
BC041616 mRNA Translation: AAH41616.1
BC051000 mRNA Translation: AAH51000.1
CCDSiCCDS32151.1
RefSeqiNP_004909.1, NM_004918.3
UniGeneiHs.632346

Genome annotation databases

EnsembliENST00000340722; ENSP00000343223; ENSG00000213231
GeneIDi9623
KEGGihsa:9623
UCSCiuc001yez.3 human

Keywords - Coding sequence diversityi

Chromosomal rearrangement, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018563 mRNA Translation: BAA76712.1
AB025274 Genomic DNA Translation: BAA82476.1
AF110465 Genomic DNA Translation: AAD16996.1
AF110466 mRNA Translation: AAD16997.1
AF137027 mRNA Translation: AAD30130.1
CR457087 mRNA Translation: CAG33368.1
AL133467 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81619.1
BC041616 mRNA Translation: AAH41616.1
BC051000 mRNA Translation: AAH51000.1
CCDSiCCDS32151.1
RefSeqiNP_004909.1, NM_004918.3
UniGeneiHs.632346

3D structure databases

ProteinModelPortaliO95988
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114983, 32 interactors
IntActiO95988, 10 interactors
STRINGi9606.ENSP00000343223

PTM databases

iPTMnetiO95988
PhosphoSitePlusiO95988

Polymorphism and mutation databases

BioMutaiTCL1B

Proteomic databases

PaxDbiO95988
PeptideAtlasiO95988
PRIDEiO95988
ProteomicsDBi51164

Protocols and materials databases

DNASUi9623
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340722; ENSP00000343223; ENSG00000213231
GeneIDi9623
KEGGihsa:9623
UCSCiuc001yez.3 human

Organism-specific databases

CTDi9623
DisGeNETi9623
EuPathDBiHostDB:ENSG00000213231.12
GeneCardsiTCL1B
HGNCiHGNC:11649 TCL1B
HPAiHPA053163
MIMi603769 gene
neXtProtiNX_O95988
OpenTargetsiENSG00000213231
PharmGKBiPA36401
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JEJH Eukaryota
ENOG41114XX LUCA
GeneTreeiENSGT00390000006885
HOGENOMiHOG000037945
InParanoidiO95988
KOiK16836
OMAiEWARASN
OrthoDBiEOG091G0SNX
PhylomeDBiO95988
TreeFamiTF340217

Enzyme and pathway databases

SIGNORiO95988

Miscellaneous databases

ChiTaRSiTCL1B human
GeneWikiiTCL1B
GenomeRNAii9623
PROiPR:O95988
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000213231 Expressed in 18 organ(s), highest expression level in testis
CleanExiHS_TCL1B
ExpressionAtlasiO95988 baseline and differential
GenevisibleiO95988 HS

Family and domain databases

Gene3Di2.40.15.10, 1 hit
InterProiView protein in InterPro
IPR004832 TCL1_MTCP1
IPR036672 TCL1_MTCP1_sf
PANTHERiPTHR14060 PTHR14060, 1 hit
PfamiView protein in Pfam
PF01840 TCL1_MTCP1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD015575 TCL1_MTCP1, 1 hit
SUPFAMiSSF50904 SSF50904, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTCL1B_HUMAN
AccessioniPrimary (citable) accession number: O95988
Secondary accession number(s): A6NEK7, Q6IAR7, Q9UBQ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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