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UniProtKB - O95977 (S1PR4_HUMAN)

Entry version 166 (10 Feb 2021)
Sequence version 1 (01 May 1999)
Previous versions | rss
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Protein

Sphingosine 1-phosphate receptor 4

Gene

S1PR4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O95977

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-418594, G alpha (i) signalling events
R-HSA-419408, Lysosphingolipid and LPA receptors

SIGNOR Signaling Network Open Resource

More...SIGNORi		O95977

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sphingosine 1-phosphate receptor 4
Short name:
S1P receptor 4
Short name:
S1P4
Alternative name(s):
Endothelial differentiation G-protein coupled receptor 6
Sphingosine 1-phosphate receptor Edg-6
Short name:
S1P receptor Edg-6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:S1PR4
Synonyms:EDG6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:3170, S1PR4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603751, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O95977

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000125910.5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 50ExtracellularBy similarityAdd BLAST50
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei51 – 71Helical; Name=1By similarityAdd BLAST21
Topological domaini72 – 84CytoplasmicBy similarityAdd BLAST13
Transmembranei85 – 105Helical; Name=2By similarityAdd BLAST21
Topological domaini106 – 117ExtracellularBy similarityAdd BLAST12
Transmembranei118 – 138Helical; Name=3By similarityAdd BLAST21
Topological domaini139 – 161CytoplasmicBy similarityAdd BLAST23
Transmembranei162 – 182Helical; Name=4By similarityAdd BLAST21
Topological domaini183 – 206ExtracellularBy similarityAdd BLAST24
Transmembranei207 – 227Helical; Name=5By similarityAdd BLAST21
Topological domaini228 – 252CytoplasmicBy similarityAdd BLAST25
Transmembranei253 – 273Helical; Name=6By similarityAdd BLAST21
Topological domaini274 – 288ExtracellularBy similarityAdd BLAST15
Transmembranei289 – 309Helical; Name=7By similarityAdd BLAST21
Topological domaini310 – 384CytoplasmicBy similarityAdd BLAST75

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		8698

Open Targets

More...OpenTargetsi		ENSG00000125910

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162402371

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O95977, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3230

Drug and drug target database

More...DrugBanki		DB08868, Fingolimod

DrugCentral

More...DrugCentrali		O95977

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		278

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		S1PR4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000694311 – 384Sphingosine 1-phosphate receptor 4Add BLAST384

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi2N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi30N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi323S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O95977

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O95977

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O95977

PeptideAtlas

More...PeptideAtlasi		O95977

PRoteomics IDEntifications database

More...PRIDEi		O95977

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51157

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O95977, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O95977

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O95977

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O95977

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Specifically expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung. Considerable level of expression in adult and fetal spleen as well as adult peripheral leukocytes and lung. Lower expression in adult thymus, lymph node, bone marrow, and appendix as well as in fetal liver, thymus, and lung.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000125910, Expressed in blood and 154 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O95977, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000125910, Group enriched (blood, bone marrow, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114243, 6 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O95977

Protein interaction database and analysis system

More...IntActi		O95977, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000246115

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		O95977

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O95977, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1384
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O95977

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O95977

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QQUE, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01010000222268

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_047979_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O95977

Identification of Orthologs from Complete Genome Data

More...OMAi		YVCIANI

Database of Orthologous Groups

More...OrthoDBi		981486at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O95977

TreeFam database of animal gene trees

More...TreeFami		TF330052

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004064, EDG6_rcpt
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR004061, S1P_rcpt

The PANTHER Classification System

More...PANTHERi		PTHR22750:SF13, PTHR22750:SF13, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01526, EDG6RECEPTOR
PR00237, GPCRRHODOPSN
PR01523, S1PRECEPTOR

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O95977-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNATGTPVAP ESCQQLAAGG HSRLIVLHYN HSGRLAGRGG PEDGGLGALR 
        60         70         80         90        100
GLSVAASCLV VLENLLVLAA ITSHMRSRRW VYYCLVNITL SDLLTGAAYL 
       110        120        130        140        150
ANVLLSGART FRLAPAQWFL REGLLFTALA ASTFSLLFTA GERFATMVRP 
       160        170        180        190        200
VAESGATKTS RVYGFIGLCW LLAALLGMLP LLGWNCLCAF DRCSSLLPLY 
       210        220        230        240        250
SKRYILFCLV IFAGVLATIM GLYGAIFRLV QASGQKAPRP AARRKARRLL 
       260        270        280        290        300
KTVLMILLAF LVCWGPLFGL LLADVFGSNL WAQEYLRGMD WILALAVLNS 
       310        320        330        340        350
AVNPIIYSFR SREVCRAVLS FLCCGCLRLG MRGPGDCLAR AVEAHSGAST 
       360        370        380 
TDSSLRPRDS FRGSRSLSFR MREPLSSISS VRSI
Length:384
Mass (Da):41,623
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i369A7BC56AB46A47
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_022066365R → L. Corresponds to variant dbSNP:rs3746072Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ000479 mRNA Translation: CAA04118.1
AY322537 Genomic DNA Translation: AAP84350.1
CH471139 Genomic DNA Translation: EAW69336.1
CH471139 Genomic DNA Translation: EAW69337.1
BC014970 mRNA Translation: AAH14970.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12105.1

NCBI Reference Sequences

More...RefSeqi		NP_003766.1, NM_003775.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000246115; ENSP00000246115; ENSG00000125910

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8698

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8698

UCSC genome browser

More...UCSCi		uc002lxg.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000479 mRNA Translation: CAA04118.1
AY322537 Genomic DNA Translation: AAP84350.1
CH471139 Genomic DNA Translation: EAW69336.1
CH471139 Genomic DNA Translation: EAW69337.1
BC014970 mRNA Translation: AAH14970.1
CCDSiCCDS12105.1
RefSeqiNP_003766.1, NM_003775.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DCONMR-A105-118[»]
SMRiO95977
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114243, 6 interactors
CORUMiO95977
IntActiO95977, 3 interactors
STRINGi9606.ENSP00000246115

Chemistry databases

BindingDBiO95977
ChEMBLiCHEMBL3230
DrugBankiDB08868, Fingolimod
DrugCentraliO95977
GuidetoPHARMACOLOGYi278

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniO95977, 2 sites
iPTMnetiO95977
PhosphoSitePlusiO95977
SwissPalmiO95977

Genetic variation databases

BioMutaiS1PR4

Proteomic databases

jPOSTiO95977
MassIVEiO95977
PaxDbiO95977
PeptideAtlasiO95977
PRIDEiO95977
ProteomicsDBi51157

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		10967, 363 antibodies

The DNASU plasmid repository

More...DNASUi		8698

Genome annotation databases

EnsembliENST00000246115; ENSP00000246115; ENSG00000125910
GeneIDi8698
KEGGihsa:8698
UCSCiuc002lxg.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8698
DisGeNETi8698

GeneCards: human genes, protein and diseases

More...GeneCardsi		S1PR4
HGNCiHGNC:3170, S1PR4
HPAiENSG00000125910, Group enriched (blood, bone marrow, lymphoid tissue)
MIMi603751, gene
neXtProtiNX_O95977
OpenTargetsiENSG00000125910
PharmGKBiPA162402371
VEuPathDBiHostDB:ENSG00000125910.5

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QQUE, Eukaryota
GeneTreeiENSGT01010000222268
HOGENOMiCLU_047979_1_1_1
InParanoidiO95977
OMAiYVCIANI
OrthoDBi981486at2759
PhylomeDBiO95977
TreeFamiTF330052

Enzyme and pathway databases

PathwayCommonsiO95977
ReactomeiR-HSA-418594, G alpha (i) signalling events
R-HSA-419408, Lysosphingolipid and LPA receptors
SIGNORiO95977

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8698, 9 hits in 870 CRISPR screens
EvolutionaryTraceiO95977

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		S1PR4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8698
PharosiO95977, Tclin

Protein Ontology

More...PROi		PR:O95977
RNActiO95977, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000125910, Expressed in blood and 154 other tissues
GenevisibleiO95977, HS

Family and domain databases

InterProiView protein in InterPro
IPR004064, EDG6_rcpt
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR004061, S1P_rcpt
PANTHERiPTHR22750:SF13, PTHR22750:SF13, 1 hit
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR01526, EDG6RECEPTOR
PR00237, GPCRRHODOPSN
PR01523, S1PRECEPTOR
PROSITEiView protein in PROSITE
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS1PR4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95977
Secondary accession number(s): D6W612
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: May 1, 1999
Last modified: February 10, 2021
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human variants curated from literature reports
    Index of human variants curated from literature reports
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  7. Human entries with genetic variants
    List of human entries with genetic variants
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