UniProtKB - O95977 (S1PR4_HUMAN)

BLAST

>sp|O95977|S1PR4_HUMAN Sphingosine 1-phosphate receptor 4 OS=Homo sapiens OX=9606 GN=S1PR4 PE=1 SV=1
MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLV
VLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFL
REGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLP
LLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRP
AARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNS
AVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDS
FRGSRSLSFRMREPLSSISSVRSI

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History
Entry version 150 (07 Nov 2018)
Sequence version 1 (01 May 1999)
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Protein

Sphingosine 1-phosphate receptor 4

Gene

S1PR4

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes.2 Publications

GO - Molecular functionⁱ

G protein-coupled receptor activity
Source: ProtInc
Traceable author statementⁱ
- 10679247
lipid binding
Source: ProtInc
Traceable author statementⁱ
- 10679247
sphingosine-1-phosphate receptor activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of phospholipase C activity
Source: ProtInc
Traceable author statementⁱ
- 10679247
adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: Ensembl
G protein-coupled receptor signaling pathway Source: Reactome
immune response
Source: ProtInc
Traceable author statementⁱ
- 9790765
positive regulation of cytosolic calcium ion concentration
Source: ProtInc
Traceable author statementⁱ
- 10679247

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-HSA-418594 G alpha (i) signalling events R-HSA-419408 Lysosphingolipid and LPA receptors

Reactomeⁱ

R-HSA-418594 G alpha (i) signalling events
R-HSA-419408 Lysosphingolipid and LPA receptors

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Sphingosine 1-phosphate receptor 4 Short name: S1P receptor 4 Short name: S1P4 Alternative name(s): Endothelial differentiation G-protein coupled receptor 6 Sphingosine 1-phosphate receptor Edg-6 Short name: S1P receptor Edg-6
Gene namesⁱ	Name:S1PR4 Synonyms:EDG6
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000125910.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3170 S1PR4
MIMⁱ	603751 gene
neXtProtⁱ	NX_O95977

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 50	ExtracellularBy similarityAdd BLAST	50
Transmembraneⁱ	51 – 71	Helical; Name=1By similarityAdd BLAST	21
Topological domainⁱ	72 – 84	CytoplasmicBy similarityAdd BLAST	13
Transmembraneⁱ	85 – 105	Helical; Name=2By similarityAdd BLAST	21
Topological domainⁱ	106 – 117	ExtracellularBy similarityAdd BLAST	12
Transmembraneⁱ	118 – 138	Helical; Name=3By similarityAdd BLAST	21
Topological domainⁱ	139 – 161	CytoplasmicBy similarityAdd BLAST	23
Transmembraneⁱ	162 – 182	Helical; Name=4By similarityAdd BLAST	21
Topological domainⁱ	183 – 206	ExtracellularBy similarityAdd BLAST	24
Transmembraneⁱ	207 – 227	Helical; Name=5By similarityAdd BLAST	21
Topological domainⁱ	228 – 252	CytoplasmicBy similarityAdd BLAST	25
Transmembraneⁱ	253 – 273	Helical; Name=6By similarityAdd BLAST	21
Topological domainⁱ	274 – 288	ExtracellularBy similarityAdd BLAST	15
Transmembraneⁱ	289 – 309	Helical; Name=7By similarityAdd BLAST	21
Topological domainⁱ	310 – 384	CytoplasmicBy similarityAdd BLAST	75

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8698
Open Targets More...OpenTargetsⁱ	ENSG00000125910
PharmGKBⁱ	PA162402371

Chemistry databases

ChEMBLⁱ	CHEMBL3230
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	278

Polymorphism and mutation databases

BioMutaⁱ	S1PR4

BioMutaⁱ

S1PR4

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069431	1 – 384	Sphingosine 1-phosphate receptor 4Add BLAST		384

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	2	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	30	N-linked (GlcNAc...) asparagineSequence analysis	1
Lipidationⁱ	323	S-palmitoyl cysteineBy similarity	1

Keywords - PTMⁱ

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbⁱ	O95977
PeptideAtlas More...PeptideAtlasⁱ	O95977
PRIDEⁱ	O95977
ProteomicsDBⁱ	51157

PTM databases

iPTMnetⁱ	O95977
PhosphoSitePlusⁱ	O95977
SwissPalmⁱ	O95977

Expressionⁱ

Tissue specificityⁱ

Specifically expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung. Considerable level of expression in adult and fetal spleen as well as adult peripheral leukocytes and lung. Lower expression in adult thymus, lymph node, bone marrow, and appendix as well as in fetal liver, thymus, and lung.

Gene expression databases

Bgeeⁱ	ENSG00000125910 Expressed in 136 organ(s), highest expression level in blood
CleanExⁱ	HS_S1PR4
Genevisibleⁱ	O95977 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA060601 HPA067232

HPAⁱ

HPA060601
HPA067232

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	114243, 5 interactors
CORUMⁱ	O95977
IntActⁱ	O95977, 1 interactor
STRINGⁱ	9606.ENSP00000246115

Chemistry databases

BindingDBⁱ

O95977

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Helixⁱ	108 – 111	Combined sources		4
Beta strandⁱ	113 – 116	Combined sources		4

Show more details

3D structure databases

ProteinModelPortalⁱ	O95977
SMRⁱ	O95977
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

O95977

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IFA2 Eukaryota ENOG41116IH LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118804
HOGENOMⁱ	HOG000233501
HOVERGENⁱ	HBG103071
InParanoidⁱ	O95977
KEGG Orthology (KO) More...KOⁱ	K04293
OMAⁱ	AFQRCSS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DD4
PhylomeDBⁱ	O95977
TreeFamⁱ	TF330052

Family and domain databases

InterProⁱ	View protein in InterPro IPR004064 EDG6_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR004061 S1P_rcpt
PANTHERⁱ	PTHR22750:SF13 PTHR22750:SF13, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR01526 EDG6RECEPTOR PR00237 GPCRRHODOPSN PR01523 S1PRECEPTOR
PROSITEⁱ	View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O95977-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNATGTPVAP ESCQQLAAGG HSRLIVLHYN HSGRLAGRGG PEDGGLGALR 
        60         70         80         90        100
GLSVAASCLV VLENLLVLAA ITSHMRSRRW VYYCLVNITL SDLLTGAAYL 
       110        120        130        140        150
ANVLLSGART FRLAPAQWFL REGLLFTALA ASTFSLLFTA GERFATMVRP 
       160        170        180        190        200
VAESGATKTS RVYGFIGLCW LLAALLGMLP LLGWNCLCAF DRCSSLLPLY 
       210        220        230        240        250
SKRYILFCLV IFAGVLATIM GLYGAIFRLV QASGQKAPRP AARRKARRLL 
       260        270        280        290        300
KTVLMILLAF LVCWGPLFGL LLADVFGSNL WAQEYLRGMD WILALAVLNS 
       310        320        330        340        350
AVNPIIYSFR SREVCRAVLS FLCCGCLRLG MRGPGDCLAR AVEAHSGAST 
       360        370        380 
TDSSLRPRDS FRGSRSLSFR MREPLSSISS VRSI

Length:384

Mass (Da):41,623

Last modified:May 1, 1999 - v1

Checksum:ⁱ369A7BC56AB46A47

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_022066	365	R → L. Corresponds to variant dbSNP:rs3746072Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ000479 mRNA Translation: CAA04118.1 AY322537 Genomic DNA Translation: AAP84350.1 CH471139 Genomic DNA Translation: EAW69336.1 CH471139 Genomic DNA Translation: EAW69337.1 BC014970 mRNA Translation: AAH14970.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12105.1
NCBI Reference Sequences More...RefSeqⁱ	NP_003766.1, NM_003775.3
UniGeneⁱ	Hs.662006

Genome annotation databases

Ensemblⁱ	ENST00000246115; ENSP00000246115; ENSG00000125910
GeneIDⁱ	8698
KEGGⁱ	hsa:8698
UCSC genome browser More...UCSCⁱ	uc002lxg.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O95977	S1PR4 isoform 1		PANTR		384	UniRef100_O95977

Protein	Similar proteins		Species	Score	Length	Source
O95977	S1PR4 isoform 1		PANTR		384	UniRef90_O95977
Sphingosine 1-phosphate receptor 4		MACMU		384
Uncharacterized protein		PAPAN		384
Uncharacterized protein		MACFA		384
S1PR4 isoform 2		PONAB		384
+18

Protein	Similar proteins		Species	Score	Length	Source
O95977	S1PR4 isoform 1		PANTR		384	UniRef50_O95977
Uncharacterized protein		MACNE		384
Uncharacterized protein		OTOGA		384
Sphingosine 1-phosphate receptor 4		MACMU		384
Uncharacterized protein		PAPAN		384
+76

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ000479 mRNA Translation: CAA04118.1 AY322537 Genomic DNA Translation: AAP84350.1 CH471139 Genomic DNA Translation: EAW69336.1 CH471139 Genomic DNA Translation: EAW69337.1 BC014970 mRNA Translation: AAH14970.1
CCDSⁱ	CCDS12105.1
RefSeqⁱ	NP_003766.1, NM_003775.3
UniGeneⁱ	Hs.662006

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2DCO	NMR	-	A	105-118	[»]
ProteinModelPortalⁱ	O95977
SMRⁱ	O95977
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114243, 5 interactors
CORUMⁱ	O95977
IntActⁱ	O95977, 1 interactor
STRINGⁱ	9606.ENSP00000246115

Chemistry databases

BindingDBⁱ	O95977
ChEMBLⁱ	CHEMBL3230
GuidetoPHARMACOLOGYⁱ	278

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	O95977
PhosphoSitePlusⁱ	O95977
SwissPalmⁱ	O95977

Polymorphism and mutation databases

BioMutaⁱ	S1PR4

BioMutaⁱ

S1PR4

Proteomic databases

PaxDbⁱ	O95977
PeptideAtlasⁱ	O95977
PRIDEⁱ	O95977
ProteomicsDBⁱ	51157

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	8698
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000246115; ENSP00000246115; ENSG00000125910
GeneIDⁱ	8698
KEGGⁱ	hsa:8698
UCSCⁱ	uc002lxg.4 human

Organism-specific databases

CTDⁱ	8698
DisGeNETⁱ	8698
EuPathDBⁱ	HostDB:ENSG00000125910.5
GeneCardsⁱ	S1PR4
H-InvDBⁱ	HIX0174310
HGNCⁱ	HGNC:3170 S1PR4
HPAⁱ	HPA060601 HPA067232
MIMⁱ	603751 gene
neXtProtⁱ	NX_O95977
OpenTargetsⁱ	ENSG00000125910
PharmGKBⁱ	PA162402371
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IFA2 Eukaryota ENOG41116IH LUCA
GeneTreeⁱ	ENSGT00760000118804
HOGENOMⁱ	HOG000233501
HOVERGENⁱ	HBG103071
InParanoidⁱ	O95977
KOⁱ	K04293
OMAⁱ	AFQRCSS
OrthoDBⁱ	EOG091G0DD4
PhylomeDBⁱ	O95977
TreeFamⁱ	TF330052

Enzyme and pathway databases

Reactomeⁱ	R-HSA-418594 G alpha (i) signalling events R-HSA-419408 Lysosphingolipid and LPA receptors

Reactomeⁱ

R-HSA-418594 G alpha (i) signalling events
R-HSA-419408 Lysosphingolipid and LPA receptors

Miscellaneous databases

EvolutionaryTraceⁱ	O95977
GeneWikiⁱ	S1PR4
GenomeRNAiⁱ	8698
Protein Ontology More...PROⁱ	PR:O95977
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000125910 Expressed in 136 organ(s), highest expression level in blood
CleanExⁱ	HS_S1PR4
Genevisibleⁱ	O95977 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR004064 EDG6_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR004061 S1P_rcpt
PANTHERⁱ	PTHR22750:SF13 PTHR22750:SF13, 1 hit
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR01526 EDG6RECEPTOR PR00237 GPCRRHODOPSN PR01523 S1PRECEPTOR
PROSITEⁱ	View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	S1PR4_HUMAN
Accessionⁱ	O95977Primary (citable) accession number: O95977 Secondary accession number(s): D6W612
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 16, 2004
	Last sequence update:	May 1, 1999
	Last modified:	November 7, 2018
	This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

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Supporting data

UniProtKB - O95977 (S1PR4_HUMAN)

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Sphingosine 1-phosphate receptor 4

S1PR4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Mitochondrion

Plasma Membrane

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ