UniProtKB - O95977 (S1PR4_HUMAN)
Protein
Sphingosine 1-phosphate receptor 4
Gene
S1PR4
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes.2 Publications
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
- lipid binding Source: ProtInc
- sphingosine-1-phosphate receptor activity Source: InterPro
GO - Biological processi
- activation of phospholipase C activity Source: ProtInc
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: GO_Central
- G protein-coupled receptor signaling pathway Source: Reactome
- immune response Source: ProtInc
- positive regulation of cytosolic calcium ion concentration Source: ProtInc
- regulation of metabolic process Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | O95977 |
Reactomei | R-HSA-418594, G alpha (i) signalling events R-HSA-419408, Lysosphingolipid and LPA receptors |
SIGNORi | O95977 |
Names & Taxonomyi
Protein namesi | Recommended name: Sphingosine 1-phosphate receptor 4Short name: S1P receptor 4 Short name: S1P4 Alternative name(s): Endothelial differentiation G-protein coupled receptor 6 Sphingosine 1-phosphate receptor Edg-6 Short name: S1P receptor Edg-6 |
Gene namesi | Name:S1PR4 Synonyms:EDG6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3170, S1PR4 |
MIMi | 603751, gene |
neXtProti | NX_O95977 |
VEuPathDBi | HostDB:ENSG00000125910.5 |
Subcellular locationi
Plasma membrane
Mitochondrion
- mitochondrion Source: HPA
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 50 | ExtracellularBy similarityAdd BLAST | 50 | |
Transmembranei | 51 – 71 | Helical; Name=1By similarityAdd BLAST | 21 | |
Topological domaini | 72 – 84 | CytoplasmicBy similarityAdd BLAST | 13 | |
Transmembranei | 85 – 105 | Helical; Name=2By similarityAdd BLAST | 21 | |
Topological domaini | 106 – 117 | ExtracellularBy similarityAdd BLAST | 12 | |
Transmembranei | 118 – 138 | Helical; Name=3By similarityAdd BLAST | 21 | |
Topological domaini | 139 – 161 | CytoplasmicBy similarityAdd BLAST | 23 | |
Transmembranei | 162 – 182 | Helical; Name=4By similarityAdd BLAST | 21 | |
Topological domaini | 183 – 206 | ExtracellularBy similarityAdd BLAST | 24 | |
Transmembranei | 207 – 227 | Helical; Name=5By similarityAdd BLAST | 21 | |
Topological domaini | 228 – 252 | CytoplasmicBy similarityAdd BLAST | 25 | |
Transmembranei | 253 – 273 | Helical; Name=6By similarityAdd BLAST | 21 | |
Topological domaini | 274 – 288 | ExtracellularBy similarityAdd BLAST | 15 | |
Transmembranei | 289 – 309 | Helical; Name=7By similarityAdd BLAST | 21 | |
Topological domaini | 310 – 384 | CytoplasmicBy similarityAdd BLAST | 75 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 8698 |
OpenTargetsi | ENSG00000125910 |
PharmGKBi | PA162402371 |
Miscellaneous databases
Pharosi | O95977, Tclin |
Chemistry databases
ChEMBLi | CHEMBL3230 |
DrugBanki | DB08868, Fingolimod |
DrugCentrali | O95977 |
GuidetoPHARMACOLOGYi | 278 |
Genetic variation databases
BioMutai | S1PR4 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069431 | 1 – 384 | Sphingosine 1-phosphate receptor 4Add BLAST | 384 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 2 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 30 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 323 | S-palmitoyl cysteineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, Lipoprotein, PalmitateProteomic databases
jPOSTi | O95977 |
MassIVEi | O95977 |
PaxDbi | O95977 |
PeptideAtlasi | O95977 |
PRIDEi | O95977 |
ProteomicsDBi | 51157 |
PTM databases
GlyGeni | O95977, 2 sites |
iPTMneti | O95977 |
PhosphoSitePlusi | O95977 |
SwissPalmi | O95977 |
Expressioni
Tissue specificityi
Specifically expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung. Considerable level of expression in adult and fetal spleen as well as adult peripheral leukocytes and lung. Lower expression in adult thymus, lymph node, bone marrow, and appendix as well as in fetal liver, thymus, and lung.
Gene expression databases
Bgeei | ENSG00000125910, Expressed in blood and 154 other tissues |
Genevisiblei | O95977, HS |
Organism-specific databases
HPAi | ENSG00000125910, Group enriched (blood, bone marrow, lymphoid tissue) |
Interactioni
Binary interactionsi
O95977
With | #Exp. | IntAct |
---|---|---|
GEMIN4 [P57678] | 3 | EBI-12194739,EBI-356700 |
Protein-protein interaction databases
BioGRIDi | 114243, 6 interactors |
CORUMi | O95977 |
IntActi | O95977, 3 interactors |
STRINGi | 9606.ENSP00000246115 |
Chemistry databases
BindingDBi | O95977 |
Miscellaneous databases
RNActi | O95977, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O95977 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O95977 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QQUE, Eukaryota |
GeneTreei | ENSGT01010000222268 |
HOGENOMi | CLU_047979_1_1_1 |
InParanoidi | O95977 |
OMAi | YVCIANI |
OrthoDBi | 981486at2759 |
PhylomeDBi | O95977 |
TreeFami | TF330052 |
Family and domain databases
InterProi | View protein in InterPro IPR004064, EDG6_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR004061, S1P_rcpt |
PANTHERi | PTHR22750:SF13, PTHR22750:SF13, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01526, EDG6RECEPTOR PR00237, GPCRRHODOPSN PR01523, S1PRECEPTOR |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
O95977-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNATGTPVAP ESCQQLAAGG HSRLIVLHYN HSGRLAGRGG PEDGGLGALR
60 70 80 90 100
GLSVAASCLV VLENLLVLAA ITSHMRSRRW VYYCLVNITL SDLLTGAAYL
110 120 130 140 150
ANVLLSGART FRLAPAQWFL REGLLFTALA ASTFSLLFTA GERFATMVRP
160 170 180 190 200
VAESGATKTS RVYGFIGLCW LLAALLGMLP LLGWNCLCAF DRCSSLLPLY
210 220 230 240 250
SKRYILFCLV IFAGVLATIM GLYGAIFRLV QASGQKAPRP AARRKARRLL
260 270 280 290 300
KTVLMILLAF LVCWGPLFGL LLADVFGSNL WAQEYLRGMD WILALAVLNS
310 320 330 340 350
AVNPIIYSFR SREVCRAVLS FLCCGCLRLG MRGPGDCLAR AVEAHSGAST
360 370 380
TDSSLRPRDS FRGSRSLSFR MREPLSSISS VRSI
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_022066 | 365 | R → L. Corresponds to variant dbSNP:rs3746072Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ000479 mRNA Translation: CAA04118.1 AY322537 Genomic DNA Translation: AAP84350.1 CH471139 Genomic DNA Translation: EAW69336.1 CH471139 Genomic DNA Translation: EAW69337.1 BC014970 mRNA Translation: AAH14970.1 |
CCDSi | CCDS12105.1 |
RefSeqi | NP_003766.1, NM_003775.3 |
Genome annotation databases
Ensembli | ENST00000246115; ENSP00000246115; ENSG00000125910 |
GeneIDi | 8698 |
KEGGi | hsa:8698 |
UCSCi | uc002lxg.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ000479 mRNA Translation: CAA04118.1 AY322537 Genomic DNA Translation: AAP84350.1 CH471139 Genomic DNA Translation: EAW69336.1 CH471139 Genomic DNA Translation: EAW69337.1 BC014970 mRNA Translation: AAH14970.1 |
CCDSi | CCDS12105.1 |
RefSeqi | NP_003766.1, NM_003775.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2DCO | NMR | - | A | 105-118 | [»] | |
SMRi | O95977 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114243, 6 interactors |
CORUMi | O95977 |
IntActi | O95977, 3 interactors |
STRINGi | 9606.ENSP00000246115 |
Chemistry databases
BindingDBi | O95977 |
ChEMBLi | CHEMBL3230 |
DrugBanki | DB08868, Fingolimod |
DrugCentrali | O95977 |
GuidetoPHARMACOLOGYi | 278 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | O95977, 2 sites |
iPTMneti | O95977 |
PhosphoSitePlusi | O95977 |
SwissPalmi | O95977 |
Genetic variation databases
BioMutai | S1PR4 |
Proteomic databases
jPOSTi | O95977 |
MassIVEi | O95977 |
PaxDbi | O95977 |
PeptideAtlasi | O95977 |
PRIDEi | O95977 |
ProteomicsDBi | 51157 |
Protocols and materials databases
Antibodypediai | 10967, 363 antibodies |
DNASUi | 8698 |
Genome annotation databases
Ensembli | ENST00000246115; ENSP00000246115; ENSG00000125910 |
GeneIDi | 8698 |
KEGGi | hsa:8698 |
UCSCi | uc002lxg.4, human |
Organism-specific databases
CTDi | 8698 |
DisGeNETi | 8698 |
GeneCardsi | S1PR4 |
HGNCi | HGNC:3170, S1PR4 |
HPAi | ENSG00000125910, Group enriched (blood, bone marrow, lymphoid tissue) |
MIMi | 603751, gene |
neXtProti | NX_O95977 |
OpenTargetsi | ENSG00000125910 |
PharmGKBi | PA162402371 |
VEuPathDBi | HostDB:ENSG00000125910.5 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQUE, Eukaryota |
GeneTreei | ENSGT01010000222268 |
HOGENOMi | CLU_047979_1_1_1 |
InParanoidi | O95977 |
OMAi | YVCIANI |
OrthoDBi | 981486at2759 |
PhylomeDBi | O95977 |
TreeFami | TF330052 |
Enzyme and pathway databases
PathwayCommonsi | O95977 |
Reactomei | R-HSA-418594, G alpha (i) signalling events R-HSA-419408, Lysosphingolipid and LPA receptors |
SIGNORi | O95977 |
Miscellaneous databases
BioGRID-ORCSi | 8698, 9 hits in 870 CRISPR screens |
EvolutionaryTracei | O95977 |
GeneWikii | S1PR4 |
GenomeRNAii | 8698 |
Pharosi | O95977, Tclin |
PROi | PR:O95977 |
RNActi | O95977, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000125910, Expressed in blood and 154 other tissues |
Genevisiblei | O95977, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004064, EDG6_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR004061, S1P_rcpt |
PANTHERi | PTHR22750:SF13, PTHR22750:SF13, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01526, EDG6RECEPTOR PR00237, GPCRRHODOPSN PR01523, S1PRECEPTOR |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S1PR4_HUMAN | |
Accessioni | O95977Primary (citable) accession number: O95977 Secondary accession number(s): D6W612 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 16, 2004 |
Last sequence update: | May 1, 1999 | |
Last modified: | February 10, 2021 | |
This is version 166 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants