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Protein

CD160 antigen

Gene

CD160

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor showing broad specificity for both classical and non-classical MHC class I molecules.1 Publication

GO - Molecular functioni

  • MHC class I receptor activity Source: HGNC
  • signaling receptor activity Source: ProtInc
  • signaling receptor binding Source: HGNC

GO - Biological processi

  • cell proliferation Source: ProtInc
  • cell surface receptor signaling pathway Source: ProtInc
  • cellular defense response Source: ProtInc
  • defense response to Gram-negative bacterium Source: Ensembl
  • regulation of immune response Source: Reactome

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyi

Protein namesi
Recommended name:
CD160 antigen
Alternative name(s):
Natural killer cell receptor BY55
CD_antigen: CD160
Gene namesi
Name:CD160
Synonyms:BY55
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000117281.15
HGNCiHGNC:17013 CD160
MIMi604463 gene
neXtProtiNX_O95971

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi11126
OpenTargetsiENSG00000117281
PharmGKBiPA134943137

Polymorphism and mutation databases

BioMutaiCD160

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001454327 – 159CD160 antigenAdd BLAST133
PropeptideiPRO_0000014544160 – 181Removed in mature formSequence analysisAdd BLAST22

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi28N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi44 ↔ 112Sequence analysis
Disulfide bondi61 ↔ 68Sequence analysis
Glycosylationi137N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi159GPI-anchor amidated serineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiO95971
PaxDbiO95971
PeptideAtlasiO95971
PRIDEiO95971
ProteomicsDBi51154

PTM databases

iPTMnetiO95971
PhosphoSitePlusiO95971

Expressioni

Tissue specificityi

Expressed in spleen, peripheral blood, and small intestine. Expression is restricted to functional NK and T cytotoxic lymphocytes.

Gene expression databases

BgeeiENSG00000117281
CleanExiHS_CD160
ExpressionAtlasiO95971 baseline and differential
GenevisibleiO95971 HS

Interactioni

Subunit structurei

Homomultimer; disulfide-linked.

Binary interactionsi

Show more details

GO - Molecular functioni

  • signaling receptor binding Source: HGNC

Protein-protein interaction databases

BioGridi116299, 41 interactors
IntActiO95971, 9 interactors
MINTiO95971
STRINGi9606.ENSP00000235933

Structurei

3D structure databases

ProteinModelPortaliO95971
SMRiO95971
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 122Ig-like V-typeAdd BLAST96

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410IX7D Eukaryota
ENOG411156J LUCA
GeneTreeiENSGT00390000007258
HOVERGENiHBG018849
InParanoidiO95971
KOiK06542
PhylomeDBiO95971
TreeFamiTF338321

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
SUPFAMiSSF48726 SSF48726, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95971-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLEPGRGCC ALAILLAIVD IQSGGCINIT SSASQEGTRL NLICTVWHKK
60 70 80 90 100
EEAEGFVVFL CKDRSGDCSP ETSLKQLRLK RDPGIDGVGE ISSQLMFTIS
110 120 130 140 150
QVTPLHSGTY QCCARSQKSG IRLQGHFFSI LFTETGNYTV TGLKQRQHLE
160 170 180
FSHNEGTLSS GFLQEKVWVM LVTSLVALQA L
Length:181
Mass (Da):19,810
Last modified:May 1, 1999 - v1
Checksum:iEF0B981ACC7478BD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02774791I → V. Corresponds to variant dbSNP:rs2231373Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060981 mRNA Translation: AAC72302.1
BC014465 mRNA Translation: AAH14465.1
CCDSiCCDS72861.1
RefSeqiNP_008984.1, NM_007053.3
UniGeneiHs.488237
Hs.740780

Genome annotation databases

EnsembliENST00000235933; ENSP00000235933; ENSG00000117281
ENST00000369288; ENSP00000358294; ENSG00000117281
GeneIDi11126
KEGGihsa:11126

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBY55_HUMAN
AccessioniPrimary (citable) accession number: O95971
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 1, 1999
Last modified: July 18, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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