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Protein

Leucine-rich glioma-inactivated protein 1

Gene

LGI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors (By similarity). Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival.By similarity2 Publications

GO - Molecular functioni

  • signaling receptor binding Source: DFLAT

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-5682910 LGI-ADAM interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich glioma-inactivated protein 1
Alternative name(s):
Epitempin-1
Gene namesi
Name:LGI1
Synonyms:EPT
ORF Names:UNQ775/PRO1569
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000108231.11
HGNCiHGNC:6572 LGI1
MIMi604619 gene
neXtProtiNX_O95970

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Secreted, Synapse

Pathology & Biotechi

Involvement in diseasei

Epilepsy, familial temporal lobe, 1 (ETL1)10 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA focal form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lobe. Seizures are usually accompanied by sensory symptoms, most often auditory in nature.
See also OMIM:600512
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01577126L → R in ETL1; probably affects signal sequence processing and secretion. 1 Publication1
Natural variantiVAR_02300842C → G in ETL1. 1 PublicationCorresponds to variant dbSNP:rs797044996EnsemblClinVar.1
Natural variantiVAR_05853842C → R in ETL1. Corresponds to variant dbSNP:rs797044996EnsemblClinVar.1
Natural variantiVAR_01577246C → R in ETL1; loss of protein secretion; does not affect glycosylation status of the protein. 2 PublicationsCorresponds to variant dbSNP:rs104894166EnsemblClinVar.1
Natural variantiVAR_058539110A → D in ETL1. 1
Natural variantiVAR_058540122I → K in ETL1. 1 PublicationCorresponds to variant dbSNP:rs119488100EnsemblClinVar.1
Natural variantiVAR_058541123E → K in ETL1. 1 Publication1
Natural variantiVAR_058542136R → W in ETL1. 1 PublicationCorresponds to variant dbSNP:rs119488099EnsemblClinVar.1
Natural variantiVAR_058543145S → R in ETL1; loss of protein secretion; does not affect glycosylation status of the protein. 1 Publication1
Natural variantiVAR_058544154L → P in ETL1. 1
Natural variantiVAR_058545200C → R in ETL1; loss of protein secretion; does not affect glycosylation status of the protein. 1 Publication1
Natural variantiVAR_058546232L → P in ETL1; loss of protein secretion. 1 PublicationCorresponds to variant dbSNP:rs104894167EnsemblClinVar.1
Natural variantiVAR_058547298I → T in ETL1. 1
Natural variantiVAR_015774318F → C in ETL1; loss of protein secretion; protein is retained in the endoplasmic reticulum; does not affect glycosylation status of the protein. 2 PublicationsCorresponds to variant dbSNP:rs28939075EnsemblClinVar.1
Natural variantiVAR_015773383E → A in ETL1; loss of protein secretion; protein is retained in the endoplasmic reticulum; does not affect glycosylation status of the protein. 3 PublicationsCorresponds to variant dbSNP:rs28937874EnsemblClinVar.1
Natural variantiVAR_058548432V → E in ETL1. 1
Natural variantiVAR_023009473S → L in ETL1. 1 PublicationCorresponds to variant dbSNP:rs797044999EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi192N → Q: Affects glycosylation; when associated with Q-277 and Q-422. Loss of protein secretion; when associated with Q-277 and Q-422. 1 Publication1
Mutagenesisi277N → Q: Affects glycosylation; when associated with Q-192 and Q-422. Loss of protein secretion; when associated with Q-192 and Q-422. 1 Publication1
Mutagenesisi422N → Q: Affects glycosylation; when associated with Q-192 and Q-277. Loss of protein secretion; when associated with Q-192 and Q-277. 1 Publication1

Keywords - Diseasei

Disease mutation, Epilepsy

Organism-specific databases

DisGeNETi9211
GeneReviewsiLGI1
MalaCardsiLGI1
MIMi600512 phenotype
OpenTargetsiENSG00000108231
Orphaneti101046 Autosomal dominant epilepsy with auditory features
PharmGKBiPA30349

Polymorphism and mutation databases

BioMutaiLGI1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000001770535 – 557Leucine-rich glioma-inactivated protein 1Add BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi277N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi422N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiO95970
PaxDbiO95970
PeptideAtlasiO95970
PRIDEiO95970
ProteomicsDBi51151
51152 [O95970-2]
51153 [O95970-3]
TopDownProteomicsiO95970-3 [O95970-3]

PTM databases

iPTMnetiO95970
PhosphoSitePlusiO95970

Expressioni

Tissue specificityi

Predominantly expressed in neural tissues, especially in brain. Expression is reduced in low-grade brain tumors and significantly reduced or absent in malignant gliomas. Isoform 1 is absent in the cerebellum and is detectable in the occipital cortex and hippocampus; higher amounts are observed in the parietal and frontal cortices, putamen, and, particularly, in the temporal neocortex, where it is 3.5 times more abundant than in the hippocampus (at protein level). Isoform 3 shows the highest expression in the occipital cortex and the lowest in the hippocampus (at protein level).2 Publications

Inductioni

Down-regulated in neuroblastoma cells.1 Publication

Gene expression databases

BgeeiENSG00000108231 Expressed in 133 organ(s), highest expression level in caudate nucleus
CleanExiHS_LGI1
ExpressionAtlasiO95970 baseline and differential
GenevisibleiO95970 HS

Interactioni

Subunit structurei

Oligomer. Interacts with KCNA1 within a complex containing KCNA1, KCNA4 and KCNAB1. Part of a complex containing ADAM22, DLG4/PSD95 and CACNG2/Stargazin (PubMed:27066583). Can bind to ADAM11 and ADAM23.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114645, 2 interactors
STRINGi9606.ENSP00000360472

Structurei

Secondary structure

1557
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO95970
SMRiO95970
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 72LRRNTAdd BLAST38
Repeati92 – 113LRR 1Add BLAST22
Repeati116 – 137LRR 2Add BLAST22
Repeati140 – 161LRR 3Add BLAST22
Domaini173 – 223LRRCTAdd BLAST51
Repeati225 – 267EAR 1PROSITE-ProRule annotationAdd BLAST43
Repeati271 – 313EAR 2PROSITE-ProRule annotationAdd BLAST43
Repeati317 – 364EAR 3PROSITE-ProRule annotationAdd BLAST48
Repeati366 – 415EAR 4PROSITE-ProRule annotationAdd BLAST50
Repeati419 – 462EAR 5PROSITE-ProRule annotationAdd BLAST44
Repeati464 – 506EAR 6PROSITE-ProRule annotationAdd BLAST43
Repeati510 – 552EAR 7PROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IIXR Eukaryota
ENOG410XSZV LUCA
GeneTreeiENSGT00930000150915
HOVERGENiHBG036744
InParanoidiO95970
OMAiIYQWNKG
OrthoDBiEOG091G03ZX
PhylomeDBiO95970
TreeFamiTF333155

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR009039 EAR
IPR005492 EPTP
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF03736 EPTP, 7 hits
PF13855 LRR_8, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 3 hits
SM00082 LRRCT, 1 hit
PROSITEiView protein in PROSITE
PS50912 EAR, 7 hits

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95970-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESERSKRMG NACIPLKRIA YFLCLLSALL LTEGKKPAKP KCPAVCTCTK
60 70 80 90 100
DNALCENARS IPRTVPPDVI SLSFVRSGFT EISEGSFLFT PSLQLLLFTS
110 120 130 140 150
NSFDVISDDA FIGLPHLEYL FIENNNIKSI SRHTFRGLKS LIHLSLANNN
160 170 180 190 200
LQTLPKDIFK GLDSLTNVDL RGNSFNCDCK LKWLVEWLGH TNATVEDIYC
210 220 230 240 250
EGPPEYKKRK INSLSSKDFD CIITEFAKSQ DLPYQSLSID TFSYLNDEYV
260 270 280 290 300
VIAQPFTGKC IFLEWDHVEK TFRNYDNITG TSTVVCKPIV IETQLYVIVA
310 320 330 340 350
QLFGGSHIYK RDSFANKFIK IQDIEILKIR KPNDIETFKI ENNWYFVVAD
360 370 380 390 400
SSKAGFTTIY KWNGNGFYSH QSLHAWYRDT DVEYLEIVRT PQTLRTPHLI
410 420 430 440 450
LSSSSQRPVI YQWNKATQLF TNQTDIPNME DVYAVKHFSV KGDVYICLTR
460 470 480 490 500
FIGDSKVMKW GGSSFQDIQR MPSRGSMVFQ PLQINNYQYA ILGSDYSFTQ
510 520 530 540 550
VYNWDAEKAK FVKFQELNVQ APRSFTHVSI NKRNFLFASS FKGNTQIYKH

VIVDLSA
Length:557
Mass (Da):63,818
Last modified:May 1, 1999 - v1
Checksum:i890EEDA08D95C854
GO
Isoform 2 (identifier: O95970-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     280-291: GTSTVVCKPIVI → VLREIHRFTNMS
     292-557: Missing.

Show »
Length:291
Mass (Da):33,121
Checksum:iBC10E3E110E016D0
GO
Isoform 3 (identifier: O95970-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     96-143: Missing.

Show »
Length:509
Mass (Da):58,302
Checksum:iEA28D9DACAFE97BD
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GUD3A0A1B0GUD3_HUMAN
Leucine-rich glioma-inactivated pro...
LGI1
281Annotation score:
A0A0D9SFU4A0A0D9SFU4_HUMAN
Leucine-rich glioma-inactivated pro...
LGI1
533Annotation score:
A0A1B0GV33A0A1B0GV33_HUMAN
Leucine-rich glioma-inactivated pro...
LGI1
287Annotation score:
A0A0D9SFH6A0A0D9SFH6_HUMAN
Leucine-rich glioma-inactivated pro...
LGI1
168Annotation score:
A0A1B0GWB4A0A1B0GWB4_HUMAN
Leucine-rich glioma-inactivated pro...
LGI1
236Annotation score:
A0A1B0GTM5A0A1B0GTM5_HUMAN
Leucine-rich glioma-inactivated pro...
LGI1
151Annotation score:
A0A0D9SFS5A0A0D9SFS5_HUMAN
Leucine-rich glioma inactivated 1 i...
LGI1
72Annotation score:
A0A0D9SFE3A0A0D9SFE3_HUMAN
Leucine-rich glioma-inactivated pro...
LGI1
96Annotation score:
A0A1B0GVP2A0A1B0GVP2_HUMAN
Leucine-rich glioma-inactivated pro...
LGI1
52Annotation score:
A0A1B0GVF6A0A1B0GVF6_HUMAN
Leucine-rich glioma-inactivated pro...
LGI1
100Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01577126L → R in ETL1; probably affects signal sequence processing and secretion. 1 Publication1
Natural variantiVAR_02300842C → G in ETL1. 1 PublicationCorresponds to variant dbSNP:rs797044996EnsemblClinVar.1
Natural variantiVAR_05853842C → R in ETL1. Corresponds to variant dbSNP:rs797044996EnsemblClinVar.1
Natural variantiVAR_01577246C → R in ETL1; loss of protein secretion; does not affect glycosylation status of the protein. 2 PublicationsCorresponds to variant dbSNP:rs104894166EnsemblClinVar.1
Natural variantiVAR_058539110A → D in ETL1. 1
Natural variantiVAR_058540122I → K in ETL1. 1 PublicationCorresponds to variant dbSNP:rs119488100EnsemblClinVar.1
Natural variantiVAR_058541123E → K in ETL1. 1 Publication1
Natural variantiVAR_058542136R → W in ETL1. 1 PublicationCorresponds to variant dbSNP:rs119488099EnsemblClinVar.1
Natural variantiVAR_058543145S → R in ETL1; loss of protein secretion; does not affect glycosylation status of the protein. 1 Publication1
Natural variantiVAR_058544154L → P in ETL1. 1
Natural variantiVAR_058545200C → R in ETL1; loss of protein secretion; does not affect glycosylation status of the protein. 1 Publication1
Natural variantiVAR_058546232L → P in ETL1; loss of protein secretion. 1 PublicationCorresponds to variant dbSNP:rs104894167EnsemblClinVar.1
Natural variantiVAR_058547298I → T in ETL1. 1
Natural variantiVAR_015774318F → C in ETL1; loss of protein secretion; protein is retained in the endoplasmic reticulum; does not affect glycosylation status of the protein. 2 PublicationsCorresponds to variant dbSNP:rs28939075EnsemblClinVar.1
Natural variantiVAR_015773383E → A in ETL1; loss of protein secretion; protein is retained in the endoplasmic reticulum; does not affect glycosylation status of the protein. 3 PublicationsCorresponds to variant dbSNP:rs28937874EnsemblClinVar.1
Natural variantiVAR_058548432V → E in ETL1. 1
Natural variantiVAR_023009473S → L in ETL1. 1 PublicationCorresponds to variant dbSNP:rs797044999EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03823496 – 143Missing in isoform 3. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_007678280 – 291GTSTV…KPIVI → VLREIHRFTNMS in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_007679292 – 557Missing in isoform 2. 1 PublicationAdd BLAST266

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055636 mRNA Translation: AAC99316.1
AF473548 mRNA Translation: AAM22074.1
AY358885 mRNA Translation: AAQ89244.1
AK289706 mRNA Translation: BAF82395.1
AK303956 mRNA Translation: BAG64882.1
AL157396 Genomic DNA No translation available.
AL358154 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW50052.1
BC022500 mRNA Translation: AAH22500.1
CCDSiCCDS7431.1 [O95970-1]
CCDS76325.1 [O95970-2]
CCDS81490.1 [O95970-3]
RefSeqiNP_001295204.1, NM_001308275.1 [O95970-2]
NP_001295205.1, NM_001308276.1 [O95970-3]
NP_005088.1, NM_005097.3 [O95970-1]
UniGeneiHs.533670

Genome annotation databases

EnsembliENST00000371413; ENSP00000360467; ENSG00000108231 [O95970-2]
ENST00000371418; ENSP00000360472; ENSG00000108231 [O95970-1]
ENST00000630047; ENSP00000485917; ENSG00000108231 [O95970-3]
GeneIDi9211
KEGGihsa:9211
UCSCiuc001kjc.5 human [O95970-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055636 mRNA Translation: AAC99316.1
AF473548 mRNA Translation: AAM22074.1
AY358885 mRNA Translation: AAQ89244.1
AK289706 mRNA Translation: BAF82395.1
AK303956 mRNA Translation: BAG64882.1
AL157396 Genomic DNA No translation available.
AL358154 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW50052.1
BC022500 mRNA Translation: AAH22500.1
CCDSiCCDS7431.1 [O95970-1]
CCDS76325.1 [O95970-2]
CCDS81490.1 [O95970-3]
RefSeqiNP_001295204.1, NM_001308275.1 [O95970-2]
NP_001295205.1, NM_001308276.1 [O95970-3]
NP_005088.1, NM_005097.3 [O95970-1]
UniGeneiHs.533670

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5Y2ZX-ray2.67B/D/F/H/J/L224-557[»]
5Y30X-ray1.78A37-223[»]
5Y31X-ray7.12B/D37-557[»]
ProteinModelPortaliO95970
SMRiO95970
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114645, 2 interactors
STRINGi9606.ENSP00000360472

PTM databases

iPTMnetiO95970
PhosphoSitePlusiO95970

Polymorphism and mutation databases

BioMutaiLGI1

Proteomic databases

EPDiO95970
PaxDbiO95970
PeptideAtlasiO95970
PRIDEiO95970
ProteomicsDBi51151
51152 [O95970-2]
51153 [O95970-3]
TopDownProteomicsiO95970-3 [O95970-3]

Protocols and materials databases

DNASUi9211
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371413; ENSP00000360467; ENSG00000108231 [O95970-2]
ENST00000371418; ENSP00000360472; ENSG00000108231 [O95970-1]
ENST00000630047; ENSP00000485917; ENSG00000108231 [O95970-3]
GeneIDi9211
KEGGihsa:9211
UCSCiuc001kjc.5 human [O95970-1]

Organism-specific databases

CTDi9211
DisGeNETi9211
EuPathDBiHostDB:ENSG00000108231.11
GeneCardsiLGI1
GeneReviewsiLGI1
HGNCiHGNC:6572 LGI1
MalaCardsiLGI1
MIMi600512 phenotype
604619 gene
neXtProtiNX_O95970
OpenTargetsiENSG00000108231
Orphaneti101046 Autosomal dominant epilepsy with auditory features
PharmGKBiPA30349
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIXR Eukaryota
ENOG410XSZV LUCA
GeneTreeiENSGT00930000150915
HOVERGENiHBG036744
InParanoidiO95970
OMAiIYQWNKG
OrthoDBiEOG091G03ZX
PhylomeDBiO95970
TreeFamiTF333155

Enzyme and pathway databases

ReactomeiR-HSA-5682910 LGI-ADAM interactions

Miscellaneous databases

ChiTaRSiLGI1 human
GeneWikiiLGI1
GenomeRNAii9211
PROiPR:O95970
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108231 Expressed in 133 organ(s), highest expression level in caudate nucleus
CleanExiHS_LGI1
ExpressionAtlasiO95970 baseline and differential
GenevisibleiO95970 HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR009039 EAR
IPR005492 EPTP
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF03736 EPTP, 7 hits
PF13855 LRR_8, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 3 hits
SM00082 LRRCT, 1 hit
PROSITEiView protein in PROSITE
PS50912 EAR, 7 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLGI1_HUMAN
AccessioniPrimary (citable) accession number: O95970
Secondary accession number(s): A8K0Z1
, B4E1S0, Q5W001, Q5W002, Q8NI23, Q96LF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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