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Protein

Secretoglobin family 1D member 2

Gene

SCGB1D2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.

Names & Taxonomyi

Protein namesi
Recommended name:
Secretoglobin family 1D member 2
Alternative name(s):
Lipophilin-B
Gene namesi
Name:SCGB1D2
Synonyms:LIPHB, LPNB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000124935.3
HGNCiHGNC:18396 SCGB1D2
MIMi615061 gene
neXtProtiNX_O95969

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi10647
OpenTargetsiENSG00000124935
PharmGKBiPA34991

Polymorphism and mutation databases

BioMutaiSCGB1D2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000003637922 – 90Secretoglobin family 1D member 2Add BLAST69

Proteomic databases

EPDiO95969
PaxDbiO95969
PeptideAtlasiO95969
PRIDEiO95969
ProteomicsDBi51150

Expressioni

Tissue specificityi

Highest expression was found in skeletal muscle. Expressed as well in thymus, trachea, kidney, steroid responsive tissues (prostate, testis, uterus, breast and ovary) and salivary gland.

Gene expression databases

BgeeiENSG00000124935 Expressed in 121 organ(s), highest expression level in epithelium of mammary gland
CleanExiHS_SCGB1D2
GenevisibleiO95969 HS

Organism-specific databases

HPAiHPA035318

Interactioni

Protein-protein interaction databases

BioGridi115891, 9 interactors
STRINGi9606.ENSP00000244926

Structurei

3D structure databases

ProteinModelPortaliO95969
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J2K1 Eukaryota
ENOG41113E2 LUCA
GeneTreeiENSGT00530000063866
HOGENOMiHOG000220914
HOVERGENiHBG006291
InParanoidiO95969
OMAiCYQANAE
OrthoDBiEOG091G16OR
PhylomeDBiO95969
TreeFamiTF338526

Family and domain databases

CDDicd00633 Secretoglobin, 1 hit
InterProiView protein in InterPro
IPR016126 Secretoglobin
IPR035960 Secretoglobin_sf
PfamiView protein in Pfam
PF01099 Uteroglobin, 1 hit
SUPFAMiSSF48201 SSF48201, 1 hit
PROSITEiView protein in PROSITE
PS51311 SCGB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95969-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLSVCLLLV TLALCCYQAN AEFCPALVSE LLDFFFISEP LFKLSLAKFD
60 70 80 90
APPEAVAAKL GVKRCTDQMS LQKRSLIAEV LVKILKKCSV
Length:90
Mass (Da):9,925
Last modified:May 1, 1999 - v1
Checksum:i17BB555ED035D1AF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02025453P → L. Corresponds to variant dbSNP:rs2232950Ensembl.1
Natural variantiVAR_02025580V → A. Corresponds to variant dbSNP:rs2276427Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224172 mRNA Translation: CAA11864.1
BC069290 mRNA Translation: AAH69290.1
BC104838 mRNA Translation: AAI04839.1
BC104840 mRNA Translation: AAI04841.1
CCDSiCCDS8017.1
RefSeqiNP_006542.1, NM_006551.3
UniGeneiHs.204096

Genome annotation databases

EnsembliENST00000244926; ENSP00000244926; ENSG00000124935
GeneIDi10647
KEGGihsa:10647
UCSCiuc001ntb.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224172 mRNA Translation: CAA11864.1
BC069290 mRNA Translation: AAH69290.1
BC104838 mRNA Translation: AAI04839.1
BC104840 mRNA Translation: AAI04841.1
CCDSiCCDS8017.1
RefSeqiNP_006542.1, NM_006551.3
UniGeneiHs.204096

3D structure databases

ProteinModelPortaliO95969
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115891, 9 interactors
STRINGi9606.ENSP00000244926

Polymorphism and mutation databases

BioMutaiSCGB1D2

Proteomic databases

EPDiO95969
PaxDbiO95969
PeptideAtlasiO95969
PRIDEiO95969
ProteomicsDBi51150

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244926; ENSP00000244926; ENSG00000124935
GeneIDi10647
KEGGihsa:10647
UCSCiuc001ntb.4 human

Organism-specific databases

CTDi10647
DisGeNETi10647
EuPathDBiHostDB:ENSG00000124935.3
GeneCardsiSCGB1D2
HGNCiHGNC:18396 SCGB1D2
HPAiHPA035318
MIMi615061 gene
neXtProtiNX_O95969
OpenTargetsiENSG00000124935
PharmGKBiPA34991
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J2K1 Eukaryota
ENOG41113E2 LUCA
GeneTreeiENSGT00530000063866
HOGENOMiHOG000220914
HOVERGENiHBG006291
InParanoidiO95969
OMAiCYQANAE
OrthoDBiEOG091G16OR
PhylomeDBiO95969
TreeFamiTF338526

Miscellaneous databases

GeneWikiiSCGB1D2
GenomeRNAii10647
PROiPR:O95969
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124935 Expressed in 121 organ(s), highest expression level in epithelium of mammary gland
CleanExiHS_SCGB1D2
GenevisibleiO95969 HS

Family and domain databases

CDDicd00633 Secretoglobin, 1 hit
InterProiView protein in InterPro
IPR016126 Secretoglobin
IPR035960 Secretoglobin_sf
PfamiView protein in Pfam
PF01099 Uteroglobin, 1 hit
SUPFAMiSSF48201 SSF48201, 1 hit
PROSITEiView protein in PROSITE
PS51311 SCGB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSG1D2_HUMAN
AccessioniPrimary (citable) accession number: O95969
Secondary accession number(s): Q2M3N9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: September 12, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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