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Entry version 167 (18 Sep 2019)
Sequence version 1 (01 May 1999)
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Protein

Integrin beta-like protein 1

Gene

ITGBL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • integrin binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8941332 RUNX2 regulates genes involved in cell migration

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Integrin beta-like protein 1
Alternative name(s):
Osteoblast-specific cysteine-rich protein
Ten integrin EGF-like repeat domain-containing protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ITGBL1
Synonyms:OSCP, TIED
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6164 ITGBL1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604234 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95965

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9358

Open Targets

More...
OpenTargetsi
ENSG00000198542

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29963

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ITGBL1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500005438624 – 494Integrin beta-like protein 1Add BLAST471

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi405N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O95965

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O95965

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O95965

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O95965

PeptideAtlas

More...
PeptideAtlasi
O95965

PRoteomics IDEntifications database

More...
PRIDEi
O95965

ProteomicsDB human proteome resource

More...
ProteomicsDBi
3685
4831
51147 [O95965-1]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
O95965-1 [O95965-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O95965

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O95965

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed in many tissues, but readily detectable only in aorta.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198542 Expressed in 206 organ(s), highest expression level in tendon

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O95965 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O95965 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA005676

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000365351

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O95965

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati51 – 95IAdd BLAST45
Repeati96 – 142IIAdd BLAST47
Repeati143 – 184IIIAdd BLAST42
Repeati185 – 230IVAdd BLAST46
Repeati231 – 275VAdd BLAST45
Repeati276 – 326VIAdd BLAST51
Repeati327 – 367VIIAdd BLAST41
Repeati368 – 414VIIIAdd BLAST47
Repeati415 – 454IXAdd BLAST40
Repeati455 – 494XAdd BLAST40

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni51 – 494Cysteine-rich tandem repeatsAdd BLAST444

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains ten tandem EGF-like repeats strikingly similar to those found in the cysteine rich 'stalk-like' structure of integrin beta-subunits.

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1226 Eukaryota
ENOG410XP60 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00970000193422

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113115

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O95965

Identification of Orthologs from Complete Genome Data

More...
OMAi
CQYPTHC

Database of Orthologous Groups

More...
OrthoDBi
18592at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O95965

TreeFam database of animal gene trees

More...
TreeFami
TF332636

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000742 EGF-like_dom
IPR013111 EGF_extracell
IPR027070 Integrin_b-like_p1
IPR015812 Integrin_bsu

The PANTHER Classification System

More...
PANTHERi
PTHR10082 PTHR10082, 1 hit
PTHR10082:SF3 PTHR10082:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07974 EGF_2, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 5 hits
PS01186 EGF_2, 5 hits
PS00243 INTEGRIN_BETA, 10 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95965-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRPPGFRNFL LLASSLLFAG LSAVPQSFSP SLRSWPGAAC RLSRAESERR
60 70 80 90 100
CRAPGQPPGA ALCHGRGRCD CGVCICHVTE PGMFFGPLCE CHEWVCETYD
110 120 130 140 150
GSTCAGHGKC DCGKCKCDQG WYGDACQYPT NCDLTKKKSN QMCKNSQDII
160 170 180 190 200
CSNAGTCHCG RCKCDNSDGS GLVYGKFCEC DDRECIDDET EEICGGHGKC
210 220 230 240 250
YCGNCYCKAG WHGDKCEFQC DITPWESKRR CTSPDGKICS NRGTCVCGEC
260 270 280 290 300
TCHDVDPTGD WGDIHGDTCE CDERDCRAVY DRYSDDFCSG HGQCNCGRCD
310 320 330 340 350
CKAGWYGKKC EHPQSCTLSA EESIRKCQGS SDLPCSGRGK CECGKCTCYP
360 370 380 390 400
PGDRRVYGKT CECDDRRCED LDGVVCGGHG TCSCGRCVCE RGWFGKLCQH
410 420 430 440 450
PRKCNMTEEQ SKNLCESADG ILCSGKGSCH CGKCICSAEE WYISGEFCDC
460 470 480 490
DDRDCDKHDG LICTGNGICS CGNCECWDGW NGNACEIWLG SEYP
Length:494
Mass (Da):53,921
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i72E095D0BD4ECFF3
GO
Isoform 2 (identifier: O95965-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-141: Missing.

Note: No experimental confirmation available.
Show »
Length:353
Mass (Da):38,666
Checksum:i6C5A19BEBD3C8441
GO
Isoform 3 (identifier: O95965-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-105: MRPPGFRNFL...CETYDGSTCA → MNLVAVMGAFNK

Note: No experimental confirmation available.
Show »
Length:401
Mass (Da):43,909
Checksum:i381A65DB123E0DCE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WY35A0A087WY35_HUMAN
Integrin beta-like protein 1
ITGBL1
445Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WXI7A0A087WXI7_HUMAN
Integrin beta-like protein 1
ITGBL1
401Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KPX5U3KPX5_HUMAN
Integrin beta-like protein 1
ITGBL1
208Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3P → S in BAF84029 (PubMed:14702039).Curated1
Sequence conflicti453R → G in BAF84029 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_039542154A → S. Corresponds to variant dbSNP:rs1140605Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0547991 – 141Missing in isoform 2. 1 PublicationAdd BLAST141
Alternative sequenceiVSP_0548001 – 105MRPPG…GSTCA → MNLVAVMGAFNK in isoform 3. 1 PublicationAdd BLAST105

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF072752 mRNA Translation: AAD17666.1
AK095875 mRNA Translation: BAG53153.1
AK291340 mRNA Translation: BAF84029.1
AK298571 mRNA Translation: BAG60764.1
AE014293 Genomic DNA Translation: AAN16024.1
AL139800 Genomic DNA No translation available.
AL160153 Genomic DNA No translation available.
AL355807 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX09052.1
BC036788 mRNA Translation: AAH36788.2
AL359052 mRNA Translation: CAB94388.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS61361.1 [O95965-3]
CCDS61362.1 [O95965-2]
CCDS9499.1 [O95965-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001258683.1, NM_001271754.1 [O95965-2]
NP_001258684.1, NM_001271755.1
NP_001258685.1, NM_001271756.1 [O95965-3]
NP_004782.1, NM_004791.2 [O95965-1]
XP_005254157.1, XM_005254100.4 [O95965-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000376162; ENSP00000365332; ENSG00000198542 [O95965-3]
ENST00000376180; ENSP00000365351; ENSG00000198542 [O95965-1]
ENST00000545560; ENSP00000439903; ENSG00000198542 [O95965-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9358

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9358

UCSC genome browser

More...
UCSCi
uc001vpb.5 human [O95965-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072752 mRNA Translation: AAD17666.1
AK095875 mRNA Translation: BAG53153.1
AK291340 mRNA Translation: BAF84029.1
AK298571 mRNA Translation: BAG60764.1
AE014293 Genomic DNA Translation: AAN16024.1
AL139800 Genomic DNA No translation available.
AL160153 Genomic DNA No translation available.
AL355807 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX09052.1
BC036788 mRNA Translation: AAH36788.2
AL359052 mRNA Translation: CAB94388.1
CCDSiCCDS61361.1 [O95965-3]
CCDS61362.1 [O95965-2]
CCDS9499.1 [O95965-1]
RefSeqiNP_001258683.1, NM_001271754.1 [O95965-2]
NP_001258684.1, NM_001271755.1
NP_001258685.1, NM_001271756.1 [O95965-3]
NP_004782.1, NM_004791.2 [O95965-1]
XP_005254157.1, XM_005254100.4 [O95965-1]

3D structure databases

SMRiO95965
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000365351

PTM databases

iPTMnetiO95965
PhosphoSitePlusiO95965

Polymorphism and mutation databases

BioMutaiITGBL1

Proteomic databases

jPOSTiO95965
MassIVEiO95965
MaxQBiO95965
PaxDbiO95965
PeptideAtlasiO95965
PRIDEiO95965
ProteomicsDBi3685
4831
51147 [O95965-1]
TopDownProteomicsiO95965-1 [O95965-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376162; ENSP00000365332; ENSG00000198542 [O95965-3]
ENST00000376180; ENSP00000365351; ENSG00000198542 [O95965-1]
ENST00000545560; ENSP00000439903; ENSG00000198542 [O95965-2]
GeneIDi9358
KEGGihsa:9358
UCSCiuc001vpb.5 human [O95965-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9358
DisGeNETi9358

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ITGBL1
HGNCiHGNC:6164 ITGBL1
HPAiHPA005676
MIMi604234 gene
neXtProtiNX_O95965
OpenTargetsiENSG00000198542
PharmGKBiPA29963

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1226 Eukaryota
ENOG410XP60 LUCA
GeneTreeiENSGT00970000193422
HOGENOMiHOG000113115
InParanoidiO95965
OMAiCQYPTHC
OrthoDBi18592at2759
PhylomeDBiO95965
TreeFamiTF332636

Enzyme and pathway databases

ReactomeiR-HSA-8941332 RUNX2 regulates genes involved in cell migration

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9358

Pharos

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Pharosi
O95965

Protein Ontology

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PROi
PR:O95965

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000198542 Expressed in 206 organ(s), highest expression level in tendon
ExpressionAtlasiO95965 baseline and differential
GenevisibleiO95965 HS

Family and domain databases

InterProiView protein in InterPro
IPR000742 EGF-like_dom
IPR013111 EGF_extracell
IPR027070 Integrin_b-like_p1
IPR015812 Integrin_bsu
PANTHERiPTHR10082 PTHR10082, 1 hit
PTHR10082:SF3 PTHR10082:SF3, 1 hit
PfamiView protein in Pfam
PF07974 EGF_2, 4 hits
SMARTiView protein in SMART
SM00181 EGF, 6 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 5 hits
PS01186 EGF_2, 5 hits
PS00243 INTEGRIN_BETA, 10 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiITGBL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95965
Secondary accession number(s): A8K5M5
, B3KTP1, B4DQ02, Q8N172, Q9NPR0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 1, 1999
Last modified: September 18, 2019
This is version 167 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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