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Protein

One cut domain family member 2

Gene

ONECUT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B.

Caution

It is uncertain whether Met-1 or Met-20 is the initiator.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi324 – 410CUTPROSITE-ProRule annotationAdd BLAST87
DNA bindingi426 – 485HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
One cut domain family member 2
Alternative name(s):
Hepatocyte nuclear factor 6-beta
Short name:
HNF-6-beta
One cut homeobox 2
Transcription factor ONECUT-2
Short name:
OC-2
Gene namesi
Name:ONECUT2
Synonyms:HNF6B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000119547.5
HGNCiHGNC:8139 ONECUT2
MIMi604894 gene
neXtProtiNX_O95948

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9480
OpenTargetsiENSG00000119547
PharmGKBiPA31925

Polymorphism and mutation databases

BioMutaiONECUT2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002024051 – 504One cut domain family member 2Add BLAST504

Proteomic databases

PaxDbiO95948
PeptideAtlasiO95948
PRIDEiO95948
ProteomicsDBi51141
TopDownProteomicsiO95948

PTM databases

iPTMnetiO95948
PhosphoSitePlusiO95948

Expressioni

Gene expression databases

BgeeiENSG00000119547 Expressed in 83 organ(s), highest expression level in jejunal mucosa
CleanExiHS_ONECUT2
GenevisibleiO95948 HS

Organism-specific databases

HPAiHPA057058

Interactioni

Protein-protein interaction databases

BioGridi114865, 1 interactor
STRINGi9606.ENSP00000262095

Structurei

3D structure databases

ProteinModelPortaliO95948
SMRiO95948
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi37 – 56Poly-GlyAdd BLAST20
Compositional biasi81 – 85Poly-Pro5
Compositional biasi94 – 101Poly-Ala8
Compositional biasi168 – 184Poly-HisAdd BLAST17
Compositional biasi317 – 322Poly-Ser6

Sequence similaritiesi

Belongs to the CUT homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG2252 Eukaryota
ENOG410YWY4 LUCA
GeneTreeiENSGT00530000063019
HOGENOMiHOG000232114
HOVERGENiHBG005981
InParanoidiO95948
OMAiNGMHHPG
OrthoDBiEOG091G0E7H
PhylomeDBiO95948
TreeFamiTF318206

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR003350 CUT_dom
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
PfamiView protein in Pfam
PF02376 CUT, 1 hit
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM01109 CUT, 1 hit
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS51042 CUT, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

O95948-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKAAYTAYRC LTKDLEGCAM NPELTMESLG TLHGPAGGGS GGGGGGGGGG
60 70 80 90 100
GGGGPGHEQE LLASPSPHHA GRGAAGSLRG PPPPPTAHQE LGTAAAAAAA
110 120 130 140 150
ASRSAMVTSM ASILDGGDYR PELSIPLHHA MSMSCDSSPP GMGMSNTYTT
160 170 180 190 200
LTPLQPLPPI STVSDKFHHP HPHHHPHHHH HHHHQRLSGN VSGSFTLMRD
210 220 230 240 250
ERGLPAMNNL YSPYKEMPGM SQSLSPLAAT PLGNGLGGLH NAQQSLPNYG
260 270 280 290 300
PPGHDKMLSP NFDAHHTAML TRGEQHLSRG LGTPPAAMMS HLNGLHHPGH
310 320 330 340 350
TQSHGPVLAP SRERPPSSSS GSQVATSGQL EEINTKEVAQ RITAELKRYS
360 370 380 390 400
IPQAIFAQRV LCRSQGTLSD LLRNPKPWSK LKSGRETFRR MWKWLQEPEF
410 420 430 440 450
QRMSALRLAA CKRKEQEPNK DRNNSQKKSR LVFTDLQRRT LFAIFKENKR
460 470 480 490 500
PSKEMQITIS QQLGLELTTV SNFFMNARRR SLEKWQDDLS TGGSSSTSST

CTKA
Length:504
Mass (Da):54,303
Last modified:April 20, 2010 - v2
Checksum:i09762F3C8BD6DD6B
GO

Sequence cautioni

The sequence CAB38253 differs from that shown. Reason: Frameshift at position 18.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17G → R in CAB38253 (PubMed:9915796).Curated1
Sequence conflicti35 – 36PA → AR in CAB38253 (PubMed:9915796).Curated2
Sequence conflicti71G → R in CAB38253 (PubMed:9915796).Curated1
Sequence conflicti74 – 75AA → PR in CAB38253 (PubMed:9915796).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18198 mRNA Translation: CAB38253.1 Frameshift.
AC090340 Genomic DNA No translation available.
CCDSiCCDS42440.1
RefSeqiNP_004843.2, NM_004852.2
UniGeneiHs.194725

Genome annotation databases

EnsembliENST00000491143; ENSP00000419185; ENSG00000119547
GeneIDi9480
KEGGihsa:9480
UCSCiuc002lgo.4 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Hepatocyte nuclear factors entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18198 mRNA Translation: CAB38253.1 Frameshift.
AC090340 Genomic DNA No translation available.
CCDSiCCDS42440.1
RefSeqiNP_004843.2, NM_004852.2
UniGeneiHs.194725

3D structure databases

ProteinModelPortaliO95948
SMRiO95948
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114865, 1 interactor
STRINGi9606.ENSP00000262095

PTM databases

iPTMnetiO95948
PhosphoSitePlusiO95948

Polymorphism and mutation databases

BioMutaiONECUT2

Proteomic databases

PaxDbiO95948
PeptideAtlasiO95948
PRIDEiO95948
ProteomicsDBi51141
TopDownProteomicsiO95948

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000491143; ENSP00000419185; ENSG00000119547
GeneIDi9480
KEGGihsa:9480
UCSCiuc002lgo.4 human

Organism-specific databases

CTDi9480
DisGeNETi9480
EuPathDBiHostDB:ENSG00000119547.5
GeneCardsiONECUT2
H-InvDBiHIX0039750
HGNCiHGNC:8139 ONECUT2
HPAiHPA057058
MIMi604894 gene
neXtProtiNX_O95948
OpenTargetsiENSG00000119547
PharmGKBiPA31925
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2252 Eukaryota
ENOG410YWY4 LUCA
GeneTreeiENSGT00530000063019
HOGENOMiHOG000232114
HOVERGENiHBG005981
InParanoidiO95948
OMAiNGMHHPG
OrthoDBiEOG091G0E7H
PhylomeDBiO95948
TreeFamiTF318206

Miscellaneous databases

ChiTaRSiONECUT2 human
GenomeRNAii9480
PROiPR:O95948
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000119547 Expressed in 83 organ(s), highest expression level in jejunal mucosa
CleanExiHS_ONECUT2
GenevisibleiO95948 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR003350 CUT_dom
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
PfamiView protein in Pfam
PF02376 CUT, 1 hit
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM01109 CUT, 1 hit
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS51042 CUT, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiONEC2_HUMAN
AccessioniPrimary (citable) accession number: O95948
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 20, 2010
Last modified: November 7, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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