ONECUT2

Functionⁱ

Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B.

Caution

It is uncertain whether Met-1 or Met-20 is the initiator.Curated

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	324 – 410	CUTPROSITE-ProRule annotationAdd BLAST		87
DNA bindingⁱ	426 – 485	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- 11478782
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 11478782

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

animal organ morphogenesis
Source: ProtInc
Traceable author statementⁱ
- 9915796
cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cell fate commitment Source: Ensembl
cilium assembly Source: Ensembl
endocrine pancreas development Source: Ensembl
epithelial cell development Source: Ensembl
liver development Source: Ensembl
negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
peripheral nervous system neuron development Source: Ensembl
positive regulation of cell migration Source: Ensembl
positive regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 11478782
regulation of cell-matrix adhesion Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: One cut domain family member 2 Alternative name(s): Hepatocyte nuclear factor 6-beta Short name: HNF-6-beta One cut homeobox 2 Transcription factor ONECUT-2 Short name: OC-2
Gene namesⁱ	Name:ONECUT2 Synonyms:HNF6B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 18

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000119547.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8139 ONECUT2
MIMⁱ	604894 gene
neXtProtⁱ	NX_O95948

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9480
Open Targets More...OpenTargetsⁱ	ENSG00000119547
PharmGKBⁱ	PA31925

Polymorphism and mutation databases

BioMutaⁱ	ONECUT2

BioMutaⁱ

ONECUT2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000202405	1 – 504	One cut domain family member 2Add BLAST		504

Proteomic databases

PaxDbⁱ	O95948
PeptideAtlas More...PeptideAtlasⁱ	O95948
PRIDEⁱ	O95948
ProteomicsDBⁱ	51141
TopDownProteomicsⁱ	O95948

PTM databases

iPTMnetⁱ	O95948
PhosphoSitePlusⁱ	O95948

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000119547 Expressed in 83 organ(s), highest expression level in jejunal mucosa
CleanExⁱ	HS_ONECUT2
Genevisibleⁱ	O95948 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA057058

HPAⁱ

HPA057058

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	114865, 1 interactor
STRINGⁱ	9606.ENSP00000262095

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O95948
SMRⁱ	O95948
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	37 – 56	Poly-GlyAdd BLAST	20
Compositional biasⁱ	81 – 85	Poly-Pro	5
Compositional biasⁱ	94 – 101	Poly-Ala	8
Compositional biasⁱ	168 – 184	Poly-HisAdd BLAST	17
Compositional biasⁱ	317 – 322	Poly-Ser	6

Sequence similaritiesⁱ

Belongs to the CUT homeobox family.Curated

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG2252 Eukaryota ENOG410YWY4 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063019
HOGENOMⁱ	HOG000232114
HOVERGENⁱ	HBG005981
InParanoidⁱ	O95948
OMAⁱ	NGMHHPG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0E7H
PhylomeDBⁱ	O95948
TreeFamⁱ	TF318206

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR003350 CUT_dom IPR009057 Homeobox-like_sf IPR001356 Homeobox_dom IPR010982 Lambda_DNA-bd_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02376 CUT, 1 hit PF00046 Homeobox, 1 hit
SMARTⁱ	View protein in SMART SM01109 CUT, 1 hit SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit SSF47413 SSF47413, 1 hit
PROSITEⁱ	View protein in PROSITE PS51042 CUT, 1 hit PS50071 HOMEOBOX_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O95948-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKAAYTAYRC LTKDLEGCAM NPELTMESLG TLHGPAGGGS GGGGGGGGGG 
        60         70         80         90        100
GGGGPGHEQE LLASPSPHHA GRGAAGSLRG PPPPPTAHQE LGTAAAAAAA 
       110        120        130        140        150
ASRSAMVTSM ASILDGGDYR PELSIPLHHA MSMSCDSSPP GMGMSNTYTT 
       160        170        180        190        200
LTPLQPLPPI STVSDKFHHP HPHHHPHHHH HHHHQRLSGN VSGSFTLMRD 
       210        220        230        240        250
ERGLPAMNNL YSPYKEMPGM SQSLSPLAAT PLGNGLGGLH NAQQSLPNYG 
       260        270        280        290        300
PPGHDKMLSP NFDAHHTAML TRGEQHLSRG LGTPPAAMMS HLNGLHHPGH 
       310        320        330        340        350
TQSHGPVLAP SRERPPSSSS GSQVATSGQL EEINTKEVAQ RITAELKRYS 
       360        370        380        390        400
IPQAIFAQRV LCRSQGTLSD LLRNPKPWSK LKSGRETFRR MWKWLQEPEF 
       410        420        430        440        450
QRMSALRLAA CKRKEQEPNK DRNNSQKKSR LVFTDLQRRT LFAIFKENKR 
       460        470        480        490        500
PSKEMQITIS QQLGLELTTV SNFFMNARRR SLEKWQDDLS TGGSSSTSST 

CTKA

Length:504

Mass (Da):54,303

Last modified:April 20, 2010 - v2

Checksum:ⁱ09762F3C8BD6DD6B

GO

Sequence cautionⁱ

The sequence CAB38253 differs from that shown. Reason: Frameshift at position 18.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	17	G → R in CAB38253 (PubMed:9915796).Curated	1
Sequence conflictⁱ	35 – 36	PA → AR in CAB38253 (PubMed:9915796).Curated	2
Sequence conflictⁱ	71	G → R in CAB38253 (PubMed:9915796).Curated	1
Sequence conflictⁱ	74 – 75	AA → PR in CAB38253 (PubMed:9915796).Curated	2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y18198 mRNA Translation: CAB38253.1 Frameshift. AC090340 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS42440.1
NCBI Reference Sequences More...RefSeqⁱ	NP_004843.2, NM_004852.2
UniGeneⁱ	Hs.194725

Genome annotation databases

Ensemblⁱ	ENST00000491143; ENSP00000419185; ENSG00000119547
GeneIDⁱ	9480
KEGGⁱ	hsa:9480
UCSC genome browser More...UCSCⁱ	uc002lgo.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O95948	One cut domain family member		PANTR		504	UniRef100_O95948
One cut domain family member		CERAT		504
One cut domain family member		PAPAN		504
One cut domain family member		CHLSB		504

Protein	Similar proteins		Species	Score	Length	Source
O95948	One cut domain family member 2		MOUSE		505	UniRef90_Q6XBJ3
One cut domain family member		DELLE		509
One cut domain family member		CALJA		505
One cut domain family member		PANTR		504
One cut domain family member		CERAT		504
+56

Protein	Similar proteins		Species	Score	Length	Source
O95948	Hepatocyte nuclear factor 6	)	MOUSE		465	UniRef50_O08755
Hepatocyte nuclear factor 6	)	RAT		465
Hepatocyte nuclear factor 6		HUMAN		465
One cut domain family member		MYOLU		467
One cut domain family member		PHYCD		466
+474

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Hepatocyte nuclear factors entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y18198 mRNA Translation: CAB38253.1 Frameshift. AC090340 Genomic DNA No translation available.
CCDSⁱ	CCDS42440.1
RefSeqⁱ	NP_004843.2, NM_004852.2
UniGeneⁱ	Hs.194725

3D structure databases

ProteinModelPortalⁱ	O95948
SMRⁱ	O95948
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114865, 1 interactor
STRINGⁱ	9606.ENSP00000262095

PTM databases

iPTMnetⁱ	O95948
PhosphoSitePlusⁱ	O95948

Polymorphism and mutation databases

BioMutaⁱ	ONECUT2

BioMutaⁱ

ONECUT2

Proteomic databases

PaxDbⁱ	O95948
PeptideAtlasⁱ	O95948
PRIDEⁱ	O95948
ProteomicsDBⁱ	51141
TopDownProteomicsⁱ	O95948

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000491143; ENSP00000419185; ENSG00000119547
GeneIDⁱ	9480
KEGGⁱ	hsa:9480
UCSCⁱ	uc002lgo.4 human

Organism-specific databases

CTDⁱ	9480
DisGeNETⁱ	9480
EuPathDBⁱ	HostDB:ENSG00000119547.5
GeneCardsⁱ	ONECUT2
H-InvDBⁱ	HIX0039750
HGNCⁱ	HGNC:8139 ONECUT2
HPAⁱ	HPA057058
MIMⁱ	604894 gene
neXtProtⁱ	NX_O95948
OpenTargetsⁱ	ENSG00000119547
PharmGKBⁱ	PA31925
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2252 Eukaryota ENOG410YWY4 LUCA
GeneTreeⁱ	ENSGT00530000063019
HOGENOMⁱ	HOG000232114
HOVERGENⁱ	HBG005981
InParanoidⁱ	O95948
OMAⁱ	NGMHHPG
OrthoDBⁱ	EOG091G0E7H
PhylomeDBⁱ	O95948
TreeFamⁱ	TF318206

Miscellaneous databases

ChiTaRSⁱ	ONECUT2 human
GenomeRNAiⁱ	9480
Protein Ontology More...PROⁱ	PR:O95948
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000119547 Expressed in 83 organ(s), highest expression level in jejunal mucosa
CleanExⁱ	HS_ONECUT2
Genevisibleⁱ	O95948 HS

Family and domain databases

CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR003350 CUT_dom IPR009057 Homeobox-like_sf IPR001356 Homeobox_dom IPR010982 Lambda_DNA-bd_dom_sf
Pfamⁱ	View protein in Pfam PF02376 CUT, 1 hit PF00046 Homeobox, 1 hit
SMARTⁱ	View protein in SMART SM01109 CUT, 1 hit SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit SSF47413 SSF47413, 1 hit
PROSITEⁱ	View protein in PROSITE PS51042 CUT, 1 hit PS50071 HOMEOBOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ONEC2_HUMAN
Accessionⁱ	O95948Primary (citable) accession number: O95948
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
	Last sequence update:	April 20, 2010
	Last modified:	November 7, 2018
	This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM

UniProtKB

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Help

UniRef

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Annotation systems

Supporting data

UniProtKB - O95948 (ONEC2_HUMAN)

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One cut domain family member 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytoskeleton

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ