UniProtKB - O95948 (ONEC2_HUMAN)
Protein
One cut domain family member 2
Gene
ONECUT2
Organism
Homo sapiens (Human)
Status
Functioni
Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B.
Caution
It is uncertain whether Met-1 or Met-20 is the initiator.Curated
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 324 – 410 | CUTPROSITE-ProRule annotationAdd BLAST | 87 | |
DNA bindingi | 426 – 485 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- animal organ morphogenesis Source: ProtInc
- cell fate commitment Source: Ensembl
- cilium assembly Source: Ensembl
- endocrine pancreas development Source: Ensembl
- epithelial cell development Source: Ensembl
- liver development Source: Ensembl
- negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
- peripheral nervous system neuron development Source: Ensembl
- positive regulation of cell migration Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of cell-matrix adhesion Source: Ensembl
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | O95948 |
Names & Taxonomyi
Protein namesi | Recommended name: One cut domain family member 2Alternative name(s): Hepatocyte nuclear factor 6-beta Short name: HNF-6-beta One cut homeobox 2 Transcription factor ONECUT-2 Short name: OC-2 |
Gene namesi | Name:ONECUT2 Synonyms:HNF6B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8139, ONECUT2 |
MIMi | 604894, gene |
neXtProti | NX_O95948 |
VEuPathDBi | HostDB:ENSG00000119547.5 |
Subcellular locationi
Nucleus
Cytoskeleton
- actin cytoskeleton Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Other locations
- chromatin Source: NTNU_SB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 9480 |
OpenTargetsi | ENSG00000119547 |
PharmGKBi | PA31925 |
Miscellaneous databases
Pharosi | O95948, Tbio |
Genetic variation databases
BioMutai | ONECUT2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000202405 | 1 – 504 | One cut domain family member 2Add BLAST | 504 |
Proteomic databases
jPOSTi | O95948 |
MassIVEi | O95948 |
PaxDbi | O95948 |
PeptideAtlasi | O95948 |
PRIDEi | O95948 |
ProteomicsDBi | 51141 |
TopDownProteomicsi | O95948 |
PTM databases
iPTMneti | O95948 |
PhosphoSitePlusi | O95948 |
Expressioni
Gene expression databases
Bgeei | ENSG00000119547, Expressed in jejunal mucosa and 91 other tissues |
Genevisiblei | O95948, HS |
Organism-specific databases
HPAi | ENSG00000119547, Tissue enhanced (brain, gallbladder, intestine) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 114865, 4 interactors |
STRINGi | 9606.ENSP00000419185 |
Miscellaneous databases
RNActi | O95948, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 37 – 56 | Poly-GlyAdd BLAST | 20 | |
Compositional biasi | 81 – 85 | Poly-Pro | 5 | |
Compositional biasi | 94 – 101 | Poly-Ala | 8 | |
Compositional biasi | 168 – 184 | Poly-HisAdd BLAST | 17 | |
Compositional biasi | 317 – 322 | Poly-Ser | 6 |
Sequence similaritiesi
Belongs to the CUT homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG2252, Eukaryota |
GeneTreei | ENSGT00950000183103 |
HOGENOMi | CLU_018642_0_0_1 |
InParanoidi | O95948 |
OMAi | PSHTQSH |
OrthoDBi | 709082at2759 |
PhylomeDBi | O95948 |
TreeFami | TF318206 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
Gene3Di | 1.10.260.40, 1 hit |
InterProi | View protein in InterPro IPR003350, CUT_dom IPR009057, Homeobox-like_sf IPR001356, Homeobox_dom IPR010982, Lambda_DNA-bd_dom_sf |
Pfami | View protein in Pfam PF02376, CUT, 1 hit PF00046, Homeodomain, 1 hit |
SMARTi | View protein in SMART SM01109, CUT, 1 hit SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit SSF47413, SSF47413, 1 hit |
PROSITEi | View protein in PROSITE PS51042, CUT, 1 hit PS50071, HOMEOBOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
O95948-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKAAYTAYRC LTKDLEGCAM NPELTMESLG TLHGPAGGGS GGGGGGGGGG
60 70 80 90 100
GGGGPGHEQE LLASPSPHHA GRGAAGSLRG PPPPPTAHQE LGTAAAAAAA
110 120 130 140 150
ASRSAMVTSM ASILDGGDYR PELSIPLHHA MSMSCDSSPP GMGMSNTYTT
160 170 180 190 200
LTPLQPLPPI STVSDKFHHP HPHHHPHHHH HHHHQRLSGN VSGSFTLMRD
210 220 230 240 250
ERGLPAMNNL YSPYKEMPGM SQSLSPLAAT PLGNGLGGLH NAQQSLPNYG
260 270 280 290 300
PPGHDKMLSP NFDAHHTAML TRGEQHLSRG LGTPPAAMMS HLNGLHHPGH
310 320 330 340 350
TQSHGPVLAP SRERPPSSSS GSQVATSGQL EEINTKEVAQ RITAELKRYS
360 370 380 390 400
IPQAIFAQRV LCRSQGTLSD LLRNPKPWSK LKSGRETFRR MWKWLQEPEF
410 420 430 440 450
QRMSALRLAA CKRKEQEPNK DRNNSQKKSR LVFTDLQRRT LFAIFKENKR
460 470 480 490 500
PSKEMQITIS QQLGLELTTV SNFFMNARRR SLEKWQDDLS TGGSSSTSST
CTKA
Sequence cautioni
The sequence CAB38253 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 17 | G → R in CAB38253 (PubMed:9915796).Curated | 1 | |
Sequence conflicti | 35 – 36 | PA → AR in CAB38253 (PubMed:9915796).Curated | 2 | |
Sequence conflicti | 71 | G → R in CAB38253 (PubMed:9915796).Curated | 1 | |
Sequence conflicti | 74 – 75 | AA → PR in CAB38253 (PubMed:9915796).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y18198 mRNA Translation: CAB38253.1 Frameshift. AC090340 Genomic DNA No translation available. |
CCDSi | CCDS42440.1 |
RefSeqi | NP_004843.2, NM_004852.2 |
Genome annotation databases
Ensembli | ENST00000491143; ENSP00000419185; ENSG00000119547 |
GeneIDi | 9480 |
KEGGi | hsa:9480 |
UCSCi | uc002lgo.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Hepatocyte nuclear factors entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y18198 mRNA Translation: CAB38253.1 Frameshift. AC090340 Genomic DNA No translation available. |
CCDSi | CCDS42440.1 |
RefSeqi | NP_004843.2, NM_004852.2 |
3D structure databases
SMRi | O95948 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114865, 4 interactors |
STRINGi | 9606.ENSP00000419185 |
PTM databases
iPTMneti | O95948 |
PhosphoSitePlusi | O95948 |
Genetic variation databases
BioMutai | ONECUT2 |
Proteomic databases
jPOSTi | O95948 |
MassIVEi | O95948 |
PaxDbi | O95948 |
PeptideAtlasi | O95948 |
PRIDEi | O95948 |
ProteomicsDBi | 51141 |
TopDownProteomicsi | O95948 |
Protocols and materials databases
Antibodypediai | 5415, 147 antibodies |
Genome annotation databases
Ensembli | ENST00000491143; ENSP00000419185; ENSG00000119547 |
GeneIDi | 9480 |
KEGGi | hsa:9480 |
UCSCi | uc002lgo.4, human |
Organism-specific databases
CTDi | 9480 |
DisGeNETi | 9480 |
GeneCardsi | ONECUT2 |
HGNCi | HGNC:8139, ONECUT2 |
HPAi | ENSG00000119547, Tissue enhanced (brain, gallbladder, intestine) |
MIMi | 604894, gene |
neXtProti | NX_O95948 |
OpenTargetsi | ENSG00000119547 |
PharmGKBi | PA31925 |
VEuPathDBi | HostDB:ENSG00000119547.5 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2252, Eukaryota |
GeneTreei | ENSGT00950000183103 |
HOGENOMi | CLU_018642_0_0_1 |
InParanoidi | O95948 |
OMAi | PSHTQSH |
OrthoDBi | 709082at2759 |
PhylomeDBi | O95948 |
TreeFami | TF318206 |
Enzyme and pathway databases
PathwayCommonsi | O95948 |
Miscellaneous databases
BioGRID-ORCSi | 9480, 5 hits in 1013 CRISPR screens |
ChiTaRSi | ONECUT2, human |
GenomeRNAii | 9480 |
Pharosi | O95948, Tbio |
PROi | PR:O95948 |
RNActi | O95948, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000119547, Expressed in jejunal mucosa and 91 other tissues |
Genevisiblei | O95948, HS |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
Gene3Di | 1.10.260.40, 1 hit |
InterProi | View protein in InterPro IPR003350, CUT_dom IPR009057, Homeobox-like_sf IPR001356, Homeobox_dom IPR010982, Lambda_DNA-bd_dom_sf |
Pfami | View protein in Pfam PF02376, CUT, 1 hit PF00046, Homeodomain, 1 hit |
SMARTi | View protein in SMART SM01109, CUT, 1 hit SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit SSF47413, SSF47413, 1 hit |
PROSITEi | View protein in PROSITE PS51042, CUT, 1 hit PS50071, HOMEOBOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ONEC2_HUMAN | |
Accessioni | O95948Primary (citable) accession number: O95948 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | April 20, 2010 | |
Last modified: | April 7, 2021 | |
This is version 165 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families