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Protein

Natural cytotoxicity triggering receptor 2

Gene

NCR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.1 Publication

GO - Molecular functioni

  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-2172127 DAP12 interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Natural cytotoxicity triggering receptor 2
Alternative name(s):
Lymphocyte antigen 95 homolog
NK cell-activating receptor
Natural killer cell p44-related protein
Short name:
NK-p44
Short name:
NKp44
CD_antigen: CD336
Gene namesi
Name:NCR2
Synonyms:LY95
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000096264.13
HGNCiHGNC:6732 NCR2
MIMi604531 gene
neXtProtiNX_O95944

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 192ExtracellularSequence analysisAdd BLAST171
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Topological domaini214 – 276CytoplasmicSequence analysisAdd BLAST63

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9436
OpenTargetsiENSG00000096264
PharmGKBiPA30496

Polymorphism and mutation databases

BioMutaiNCR2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001503122 – 276Natural cytotoxicity triggering receptor 2Add BLAST255

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi40 ↔ 109PROSITE-ProRule annotation
Disulfide bondi55 ↔ 63PROSITE-ProRule annotation
Glycosylationi180N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO95944
PeptideAtlasiO95944
PRIDEiO95944
ProteomicsDBi51137
51138 [O95944-2]
51139 [O95944-3]

PTM databases

iPTMnetiO95944
PhosphoSitePlusiO95944

Expressioni

Tissue specificityi

Selectively expressed by activated NK cells and by in vitro cultured (i.e. activated) TCRg/d lymphoid cells.1 Publication

Gene expression databases

BgeeiENSG00000096264 Expressed in 106 organ(s), highest expression level in pleura
CleanExiHS_NCR2
GenevisibleiO95944 HS

Organism-specific databases

HPAiHPA067249

Interactioni

Subunit structurei

Interacts with TYROBP/DAP12. Interacts with KMT2E isoform NKp44L.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi114827, 1 interactor
IntActiO95944, 4 interactors
STRINGi9606.ENSP00000362181

Structurei

Secondary structure

1276
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO95944
SMRiO95944
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95944

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 120Ig-likeAdd BLAST99

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi269 – 272Poly-Asp4

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JAGF Eukaryota
ENOG41117WD LUCA
GeneTreeiENSGT00530000064177
HOGENOMiHOG000293324
HOVERGENiHBG052589
InParanoidiO95944
KOiK06742
OMAiYWCRIYH
OrthoDBiEOG091G0GQ4
PhylomeDBiO95944
TreeFamiTF334441

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O95944-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAWRALHPLL LLLLLFPGSQ AQSKAQVLQS VAGQTLTVRC QYPPTGSLYE
60 70 80 90 100
KKGWCKEASA LVCIRLVTSS KPRTMAWTSR FTIWDDPDAG FFTVTMTDLR
110 120 130 140 150
EEDSGHYWCR IYRPSDNSVS KSVRFYLVVS PASASTQTSW TPRDLVSSQT
160 170 180 190 200
QTQSCVPPTA GARQAPESPS TIPVPSQPQN STLRPGPAAP IALVPVFCGL
210 220 230 240 250
LVAKSLVLSA LLVWWGDIWW KTMMELRSLD TQKATCHLQQ VTDLPWTSVS
260 270
SPVEREILYH TVARTKISDD DDEHTL
Length:276
Mass (Da):30,677
Last modified:July 7, 2009 - v2
Checksum:i4B7AF3F451CA9F9E
GO
Isoform 2 (identifier: O95944-2) [UniParc]FASTAAdd to basket
Also known as: NKp44RG2

The sequence of this isoform differs from the canonical sequence as follows:
     177-177: Q → HPSSPLPVPLPSR
     216-276: GDIWWKTMME...ISDDDDEHTL → VLRNRHMQHQ...APGGTYGGKP

Note: No experimental confirmation available.
Show »
Length:270
Mass (Da):29,668
Checksum:i32791A7B49367E46
GO
Isoform 3 (identifier: O95944-3) [UniParc]FASTAAdd to basket
Also known as: NKp44RG1

The sequence of this isoform differs from the canonical sequence as follows:
     216-276: GDIWWKTMME...ISDDDDEHTL → VLRNRHMQHQ...APGGTYGGKP

Note: No experimental confirmation available.
Show »
Length:258
Mass (Da):28,431
Checksum:iF21D9055BCA5DF0F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01863475M → V. Corresponds to variant dbSNP:rs9471577Ensembl.1
Natural variantiVAR_018635139S → P2 PublicationsCorresponds to variant dbSNP:rs2236369Ensembl.1
Natural variantiVAR_018636218I → K. Corresponds to variant dbSNP:rs2273961Ensembl.1
Natural variantiVAR_018637223M → V1 PublicationCorresponds to variant dbSNP:rs2273962Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010409177Q → HPSSPLPVPLPSR in isoform 2. 1 Publication1
Alternative sequenceiVSP_010410216 – 276GDIWW…DEHTL → VLRNRHMQHQGRSLLHPAQP RPQAHRHFPLSHRAPGGTYG GKP in isoform 2 and isoform 3. 1 PublicationAdd BLAST61

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ225109 mRNA Translation: CAB39168.1
AJ010099 mRNA Translation: CAB52289.1
AJ010100 mRNA Translation: CAB52290.1
AL136967 Genomic DNA No translation available.
CCDSiCCDS4855.1 [O95944-1]
CCDS56428.1 [O95944-2]
CCDS56429.1 [O95944-3]
RefSeqiNP_001186438.1, NM_001199509.1 [O95944-2]
NP_001186439.1, NM_001199510.1 [O95944-3]
NP_004819.2, NM_004828.3 [O95944-1]
UniGeneiHs.194721

Genome annotation databases

EnsembliENST00000373083; ENSP00000362175; ENSG00000096264 [O95944-3]
ENST00000373086; ENSP00000362178; ENSG00000096264 [O95944-2]
ENST00000373089; ENSP00000362181; ENSG00000096264 [O95944-1]
GeneIDi9436
KEGGihsa:9436
UCSCiuc003oqh.3 human [O95944-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ225109 mRNA Translation: CAB39168.1
AJ010099 mRNA Translation: CAB52289.1
AJ010100 mRNA Translation: CAB52290.1
AL136967 Genomic DNA No translation available.
CCDSiCCDS4855.1 [O95944-1]
CCDS56428.1 [O95944-2]
CCDS56429.1 [O95944-3]
RefSeqiNP_001186438.1, NM_001199509.1 [O95944-2]
NP_001186439.1, NM_001199510.1 [O95944-3]
NP_004819.2, NM_004828.3 [O95944-1]
UniGeneiHs.194721

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HKFX-ray2.20A19-130[»]
ProteinModelPortaliO95944
SMRiO95944
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114827, 1 interactor
IntActiO95944, 4 interactors
STRINGi9606.ENSP00000362181

PTM databases

iPTMnetiO95944
PhosphoSitePlusiO95944

Polymorphism and mutation databases

BioMutaiNCR2

Proteomic databases

PaxDbiO95944
PeptideAtlasiO95944
PRIDEiO95944
ProteomicsDBi51137
51138 [O95944-2]
51139 [O95944-3]

Protocols and materials databases

DNASUi9436
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373083; ENSP00000362175; ENSG00000096264 [O95944-3]
ENST00000373086; ENSP00000362178; ENSG00000096264 [O95944-2]
ENST00000373089; ENSP00000362181; ENSG00000096264 [O95944-1]
GeneIDi9436
KEGGihsa:9436
UCSCiuc003oqh.3 human [O95944-1]

Organism-specific databases

CTDi9436
DisGeNETi9436
EuPathDBiHostDB:ENSG00000096264.13
GeneCardsiNCR2
H-InvDBiHIX0165054
HGNCiHGNC:6732 NCR2
HPAiHPA067249
MIMi604531 gene
neXtProtiNX_O95944
OpenTargetsiENSG00000096264
PharmGKBiPA30496
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JAGF Eukaryota
ENOG41117WD LUCA
GeneTreeiENSGT00530000064177
HOGENOMiHOG000293324
HOVERGENiHBG052589
InParanoidiO95944
KOiK06742
OMAiYWCRIYH
OrthoDBiEOG091G0GQ4
PhylomeDBiO95944
TreeFamiTF334441

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-2172127 DAP12 interactions

Miscellaneous databases

EvolutionaryTraceiO95944
GeneWikiiNCR2
GenomeRNAii9436
PROiPR:O95944
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000096264 Expressed in 106 organ(s), highest expression level in pleura
CleanExiHS_NCR2
GenevisibleiO95944 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNCTR2_HUMAN
AccessioniPrimary (citable) accession number: O95944
Secondary accession number(s): Q9H562
, Q9H563, Q9H564, Q9UMT1, Q9UMT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: July 7, 2009
Last modified: November 7, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  7. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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