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Entry version 158 (13 Feb 2019)
Sequence version 3 (16 Aug 2005)
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Protein

Protein-glutamine gamma-glutamyltransferase 6

Gene

TGM6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+By similarityNote: Binds up to 3 Ca2+ cations per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi223Calcium 1; via carbonyl oxygenSequence analysis1
Metal bindingi226Calcium 1Sequence analysis1
Metal bindingi228Calcium 1; via carbonyl oxygenSequence analysis1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei274PROSITE-ProRule annotation1
Metal bindingi303Calcium 2By similarity1
Metal bindingi305Calcium 2By similarity1
Metal bindingi307Calcium 2By similarity1
Metal bindingi309Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi327Calcium 2By similarity1
Active sitei333PROSITE-ProRule annotation1
Active sitei356PROSITE-ProRule annotation1
Metal bindingi396Calcium 3By similarity1
Metal bindingi417Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi445Calcium 3By similarity1
Metal bindingi450Calcium 3By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • protein-glutamine gamma-glutamyltransferase activity Source: MGI

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase
LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein-glutamine gamma-glutamyltransferase 6 (EC:2.3.2.13)
Alternative name(s):
Transglutaminase Y
Short name:
TGY
Short name:
TGase Y
Transglutaminase-3-like
Short name:
TGase-3-like
Transglutaminase-6
Short name:
TG6
Short name:
TGase-6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TGM6
Synonyms:TGM3L
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000166948.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16255 TGM6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613900 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95932

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spinocerebellar ataxia 35 (SCA35)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA35 patients commonly show upper limb involvement and torticollis. There is no cognitive impairment.
See also OMIM:613908
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_072179111R → C in SCA35; impairs transglutaminase activity. 1 PublicationCorresponds to variant dbSNP:rs372250159EnsemblClinVar.1
Natural variantiVAR_065360327D → G in SCA35; decreased transglutaminase activity; decreased protein stability. 2 PublicationsCorresponds to variant dbSNP:rs387907098EnsemblClinVar.1
Natural variantiVAR_080737426T → N in SCA35; decreased protein stability. 1 Publication1
Natural variantiVAR_072180510D → H in SCA35; impairs transglutaminase activity. 2 PublicationsCorresponds to variant dbSNP:rs201964784EnsemblClinVar.1
Natural variantiVAR_065361517L → W in SCA35; decreased transglutaminase activity; decreased protein stability. 2 PublicationsCorresponds to variant dbSNP:rs387907097EnsemblClinVar.1
Natural variantiVAR_072181574Missing in SCA35; impairs transglutaminase activity. 1 Publication1

Keywords - Diseasei

Disease mutation, Neurodegeneration, Spinocerebellar ataxia

Organism-specific databases

DisGeNET

More...
DisGeNETi
343641

MalaCards human disease database

More...
MalaCardsi
TGM6
MIMi613908 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000166948

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
319465 Inherited acute myeloid leukemia
276193 Spinocerebellar ataxia type 35

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38098

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2079852

Drug and drug target database

More...
DrugBanki
DB00130 L-Glutamine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TGM6

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002137151 – 706Protein-glutamine gamma-glutamyltransferase 6Add BLAST706

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O95932

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O95932

PeptideAtlas

More...
PeptideAtlasi
O95932

PRoteomics IDEntifications database

More...
PRIDEi
O95932

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51132
51133 [O95932-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
O95932-1 [O95932-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O95932

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O95932

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166948 Expressed in 12 organ(s), highest expression level in placenta

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O95932 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA059196

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
O95932, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000202625

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O95932

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O95932

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O95932

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFMV Eukaryota
ENOG410XQEZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153315

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231695

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG004342

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O95932

KEGG Orthology (KO)

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KOi
K05624

Identification of Orthologs from Complete Genome Data

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OMAi
DVSCRHD

Database of Orthologous Groups

More...
OrthoDBi
297055at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O95932

TreeFam database of animal gene trees

More...
TreeFami
TF324278

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 3 hits
3.90.260.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR038765 Papain_like_cys_pep_sf
IPR002931 Transglutaminase-like
IPR036985 Transglutaminase-like_sf
IPR023608 Transglutaminase_animal
IPR013808 Transglutaminase_AS
IPR008958 Transglutaminase_C
IPR036238 Transglutaminase_C_sf
IPR001102 Transglutaminase_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00927 Transglut_C, 2 hits
PF01841 Transglut_core, 1 hit
PF00868 Transglut_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000459 TGM_EBP42, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00460 TGc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49309 SSF49309, 2 hits
SSF54001 SSF54001, 1 hit
SSF81296 SSF81296, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00547 TRANSGLUTAMINASES, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O95932-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGIRVTKVD WQRSRNGAAH HTQEYPCPEL VVRRGQSFSL TLELSRALDC
60 70 80 90 100
EEILIFTMET GPRASEALHT KAVFQTSELE RGEGWTAARE AQMEKTLTVS
110 120 130 140 150
LASPPSAVIG RYLLSIRLSS HRKHSNRRLG EFVLLFNPWC AEDDVFLASE
160 170 180 190 200
EERQEYVLSD SGIIFRGVEK HIRAQGWNYG QFEEDILNIC LSILDRSPGH
210 220 230 240 250
QNNPATDVSC RHNPIYVTRV ISAMVNSNND RGVVQGQWQG KYGGGTSPLH
260 270 280 290 300
WRGSVAILQK WLKGRYKPVK YGQCWVFAGV LCTVLRCLGI ATRVVSNFNS
310 320 330 340 350
AHDTDQNLSV DKYVDSFGRT LEDLTEDSMW NFHVWNESWF ARQDLGPSYN
360 370 380 390 400
GWQVLDATPQ EESEGVFRCG PASVTAIREG DVHLAHDGPF VFAEVNADYI
410 420 430 440 450
TWLWHEDESR ERVYSNTKKI GRCISTKAVG SDSRVDITDL YKYPEGSRKE
460 470 480 490 500
RQVYSKAVNR LFGVEASGRR IWIRRAGGRC LWRDDLLEPA TKPSIAGKFK
510 520 530 540 550
VLEPPMLGHD LRLALCLANL TSRAQRVRVN LSGATILYTR KPVAEILHES
560 570 580 590 600
HAVRLGPQEE KRIPITISYS KYKEDLTEDK KILLAAMCLV TKGEKLLVEK
610 620 630 640 650
DITLEDFITI KVLGPAMVGV AVTVEVTVVN PLIERVKDCA LMVEGSGLLQ
660 670 680 690 700
EQLSIDVPTL EPQERASVQF DITPSKSGPR QLQVDLVSPH FPDIKGFVIV

HVATAK
Length:706
Mass (Da):79,312
Last modified:August 16, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i97BBE2043C5FF834
GO
Isoform 2 (identifier: O95932-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     612-625: VLGPAMVGVAVTVE → RAYPGASGEGLSPV
     626-706: Missing.

Show »
Length:625
Mass (Da):70,516
Checksum:i4E91DB6E8EFBEBAA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01325058M → V1 PublicationCorresponds to variant dbSNP:rs2076405EnsemblClinVar.1
Natural variantiVAR_072179111R → C in SCA35; impairs transglutaminase activity. 1 PublicationCorresponds to variant dbSNP:rs372250159EnsemblClinVar.1
Natural variantiVAR_065360327D → G in SCA35; decreased transglutaminase activity; decreased protein stability. 2 PublicationsCorresponds to variant dbSNP:rs387907098EnsemblClinVar.1
Natural variantiVAR_080737426T → N in SCA35; decreased protein stability. 1 Publication1
Natural variantiVAR_072180510D → H in SCA35; impairs transglutaminase activity. 2 PublicationsCorresponds to variant dbSNP:rs201964784EnsemblClinVar.1
Natural variantiVAR_065361517L → W in SCA35; decreased transglutaminase activity; decreased protein stability. 2 PublicationsCorresponds to variant dbSNP:rs387907097EnsemblClinVar.1
Natural variantiVAR_072181574Missing in SCA35; impairs transglutaminase activity. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_015103612 – 625VLGPA…AVTVE → RAYPGASGEGLSPV in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_015104626 – 706Missing in isoform 2. 1 PublicationAdd BLAST81

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF540969 mRNA Translation: AAQ10751.1
AF540970 mRNA Translation: AAQ10752.1
AL049650 Genomic DNA No translation available.
AL031678 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13025.1 [O95932-1]
CCDS58761.1 [O95932-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001241663.1, NM_001254734.1 [O95932-2]
NP_945345.2, NM_198994.2 [O95932-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.452039

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000202625; ENSP00000202625; ENSG00000166948 [O95932-1]
ENST00000381423; ENSP00000370831; ENSG00000166948 [O95932-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
343641

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:343641

UCSC genome browser

More...
UCSCi
uc002wfy.1 human [O95932-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF540969 mRNA Translation: AAQ10751.1
AF540970 mRNA Translation: AAQ10752.1
AL049650 Genomic DNA No translation available.
AL031678 Genomic DNA No translation available.
CCDSiCCDS13025.1 [O95932-1]
CCDS58761.1 [O95932-2]
RefSeqiNP_001241663.1, NM_001254734.1 [O95932-2]
NP_945345.2, NM_198994.2 [O95932-1]
UniGeneiHs.452039

3D structure databases

ProteinModelPortaliO95932
SMRiO95932
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO95932, 1 interactor
STRINGi9606.ENSP00000202625

Chemistry databases

BindingDBiO95932
ChEMBLiCHEMBL2079852
DrugBankiDB00130 L-Glutamine

PTM databases

iPTMnetiO95932
PhosphoSitePlusiO95932

Polymorphism and mutation databases

BioMutaiTGM6

Proteomic databases

jPOSTiO95932
PaxDbiO95932
PeptideAtlasiO95932
PRIDEiO95932
ProteomicsDBi51132
51133 [O95932-2]
TopDownProteomicsiO95932-1 [O95932-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
343641
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000202625; ENSP00000202625; ENSG00000166948 [O95932-1]
ENST00000381423; ENSP00000370831; ENSG00000166948 [O95932-2]
GeneIDi343641
KEGGihsa:343641
UCSCiuc002wfy.1 human [O95932-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
343641
DisGeNETi343641
EuPathDBiHostDB:ENSG00000166948.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TGM6

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0040537
HGNCiHGNC:16255 TGM6
HPAiHPA059196
MalaCardsiTGM6
MIMi613900 gene
613908 phenotype
neXtProtiNX_O95932
OpenTargetsiENSG00000166948
Orphaneti319465 Inherited acute myeloid leukemia
276193 Spinocerebellar ataxia type 35
PharmGKBiPA38098

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IFMV Eukaryota
ENOG410XQEZ LUCA
GeneTreeiENSGT00940000153315
HOGENOMiHOG000231695
HOVERGENiHBG004342
InParanoidiO95932
KOiK05624
OMAiDVSCRHD
OrthoDBi297055at2759
PhylomeDBiO95932
TreeFamiTF324278

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TGM6 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
343641

Protein Ontology

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PROi
PR:O95932

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000166948 Expressed in 12 organ(s), highest expression level in placenta
GenevisibleiO95932 HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.90.260.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR038765 Papain_like_cys_pep_sf
IPR002931 Transglutaminase-like
IPR036985 Transglutaminase-like_sf
IPR023608 Transglutaminase_animal
IPR013808 Transglutaminase_AS
IPR008958 Transglutaminase_C
IPR036238 Transglutaminase_C_sf
IPR001102 Transglutaminase_N
PfamiView protein in Pfam
PF00927 Transglut_C, 2 hits
PF01841 Transglut_core, 1 hit
PF00868 Transglut_N, 1 hit
PIRSFiPIRSF000459 TGM_EBP42, 1 hit
SMARTiView protein in SMART
SM00460 TGc, 1 hit
SUPFAMiSSF49309 SSF49309, 2 hits
SSF54001 SSF54001, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS00547 TRANSGLUTAMINASES, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTGM3L_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95932
Secondary accession number(s): Q5JXU4
, Q5JXU5, Q719M2, Q719M3, Q9Y4U8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: August 16, 2005
Last modified: February 13, 2019
This is version 158 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
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