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Entry version 152 (13 Feb 2019)
Sequence version 1 (01 May 1999)
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Protein

Probable tubulin polyglutamylase TTLL1

Gene

TTLL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytic subunit of the neuronal tubulin polyglutamylase complex. Modifies alpha- and beta-tubulin, generating side chains of glutamate on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei194ATPBy similarity1
Binding sitei196ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi181 – 184ATP bindingBy similarity4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • tubulin-glutamic acid ligase activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable tubulin polyglutamylase TTLL1 (EC:6.-.-.-)
Alternative name(s):
Tubulin polyglutamylase complex subunit 3
Short name:
PGs3
Tubulin--tyrosine ligase-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TTLL1
Synonyms:C22orf7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000100271.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1312 TTLL1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608955 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95922

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
25809

Open Targets

More...
OpenTargetsi
ENSG00000100271

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35030

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TTLL1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002124381 – 423Probable tubulin polyglutamylase TTLL1Add BLAST423

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O95922

PeptideAtlas

More...
PeptideAtlasi
O95922

PRoteomics IDEntifications database

More...
PRIDEi
O95922

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51124
51125 [O95922-2]
51126 [O95922-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O95922

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O95922

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in a wide range of tissues. Has a stronger expression in heart, brain and testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000100271 Expressed in 188 organ(s), highest expression level in brain

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O95922 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O95922 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA048392

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117340, 20 interactors

Protein interaction database and analysis system

More...
IntActi
O95922, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000266254

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O95922

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 367TTLPROSITE-ProRule annotationAdd BLAST367

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tubulin polyglutamylase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2157 Eukaryota
ENOG410XQDM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156720

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000256695

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG066341

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O95922

KEGG Orthology (KO)

More...
KOi
K16599

Identification of Orthologs from Complete Genome Data

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OMAi
KHGGEYN

Database of Orthologous Groups

More...
OrthoDBi
584228at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O95922

TreeFam database of animal gene trees

More...
TreeFami
TF313087

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1490.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013815 ATP_grasp_subdomain_1
IPR004344 TTL/TTLL_fam
IPR027750 TTLL1

The PANTHER Classification System

More...
PANTHERi
PTHR12241:SF31 PTHR12241:SF31, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03133 TTL, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51221 TTL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.
Isoform A (identifier: O95922-1) [UniParc]FASTAAdd to basket
Also known as: TTLL1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGKVKWVTD IEKSVLINNF EKRGWVQVTE NEDWNFYWMS VQTIRNVFSV
60 70 80 90 100
EAGYRLSDDQ IVNHFPNHYE LTRKDLMVKN IKRYRKELEK EGSPLAEKDE
110 120 130 140 150
NGKYLYLDFV PVTYMLPADY NLFVEEFRKS PSSTWIMKPC GKAQGKGIFL
160 170 180 190 200
INKLSQIKKW SRDSKTSSFV SQSNKEAYVI SLYINNPLLI GGRKFDLRLY
210 220 230 240 250
VLVSTYRPLR CYMYKLGFCR FCTVKYTPST SELDNMFVHL TNVAIQKHGE
260 270 280 290 300
DYNHIHGGKW TVSNLRLYLE STRGKEVTSK LFDEIHWIIV QSLKAVAPVM
310 320 330 340 350
NNDKHCFECY GYDIIIDDKL KPWLIEVNAS PSLTSSTAND RILKYNLIND
360 370 380 390 400
TLNIAVPNGE IPDCKWNKSP PKEVLGNYEI LYDEELAQGD GADRELRSRQ
410 420
GQSLGPRAGR SRDSGRAVLT TWK
Length:423
Mass (Da):48,988
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAFFDEEE008D2E655
GO
Isoform B (identifier: O95922-2) [UniParc]FASTAAdd to basket
Also known as: TTLL1b, Truncated

The sequence of this isoform differs from the canonical sequence as follows:
     39-59: MSVQTIRNVFSVEAGYRLSDD → LLDLPEFRYRSCLNEFPDFRV
     60-423: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:59
Mass (Da):7,273
Checksum:i265D7617B298E223
GO
Isoform 4 (identifier: O95922-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     298-326: Missing.

Note: No experimental confirmation available.
Show »
Length:394
Mass (Da):45,493
Checksum:i3BEB10DE2B04FE34
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB51423 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052409168S → L. Corresponds to variant dbSNP:rs6003030Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00667139 – 59MSVQT…RLSDD → LLDLPEFRYRSCLNEFPDFR V in isoform B. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_00667260 – 423Missing in isoform B. 2 PublicationsAdd BLAST364
Alternative sequenceiVSP_011825298 – 326Missing in isoform 4. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF104927 mRNA Translation: AAG29879.1
AF173935 mRNA Translation: AAF91088.1
AL136687 mRNA Translation: CAB66622.1
AL096883 mRNA Translation: CAB51423.1 Sequence problems.
AL096886 mRNA Translation: CAB51469.1
AL589867 mRNA Translation: CAC34478.1
CR456599 mRNA Translation: CAG30485.1
AK315658 mRNA Translation: BAG38024.1
AL022476 Genomic DNA No translation available.
CH471138 Genomic DNA Translation: EAW73279.1
BC014968 mRNA Translation: AAH14968.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14043.1 [O95922-1]

NCBI Reference Sequences

More...
RefSeqi
NP_036395.1, NM_012263.4 [O95922-1]
XP_011528410.1, XM_011530108.2
XP_016884240.1, XM_017028751.1 [O95922-1]
XP_016884241.1, XM_017028752.1 [O95922-1]
XP_016884242.1, XM_017028753.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.660298

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000266254; ENSP00000266254; ENSG00000100271 [O95922-1]
ENST00000331018; ENSP00000333734; ENSG00000100271 [O95922-4]
ENST00000439248; ENSP00000401518; ENSG00000100271 [O95922-2]
ENST00000440761; ENSP00000403332; ENSG00000100271 [O95922-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
25809

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:25809

UCSC genome browser

More...
UCSCi
uc003bdi.5 human [O95922-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF104927 mRNA Translation: AAG29879.1
AF173935 mRNA Translation: AAF91088.1
AL136687 mRNA Translation: CAB66622.1
AL096883 mRNA Translation: CAB51423.1 Sequence problems.
AL096886 mRNA Translation: CAB51469.1
AL589867 mRNA Translation: CAC34478.1
CR456599 mRNA Translation: CAG30485.1
AK315658 mRNA Translation: BAG38024.1
AL022476 Genomic DNA No translation available.
CH471138 Genomic DNA Translation: EAW73279.1
BC014968 mRNA Translation: AAH14968.1
CCDSiCCDS14043.1 [O95922-1]
RefSeqiNP_036395.1, NM_012263.4 [O95922-1]
XP_011528410.1, XM_011530108.2
XP_016884240.1, XM_017028751.1 [O95922-1]
XP_016884241.1, XM_017028752.1 [O95922-1]
XP_016884242.1, XM_017028753.1
UniGeneiHs.660298

3D structure databases

ProteinModelPortaliO95922
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117340, 20 interactors
IntActiO95922, 4 interactors
STRINGi9606.ENSP00000266254

PTM databases

iPTMnetiO95922
PhosphoSitePlusiO95922

Polymorphism and mutation databases

BioMutaiTTLL1

Proteomic databases

PaxDbiO95922
PeptideAtlasiO95922
PRIDEiO95922
ProteomicsDBi51124
51125 [O95922-2]
51126 [O95922-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
25809
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266254; ENSP00000266254; ENSG00000100271 [O95922-1]
ENST00000331018; ENSP00000333734; ENSG00000100271 [O95922-4]
ENST00000439248; ENSP00000401518; ENSG00000100271 [O95922-2]
ENST00000440761; ENSP00000403332; ENSG00000100271 [O95922-2]
GeneIDi25809
KEGGihsa:25809
UCSCiuc003bdi.5 human [O95922-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
25809
DisGeNETi25809
EuPathDBiHostDB:ENSG00000100271.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TTLL1
HGNCiHGNC:1312 TTLL1
HPAiHPA048392
MIMi608955 gene
neXtProtiNX_O95922
OpenTargetsiENSG00000100271
PharmGKBiPA35030

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2157 Eukaryota
ENOG410XQDM LUCA
GeneTreeiENSGT00940000156720
HOGENOMiHOG000256695
HOVERGENiHBG066341
InParanoidiO95922
KOiK16599
OMAiKHGGEYN
OrthoDBi584228at2759
PhylomeDBiO95922
TreeFamiTF313087

Enzyme and pathway databases

ReactomeiR-HSA-8955332 Carboxyterminal post-translational modifications of tubulin

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TTLL1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TTLL1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
25809

Protein Ontology

More...
PROi
PR:O95922

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000100271 Expressed in 188 organ(s), highest expression level in brain
ExpressionAtlasiO95922 baseline and differential
GenevisibleiO95922 HS

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
InterProiView protein in InterPro
IPR013815 ATP_grasp_subdomain_1
IPR004344 TTL/TTLL_fam
IPR027750 TTLL1
PANTHERiPTHR12241:SF31 PTHR12241:SF31, 1 hit
PfamiView protein in Pfam
PF03133 TTL, 1 hit
PROSITEiView protein in PROSITE
PS51221 TTL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTTLL1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95922
Secondary accession number(s): B2RDS7
, Q9BR27, Q9NRS9, Q9UMU0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 1, 1999
Last modified: February 13, 2019
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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