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Protein

Olfactory receptor 2H2

Gene

OR2H2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: GO_Central

GO - Biological processi

  • defense response Source: ProtInc
  • mating Source: ProtInc

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2H2
Alternative name(s):
Hs6M1-12
Olfactory receptor 2H3
Olfactory receptor-like protein FAT11
Gene namesi
Name:OR2H2
Synonyms:FAT11, OLFR2, OR2H3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204657.3
HGNCiHGNC:8253 OR2H2
MIMi600578 gene
neXtProtiNX_O95918

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 47Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini48 – 55CytoplasmicSequence analysis8
Transmembranei56 – 77Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini78 – 98ExtracellularSequence analysisAdd BLAST21
Transmembranei99 – 118Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 156Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini157 – 193ExtracellularSequence analysisAdd BLAST37
Transmembranei194 – 217Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini218 – 234CytoplasmicSequence analysisAdd BLAST17
Transmembranei235 – 257Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini258 – 270ExtracellularSequence analysisAdd BLAST13
Transmembranei271 – 290Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini291 – 312CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7932
OpenTargetsiENSG00000204657
PharmGKBiPA32162

Polymorphism and mutation databases

BioMutaiOR2H2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504801 – 312Olfactory receptor 2H2Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO95918
PeptideAtlasiO95918
PRIDEiO95918
ProteomicsDBi51123

PTM databases

iPTMnetiO95918
PhosphoSitePlusiO95918

Expressioni

Gene expression databases

BgeeiENSG00000204657 Expressed in 118 organ(s), highest expression level in sperm
CleanExiHS_OR2H2
ExpressionAtlasiO95918 baseline and differential
GenevisibleiO95918 HS

Interactioni

Protein-protein interaction databases

BioGridi113659, 1 interactor
STRINGi9606.ENSP00000373136

Structurei

3D structure databases

ProteinModelPortaliO95918
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JAPF Eukaryota
ENOG41117A7 LUCA
GeneTreeiENSGT00900000140946
HOVERGENiHBG017625
InParanoidiO95918
KOiK04257
OMAiPHRQVDD
OrthoDBiEOG09370984
PhylomeDBiO95918
TreeFamiTF336512

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O95918-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVNQSSTPGF LLLGFSEHPG LERTLFVVVL TSYLLTLVGN TLIILLSALD
60 70 80 90 100
PKLHSPMYFF LSNLSFLDLC FTTSCVPQML VNLWGPKKTI SFLDCSVQIF
110 120 130 140 150
IFLSLGTTEC ILLTVMAFDR YVAVCQPLHY ATIIHPRLCW QLASVAWVIG
160 170 180 190 200
LVESVVQTPS TLHLPFCPDR QVDDFVCEVP ALIRLSCEDT SYNEIQVAVA
210 220 230 240 250
SVFILVVPLS LILVSYGAIT WAVLRINSAK GRRKAFGTCS SHLTVVTLFY
260 270 280 290 300
SSVIAVYLQP KNPYAQERGK FFGLFYAVGT PSLNPLIYTL RNKEVTRAFR
310
RLLGKEMGLT QS
Length:312
Mass (Da):34,763
Last modified:November 2, 2010 - v2
Checksum:i4E18B444768AAFC5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2V → D in AAB36567 (PubMed:7665158).Curated1
Sequence conflicti2V → D in AAH69146 (PubMed:15489334).Curated1
Sequence conflicti22E → G in AAB36567 (PubMed:7665158).Curated1
Sequence conflicti28V → D in AAB36567 (PubMed:7665158).Curated1
Sequence conflicti51P → T in AAB36567 (PubMed:7665158).Curated1
Sequence conflicti81V → A in AAB36567 (PubMed:7665158).Curated1
Sequence conflicti113 – 114LT → MK in AAB36567 (PubMed:7665158).Curated2
Sequence conflicti153E → G in AAB36567 (PubMed:7665158).Curated1
Sequence conflicti230 – 232KGR → TAW in AAB36567 (PubMed:7665158).Curated3
Sequence conflicti267E → G in AAB36567 (PubMed:7665158).Curated1
Sequence conflicti287I → V in AAB36567 (PubMed:7665158).Curated1
Sequence conflicti295 – 296VT → IK in AAB36567 (PubMed:7665158).Curated2
Sequence conflicti299F → L in AAB36567 (PubMed:7665158).Curated1
Sequence conflicti307 – 312MGLTQS → RDSRESWRAA in AAB36567 (PubMed:7665158).Curated6

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05808730L → F4 PublicationsCorresponds to variant dbSNP:rs3129034Ensembl.1
Natural variantiVAR_02323130L → I1 PublicationCorresponds to variant dbSNP:rs3129034Ensembl.1
Natural variantiVAR_01022730L → S1 Publication1
Natural variantiVAR_05754038V → M. Corresponds to variant dbSNP:rs11966382Ensembl.1
Natural variantiVAR_01022848A → V3 PublicationsCorresponds to variant dbSNP:rs1233387Ensembl.1
Natural variantiVAR_010229220T → A1 PublicationCorresponds to variant dbSNP:rs141430371Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35475 Genomic DNA Translation: AAB36567.1
AF211939 Genomic DNA Translation: AAF98751.1
AF211940 Genomic DNA Translation: AAF98752.1
AF211941 Genomic DNA Translation: AAF98753.1
AF211942 Genomic DNA Translation: AAF98754.1
AB065965 Genomic DNA Translation: BAC06177.1
AL031983 Genomic DNA Translation: CAA21455.1
AL645936 Genomic DNA No translation available.
AL662826 Genomic DNA No translation available.
BX000688 Genomic DNA No translation available.
BX927223 Genomic DNA No translation available.
CR759766 Genomic DNA No translation available.
CR759870 Genomic DNA No translation available.
CR788300 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03204.1
BC069146 mRNA Translation: AAH69146.1
BC101683 mRNA Translation: AAI01684.1
BC112176 mRNA Translation: AAI12177.1
AF399631 Genomic DNA Translation: AAK95116.1
BK004225 Genomic DNA Translation: DAA04623.1
CCDSiCCDS34365.1
PIRiA57069
RefSeqiNP_009091.3, NM_007160.3
UniGeneiHs.529493
Hs.697691

Genome annotation databases

EnsembliENST00000376947; ENSP00000366146; ENSG00000206512
ENST00000383546; ENSP00000373038; ENSG00000206467
ENST00000383640; ENSP00000373136; ENSG00000204657
ENST00000411574; ENSP00000410227; ENSG00000229680
ENST00000439874; ENSP00000403604; ENSG00000229185
ENST00000453513; ENSP00000414688; ENSG00000224319
ENST00000454628; ENSP00000409339; ENSG00000227044
ENST00000641840; ENSP00000492959; ENSG00000204657
GeneIDi7932
KEGGihsa:7932
UCSCiuc003nmr.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35475 Genomic DNA Translation: AAB36567.1
AF211939 Genomic DNA Translation: AAF98751.1
AF211940 Genomic DNA Translation: AAF98752.1
AF211941 Genomic DNA Translation: AAF98753.1
AF211942 Genomic DNA Translation: AAF98754.1
AB065965 Genomic DNA Translation: BAC06177.1
AL031983 Genomic DNA Translation: CAA21455.1
AL645936 Genomic DNA No translation available.
AL662826 Genomic DNA No translation available.
BX000688 Genomic DNA No translation available.
BX927223 Genomic DNA No translation available.
CR759766 Genomic DNA No translation available.
CR759870 Genomic DNA No translation available.
CR788300 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03204.1
BC069146 mRNA Translation: AAH69146.1
BC101683 mRNA Translation: AAI01684.1
BC112176 mRNA Translation: AAI12177.1
AF399631 Genomic DNA Translation: AAK95116.1
BK004225 Genomic DNA Translation: DAA04623.1
CCDSiCCDS34365.1
PIRiA57069
RefSeqiNP_009091.3, NM_007160.3
UniGeneiHs.529493
Hs.697691

3D structure databases

ProteinModelPortaliO95918
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113659, 1 interactor
STRINGi9606.ENSP00000373136

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO95918
PhosphoSitePlusiO95918

Polymorphism and mutation databases

BioMutaiOR2H2

Proteomic databases

PaxDbiO95918
PeptideAtlasiO95918
PRIDEiO95918
ProteomicsDBi51123

Protocols and materials databases

DNASUi7932
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376947; ENSP00000366146; ENSG00000206512
ENST00000383546; ENSP00000373038; ENSG00000206467
ENST00000383640; ENSP00000373136; ENSG00000204657
ENST00000411574; ENSP00000410227; ENSG00000229680
ENST00000439874; ENSP00000403604; ENSG00000229185
ENST00000453513; ENSP00000414688; ENSG00000224319
ENST00000454628; ENSP00000409339; ENSG00000227044
ENST00000641840; ENSP00000492959; ENSG00000204657
GeneIDi7932
KEGGihsa:7932
UCSCiuc003nmr.2 human

Organism-specific databases

CTDi7932
DisGeNETi7932
EuPathDBiHostDB:ENSG00000204657.3
GeneCardsiOR2H2
H-InvDBiHIX0201049
HGNCiHGNC:8253 OR2H2
MIMi600578 gene
neXtProtiNX_O95918
OpenTargetsiENSG00000204657
PharmGKBiPA32162
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JAPF Eukaryota
ENOG41117A7 LUCA
GeneTreeiENSGT00900000140946
HOVERGENiHBG017625
InParanoidiO95918
KOiK04257
OMAiPHRQVDD
OrthoDBiEOG09370984
PhylomeDBiO95918
TreeFamiTF336512

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR2H2
GenomeRNAii7932
PROiPR:O95918
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204657 Expressed in 118 organ(s), highest expression level in sperm
CleanExiHS_OR2H2
ExpressionAtlasiO95918 baseline and differential
GenevisibleiO95918 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOR2H2_HUMAN
AccessioniPrimary (citable) accession number: O95918
Secondary accession number(s): Q15062
, Q2M1Y3, Q5STL8, Q5SUK1, Q6IFN7, Q6NTB7, Q96R14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 2, 2010
Last modified: November 7, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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