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Protein

Monocarboxylate transporter 3

Gene

SLC16A8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • lactate transport Source: ProtInc
  • leukocyte migration Source: Reactome
  • monocarboxylic acid transport Source: GO_Central
  • pyruvate metabolic process Source: Reactome

Keywordsi

Biological processSymport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-210991 Basigin interactions
R-HSA-433692 Proton-coupled monocarboxylate transport
R-HSA-70268 Pyruvate metabolism

Protein family/group databases

TCDBi2.A.1.13.9 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 3
Short name:
MCT 3
Alternative name(s):
Solute carrier family 16 member 8
Gene namesi
Name:SLC16A8
Synonyms:MCT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100156.10
HGNCiHGNC:16270 SLC16A8
MIMi610409 gene
neXtProtiNX_O95907

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14CytoplasmicSequence analysisAdd BLAST14
Transmembranei15 – 35HelicalSequence analysisAdd BLAST21
Topological domaini36 – 58ExtracellularSequence analysisAdd BLAST23
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Topological domaini80 – 85CytoplasmicSequence analysis6
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Topological domaini107 – 115ExtracellularSequence analysis9
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Topological domaini137 – 143CytoplasmicSequence analysis7
Transmembranei144 – 164HelicalSequence analysisAdd BLAST21
Topological domaini165 – 172ExtracellularSequence analysis8
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Topological domaini194 – 254CytoplasmicSequence analysisAdd BLAST61
Transmembranei255 – 275HelicalSequence analysisAdd BLAST21
Topological domaini276 – 289ExtracellularSequence analysisAdd BLAST14
Transmembranei290 – 310HelicalSequence analysisAdd BLAST21
Topological domaini311 – 318CytoplasmicSequence analysis8
Transmembranei319 – 335HelicalSequence analysisAdd BLAST17
Topological domaini336 – 342ExtracellularSequence analysis7
Transmembranei343 – 363HelicalSequence analysisAdd BLAST21
Topological domaini364 – 376CytoplasmicSequence analysisAdd BLAST13
Transmembranei377 – 397HelicalSequence analysisAdd BLAST21
Topological domaini398 – 410ExtracellularSequence analysisAdd BLAST13
Transmembranei411 – 431HelicalSequence analysisAdd BLAST21
Topological domaini432 – 504CytoplasmicSequence analysisAdd BLAST73

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23539
OpenTargetsiENSG00000100156
PharmGKBiPA38106

Chemistry databases

ChEMBLiCHEMBL3308921
DrugBankiDB00119 Pyruvic acid

Polymorphism and mutation databases

BioMutaiSLC16A8

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002113901 – 504Monocarboxylate transporter 3Add BLAST504

Proteomic databases

PaxDbiO95907
PeptideAtlasiO95907
PRIDEiO95907
ProteomicsDBi51122

PTM databases

iPTMnetiO95907
PhosphoSitePlusiO95907

Expressioni

Tissue specificityi

Retinal pigment epithelium.

Gene expression databases

BgeeiENSG00000100156 Expressed in 122 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_SLC16A8
ExpressionAtlasiO95907 baseline and differential
GenevisibleiO95907 HS

Organism-specific databases

HPAiHPA075017

Interactioni

Protein-protein interaction databases

BioGridi117083, 2 interactors
IntActiO95907, 2 interactors
STRINGi9606.ENSP00000321735

Structurei

3D structure databases

ProteinModelPortaliO95907
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2504 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00760000118926
HOGENOMiHOG000280688
HOVERGENiHBG006384
InParanoidiO95907
KOiK08185
OMAiCTDRAFA
OrthoDBiEOG091G05SW
PhylomeDBiO95907
TreeFamiTF313792

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR004743 MCT
IPR030759 MCT3
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PANTHERiPTHR11360:SF26 PTHR11360:SF26, 1 hit
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00892 2A0113, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O95907-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAGGPRRGE GPPDGGWGWV VLGACFVVTG FAYGFPKAVS VFFRALMRDF
60 70 80 90 100
DAGYSDTAWV SSIMLAMLYG TGPVSSILVT RFGCRPVMLA GGLLASAGMI
110 120 130 140 150
LASFATRLLE LYLTAGVLTG LGLALNFQPS LIMLGLYFER RRPLANGLAA
160 170 180 190 200
AGSPVFLSAL SPLGQQLLER FGWRGGFLLL GGLLLHCCAC GAVMRPPPGP
210 220 230 240 250
GPRPRRDSAG DRAGDAPGEA EADGAGLQLR EASPRVRPRR RLLDLAVCTD
260 270 280 290 300
RAFAVYAVTK FLMALGLFVP AILLVNYAKD AGVPDTDAAF LLSIVGFVDI
310 320 330 340 350
VARPACGALA GLARLRPHVP YLFSLALLAN GLTDLSSARA RSYGALVAFC
360 370 380 390 400
VAFGLSYGMV GALQFEVLMA AVGAPRFPSA LGLVLLVEAA AVLIGPPSAG
410 420 430 440 450
RLVDVLKNYE IIFYLAGSEV ALAGVFMAVA TNCCLRCAKA APSGPGTEGG
460 470 480 490 500
ASDTEDAEAE GDSEPLPVVA EEPGNLEALE VLSARGEPTE PEIEARPRLA

AESV
Length:504
Mass (Da):52,319
Last modified:May 1, 1999 - v1
Checksum:iE924D4FC31340398
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0QYL4B0QYL4_HUMAN
Monocarboxylate transporter 3
SLC16A8
97Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060107235R → W1 PublicationCorresponds to variant dbSNP:rs4289289Ensembl.1
Natural variantiVAR_053654405V → A1 PublicationCorresponds to variant dbSNP:rs2076371Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132610 mRNA Translation: AAF03565.1
AF132611 Genomic DNA Translation: AAF03489.1
AL031587 Genomic DNA No translation available.
CCDSiCCDS13966.1
RefSeqiNP_037488.2, NM_013356.2
XP_016884174.1, XM_017028685.1
UniGeneiHs.745256

Genome annotation databases

EnsembliENST00000320521; ENSP00000321735; ENSG00000100156
GeneIDi23539
KEGGihsa:23539
UCSCiuc003auu.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132610 mRNA Translation: AAF03565.1
AF132611 Genomic DNA Translation: AAF03489.1
AL031587 Genomic DNA No translation available.
CCDSiCCDS13966.1
RefSeqiNP_037488.2, NM_013356.2
XP_016884174.1, XM_017028685.1
UniGeneiHs.745256

3D structure databases

ProteinModelPortaliO95907
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117083, 2 interactors
IntActiO95907, 2 interactors
STRINGi9606.ENSP00000321735

Chemistry databases

ChEMBLiCHEMBL3308921
DrugBankiDB00119 Pyruvic acid

Protein family/group databases

TCDBi2.A.1.13.9 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiO95907
PhosphoSitePlusiO95907

Polymorphism and mutation databases

BioMutaiSLC16A8

Proteomic databases

PaxDbiO95907
PeptideAtlasiO95907
PRIDEiO95907
ProteomicsDBi51122

Protocols and materials databases

DNASUi23539
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320521; ENSP00000321735; ENSG00000100156
GeneIDi23539
KEGGihsa:23539
UCSCiuc003auu.4 human

Organism-specific databases

CTDi23539
DisGeNETi23539
EuPathDBiHostDB:ENSG00000100156.10
GeneCardsiSLC16A8
H-InvDBiHIX0041123
HGNCiHGNC:16270 SLC16A8
HPAiHPA075017
MIMi610409 gene
neXtProtiNX_O95907
OpenTargetsiENSG00000100156
PharmGKBiPA38106
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2504 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00760000118926
HOGENOMiHOG000280688
HOVERGENiHBG006384
InParanoidiO95907
KOiK08185
OMAiCTDRAFA
OrthoDBiEOG091G05SW
PhylomeDBiO95907
TreeFamiTF313792

Enzyme and pathway databases

ReactomeiR-HSA-210991 Basigin interactions
R-HSA-433692 Proton-coupled monocarboxylate transport
R-HSA-70268 Pyruvate metabolism

Miscellaneous databases

GenomeRNAii23539
PROiPR:O95907
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100156 Expressed in 122 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_SLC16A8
ExpressionAtlasiO95907 baseline and differential
GenevisibleiO95907 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR004743 MCT
IPR030759 MCT3
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PANTHERiPTHR11360:SF26 PTHR11360:SF26, 1 hit
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00892 2A0113, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMOT3_HUMAN
AccessioniPrimary (citable) accession number: O95907
Secondary accession number(s): Q9UBE2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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