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Protein

Noelin-2

Gene

OLFM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation. TGF-beta induces expression and translocation of OLFM2 to the nucleus where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes (PubMed:25298399). Plays a role in AMPAR complex organization (By similarity). Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli. SMC phenotypic plasticity is essential for vascular development and remodeling (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • locomotory behavior Source: Ensembl
  • positive regulation of smooth muscle cell differentiation Source: UniProtKB
  • protein secretion Source: MGI
  • regulation of vascular smooth muscle cell dedifferentiation Source: UniProtKB
  • visual perception Source: Ensembl

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Noelin-2
Alternative name(s):
Olfactomedin-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OLFM2
Synonyms:NOE2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000105088.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17189 OLFM2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617492 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95897

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cytoplasm, Membrane, Nucleus, Secreted, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi144R → Q: No effect on secretion. 1 Publication1
Mutagenesisi420L → S: Completely blocks secretion. Also significantly inhibits secretion of OLFM1 and OLFM3. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
93145

Open Targets

More...
OpenTargetsi
ENSG00000105088

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31916

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
OLFM2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002007821 – 454Noelin-2Add BLAST434

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi155N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi195 ↔ 377PROSITE-ProRule annotation
Glycosylationi275N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi310N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi399N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi441N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O95897

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O95897

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O95897

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O95897

PeptideAtlas

More...
PeptideAtlasi
O95897

PRoteomics IDEntifications database

More...
PRIDEi
O95897

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51119

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1963

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O95897

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O95897

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in aortic smooth muscle (at protein level) (PubMed:25298399). In the fetus, expressed in the brain and ocular tissues including lens vesicle and optic cup (PubMed:27844144).2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By TGF-beta.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000105088 Expressed in 119 organ(s), highest expression level in dorsolateral prefrontal cortex

CleanEx database of gene expression profiles

More...
CleanExi
HS_OLFM2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O95897 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O95897 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA049961
HPA057771

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including OLFM2. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing. Interacts with GRIA2 (By similarity). Interacts with OLFM1 and OLFM3 (PubMed:21228389). Interacts with SRF; the interaction promotes dissociation of SRF from the transcriptional repressor HEY2 (PubMed:25298399). Interacts with RUNX2 (By similarity).By similarity2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
125007, 47 interactors

Protein interaction database and analysis system

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IntActi
O95897, 12 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000264833

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O95897

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O95897

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini194 – 446Olfactomedin-likePROSITE-ProRule annotationAdd BLAST253

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili58 – 85Sequence analysisAdd BLAST28
Coiled coili136 – 193Sequence analysisAdd BLAST58

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410INP8 Eukaryota
ENOG410ZRHT LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159148

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000232069

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG006513

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O95897

Identification of Orthologs from Complete Genome Data

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OMAi
YVRNTEN

Database of Orthologous Groups

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OrthoDBi
421994at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O95897

TreeFam database of animal gene trees

More...
TreeFami
TF315964

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR031219 Noelin-2
IPR022082 Noelin_dom
IPR003112 Olfac-like_dom

The PANTHER Classification System

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PANTHERi
PTHR23192:SF27 PTHR23192:SF27, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12308 Noelin-1, 1 hit
PF02191 OLF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00284 OLF, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51132 OLF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O95897-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWPLTVPPPL LLLLCSGLAG QTLFQNPEEG WQLYTSAQAP DGKCICTAVI
60 70 80 90 100
PAQSTCSRDG RSRELRQLME KVQNVSQSME VLELRTYRDL QYVRGMETLM
110 120 130 140 150
RSLDARLRAA DGSLSAKSFQ ELKDRMTELL PLSSVLEQYK ADTRTIVRLR
160 170 180 190 200
EEVRNLSGSL AAIQEEMGAY GYEDLQQRVM ALEARLHACA QKLGCGKLTG
210 220 230 240 250
VSNPITVRAM GSRFGSWMTD TMAPSADSRV WYMDGYYKGR RVLEFRTLGD
260 270 280 290 300
FIKGQNFIQH LLPQPWAGTG HVVYNGSLFY NKYQSNVVVK YHFRSRSVLV
310 320 330 340 350
QRSLPGAGYN NTFPYSWGGF SDMDFMVDES GLWAVYTTNQ NAGNIVVSRL
360 370 380 390 400
DPHTLEVMRS WDTGYPKRSA GEAFMICGVL YVTNSHLAGA KVYFAYFTNT
410 420 430 440 450
SSYEYTDVPF HNQYSHISML DYNPRERALY TWNNGHQVLY NVTLFHVIST

SGDP
Length:454
Mass (Da):51,386
Last modified:June 7, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEBF4AE8DF909C77F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EIS8K7EIS8_HUMAN
Noelin-2
OLFM2
376Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKW2K7EKW2_HUMAN
Noelin-2
OLFM2
335Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ELC6K7ELC6_HUMAN
Noelin-2
OLFM2
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03653286T → M in a colorectal cancer sample; somatic mutation; no effect on secretion. 2 PublicationsCorresponds to variant dbSNP:rs1298178636Ensembl.1
Natural variantiVAR_022550106R → Q1 PublicationCorresponds to variant dbSNP:rs2303100Ensembl.1
Natural variantiVAR_050423127T → M1 PublicationCorresponds to variant dbSNP:rs11556087Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF131839 mRNA Translation: AAD20056.1
AC008742 Genomic DNA No translation available.
BC011361 mRNA Translation: AAH11361.1
BK001428 Genomic DNA Translation: DAA01550.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12221.1

NCBI Reference Sequences

More...
RefSeqi
NP_001291276.1, NM_001304347.1
NP_001291277.1, NM_001304348.1
NP_477512.1, NM_058164.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.169743

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000264833; ENSP00000264833; ENSG00000105088

Database of genes from NCBI RefSeq genomes

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GeneIDi
93145

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:93145

UCSC genome browser

More...
UCSCi
uc002mmp.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF131839 mRNA Translation: AAD20056.1
AC008742 Genomic DNA No translation available.
BC011361 mRNA Translation: AAH11361.1
BK001428 Genomic DNA Translation: DAA01550.1
CCDSiCCDS12221.1
RefSeqiNP_001291276.1, NM_001304347.1
NP_001291277.1, NM_001304348.1
NP_477512.1, NM_058164.3
UniGeneiHs.169743

3D structure databases

ProteinModelPortaliO95897
SMRiO95897
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125007, 47 interactors
IntActiO95897, 12 interactors
STRINGi9606.ENSP00000264833

PTM databases

GlyConnecti1963
iPTMnetiO95897
PhosphoSitePlusiO95897

Polymorphism and mutation databases

BioMutaiOLFM2

Proteomic databases

EPDiO95897
jPOSTiO95897
MaxQBiO95897
PaxDbiO95897
PeptideAtlasiO95897
PRIDEiO95897
ProteomicsDBi51119

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
93145
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264833; ENSP00000264833; ENSG00000105088
GeneIDi93145
KEGGihsa:93145
UCSCiuc002mmp.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
93145
DisGeNETi93145
EuPathDBiHostDB:ENSG00000105088.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
OLFM2
HGNCiHGNC:17189 OLFM2
HPAiHPA049961
HPA057771
MIMi617492 gene
neXtProtiNX_O95897
OpenTargetsiENSG00000105088
PharmGKBiPA31916

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410INP8 Eukaryota
ENOG410ZRHT LUCA
GeneTreeiENSGT00940000159148
HOGENOMiHOG000232069
HOVERGENiHBG006513
InParanoidiO95897
OMAiYVRNTEN
OrthoDBi421994at2759
PhylomeDBiO95897
TreeFamiTF315964

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
OLFM2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
OLFM2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
93145

Protein Ontology

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PROi
PR:O95897

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000105088 Expressed in 119 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExiHS_OLFM2
ExpressionAtlasiO95897 baseline and differential
GenevisibleiO95897 HS

Family and domain databases

InterProiView protein in InterPro
IPR031219 Noelin-2
IPR022082 Noelin_dom
IPR003112 Olfac-like_dom
PANTHERiPTHR23192:SF27 PTHR23192:SF27, 1 hit
PfamiView protein in Pfam
PF12308 Noelin-1, 1 hit
PF02191 OLF, 1 hit
SMARTiView protein in SMART
SM00284 OLF, 1 hit
PROSITEiView protein in PROSITE
PS51132 OLF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNOE2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95897
Secondary accession number(s): Q6IMJ3, Q96FC2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: June 7, 2005
Last modified: January 16, 2019
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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