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Protein

Noelin-2

Gene

OLFM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation. TGF-beta induces expression and translocation of OLFM2 to the nucleus where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes (PubMed:25298399). Plays a role in AMPAR complex organization (By similarity). Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli. SMC phenotypic plasticity is essential for vascular development and remodeling (By similarity).By similarity1 Publication

GO - Biological processi

  • locomotory behavior Source: Ensembl
  • positive regulation of smooth muscle cell differentiation Source: UniProtKB
  • protein secretion Source: MGI
  • regulation of vascular smooth muscle cell dedifferentiation Source: UniProtKB
  • visual perception Source: Ensembl

Names & Taxonomyi

Protein namesi
Recommended name:
Noelin-2
Alternative name(s):
Olfactomedin-2
Gene namesi
Name:OLFM2
Synonyms:NOE2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105088.8
HGNCiHGNC:17189 OLFM2
MIMi617492 gene
neXtProtiNX_O95897

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Membrane, Nucleus, Secreted, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi144R → Q: No effect on secretion. 1 Publication1
Mutagenesisi420L → S: Completely blocks secretion. Also significantly inhibits secretion of OLFM1 and OLFM3. 1 Publication1

Organism-specific databases

DisGeNETi93145
OpenTargetsiENSG00000105088
PharmGKBiPA31916

Polymorphism and mutation databases

BioMutaiOLFM2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000002007821 – 454Noelin-2Add BLAST434

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi155N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi195 ↔ 377PROSITE-ProRule annotation
Glycosylationi275N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi310N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi399N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi441N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiO95897
MaxQBiO95897
PaxDbiO95897
PeptideAtlasiO95897
PRIDEiO95897
ProteomicsDBi51119

PTM databases

iPTMnetiO95897
PhosphoSitePlusiO95897

Expressioni

Tissue specificityi

Expressed in aortic smooth muscle (at protein level) (PubMed:25298399). In the fetus, expressed in the brain and ocular tissues including lens vesicle and optic cup (PubMed:27844144).2 Publications

Inductioni

By TGF-beta.1 Publication

Gene expression databases

BgeeiENSG00000105088 Expressed in 119 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExiHS_OLFM2
ExpressionAtlasiO95897 baseline and differential
GenevisibleiO95897 HS

Organism-specific databases

HPAiHPA049961
HPA057771

Interactioni

Subunit structurei

Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including OLFM2. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing. Interacts with GRIA2 (By similarity). Interacts with OLFM1 and OLFM3 (PubMed:21228389). Interacts with SRF; the interaction promotes dissociation of SRF from the transcriptional repressor HEY2 (PubMed:25298399). Interacts with RUNX2 (By similarity).By similarity2 Publications

Protein-protein interaction databases

BioGridi125007, 47 interactors
IntActiO95897, 12 interactors
STRINGi9606.ENSP00000264833

Structurei

3D structure databases

ProteinModelPortaliO95897
SMRiO95897
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini194 – 446Olfactomedin-likePROSITE-ProRule annotationAdd BLAST253

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili58 – 85Sequence analysisAdd BLAST28
Coiled coili136 – 193Sequence analysisAdd BLAST58

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiENOG410INP8 Eukaryota
ENOG410ZRHT LUCA
GeneTreeiENSGT00760000119005
HOGENOMiHOG000232069
HOVERGENiHBG006513
InParanoidiO95897
OMAiYVRNTEN
OrthoDBiEOG091G05HN
PhylomeDBiO95897
TreeFamiTF315964

Family and domain databases

InterProiView protein in InterPro
IPR031219 Noelin-2
IPR022082 Noelin_dom
IPR003112 Olfac-like_dom
PANTHERiPTHR23192:SF27 PTHR23192:SF27, 1 hit
PfamiView protein in Pfam
PF12308 Noelin-1, 1 hit
PF02191 OLF, 1 hit
SMARTiView protein in SMART
SM00284 OLF, 1 hit
PROSITEiView protein in PROSITE
PS51132 OLF, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O95897-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWPLTVPPPL LLLLCSGLAG QTLFQNPEEG WQLYTSAQAP DGKCICTAVI
60 70 80 90 100
PAQSTCSRDG RSRELRQLME KVQNVSQSME VLELRTYRDL QYVRGMETLM
110 120 130 140 150
RSLDARLRAA DGSLSAKSFQ ELKDRMTELL PLSSVLEQYK ADTRTIVRLR
160 170 180 190 200
EEVRNLSGSL AAIQEEMGAY GYEDLQQRVM ALEARLHACA QKLGCGKLTG
210 220 230 240 250
VSNPITVRAM GSRFGSWMTD TMAPSADSRV WYMDGYYKGR RVLEFRTLGD
260 270 280 290 300
FIKGQNFIQH LLPQPWAGTG HVVYNGSLFY NKYQSNVVVK YHFRSRSVLV
310 320 330 340 350
QRSLPGAGYN NTFPYSWGGF SDMDFMVDES GLWAVYTTNQ NAGNIVVSRL
360 370 380 390 400
DPHTLEVMRS WDTGYPKRSA GEAFMICGVL YVTNSHLAGA KVYFAYFTNT
410 420 430 440 450
SSYEYTDVPF HNQYSHISML DYNPRERALY TWNNGHQVLY NVTLFHVIST

SGDP
Length:454
Mass (Da):51,386
Last modified:June 7, 2005 - v2
Checksum:iEBF4AE8DF909C77F
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EIS8K7EIS8_HUMAN
Noelin-2
OLFM2
376Annotation score:
K7EKW2K7EKW2_HUMAN
Noelin-2
OLFM2
335Annotation score:
K7ELC6K7ELC6_HUMAN
Noelin-2
OLFM2
78Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03653286T → M in a colorectal cancer sample; somatic mutation; no effect on secretion. 2 PublicationsCorresponds to variant dbSNP:rs1298178636Ensembl.1
Natural variantiVAR_022550106R → Q1 PublicationCorresponds to variant dbSNP:rs2303100Ensembl.1
Natural variantiVAR_050423127T → M1 PublicationCorresponds to variant dbSNP:rs11556087Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF131839 mRNA Translation: AAD20056.1
AC008742 Genomic DNA No translation available.
BC011361 mRNA Translation: AAH11361.1
BK001428 Genomic DNA Translation: DAA01550.1
CCDSiCCDS12221.1
RefSeqiNP_001291276.1, NM_001304347.1
NP_001291277.1, NM_001304348.1
NP_477512.1, NM_058164.3
UniGeneiHs.169743

Genome annotation databases

EnsembliENST00000264833; ENSP00000264833; ENSG00000105088
GeneIDi93145
KEGGihsa:93145
UCSCiuc002mmp.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF131839 mRNA Translation: AAD20056.1
AC008742 Genomic DNA No translation available.
BC011361 mRNA Translation: AAH11361.1
BK001428 Genomic DNA Translation: DAA01550.1
CCDSiCCDS12221.1
RefSeqiNP_001291276.1, NM_001304347.1
NP_001291277.1, NM_001304348.1
NP_477512.1, NM_058164.3
UniGeneiHs.169743

3D structure databases

ProteinModelPortaliO95897
SMRiO95897
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125007, 47 interactors
IntActiO95897, 12 interactors
STRINGi9606.ENSP00000264833

PTM databases

iPTMnetiO95897
PhosphoSitePlusiO95897

Polymorphism and mutation databases

BioMutaiOLFM2

Proteomic databases

EPDiO95897
MaxQBiO95897
PaxDbiO95897
PeptideAtlasiO95897
PRIDEiO95897
ProteomicsDBi51119

Protocols and materials databases

DNASUi93145
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264833; ENSP00000264833; ENSG00000105088
GeneIDi93145
KEGGihsa:93145
UCSCiuc002mmp.4 human

Organism-specific databases

CTDi93145
DisGeNETi93145
EuPathDBiHostDB:ENSG00000105088.8
GeneCardsiOLFM2
HGNCiHGNC:17189 OLFM2
HPAiHPA049961
HPA057771
MIMi617492 gene
neXtProtiNX_O95897
OpenTargetsiENSG00000105088
PharmGKBiPA31916
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INP8 Eukaryota
ENOG410ZRHT LUCA
GeneTreeiENSGT00760000119005
HOGENOMiHOG000232069
HOVERGENiHBG006513
InParanoidiO95897
OMAiYVRNTEN
OrthoDBiEOG091G05HN
PhylomeDBiO95897
TreeFamiTF315964

Miscellaneous databases

ChiTaRSiOLFM2 human
GeneWikiiOLFM2
GenomeRNAii93145
PROiPR:O95897
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105088 Expressed in 119 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExiHS_OLFM2
ExpressionAtlasiO95897 baseline and differential
GenevisibleiO95897 HS

Family and domain databases

InterProiView protein in InterPro
IPR031219 Noelin-2
IPR022082 Noelin_dom
IPR003112 Olfac-like_dom
PANTHERiPTHR23192:SF27 PTHR23192:SF27, 1 hit
PfamiView protein in Pfam
PF12308 Noelin-1, 1 hit
PF02191 OLF, 1 hit
SMARTiView protein in SMART
SM00284 OLF, 1 hit
PROSITEiView protein in PROSITE
PS51132 OLF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNOE2_HUMAN
AccessioniPrimary (citable) accession number: O95897
Secondary accession number(s): Q6IMJ3, Q96FC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: June 7, 2005
Last modified: November 7, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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