UniProtKB - O95876 (FRITZ_HUMAN)

BLAST

>sp|O95876|FRITZ_HUMAN WD repeat-containing and planar cell polarity effector protein fritz homolog OS=Homo sapiens OX=9606 GN=WDPCP PE=1 SV=2
MRREFCWDAYSKAAGSRASSPLPRQDRDSFCHQMSFCLTELHLWSLKNTLHIADRDIGIY
QYYDKKDPPATEHGNLEKKQKLAESRDYPWTLKNRRPEKLRDSLKELEELMQNSRCVLSK
WKNKYVCQLLFGSGVLVSLSLSGPQLEKVVIDRSLVGKLISDTISDALLTDSFIILSFLA
QNKLCFIQFTKKMESSDVNKRLEKLSALDYKIFYYEIPGPINKTTERHLAINCVHDRVVC
WWPLVNDDAWPWAPISSEKDRANLLLLGYAQGRLEVLSSVRTEWDPLDVRFGTKQPYQVF
TVEHSVSVDKEPMADSCIYECIRNKIQCVSVTRIPLKSKAISCCRNVTEDKLILGCEDSS
LILYETHRRVTLLAQTELLPSLISCHPSGAILLVGSNQGELQIFDMALSPINIQLLAEDR
LPRETLQFSKLFDASSSLVQMQWIAPQVVSQKGEGSDIYDLLFLRFERGPLGVLLFKLGV
FTRGQLGLIDIIFQYIHCDEIYEAINILSSMNWDTLGHQCFISMSAIVNHLLRQKLTPER
EAQLETSLGTFYAPTRPLLDSTILEYRDQISKYARRFFHHLLRYQRFEKAFLLAVDVGAR
DLFMDIHYLALDKGELALAEVARKRASDIDAESITSGVELLGPLDRGDMLNEAFIGLSLA
PQGEDSFPDNLPPSCPTHRHILQQRILNGSSNRQIIDRRNELEKDICSGFLMTNTCNAED
GELREDGREQEIRDGGSLKMIHFGLV

Align

Format
Add to basket Added to basket
History
Entry version 123 (07 Nov 2018)
Sequence version 2 (18 Mar 2008)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

WD repeat-containing and planar cell polarity effector protein fritz homolog

Gene

WDPCP

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Together with FUZ and WDPCP proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity).By similarity

Caution

It is uncertain whether Met-1 or Met-34 is the initiator.Curated

GO - Biological processⁱ

auditory receptor cell morphogenesis Source: Ensembl
camera-type eye development Source: Ensembl
cardiovascular system development Source: Ensembl
cilium assembly Source: UniProtKB
digestive system development Source: Ensembl
embryonic digit morphogenesis Source: Ensembl
establishment of protein localization
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
glomerular visceral epithelial cell migration Source: Ensembl
kidney development Source: Ensembl
regulation of embryonic cell shape Source: UniProtKB
regulation of establishment of cell polarity Source: Ensembl
regulation of fibroblast migration Source: Ensembl
regulation of focal adhesion assembly Source: Ensembl
regulation of protein localization Source: UniProtKB
regulation of ruffle assembly Source: Ensembl
respiratory system development Source: Ensembl
roof of mouth development Source: Ensembl
septin cytoskeleton organization Source: UniProtKB
smoothened signaling pathway Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cilium biogenesis/degradation

Biological process

Cilium biogenesis/degradation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: WD repeat-containing and planar cell polarity effector protein fritz homolog Short name: hFRTZ Alternative name(s): Bardet-Biedl syndrome 15 protein WD repeat-containing and planar cell polarity effector protein
Gene namesⁱ	Name:WDPCP Synonyms:BBS15, C2orf86, FRITZ
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000143951.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28027 WDPCP
MIMⁱ	613580 gene
neXtProtⁱ	NX_O95876

Keywords - Cellular componentⁱ

Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Bardet-Biedl syndrome 15 (BBS15)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA syndrome characterized by usually severe pigmentary retinopathy, early-onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. Bardet-Biedl syndrome inheritance is autosomal recessive, but three mutated alleles (two at one locus, and a third at a second locus) may be required for clinical manifestation of some forms of the disease.

Congenital heart defects, hamartomas of tongue, and polysyndactyly (CHDTHP)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disease characterized by a constellation of anomalies including tongue hamartomas, polysyndactyly, and congenital heart defects such as atrioventricular canal and coarctation of the aorta.

Keywords - Diseaseⁱ

Bardet-Biedl syndrome, Ciliopathy, Disease mutation, Mental retardation, Obesity

Organism-specific databases

DisGeNET More...DisGeNETⁱ	51057
GeneReviewsⁱ	WDPCP
MalaCards human disease database More...MalaCardsⁱ	WDPCP
MIMⁱ	217085 phenotype 615992 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000143951
Orphanetⁱ	110 Bardet-Biedl syndrome 1338 Heart defect-tongue hamartoma-polysyndactyly syndrome 564 Meckel syndrome
PharmGKBⁱ	PA164717186

Polymorphism and mutation databases

BioMutaⁱ	WDPCP

BioMutaⁱ

WDPCP

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000325802	1 – 746	WD repeat-containing and planar cell polarity effector protein fritz homologAdd BLAST		746

Proteomic databases

PaxDbⁱ	O95876
PeptideAtlas More...PeptideAtlasⁱ	O95876
PRIDEⁱ	O95876
ProteomicsDBⁱ	51114 51115 [O95876-2] 51116 [O95876-3]

PTM databases

iPTMnetⁱ	O95876
PhosphoSitePlusⁱ	O95876

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000143951 Expressed in 208 organ(s), highest expression level in nasal cavity epithelium
ExpressionAtlasⁱ	O95876 baseline and differential
Genevisibleⁱ	O95876 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA044144

HPAⁱ

HPA044144

Interactionⁱ

Subunit structureⁱ

Interacts with CPLANE1. Interacts with INTU and FUZ; FUZ, INTU and WDPCP probably form the core CPLANE (ciliogenesis and planar polarity effectors) complex.By similarity

Protein-protein interaction databases

BioGridⁱ	119249, 1 interactor
IntActⁱ	O95876, 1 interactor
STRINGⁱ	9606.ENSP00000272321

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O95876
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Repeatⁱ	326 – 374	WD 1Add BLAST		49
Repeatⁱ	375 – 414	WD 2Add BLAST		40

Sequence similaritiesⁱ

Belongs to the WD repeat fritz family.Curated

Keywords - Domainⁱ

Repeat, WD repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IGAV Eukaryota ENOG410Y1HY LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000016551
InParanoidⁱ	O95876
KEGG Orthology (KO) More...KOⁱ	K22863
OMAⁱ	SVRTEWD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03ZZ
PhylomeDBⁱ	O95876
TreeFamⁱ	TF323483

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR024511 Frtz IPR015943 WD40/YVTN_repeat-like_dom_sf IPR036322 WD40_repeat_dom_sf
PANTHERⁱ	PTHR13667 PTHR13667, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF11768 Frtz, 1 hit
SUPFAMⁱ	SSF50978 SSF50978, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O95876-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRREFCWDAY SKAAGSRASS PLPRQDRDSF CHQMSFCLTE LHLWSLKNTL 
        60         70         80         90        100
HIADRDIGIY QYYDKKDPPA TEHGNLEKKQ KLAESRDYPW TLKNRRPEKL 
       110        120        130        140        150
RDSLKELEEL MQNSRCVLSK WKNKYVCQLL FGSGVLVSLS LSGPQLEKVV 
       160        170        180        190        200
IDRSLVGKLI SDTISDALLT DSFIILSFLA QNKLCFIQFT KKMESSDVNK 
       210        220        230        240        250
RLEKLSALDY KIFYYEIPGP INKTTERHLA INCVHDRVVC WWPLVNDDAW 
       260        270        280        290        300
PWAPISSEKD RANLLLLGYA QGRLEVLSSV RTEWDPLDVR FGTKQPYQVF 
       310        320        330        340        350
TVEHSVSVDK EPMADSCIYE CIRNKIQCVS VTRIPLKSKA ISCCRNVTED 
       360        370        380        390        400
KLILGCEDSS LILYETHRRV TLLAQTELLP SLISCHPSGA ILLVGSNQGE 
       410        420        430        440        450
LQIFDMALSP INIQLLAEDR LPRETLQFSK LFDASSSLVQ MQWIAPQVVS 
       460        470        480        490        500
QKGEGSDIYD LLFLRFERGP LGVLLFKLGV FTRGQLGLID IIFQYIHCDE 
       510        520        530        540        550
IYEAINILSS MNWDTLGHQC FISMSAIVNH LLRQKLTPER EAQLETSLGT 
       560        570        580        590        600
FYAPTRPLLD STILEYRDQI SKYARRFFHH LLRYQRFEKA FLLAVDVGAR 
       610        620        630        640        650
DLFMDIHYLA LDKGELALAE VARKRASDID AESITSGVEL LGPLDRGDML 
       660        670        680        690        700
NEAFIGLSLA PQGEDSFPDN LPPSCPTHRH ILQQRILNGS SNRQIIDRRN 
       710        720        730        740 
ELEKDICSGF LMTNTCNAED GELREDGREQ EIRDGGSLKM IHFGLV

Length:746

Mass (Da):85,084

Last modified:March 18, 2008 - v2

Checksum:ⁱ585EFED0D93EB3D4

Isoform 2 (identifier: O95876-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
605-618: DIHYLALDKGELAL → ASCYLTSNYTTRLQ
619-746: Missing.

« Hide

        10         20         30         40         50
MRREFCWDAY SKAAGSRASS PLPRQDRDSF CHQMSFCLTE LHLWSLKNTL 
        60         70         80         90        100
HIADRDIGIY QYYDKKDPPA TEHGNLEKKQ KLAESRDYPW TLKNRRPEKL 
       110        120        130        140        150
RDSLKELEEL MQNSRCVLSK WKNKYVCQLL FGSGVLVSLS LSGPQLEKVV 
       160        170        180        190        200
IDRSLVGKLI SDTISDALLT DSFIILSFLA QNKLCFIQFT KKMESSDVNK 
       210        220        230        240        250
RLEKLSALDY KIFYYEIPGP INKTTERHLA INCVHDRVVC WWPLVNDDAW 
       260        270        280        290        300
PWAPISSEKD RANLLLLGYA QGRLEVLSSV RTEWDPLDVR FGTKQPYQVF 
       310        320        330        340        350
TVEHSVSVDK EPMADSCIYE CIRNKIQCVS VTRIPLKSKA ISCCRNVTED 
       360        370        380        390        400
KLILGCEDSS LILYETHRRV TLLAQTELLP SLISCHPSGA ILLVGSNQGE 
       410        420        430        440        450
LQIFDMALSP INIQLLAEDR LPRETLQFSK LFDASSSLVQ MQWIAPQVVS 
       460        470        480        490        500
QKGEGSDIYD LLFLRFERGP LGVLLFKLGV FTRGQLGLID IIFQYIHCDE 
       510        520        530        540        550
IYEAINILSS MNWDTLGHQC FISMSAIVNH LLRQKLTPER EAQLETSLGT 
       560        570        580        590        600
FYAPTRPLLD STILEYRDQI SKYARRFFHH LLRYQRFEKA FLLAVDVGAR 
       610 
DLFMASCYLT SNYTTRLQ

Show »

Length:618

Mass (Da):71,020

Checksum:ⁱ27D2487D6867E308

Isoform 3 (identifier: O95876-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-166: MRREFCWDAY...GKLISDTISD → MFSSLHS

« Hide

        10         20         30         40         50
MFSSLHSALL TDSFIILSFL AQNKLCFIQF TKKMESSDVN KRLEKLSALD 
        60         70         80         90        100
YKIFYYEIPG PINKTTERHL AINCVHDRVV CWWPLVNDDA WPWAPISSEK 
       110        120        130        140        150
DRANLLLLGY AQGRLEVLSS VRTEWDPLDV RFGTKQPYQV FTVEHSVSVD 
       160        170        180        190        200
KEPMADSCIY ECIRNKIQCV SVTRIPLKSK AISCCRNVTE DKLILGCEDS 
       210        220        230        240        250
SLILYETHRR VTLLAQTELL PSLISCHPSG AILLVGSNQG ELQIFDMALS 
       260        270        280        290        300
PINIQLLAED RLPRETLQFS KLFDASSSLV QMQWIAPQVV SQKGEGSDIY 
       310        320        330        340        350
DLLFLRFERG PLGVLLFKLG VFTRGQLGLI DIIFQYIHCD EIYEAINILS 
       360        370        380        390        400
SMNWDTLGHQ CFISMSAIVN HLLRQKLTPE REAQLETSLG TFYAPTRPLL 
       410        420        430        440        450
DSTILEYRDQ ISKYARRFFH HLLRYQRFEK AFLLAVDVGA RDLFMDIHYL 
       460        470        480        490        500
ALDKGELALA EVARKRASDI DAESITSGVE LLGPLDRGDM LNEAFIGLSL 
       510        520        530        540        550
APQGEDSFPD NLPPSCPTHR HILQQRILNG SSNRQIIDRR NELEKDICSG 
       560        570        580 
FLMTNTCNAE DGELREDGRE QEIRDGGSLK MIHFGLV

Show »

Length:587

Mass (Da):66,655

Checksum:ⁱ1F9B84EEAC6EA4E7

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H7C375	H7C375_HUMAN	WD repeat-containing and planar cel... WD repeat-containing and planar cell polarity effector protein fritz homolog	WDPCP	132	Annotation score:
H7BZ13	H7BZ13_HUMAN	WD repeat-containing and planar cel... WD repeat-containing and planar cell polarity effector protein fritz homolog	WDPCP	402	Annotation score:
E9PFG9	E9PFG9_HUMAN	WD repeat-containing and planar cel... WD repeat-containing and planar cell polarity effector protein fritz homolog	WDPCP	554	Annotation score:
C9JDS5	C9JDS5_HUMAN	WD repeat-containing and planar cel... WD repeat-containing and planar cell polarity effector protein fritz homolog	WDPCP	84	Annotation score:
F8WBT2	F8WBT2_HUMAN	WD repeat-containing and planar cel... WD repeat-containing and planar cell polarity effector protein fritz homolog	WDPCP	46	Annotation score:
A0A1D5RMS8	A0A1D5RMS8_HUMAN	WD repeat-containing and planar cel... WD repeat-containing and planar cell polarity effector protein fritz homolog	WDPCP	8	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_073251	54	D → N in CHDTHP; impairs protein stability. 2 PublicationsCorresponds to variant dbSNP:rs200322968EnsemblClinVar.	1
Natural variantⁱVAR_064770	55	R → K in a patient with Meckel syndrome compound heterozygous for mutations in CC2D2A. 1 PublicationCorresponds to variant dbSNP:rs267606693EnsemblClinVar.	1
Natural variantⁱVAR_064771	205	L → F in a patient with Bardet-Biedl syndrome compound heterozygous for mutations in BBS12. 1 Publication	1
Natural variantⁱVAR_039919	268	G → S. Corresponds to variant dbSNP:rs17617459EnsemblClinVar.	1
Natural variantⁱVAR_064772	708	S → F1 Publication	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_032408	1 – 166	MRREF…DTISD → MFSSLHS in isoform 3. 2 PublicationsAdd BLAST	166
Alternative sequenceⁱVSP_032409	605 – 618	DIHYL…GELAL → ASCYLTSNYTTRLQ in isoform 2. 1 PublicationAdd BLAST	14
Alternative sequenceⁱVSP_032410	619 – 746	Missing in isoform 2. 1 PublicationAdd BLAST	128

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF131737 mRNA Translation: AAD20026.1 BX538331 mRNA Translation: CAD98100.1 AC079353 Genomic DNA Translation: AAY24034.1 AC009501 Genomic DNA No translation available. AC067953 Genomic DNA No translation available. AC074367 Genomic DNA No translation available. BC093752 mRNA Translation: AAH93752.1 BC093754 mRNA Translation: AAH93754.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS42688.1 [O95876-1] CCDS46301.1 [O95876-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001036157.1, NM_001042692.2 [O95876-3] NP_056994.3, NM_015910.5 [O95876-1]
UniGeneⁱ	Hs.414952 Hs.682428 Hs.737299

Genome annotation databases

Ensemblⁱ	ENST00000272321; ENSP00000272321; ENSG00000143951 [O95876-1] ENST00000398544; ENSP00000381552; ENSG00000143951 [O95876-3] ENST00000409562; ENSP00000387222; ENSG00000143951 [O95876-2]
GeneIDⁱ	51057
KEGGⁱ	hsa:51057
UCSC genome browser More...UCSCⁱ	uc002scf.4 human [O95876-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O95876	Uncharacterized protein LOC51057 (Fragment)		HUMAN		53	UniRef100_O95876
WD repeat-containing and planar cell polarity effector protein fritz homolog		HUMAN		554

Protein	Similar proteins		Species	Score	Length	Source
O95876	Uncharacterized protein LOC51057 (Fragment)		HUMAN		53	UniRef90_O95876
Uncharacterized protein		NOMLE		746
WD repeat containing planar cell polarity effector		PANTR		746
Uncharacterized protein		PANPA		746
WD repeat containing planar cell polarity effector		GORGO		746
+48
O95876-2	Uncharacterized protein		MACFA		746	UniRef90_O95876-2
WD repeat containing planar cell polarity effector		SAIBB		744
Uncharacterized protein		Cebus capucinus imitator		744
Uncharacterized protein		MANLE		739
Uncharacterized protein		MACMU		731
+24
O95876-3	Uncharacterized protein		Cebus capucinus imitator		724	UniRef90_O95876-3
WD repeat containing planar cell polarity effector		PANTR		587
Uncharacterized protein		PANPA		587
Uncharacterized protein		AOTNA		587
WD repeat containing planar cell polarity effector		CALJA		587
+7

Protein	Similar proteins		Species	Score	Length	Source
O95876	WD repeat-containing and planar cell polarity effector protein fritz homolog		MOUSE		722	UniRef50_Q8C456
WD repeat-containing and planar cell polarity effector protein fritz homolog		XENLA		708
WD repeat-containing and planar cell polarity effector protein fritz homolog		RAT		726
WD repeat-containing and planar cell polarity effector protein fritz (Fragment)		CALAN		606
Uncharacterized protein		ANOCA		733
+351

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF131737 mRNA Translation: AAD20026.1 BX538331 mRNA Translation: CAD98100.1 AC079353 Genomic DNA Translation: AAY24034.1 AC009501 Genomic DNA No translation available. AC067953 Genomic DNA No translation available. AC074367 Genomic DNA No translation available. BC093752 mRNA Translation: AAH93752.1 BC093754 mRNA Translation: AAH93754.1
CCDSⁱ	CCDS42688.1 [O95876-1] CCDS46301.1 [O95876-3]
RefSeqⁱ	NP_001036157.1, NM_001042692.2 [O95876-3] NP_056994.3, NM_015910.5 [O95876-1]
UniGeneⁱ	Hs.414952 Hs.682428 Hs.737299

3D structure databases

ProteinModelPortalⁱ	O95876
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119249, 1 interactor
IntActⁱ	O95876, 1 interactor
STRINGⁱ	9606.ENSP00000272321

PTM databases

iPTMnetⁱ	O95876
PhosphoSitePlusⁱ	O95876

Polymorphism and mutation databases

BioMutaⁱ	WDPCP

BioMutaⁱ

WDPCP

Proteomic databases

PaxDbⁱ	O95876
PeptideAtlasⁱ	O95876
PRIDEⁱ	O95876
ProteomicsDBⁱ	51114 51115 [O95876-2] 51116 [O95876-3]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000272321; ENSP00000272321; ENSG00000143951 [O95876-1] ENST00000398544; ENSP00000381552; ENSG00000143951 [O95876-3] ENST00000409562; ENSP00000387222; ENSG00000143951 [O95876-2]
GeneIDⁱ	51057
KEGGⁱ	hsa:51057
UCSCⁱ	uc002scf.4 human [O95876-1]

Organism-specific databases

CTDⁱ	51057
DisGeNETⁱ	51057
EuPathDBⁱ	HostDB:ENSG00000143951.15
GeneCardsⁱ	WDPCP
GeneReviewsⁱ	WDPCP
H-InvDBⁱ	HIX0002091
HGNCⁱ	HGNC:28027 WDPCP
HPAⁱ	HPA044144
MalaCardsⁱ	WDPCP
MIMⁱ	217085 phenotype 613580 gene 615992 phenotype
neXtProtⁱ	NX_O95876
OpenTargetsⁱ	ENSG00000143951
Orphanetⁱ	110 Bardet-Biedl syndrome 1338 Heart defect-tongue hamartoma-polysyndactyly syndrome 564 Meckel syndrome
PharmGKBⁱ	PA164717186
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IGAV Eukaryota ENOG410Y1HY LUCA
GeneTreeⁱ	ENSGT00390000016551
InParanoidⁱ	O95876
KOⁱ	K22863
OMAⁱ	SVRTEWD
OrthoDBⁱ	EOG091G03ZZ
PhylomeDBⁱ	O95876
TreeFamⁱ	TF323483

Miscellaneous databases

ChiTaRSⁱ	WDPCP human
GenomeRNAiⁱ	51057
Protein Ontology More...PROⁱ	PR:O95876
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000143951 Expressed in 208 organ(s), highest expression level in nasal cavity epithelium
ExpressionAtlasⁱ	O95876 baseline and differential
Genevisibleⁱ	O95876 HS

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR024511 Frtz IPR015943 WD40/YVTN_repeat-like_dom_sf IPR036322 WD40_repeat_dom_sf
PANTHERⁱ	PTHR13667 PTHR13667, 1 hit
Pfamⁱ	View protein in Pfam PF11768 Frtz, 1 hit
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FRITZ_HUMAN
Accessionⁱ	O95876Primary (citable) accession number: O95876 Secondary accession number(s): Q53RW4, Q7Z2Z3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
	Last sequence update:	March 18, 2008
	Last modified:	November 7, 2018
	This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O95876 (FRITZ_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

WD repeat-containing and planar cell polarity effector protein fritz homolog

WDPCP

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Cytoskeleton

Cytoskeleton

Plasma Membrane

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ