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Entry version 129 (13 Feb 2019)
Sequence version 2 (11 Jan 2011)
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Protein

Uncharacterized protein C6orf47

Gene

C6orf47

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein C6orf47
Alternative name(s):
Protein G4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C6orf47
Synonyms:G4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000204439.3

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19076 C6orf47

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95873

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57827

Open Targets

More...
OpenTargetsi
ENSG00000204439

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38785

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C6orf47

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000895041 – 294Uncharacterized protein C6orf47Add BLAST294

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei34PhosphoserineBy similarity1
Modified residuei35PhosphoserineBy similarity1
Modified residuei71PhosphoserineCombined sources1
Modified residuei90PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O95873

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O95873

MaxQB - The MaxQuant DataBase

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MaxQBi
O95873

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O95873

PeptideAtlas

More...
PeptideAtlasi
O95873

PRoteomics IDEntifications database

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PRIDEi
O95873

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51113

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O95873

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O95873

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000204439 Expressed in 192 organ(s), highest expression level in tendon of biceps brachii

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O95873 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O95873 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA045281
HPA053373

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
121786, 5 interactors

Protein interaction database and analysis system

More...
IntActi
O95873, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000365076

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O95873

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O95873

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEYM Eukaryota
ENOG411158A LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009270

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG053330

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O95873

Identification of Orthologs from Complete Genome Data

More...
OMAi
GWLPRPW

Database of Orthologous Groups

More...
OrthoDBi
1410459at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O95873

TreeFam database of animal gene trees

More...
TreeFami
TF339331

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029073 DUF4661

The PANTHER Classification System

More...
PANTHERi
PTHR14307 PTHR14307, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15576 DUF4661, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O95873-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFLRRLGGWL PRPWGRRKPM RPDPPYPEPR RVDSSSENSG SDWDSAPETM
60 70 80 90 100
EDVGHPKTKD SGALRVSGAA SEPSKEEPQV EQLGSKRMDS LKWDQPISST
110 120 130 140 150
QESGRLEAGG ASPKLRWDHV DSGGTRRPGV SPEGGLSVPG PGAPLEKPGR
160 170 180 190 200
REKLLGWLRG EPGAPSRYLG GPEECLQIST NLTLHLLELL ASALLALCSR
210 220 230 240 250
PLRAALDTLG LRGPLGLWLH GLLSFLAALH GLHAVLSLLT AHPLHFACLF
260 270 280 290
GLLQALVLAV SLREPNGDEA ATDWESEGLE REGEEQRGDP GKGL
Length:294
Mass (Da):31,710
Last modified:January 11, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i59ACE578FB60284D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02291168G → R5 PublicationsCorresponds to variant dbSNP:rs3130617Ensembl.1
Natural variantiVAR_05679792K → N. Corresponds to variant dbSNP:rs2242655Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF129756 Genomic DNA Translation: AAD18083.1
BA000025 Genomic DNA Translation: BAB63388.1
AL662801 Genomic DNA No translation available.
AL662899 Genomic DNA No translation available.
AL670886 Genomic DNA No translation available.
AL805934 Genomic DNA No translation available.
BX511262 Genomic DNA No translation available.
CR753842 Genomic DNA No translation available.
CR354443 Genomic DNA No translation available.
CR759761 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03465.1
BC012950 mRNA Translation: AAH12950.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34399.1

NCBI Reference Sequences

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RefSeqi
NP_067007.3, NM_021184.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.247323

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000366431; ENSP00000375392; ENSG00000235360
ENST00000366432; ENSP00000375400; ENSG00000203623
ENST00000375911; ENSP00000365076; ENSG00000204439
ENST00000413113; ENSP00000395128; ENSG00000226103
ENST00000418357; ENSP00000398221; ENSG00000226531
ENST00000431256; ENSP00000406870; ENSG00000228435
ENST00000442972; ENSP00000407188; ENSG00000228177

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57827

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57827

UCSC genome browser

More...
UCSCi
uc003nvm.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129756 Genomic DNA Translation: AAD18083.1
BA000025 Genomic DNA Translation: BAB63388.1
AL662801 Genomic DNA No translation available.
AL662899 Genomic DNA No translation available.
AL670886 Genomic DNA No translation available.
AL805934 Genomic DNA No translation available.
BX511262 Genomic DNA No translation available.
CR753842 Genomic DNA No translation available.
CR354443 Genomic DNA No translation available.
CR759761 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03465.1
BC012950 mRNA Translation: AAH12950.1
CCDSiCCDS34399.1
RefSeqiNP_067007.3, NM_021184.3
UniGeneiHs.247323

3D structure databases

ProteinModelPortaliO95873
SMRiO95873
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121786, 5 interactors
IntActiO95873, 4 interactors
STRINGi9606.ENSP00000365076

PTM databases

iPTMnetiO95873
PhosphoSitePlusiO95873

Polymorphism and mutation databases

BioMutaiC6orf47

Proteomic databases

EPDiO95873
jPOSTiO95873
MaxQBiO95873
PaxDbiO95873
PeptideAtlasiO95873
PRIDEiO95873
ProteomicsDBi51113

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366431; ENSP00000375392; ENSG00000235360
ENST00000366432; ENSP00000375400; ENSG00000203623
ENST00000375911; ENSP00000365076; ENSG00000204439
ENST00000413113; ENSP00000395128; ENSG00000226103
ENST00000418357; ENSP00000398221; ENSG00000226531
ENST00000431256; ENSP00000406870; ENSG00000228435
ENST00000442972; ENSP00000407188; ENSG00000228177
GeneIDi57827
KEGGihsa:57827
UCSCiuc003nvm.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57827
DisGeNETi57827
EuPathDBiHostDB:ENSG00000204439.3

GeneCards: human genes, protein and diseases

More...
GeneCardsi
C6orf47

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0078436
HIX0166388
HIX0166905
HIX0167163
HIX0167401
HIX0184189
HGNCiHGNC:19076 C6orf47
HPAiHPA045281
HPA053373
neXtProtiNX_O95873
OpenTargetsiENSG00000204439
PharmGKBiPA38785

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEYM Eukaryota
ENOG411158A LUCA
GeneTreeiENSGT00390000009270
HOVERGENiHBG053330
InParanoidiO95873
OMAiGWLPRPW
OrthoDBi1410459at2759
PhylomeDBiO95873
TreeFamiTF339331

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
C6orf47 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57827

Protein Ontology

More...
PROi
PR:O95873

Gene expression databases

BgeeiENSG00000204439 Expressed in 192 organ(s), highest expression level in tendon of biceps brachii
ExpressionAtlasiO95873 baseline and differential
GenevisibleiO95873 HS

Family and domain databases

InterProiView protein in InterPro
IPR029073 DUF4661
PANTHERiPTHR14307 PTHR14307, 1 hit
PfamiView protein in Pfam
PF15576 DUF4661, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCF047_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95873
Secondary accession number(s): B0UXA1
, B0UZ50, Q5SSS6, Q95IG0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: January 11, 2011
Last modified: February 13, 2019
This is version 129 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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