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Protein

G patch domain and ankyrin repeat-containing protein 1

Gene

GPANK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
G patch domain and ankyrin repeat-containing protein 1
Alternative name(s):
Ankyrin repeat domain-containing protein 59
G patch domain-containing protein 10
HLA-B-associated transcript 4
Protein G5
Gene namesi
Name:GPANK1
Synonyms:ANKRD59, BAT4, G5, GPATCH10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204438.10
HGNCiHGNC:13920 GPANK1
MIMi142610 gene
neXtProtiNX_O95872

Pathology & Biotechi

Organism-specific databases

DisGeNETi7918
OpenTargetsiENSG00000204438
PharmGKBiPA25265

Polymorphism and mutation databases

BioMutaiGPANK1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669721 – 356G patch domain and ankyrin repeat-containing protein 1Add BLAST356

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki290Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiO95872
MaxQBiO95872
PaxDbiO95872
PeptideAtlasiO95872
PRIDEiO95872
ProteomicsDBi51112

PTM databases

iPTMnetiO95872
PhosphoSitePlusiO95872

Expressioni

Gene expression databases

BgeeiENSG00000204438 Expressed in 199 organ(s), highest expression level in testis
CleanExiHS_BAT4
ExpressionAtlasiO95872 baseline and differential
GenevisibleiO95872 HS

Organism-specific databases

HPAiHPA006301

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi113648, 18 interactors
IntActiO95872, 84 interactors
MINTiO95872
STRINGi9606.ENSP00000365057

Structurei

3D structure databases

ProteinModelPortaliO95872
SMRiO95872
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati111 – 141ANK 1Add BLAST31
Repeati142 – 172ANK 2Add BLAST31
Domaini255 – 301G-patchPROSITE-ProRule annotationAdd BLAST47

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG2384 Eukaryota
ENOG410ZSRX LUCA
GeneTreeiENSGT00390000003292
HOVERGENiHBG031112
InParanoidiO95872
OMAiDLRTYMN
OrthoDBiEOG091G0LFY
PhylomeDBiO95872
TreeFamiTF315384

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR000467 G_patch_dom
IPR039146 GPANK1
PANTHERiPTHR20923 PTHR20923, 1 hit
PfamiView protein in Pfam
PF01585 G-patch, 1 hit
SMARTiView protein in SMART
SM00443 G_patch, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50174 G_PATCH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All

O95872-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRPLLITFT PATDPSDLWK DGQQQPQPEK PESTLDGAAA RAFYEALIGD
60 70 80 90 100
ESSAPDSQRS QTEPARERKR KKRRIMKAPA AEAVAEGASG RHGQGRSLEA
110 120 130 140 150
EDKMTHRILR AAQEGDLPEL RRLLEPHEAG GAGGNINARD AFWWTPLMCA
160 170 180 190 200
ARAGQGAAVS YLLGRGAAWV GVCELSGRDA AQLAEEAGFP EVARMVRESH
210 220 230 240 250
GETRSPENRS PTPSLQYCEN CDTHFQDSNH RTSTAHLLSL SQGPQPPNLP
260 270 280 290 300
LGVPISSPGF KLLLRGGWEP GMGLGPRGEG RANPIPTVLK RDQEGLGYRS
310 320 330 340 350
APQPRVTHFP AWDTRAVAGR ERPPRVATLS WREERRREEK DRAWERDLRT

YMNLEF
Length:356
Mass (Da):39,314
Last modified:May 1, 1999 - v1
Checksum:iAA57AA938A8C10E5
GO

Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JHL1A0A0G2JHL1_HUMAN
G patch domain and ankyrin repeat-c...
GPANK1
356Annotation score:
F6QYZ9F6QYZ9_HUMAN
G patch domain and ankyrin repeat-c...
GPANK1
152Annotation score:
A0A0A0MSL4A0A0A0MSL4_HUMAN
G patch domain and ankyrin repeat-c...
GPANK1
164Annotation score:
A0A0A0MSL5A0A0A0MSL5_HUMAN
G patch domain and ankyrin repeat-c...
GPANK1
89Annotation score:
A0A0G2JK30A0A0G2JK30_HUMAN
G patch domain and ankyrin repeat-c...
GPANK1
198Annotation score:
A0A0G2JK37A0A0G2JK37_HUMAN
G patch domain and ankyrin repeat-c...
GPANK1
198Annotation score:
A0A0G2JJ73A0A0G2JJ73_HUMAN
G patch domain and ankyrin repeat-c...
GPANK1
164Annotation score:
A0A0G2JKD0A0A0G2JKD0_HUMAN
G patch domain and ankyrin repeat-c...
GPANK1
152Annotation score:
A0A0G2JJ08A0A0G2JJ08_HUMAN
G patch domain and ankyrin repeat-c...
GPANK1
107Annotation score:
A0A0G2JJI2A0A0G2JJI2_HUMAN
G patch domain and ankyrin repeat-c...
GPANK1
89Annotation score:
There is more potential isoformShow all

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04829141R → L1 PublicationCorresponds to variant dbSNP:rs3130618Ensembl.1
Natural variantiVAR_048292112A → V. Corresponds to variant dbSNP:rs35265780Ensembl.1
Natural variantiVAR_048293210S → A. Corresponds to variant dbSNP:rs34082689Ensembl.1
Natural variantiVAR_020096235A → V. Corresponds to variant dbSNP:rs2295666Ensembl.1
Natural variantiVAR_064698314T → N Found in a clear cell renal carcinoma case; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129756 Genomic DNA Translation: AAD18082.1
BA000025 Genomic DNA Translation: BAB63387.1
AL670886 Genomic DNA No translation available.
AL805934 Genomic DNA No translation available.
AL662899 Genomic DNA No translation available.
BX511262 Genomic DNA No translation available.
CR354443 Genomic DNA No translation available.
CR759761 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03467.1
BC008783 mRNA Translation: AAH08783.1
CCDSiCCDS4711.1
RefSeqiNP_001186166.1, NM_001199237.1
NP_001186167.1, NM_001199238.1
NP_001186168.1, NM_001199239.1
NP_001186169.1, NM_001199240.1
NP_149417.1, NM_033177.3
XP_005249460.1, XM_005249403.3
XP_006715267.1, XM_006715204.1
XP_011513211.1, XM_011514909.1
XP_011513212.1, XM_011514910.1
UniGeneiHs.247478
Hs.732291

Genome annotation databases

EnsembliENST00000211377; ENSP00000211377; ENSG00000236011
ENST00000375893; ENSP00000365057; ENSG00000204438
ENST00000375895; ENSP00000365059; ENSG00000204438
ENST00000375896; ENSP00000365060; ENSG00000204438
ENST00000375900; ENSP00000365065; ENSG00000204438
ENST00000375906; ENSP00000365071; ENSG00000204438
ENST00000383434; ENSP00000372926; ENSG00000206408
ENST00000383436; ENSP00000372928; ENSG00000206408
ENST00000400129; ENSP00000382994; ENSG00000206408
ENST00000400134; ENSP00000382999; ENSG00000206408
ENST00000400139; ENSP00000383005; ENSG00000206408
ENST00000414528; ENSP00000389339; ENSG00000228605
ENST00000416384; ENSP00000401376; ENSG00000223932
ENST00000417890; ENSP00000415855; ENSG00000232312
ENST00000418502; ENSP00000412321; ENSG00000223932
ENST00000422131; ENSP00000410690; ENSG00000223932
ENST00000426326; ENSP00000398927; ENSG00000228605
ENST00000427527; ENSP00000391604; ENSG00000236011
ENST00000429266; ENSP00000412884; ENSG00000223932
ENST00000433857; ENSP00000406895; ENSG00000236011
ENST00000433880; ENSP00000401272; ENSG00000228605
ENST00000439710; ENSP00000409206; ENSG00000232312
ENST00000440777; ENSP00000399890; ENSG00000223932
ENST00000447705; ENSP00000403829; ENSG00000236011
ENST00000448091; ENSP00000411691; ENSG00000232312
ENST00000449868; ENSP00000393567; ENSG00000232312
ENST00000453746; ENSP00000390746; ENSG00000232312
ENST00000453899; ENSP00000413662; ENSG00000228605
ENST00000456191; ENSP00000401276; ENSG00000236011
ENST00000457505; ENSP00000406507; ENSG00000228605
GeneIDi7918
KEGGihsa:7918
UCSCiuc003nvn.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129756 Genomic DNA Translation: AAD18082.1
BA000025 Genomic DNA Translation: BAB63387.1
AL670886 Genomic DNA No translation available.
AL805934 Genomic DNA No translation available.
AL662899 Genomic DNA No translation available.
BX511262 Genomic DNA No translation available.
CR354443 Genomic DNA No translation available.
CR759761 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03467.1
BC008783 mRNA Translation: AAH08783.1
CCDSiCCDS4711.1
RefSeqiNP_001186166.1, NM_001199237.1
NP_001186167.1, NM_001199238.1
NP_001186168.1, NM_001199239.1
NP_001186169.1, NM_001199240.1
NP_149417.1, NM_033177.3
XP_005249460.1, XM_005249403.3
XP_006715267.1, XM_006715204.1
XP_011513211.1, XM_011514909.1
XP_011513212.1, XM_011514910.1
UniGeneiHs.247478
Hs.732291

3D structure databases

ProteinModelPortaliO95872
SMRiO95872
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113648, 18 interactors
IntActiO95872, 84 interactors
MINTiO95872
STRINGi9606.ENSP00000365057

PTM databases

iPTMnetiO95872
PhosphoSitePlusiO95872

Polymorphism and mutation databases

BioMutaiGPANK1

Proteomic databases

EPDiO95872
MaxQBiO95872
PaxDbiO95872
PeptideAtlasiO95872
PRIDEiO95872
ProteomicsDBi51112

Protocols and materials databases

DNASUi7918
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000211377; ENSP00000211377; ENSG00000236011
ENST00000375893; ENSP00000365057; ENSG00000204438
ENST00000375895; ENSP00000365059; ENSG00000204438
ENST00000375896; ENSP00000365060; ENSG00000204438
ENST00000375900; ENSP00000365065; ENSG00000204438
ENST00000375906; ENSP00000365071; ENSG00000204438
ENST00000383434; ENSP00000372926; ENSG00000206408
ENST00000383436; ENSP00000372928; ENSG00000206408
ENST00000400129; ENSP00000382994; ENSG00000206408
ENST00000400134; ENSP00000382999; ENSG00000206408
ENST00000400139; ENSP00000383005; ENSG00000206408
ENST00000414528; ENSP00000389339; ENSG00000228605
ENST00000416384; ENSP00000401376; ENSG00000223932
ENST00000417890; ENSP00000415855; ENSG00000232312
ENST00000418502; ENSP00000412321; ENSG00000223932
ENST00000422131; ENSP00000410690; ENSG00000223932
ENST00000426326; ENSP00000398927; ENSG00000228605
ENST00000427527; ENSP00000391604; ENSG00000236011
ENST00000429266; ENSP00000412884; ENSG00000223932
ENST00000433857; ENSP00000406895; ENSG00000236011
ENST00000433880; ENSP00000401272; ENSG00000228605
ENST00000439710; ENSP00000409206; ENSG00000232312
ENST00000440777; ENSP00000399890; ENSG00000223932
ENST00000447705; ENSP00000403829; ENSG00000236011
ENST00000448091; ENSP00000411691; ENSG00000232312
ENST00000449868; ENSP00000393567; ENSG00000232312
ENST00000453746; ENSP00000390746; ENSG00000232312
ENST00000453899; ENSP00000413662; ENSG00000228605
ENST00000456191; ENSP00000401276; ENSG00000236011
ENST00000457505; ENSP00000406507; ENSG00000228605
GeneIDi7918
KEGGihsa:7918
UCSCiuc003nvn.4 human

Organism-specific databases

CTDi7918
DisGeNETi7918
EuPathDBiHostDB:ENSG00000204438.10
GeneCardsiGPANK1
HGNCiHGNC:13920 GPANK1
HPAiHPA006301
MIMi142610 gene
neXtProtiNX_O95872
OpenTargetsiENSG00000204438
PharmGKBiPA25265
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2384 Eukaryota
ENOG410ZSRX LUCA
GeneTreeiENSGT00390000003292
HOVERGENiHBG031112
InParanoidiO95872
OMAiDLRTYMN
OrthoDBiEOG091G0LFY
PhylomeDBiO95872
TreeFamiTF315384

Miscellaneous databases

ChiTaRSiGPANK1 human
GeneWikiiBAT4
GenomeRNAii7918
PROiPR:O95872
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204438 Expressed in 199 organ(s), highest expression level in testis
CleanExiHS_BAT4
ExpressionAtlasiO95872 baseline and differential
GenevisibleiO95872 HS

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR000467 G_patch_dom
IPR039146 GPANK1
PANTHERiPTHR20923 PTHR20923, 1 hit
PfamiView protein in Pfam
PF01585 G-patch, 1 hit
SMARTiView protein in SMART
SM00443 G_patch, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50174 G_PATCH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPAN1_HUMAN
AccessioniPrimary (citable) accession number: O95872
Secondary accession number(s): A6NG25, B0UXA2, Q5SQ49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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