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Protein

Protein ABHD16A

Gene

ABHD16A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei355Charge relay systemBy similarity1
Active sitei430Charge relay systemBy similarity1
Active sitei507Charge relay systemBy similarity1

GO - Molecular functioni

  • acylglycerol lipase activity Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Protein family/group databases

ESTHERihuman-ABHD16A AlphaBeta_hydrolase
MEROPSiS09.065

Chemistry databases

SwissLipidsiSLP:000001120

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ABHD16ACurated (EC:3.-.-.-)
Alternative name(s):
Alpha/beta hydrolase domain-containing protein 16ACurated
Short name:
Abhydrolase domain-containing protein 16AImported
HLA-B-associated transcript 5
Protein G5
Gene namesi
Name:ABHD16AImported
Synonyms:BAT5, G5, NG26
ORF Names:PP199
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204427.11
HGNCiHGNC:13921 ABHD16A
MIMi142620 gene
neXtProtiNX_O95870

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Transmembranei93 – 113HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7920
OpenTargetsiENSG00000204427
PharmGKBiPA25266

Chemistry databases

ChEMBLiCHEMBL6168

Polymorphism and mutation databases

BioMutaiABHD16A

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000648331 – 558Protein ABHD16AAdd BLAST558

Proteomic databases

EPDiO95870
MaxQBiO95870
PaxDbiO95870
PeptideAtlasiO95870
PRIDEiO95870
ProteomicsDBi51110
51111 [O95870-2]

PTM databases

iPTMnetiO95870
PhosphoSitePlusiO95870
SwissPalmiO95870

Expressioni

Gene expression databases

BgeeiENSG00000204427 Expressed in 176 organ(s), highest expression level in pituitary gland
CleanExiHS_BAT5
ExpressionAtlasiO95870 baseline and differential
GenevisibleiO95870 HS

Organism-specific databases

HPAiHPA058606

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi113650, 22 interactors
IntActiO95870, 60 interactors
MINTiO95870
STRINGi9606.ENSP00000379282

Chemistry databases

BindingDBiO95870

Structurei

3D structure databases

ProteinModelPortaliO95870
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini281 – 407AB hydrolase-1Sequence analysisAdd BLAST127

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. ABHD16 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1553 Eukaryota
ENOG410XQU4 LUCA
GeneTreeiENSGT00390000017119
HOGENOMiHOG000231967
HOVERGENiHBG050666
InParanoidiO95870
OMAiPVDFDVK
OrthoDBiEOG091G065R
PhylomeDBiO95870
TreeFamiTF314267

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
IPR026604 ABHD16A
PANTHERiPTHR12277:SF54 PTHR12277:SF54, 1 hit
PfamiView protein in Pfam
PF00561 Abhydrolase_1, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95870-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKLLSCVLG PRLYKIYRER DSERAPASVP ETPTAVTAPH SSSWDTYYQP
60 70 80 90 100
RALEKHADSI LALASVFWSI SYYSSPFAFF YLYRKGYLSL SKVVPFSHYA
110 120 130 140 150
GTLLLLLAGV ACLRGIGRWT NPQYRQFITI LEATHRNQSS ENKRQLANYN
160 170 180 190 200
FDFRSWPVDF HWEEPSSRKE SRGGPSRRGV ALLRPEPLHR GTADTLLNRV
210 220 230 240 250
KKLPCQITSY LVAHTLGRRM LYPGSVYLLQ KALMPVLLQG QARLVEECNG
260 270 280 290 300
RRAKLLACDG NEIDTMFVDR RGTAEPQGQK LVICCEGNAG FYEVGCVSTP
310 320 330 340 350
LEAGYSVLGW NHPGFAGSTG VPFPQNEANA MDVVVQFAIH RLGFQPQDII
360 370 380 390 400
IYAWSIGGFT ATWAAMSYPD VSAMILDASF DDLVPLALKV MPDSWRGLVT
410 420 430 440 450
RTVRQHLNLN NAEQLCRYQG PVLLIRRTKD EIITTTVPED IMSNRGNDLL
460 470 480 490 500
LKLLQHRYPR VMAEEGLRVV RQWLEASSQL EEASIYSRWE VEEDWCLSVL
510 520 530 540 550
RSYQAEHGPD FPWSVGEDMS ADGRRQLALF LARKHLHNFE ATHCTPLPAQ

NFQMPWHL
Length:558
Mass (Da):63,243
Last modified:January 23, 2007 - v3
Checksum:iBC46EDA0725D44EA
GO
Isoform 2 (identifier: O95870-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: MAKLLSCVLG...PFAFFYLYRK → MPPPALFLSS...SLYSGELAGG

Show »
Length:525
Mass (Da):59,383
Checksum:iA69C57A1A3550711
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JJD3A0A0G2JJD3_HUMAN
HLA-B associated transcript 5, isof...
ABHD16A BAT5, hCG_43724
601Annotation score:
F2Z3H2F2Z3H2_HUMAN
Protein ABHD16A
ABHD16A
65Annotation score:
F2Z3G6F2Z3G6_HUMAN
Protein ABHD16A
ABHD16A
46Annotation score:
F2Z3Q3F2Z3Q3_HUMAN
Protein ABHD16A
ABHD16A
65Annotation score:
A0A0G2JI89A0A0G2JI89_HUMAN
Protein ABHD16A
ABHD16A
263Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27A → V in AAG22475 (PubMed:15498874).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0438251 – 85MAKLL…YLYRK → MPPPALFLSSLYPRLEFQND FYRSCIRRSSPQPPPNLAWR PESLYSGELAGG in isoform 2. 1 PublicationAdd BLAST85

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193047 mRNA Translation: AAG22475.1
AK001207 mRNA Translation: BAA91553.1
AK023194 mRNA Translation: BAB14455.1
AK297712 mRNA Translation: BAH12652.1
AF129756 Genomic DNA Translation: AAD18079.1
BA000025 Genomic DNA Translation: BAB63383.1
AL662899 Genomic DNA No translation available.
AL670886 Genomic DNA No translation available.
AL805934 Genomic DNA No translation available.
BX248244 Genomic DNA No translation available.
BX511262 Genomic DNA No translation available.
CR354443 Genomic DNA No translation available.
CR753842 Genomic DNA No translation available.
CR759761 Genomic DNA No translation available.
CR759787 Genomic DNA No translation available.
BC031839 mRNA Translation: AAH31839.1
CCDSiCCDS4713.1 [O95870-1]
CCDS54988.1 [O95870-2]
RefSeqiNP_001170986.1, NM_001177515.1 [O95870-2]
NP_066983.1, NM_021160.2 [O95870-1]
UniGeneiHs.388188

Genome annotation databases

EnsembliENST00000395952; ENSP00000379282; ENSG00000204427 [O95870-1]
ENST00000440843; ENSP00000410347; ENSG00000204427 [O95870-2]
ENST00000446529; ENSP00000395665; ENSG00000206403 [O95870-1]
ENST00000548592; ENSP00000448431; ENSG00000206403 [O95870-2]
ENST00000549722; ENSP00000447549; ENSG00000230475 [O95870-2]
ENST00000549853; ENSP00000447846; ENSG00000236063 [O95870-2]
ENST00000550556; ENSP00000447498; ENSG00000235676 [O95870-2]
ENST00000551038; ENSP00000449579; ENSG00000231488 [O95870-2]
ENST00000552042; ENSP00000448451; ENSG00000224552 [O95870-2]
GeneIDi7920
KEGGihsa:7920
UCSCiuc003nvy.3 human [O95870-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193047 mRNA Translation: AAG22475.1
AK001207 mRNA Translation: BAA91553.1
AK023194 mRNA Translation: BAB14455.1
AK297712 mRNA Translation: BAH12652.1
AF129756 Genomic DNA Translation: AAD18079.1
BA000025 Genomic DNA Translation: BAB63383.1
AL662899 Genomic DNA No translation available.
AL670886 Genomic DNA No translation available.
AL805934 Genomic DNA No translation available.
BX248244 Genomic DNA No translation available.
BX511262 Genomic DNA No translation available.
CR354443 Genomic DNA No translation available.
CR753842 Genomic DNA No translation available.
CR759761 Genomic DNA No translation available.
CR759787 Genomic DNA No translation available.
BC031839 mRNA Translation: AAH31839.1
CCDSiCCDS4713.1 [O95870-1]
CCDS54988.1 [O95870-2]
RefSeqiNP_001170986.1, NM_001177515.1 [O95870-2]
NP_066983.1, NM_021160.2 [O95870-1]
UniGeneiHs.388188

3D structure databases

ProteinModelPortaliO95870
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113650, 22 interactors
IntActiO95870, 60 interactors
MINTiO95870
STRINGi9606.ENSP00000379282

Chemistry databases

BindingDBiO95870
ChEMBLiCHEMBL6168
SwissLipidsiSLP:000001120

Protein family/group databases

ESTHERihuman-ABHD16A AlphaBeta_hydrolase
MEROPSiS09.065

PTM databases

iPTMnetiO95870
PhosphoSitePlusiO95870
SwissPalmiO95870

Polymorphism and mutation databases

BioMutaiABHD16A

Proteomic databases

EPDiO95870
MaxQBiO95870
PaxDbiO95870
PeptideAtlasiO95870
PRIDEiO95870
ProteomicsDBi51110
51111 [O95870-2]

Protocols and materials databases

DNASUi7920
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395952; ENSP00000379282; ENSG00000204427 [O95870-1]
ENST00000440843; ENSP00000410347; ENSG00000204427 [O95870-2]
ENST00000446529; ENSP00000395665; ENSG00000206403 [O95870-1]
ENST00000548592; ENSP00000448431; ENSG00000206403 [O95870-2]
ENST00000549722; ENSP00000447549; ENSG00000230475 [O95870-2]
ENST00000549853; ENSP00000447846; ENSG00000236063 [O95870-2]
ENST00000550556; ENSP00000447498; ENSG00000235676 [O95870-2]
ENST00000551038; ENSP00000449579; ENSG00000231488 [O95870-2]
ENST00000552042; ENSP00000448451; ENSG00000224552 [O95870-2]
GeneIDi7920
KEGGihsa:7920
UCSCiuc003nvy.3 human [O95870-1]

Organism-specific databases

CTDi7920
DisGeNETi7920
EuPathDBiHostDB:ENSG00000204427.11
GeneCardsiABHD16A
H-InvDBiHIX0016012
HIX0040568
HGNCiHGNC:13921 ABHD16A
HPAiHPA058606
MIMi142620 gene
neXtProtiNX_O95870
OpenTargetsiENSG00000204427
PharmGKBiPA25266
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1553 Eukaryota
ENOG410XQU4 LUCA
GeneTreeiENSGT00390000017119
HOGENOMiHOG000231967
HOVERGENiHBG050666
InParanoidiO95870
OMAiPVDFDVK
OrthoDBiEOG091G065R
PhylomeDBiO95870
TreeFamiTF314267

Miscellaneous databases

ChiTaRSiABHD16A human
GeneWikiiBAT5
GenomeRNAii7920
PROiPR:O95870
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204427 Expressed in 176 organ(s), highest expression level in pituitary gland
CleanExiHS_BAT5
ExpressionAtlasiO95870 baseline and differential
GenevisibleiO95870 HS

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
IPR026604 ABHD16A
PANTHERiPTHR12277:SF54 PTHR12277:SF54, 1 hit
PfamiView protein in Pfam
PF00561 Abhydrolase_1, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiABHGA_HUMAN
AccessioniPrimary (citable) accession number: O95870
Secondary accession number(s): A2BEY3
, B7Z4R6, Q5SRR1, Q5SRR2, Q8WYH0, Q9NW33
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 162 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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