UniProtKB - O95863 (SNAI1_HUMAN)
Zinc finger protein SNAI1
SNAI1
Functioni
Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription (PubMed:20389281, PubMed:20562920).
The N-terminal SNAG domain competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (in vitro) (PubMed:20389281, PubMed:21300290, PubMed:23721412).
During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (By similarity).
SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (By similarity).
Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.
By similarity9 PublicationsCaution
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 154 – 176 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 178 – 202 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 208 – 230 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 236 – 259 | C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: BHF-UCL
- E-box binding Source: BHF-UCL
- kinase binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: BHF-UCL
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- aortic valve morphogenesis Source: BHF-UCL
- cartilage morphogenesis Source: Ensembl
- cell migration Source: Ensembl
- epithelial to mesenchymal transition Source: UniProtKB
- epithelial to mesenchymal transition involved in endocardial cushion formation Source: BHF-UCL
- hair follicle morphogenesis Source: Ensembl
- heterochromatin organization Source: UniProtKB
- left/right pattern formation Source: Ensembl
- mesoderm formation Source: UniProtKB
- negative regulation of cell differentiation involved in embryonic placenta development Source: Ensembl
- negative regulation of DNA damage response, signal transduction by p53 class mediator Source: BHF-UCL
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: BHF-UCL
- negative regulation of transcription by RNA polymerase II Source: BHF-UCL
- negative regulation of vitamin D biosynthetic process Source: BHF-UCL
- Notch signaling involved in heart development Source: BHF-UCL
- osteoblast differentiation Source: UniProtKB
- positive regulation of cell migration Source: UniProtKB
- positive regulation of epithelial to mesenchymal transition Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- regulation of bicellular tight junction assembly Source: BHF-UCL
- regulation of transcription by RNA polymerase II Source: GO_Central
- roof of mouth development Source: Ensembl
- trophoblast giant cell differentiation Source: Ensembl
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O95863 |
Reactomei | R-HSA-8943724, Regulation of PTEN gene transcription |
SignaLinki | O95863 |
SIGNORi | O95863 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein SNAI1Alternative name(s): Protein snail homolog 1 Short name: Protein sna |
Gene namesi | Name:SNAI1 Synonyms:SNAH |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11128, SNAI1 |
MIMi | 604238, gene |
neXtProti | NX_O95863 |
VEuPathDBi | HostDB:ENSG00000124216 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 2 Publications
Nucleus
- Nucleus 5 Publications
Note: Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and Ser-119) it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction motif and ubiquitination involving BTRC occurs.1 Publication
Cytosol
- cytosol Source: HPA
Nucleus
- fibrillar center Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- intracellular membrane-bounded organelle Source: HPA
- pericentric heterochromatin Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 2 | P → A: Abolishes repressor activity on E-cadherin/CDH1 promoter and binding to KDM1A. 2 Publications | 1 | |
Mutagenesisi | 3 | R → A: Loss of interaction with KDM1A. 1 Publication | 1 | |
Mutagenesisi | 4 | S → A: Loss of interaction with KDM1A. 1 Publication | 1 | |
Mutagenesisi | 5 | F → A: Loss of interaction with KDM1A. 1 Publication | 1 | |
Mutagenesisi | 8 | R → A: Loss of interaction with KDM1A. 1 Publication | 1 | |
Mutagenesisi | 9 | K → A: Loss of interaction with KDM1A. 1 Publication | 1 | |
Mutagenesisi | 9 | K → R: Does not affect E-cadherin/CDH1 repression; when associated with R-16. 1 Publication | 1 | |
Mutagenesisi | 11 | S → A: Abolishes PKA phosphorylation. Strongly decreases repressor activity on E-cadherin/CDH1 and CLDN1 promoters. Increases protein stability. Affects function in EMT. 1 Publication | 1 | |
Mutagenesisi | 16 | K → R: Does not affect E-cadherin repression; when associated with R-9. 1 Publication | 1 | |
Mutagenesisi | 92 | S → A: Abolishes CK2 phosphorylation. Strongly decreases repressor activity on E-cadherin/CDH1 and CLDN1 promoters. Increases protein stability. Affects function in cell survival. Abolishes phosphorylation in the serine-rich region; when associated with A-104 and A-107. 1 Publication | 1 | |
Mutagenesisi | 92 | S → E: Does not affect repressor activity on E-cadherin/CDH1 promoter. 1 Publication | 1 | |
Mutagenesisi | 96 | S → A: Abolishes recognition and ubiquitination by BTRC which increases steady state level and half-life. Preferentially localizes to the nucleus. Induces a more aggressive tissue invasion program. Lower sensitivity to BTRC-triggered degradation, impairs phosphorylation by GSK3B and does not affect NOTCH1-induced degradation; when associated with A-100. Lower sensitivity to BTRC-triggered degradation, impaired phosphorylation by GSK3B and loss of cytoplasmic localization; when associated with A-100; A-107; A-111; A-115 and A-119. 4 Publications | 1 | |
Mutagenesisi | 98 | K → R: No change. Complete loss of sensitivity to FBXL14- and BTRC-triggered degradation and loss of ability to repress E-cadherin/CDH1; when associated with R-137 and R-146. 2 Publications | 1 | |
Mutagenesisi | 100 | S → A: Lower sensitivity to BTRC-triggered degradation and impaired phosphorylation by GSK3B; when associated with A-96. Lower sensitivity to BTRC-triggered degradation, impaired phosphorylation by GSK3B and loss of cytoplasmic localization; when associated with A-96; A-107; A-111; A-115 and A-119. Does not affect NOTCH1-induced degradation; when associated with A-96. Abolishes phosphorylation at S-96. 3 Publications | 1 | |
Mutagenesisi | 104 | S → A: Increases protein stability, does not affect repressor activity on E-cadherin/CDH1 promoter, preferentially localizes to the nucleus, induces a more aggressive tissue invasion program and impairs phosphorylation by GSK3B, binding to BTRC and ubiquitination; when associated with A-107. Impairs phosphorylation in the serine-rich domain/region; when associated with A-92 and A-107. Abolishes phosphorylation at S-96. 3 Publications | 1 | |
Mutagenesisi | 107 | S → A: Lower sensitivity to BTRC-triggered degradation, impaired phosphorylation by GSK3B and loss of cytoplasmic localization; when associated with A-111; A-115 and A-119. Lower sensitivity to BTRC-triggered degradation, impaired phosphorylation by GSK3B and loss of cytoplasmic localization; when associated with A-96; A-100; A-111; A-115 and A-119. Increases protein stability, does not affect repressor activity on E-cadherin promoter, preferentially localizes to the nucleus, induces a more aggressive tissue invasion program and impairs phosphorylation by GSK3B, binding to BTRC and ubiquitination; when associated with A-104. Impairs phosphorylation in the serine-rich region; when associated with A-92 and A-104. Abolishes phosphorylation at S-96. 4 Publications | 1 | |
Mutagenesisi | 107 | S → E: Predominantly localized to the cytoplasm; when associated with E-111; E-115 and E-119. 4 Publications | 1 | |
Mutagenesisi | 111 | S → A: Lower sensitivity to BTRC-triggered degradation, impaired phosphorylation by GSK3B and loss of cytoplasmic localization; when associated with A-107; A-115 and A-119. Lower sensitivity to BTRC-triggered degradation, impaired phosphorylation by GSK3B and loss of cytoplasmic localization; when associated with A-96; A-100; A-107; A-115 and A-119. 1 Publication | 1 | |
Mutagenesisi | 111 | S → E: Predominantly localized to the cytoplasm; when associated with E-107; E-115 and E-119. 1 Publication | 1 | |
Mutagenesisi | 115 | S → A: Lower sensitivity to BTRC-triggered degradation, impaired phosphorylation by GSK3B and loss of cytoplasmic localization; when associated with A-107; A-111 and A-119. Lower sensitivity to BTRC-triggered degradation, impaired phosphorylation by GSK3B and loss of cytoplasmic localization; when associated with A-96; A-100; A-107; A-111 and A-119. 1 Publication | 1 | |
Mutagenesisi | 115 | S → E: Predominantly localized to the cytoplasm; when associated with E-107; E-111 and E-119. 1 Publication | 1 | |
Mutagenesisi | 119 | S → A: Lower sensitivity to BTRC-triggered degradation, impaired phosphorylation by GSK3B and loss of cytoplasmic localization; when associated with A-107; A-111 and A-119. Lower sensitivity to BTRC-triggered degradation, impaired phosphorylation by GSK3B and loss of cytoplasmic localization; when associated with A-96; A-100; A-107; A-111 and A-115. 1 Publication | 1 | |
Mutagenesisi | 119 | S → E: Predominantly localized to the cytoplasm; when associated with E-107; E-111 and E-115. 1 Publication | 1 | |
Mutagenesisi | 137 | K → R: Lower sensitivity to FBXL14-triggered degradation. Lower sensitivity to FBXL14-triggered degradation; when associated with R-146. Complete loss of sensitivity to FBXL14- and BTRC-triggered degradation and loss of ability to repress E-cadherin; when associated with R-98 and R-146. 2 Publications | 1 | |
Mutagenesisi | 146 | K → R: Lower sensitivity to FBXL14-triggered degradation. Lower sensitivity to FBXL14-triggered degradation; when associated with R-137. Complete loss of sensitivity to FBXL14- and BTRC-triggered degradation; when associated with R-98 and R-137. 1 Publication | 1 | |
Mutagenesisi | 151 – 152 | RK → EE: Does not affect binding to KPNB1, KPNA2, IPO7 or TNPO1. 1 Publication | 2 | |
Mutagenesisi | 156 | C → A: Abolishes binding to KPNB1, KPNA2, IPO7 and TNPO1 and nuclear localization. 1 Publication | 1 | |
Mutagenesisi | 161 | K → E: Does not affect binding to KPNB1, KPNA2, IPO7 or TNPO1. No change in subcellular localization. Impairs binding to KPNB1, KPNA2, IPO7 and TNPO1 and abolishes nuclear localization, DNA binding and repressor activity on E-cadherin/CDH1 promoter; when associated with E-170. Abolishes binding to KPNB1, KPNA2, IPO7 and TNPO1 and nuclear localization; when associated with E-187 and/or E-220. 1 Publication | 1 | |
Mutagenesisi | 170 | K → E: Does not affect binding to KPNB1, KPNA2, IPO7 or TNPO1. No change in subcellular localization. Impairs binding to KPNB1, KPNA2, IPO7 and TNPO1 and abolishes nuclear localization, DNA binding and repressor activity on E-cadherin/CDH1 promoter; when associated with E-161. 1 Publication | 1 | |
Mutagenesisi | 182 | C → A: Impairs binding to KPNB1, IPO7 and TNPO1 and abolishes binding to KPNA2. Localizes to cytoplasm and nucleus. 1 Publication | 1 | |
Mutagenesisi | 187 | K → E: Does not affect binding to KPNB1, KPNA2, IPO7 or TNPO1. Impairs binding to KPNB1, KPNA2, IPO7 and TNPO1 and abolishes nuclear localization, DNA binding and repressor activity on E-cadherin/CDH1 promoter; when associated with E-191. Abolishes binding to KPNB1, KPNA2, IPO7 and TNPO1 and nuclear localization; when associated with E-161 and/or E-220. 1 Publication | 1 | |
Mutagenesisi | 191 | R → E: Mildly reduces binding to KPNB1 and nuclear import. Strongly reduces binding to KPNB1 and nuclear import; when associated with A-193. Loss of binding to KPNB1 and nuclear import; when associated with A-193 and A-196. 1 Publication | 1 | |
Mutagenesisi | 191 | R → E: Mildly reduces binding to KPNB1. Does not affect binding to KPNA2, IPO7 or TNPO1. 1 Publication | 1 | |
Mutagenesisi | 193 | W → A: Mildly reduces binding to KPNB1 and nuclear import. Strongly reduces binding to KPNB1 and nuclear import; when associated with E-191. Loss of binding to KPNB1 and nuclear import; when associated with E-191 and A-196. 1 Publication | 1 | |
Mutagenesisi | 196 | Q → A: Loss of binding to KPNB1 and nuclear import; when associated with E-191 and A-193. 1 Publication | 1 | |
Mutagenesisi | 203 | T → A: Abolishes LATS2 phosphorylation. Does not affect binding to LATS2. Reduces protein stability. Equally distributed between nucleus and cytoplasm. Increases capacity to associate with nuclear pore importins. Unable to accumulate in the nucleus. Does not abrogate function. 1 Publication | 1 | |
Mutagenesisi | 203 | T → E: Exclusively localizes to the cytoplasm. Reduces capacity to associate with nuclear pore importins. Unable to enter the nucleus. Does not abrogate function. 1 Publication | 1 | |
Mutagenesisi | 210 | C → A: Impairs binding to KPNB1, IPO7 and TNPO1 and abolishes binding to KPNA2. Localizes to cytoplasm and nucleus. 1 Publication | 1 | |
Mutagenesisi | 215 | R → E: Impairs binding to KPNB1, KPNA2, IPO7 and TNPO1. No change in subcellular localization. 1 Publication | 1 | |
Mutagenesisi | 220 | R → E: Does not affect binding to KPNB1, KPNA2, IPO7 or TNPO1. No change in subcellular localization. Impairs binding to KPNB1, KPNA2, IPO7 and TNPO1; when associated with E-222 and E-224. Impairs binding to KPNB1, KPNA2, IPO7 and TNPO1 and abolishes nuclear localization, DNA binding and repressor activity on E-cadherin/CDH1 promoter; when associated with E-224. Abolishes binding to KPNB1, KPNA2, IPO7 and TNPO1 and nuclear localization; when associated with E-161 and/or E-187. 1 Publication | 1 | |
Mutagenesisi | 222 | N → E: Does not affect binding to KPNB1, KPNA2, IPO7 or TNPO1. No change in subcellular localization. Impairs binding to KPNB1, KPNA2, IPO7 and TNPO1; when associated with E-220 and E-224. 1 Publication | 1 | |
Mutagenesisi | 224 | R → E: Does not affect binding to KPNB1, KPNA2, IPO7 or TNPO1. No change in subcellular localization. Impairs binding to KPNB1, KPNA2, IPO7 and TNPO1; when associated with E-220 and E-222. Impairs binding to KPNB1, KPNA2, IPO7 and TNPO1 and abolishes nuclear localization, DNA binding and repressor activity on E-cadherin/CDH1 promoter; when associated with E-220. 1 Publication | 1 | |
Mutagenesisi | 224 | R → E: Mildly reduces binding to KPNB1 and nuclear import. Strongly reduces binding to KPNB1 and nuclear import; when associated with A-228. 1 Publication | 1 | |
Mutagenesisi | 228 | Q → A: Very minor effect on binding to KPNB1 and nuclear import. Strongly reduces binding to KPNB1 and nuclear import; when associated with E-224. 1 Publication | 1 | |
Mutagenesisi | 232 – 235 | DVKK → KVEE: Does not affect binding to KPNB1, KPNA2, IPO7 or TNPO1. 1 Publication | 4 | |
Mutagenesisi | 238 | C → A: Impairs binding to KPNB1 and IPO7 and abolishes binding to KPNA2 and TNPO1 and nuclear localization. 1 Publication | 1 | |
Mutagenesisi | 239 | Q → E: Does not affect binding to KPNB1, KPNA2, IPO7, TNPO1 or DNA. 1 Publication | 1 | |
Mutagenesisi | 246 | S → A: Decreases repression activity on E-cadherin/CDH1, occludin and aromatase promoters. Preferentially localizes to the cytoplasm. Abolishes phosphorylation by PAK1. 1 Publication | 1 | |
Mutagenesisi | 247 | R → E: Mildly reduces binding to KPNB1 and nuclear import. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 6615 |
OpenTargetsi | ENSG00000124216 |
PharmGKBi | PA35977 |
Miscellaneous databases
Pharosi | O95863, Tbio |
Genetic variation databases
BioMutai | SNAI1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047029 | 1 – 264 | Zinc finger protein SNAI1Add BLAST | 264 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 11 | Phosphoserine; by PKA1 Publication | 1 | |
Modified residuei | 82 | Phosphoserine1 Publication | 1 | |
Modified residuei | 92 | Phosphoserine; by CK21 Publication | 1 | |
Modified residuei | 96 | Phosphoserine1 Publication1 Publication | 1 | |
Cross-linki | 98 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) | ||
Modified residuei | 100 | Phosphoserine1 Publication | 1 | |
Modified residuei | 104 | Phosphoserine1 Publication2 Publications | 1 | |
Modified residuei | 107 | Phosphoserine1 Publication2 Publications | 1 | |
Modified residuei | 111 | Phosphoserine1 Publication | 1 | |
Glycosylationi | 112 | O-linked (GlcNAc) serine1 Publication | 1 | |
Modified residuei | 115 | Phosphoserine1 Publication | 1 | |
Modified residuei | 119 | Phosphoserine1 Publication | 1 | |
Cross-linki | 137 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) | ||
Cross-linki | 146 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) | ||
Modified residuei | 203 | Phosphothreonine; by LATS21 Publication | 1 | |
Modified residuei | 246 | Phosphoserine; by PAK11 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
ADP-ribosylation, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | O95863 |
jPOSTi | O95863 |
MassIVEi | O95863 |
PaxDbi | O95863 |
PeptideAtlasi | O95863 |
PRIDEi | O95863 |
ProteomicsDBi | 51096 |
PTM databases
GlyGeni | O95863, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | O95863 |
PhosphoSitePlusi | O95863 |
SwissPalmi | O95863 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000124216, Expressed in left coronary artery and 138 other tissues |
Genevisiblei | O95863, HS |
Organism-specific databases
HPAi | ENSG00000124216, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with FBXL14 and GSK3B.
Interacts with BTRC; interaction occurs when it is phosphorylated on the destruction motif.
Interacts (via SNAG domain) with WTIP (via LIM domains) (By similarity).
Interacts (via SNAG domain) with LIMD1 (via LIM domains), and AJUBA (via LIM domains).
Interacts with LOXL2 and LOXL3.
Interacts (via N-terminal region) with CSNK2A1.
Interacts with EGR1 upon TPA induction.
Interacts (via N-terminal region) with LATS2; the interaction is dependent on LATS2 kinase activity but independent of SNAI1 Thr-203 phosphorylation.
Interacts (via zinc fingers) with KPNB1 and TNPO1; the interactions mediate nuclear import.
Interacts (via zinc fingers) with KPNA1; the interaction disrupts the transport complex with KPNB1 and prevents nuclear import increasing SNAI1 degradation in the cytoplasm.
Interacts (via zinc fingers) with KPNA2; the interaction, in combination with KPNB1, mediates nuclear import.
Interacts with KPNA4; this interaction mediates nuclear import. May interact (via zinc fingers) with IPO7.
Interacts (via zinc fingers) with PARP1; the interaction requires SNAI1 to be poly-ADP-ribosylated and non-phosphorylated (active) by GSK3B.
Interacts (via SNAG domain) with KDM1A (PubMed:20389281, PubMed:20562920, PubMed:21300290, PubMed:23721412). Interaction with KDM1A is necessary for the down-regulation of dimethylated H3K4 mark and promoter activity of E-cadherin/CDH1, CDN7 and KRT8 (PubMed:20389281, PubMed:20562920).
Interacts with TP53/p53 and (via zinc fingers) with NOTCH1 (via intracellular domain); the interactions induce SNAI1 degradation via MDM2-mediated ubiquitination and inhibit SNAI1-induced cell invasion.
Interacts with MDM2; the interaction promotes SNAI1 ubiquitination.
Interacts (via zinc fingers) with CSNK1E.
Interacts with PAK1 (PubMed:15833848).
By similarity20 PublicationsBinary interactionsi
O95863
GO - Molecular functioni
- kinase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 112499, 508 interactors |
CORUMi | O95863 |
DIPi | DIP-50870N |
IntActi | O95863, 70 interactors |
MINTi | O95863 |
STRINGi | 9606.ENSP00000244050 |
Miscellaneous databases
RNActi | O95863, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O95863 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O95863 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 27 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 1 – 20 | SNAG domain2 PublicationsAdd BLAST | 20 | |
Regioni | 2 – 7 | Required and sufficient for interaction with KDM1A2 Publications | 6 | |
Regioni | 10 – 40 | LATS2 bindingAdd BLAST | 31 | |
Regioni | 86 – 115 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 120 – 151 | Required for FBXL14-triggered degradationAdd BLAST | 32 | |
Regioni | 151 – 264 | Required for nuclear localization and interaction with KPNB1, NOTCH1 and PARP12 PublicationsAdd BLAST | 114 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 95 – 100 | Destruction motif | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 86 – 100 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 154 – 176 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 178 – 202 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 208 – 230 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 236 – 259 | C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG2462, Eukaryota |
GeneTreei | ENSGT00940000154681 |
HOGENOMi | CLU_002678_42_3_1 |
InParanoidi | O95863 |
OMAi | TRKAFNC |
OrthoDBi | 1318335at2759 |
PhylomeDBi | O95863 |
TreeFami | TF315515 |
Family and domain databases
IDEALi | IID00363 |
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MPRSFLVRKP SDPNRKPNYS ELQDSNPEFT FQQPYDQAHL LAAIPPPEIL
60 70 80 90 100
NPTASLPMLI WDSVLAPQAQ PIAWASLRLQ ESPRVAELTS LSDEDSGKGS
110 120 130 140 150
QPPSPPSPAP SSFSSTSVSS LEAEAYAAFP GLGQVPKQLA QLSEAKDLQA
160 170 180 190 200
RKAFNCKYCN KEYLSLGALK MHIRSHTLPC VCGTCGKAFS RPWLLQGHVR
210 220 230 240 250
THTGEKPFSC PHCSRAFADR SNLRAHLQTH SDVKKYQCQA CARTFSRMSL
260
LHKHQESGCS GCPR
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 46 | P → L in BAG36039 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 154 | F → S in AAF32527 (PubMed:10655587).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_069162 | 66 | A → V. Corresponds to variant dbSNP:rs34261470EnsemblClinVar. | 1 | |
Natural variantiVAR_019969 | 118 | V → A1 PublicationCorresponds to variant dbSNP:rs4647958Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF125377 mRNA Translation: AAD17332.1 AJ245657, AJ245658, AJ245659 Genomic DNA Translation: CAB52414.1 AF155233 Genomic DNA Translation: AAD52986.1 AF177731 Genomic DNA Translation: AAD52996.1 AK313228 mRNA Translation: BAG36039.1 AL121712 Genomic DNA No translation available. BC012910 mRNA Translation: AAH12910.1 AF131208 mRNA Translation: AAF32527.1 |
CCDSi | CCDS13423.1 |
RefSeqi | NP_005976.2, NM_005985.3 |
Genome annotation databases
Ensembli | ENST00000244050; ENSP00000244050; ENSG00000124216 |
GeneIDi | 6615 |
KEGGi | hsa:6615 |
MANE-Selecti | ENST00000244050.3; ENSP00000244050.2; NM_005985.4; NP_005976.2 |
UCSCi | uc002xuz.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF125377 mRNA Translation: AAD17332.1 AJ245657, AJ245658, AJ245659 Genomic DNA Translation: CAB52414.1 AF155233 Genomic DNA Translation: AAD52986.1 AF177731 Genomic DNA Translation: AAD52996.1 AK313228 mRNA Translation: BAG36039.1 AL121712 Genomic DNA No translation available. BC012910 mRNA Translation: AAH12910.1 AF131208 mRNA Translation: AAF32527.1 |
CCDSi | CCDS13423.1 |
RefSeqi | NP_005976.2, NM_005985.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2Y48 | X-ray | 3.00 | C | 2-21 | [»] | |
3W5K | X-ray | 2.60 | B | 1-264 | [»] | |
3ZMT | X-ray | 3.10 | C | 2-7 | [»] | |
4QLI | X-ray | 1.45 | B | 175-180 | [»] | |
SMRi | O95863 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112499, 508 interactors |
CORUMi | O95863 |
DIPi | DIP-50870N |
IntActi | O95863, 70 interactors |
MINTi | O95863 |
STRINGi | 9606.ENSP00000244050 |
PTM databases
GlyGeni | O95863, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | O95863 |
PhosphoSitePlusi | O95863 |
SwissPalmi | O95863 |
Genetic variation databases
BioMutai | SNAI1 |
Proteomic databases
EPDi | O95863 |
jPOSTi | O95863 |
MassIVEi | O95863 |
PaxDbi | O95863 |
PeptideAtlasi | O95863 |
PRIDEi | O95863 |
ProteomicsDBi | 51096 |
Protocols and materials databases
Antibodypediai | 3135, 900 antibodies from 46 providers |
CPTCi | O95863, 1 antibody |
DNASUi | 6615 |
Genome annotation databases
Ensembli | ENST00000244050; ENSP00000244050; ENSG00000124216 |
GeneIDi | 6615 |
KEGGi | hsa:6615 |
MANE-Selecti | ENST00000244050.3; ENSP00000244050.2; NM_005985.4; NP_005976.2 |
UCSCi | uc002xuz.4, human |
Organism-specific databases
CTDi | 6615 |
DisGeNETi | 6615 |
GeneCardsi | SNAI1 |
HGNCi | HGNC:11128, SNAI1 |
HPAi | ENSG00000124216, Low tissue specificity |
MIMi | 604238, gene |
neXtProti | NX_O95863 |
OpenTargetsi | ENSG00000124216 |
PharmGKBi | PA35977 |
VEuPathDBi | HostDB:ENSG00000124216 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2462, Eukaryota |
GeneTreei | ENSGT00940000154681 |
HOGENOMi | CLU_002678_42_3_1 |
InParanoidi | O95863 |
OMAi | TRKAFNC |
OrthoDBi | 1318335at2759 |
PhylomeDBi | O95863 |
TreeFami | TF315515 |
Enzyme and pathway databases
PathwayCommonsi | O95863 |
Reactomei | R-HSA-8943724, Regulation of PTEN gene transcription |
SignaLinki | O95863 |
SIGNORi | O95863 |
Miscellaneous databases
BioGRID-ORCSi | 6615, 18 hits in 1067 CRISPR screens |
EvolutionaryTracei | O95863 |
GeneWikii | SNAI1 |
GenomeRNAii | 6615 |
Pharosi | O95863, Tbio |
PROi | PR:O95863 |
RNActi | O95863, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000124216, Expressed in left coronary artery and 138 other tissues |
Genevisiblei | O95863, HS |
Family and domain databases
IDEALi | IID00363 |
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | SNAI1_HUMAN | |
Accessioni | O95863Primary (citable) accession number: O95863 Secondary accession number(s): B2R842 Q9UHH7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | December 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 209 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families