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Protein

Tetraspanin-15

Gene

TSPAN15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Promotes ADAM10-mediated cleavage of CDH2. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity.1 Publication

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

GO - Biological processi

  • cell surface receptor signaling pathway Source: GO_Central
  • protein localization to plasma membrane Source: UniProtKB
  • protein maturation Source: UniProtKB

Enzyme and pathway databases

SIGNORiO95858

Protein family/group databases

TCDBi8.A.40.1.17 the tetraspanin (tetraspanin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-15
Short name:
Tspan-15
Alternative name(s):
Tetraspan NET-7
Transmembrane 4 superfamily member 15
Gene namesi
Name:TSPAN15
Synonyms:NET7, TM4SF15
ORF Names:UNQ677/PRO1311
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000099282.9
HGNCiHGNC:23298 TSPAN15
MIMi613140 gene
neXtProtiNX_O95858

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23CytoplasmicSequence analysisAdd BLAST23
Transmembranei24 – 44HelicalSequence analysisAdd BLAST21
Topological domaini45 – 62ExtracellularSequence analysisAdd BLAST18
Transmembranei63 – 83HelicalSequence analysisAdd BLAST21
Topological domaini84 – 93CytoplasmicSequence analysis10
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Topological domaini115 – 235ExtracellularSequence analysisAdd BLAST121
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 294CytoplasmicSequence analysisAdd BLAST38

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23555
OpenTargetsiENSG00000099282
PharmGKBiPA128394634

Polymorphism and mutation databases

BioMutaiTSPAN15

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192631 – 294Tetraspanin-15Add BLAST294

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi189N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi230N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiO95858
MaxQBiO95858
PaxDbiO95858
PeptideAtlasiO95858
PRIDEiO95858
ProteomicsDBi51091

PTM databases

iPTMnetiO95858
PhosphoSitePlusiO95858
SwissPalmiO95858

Expressioni

Gene expression databases

BgeeiENSG00000099282 Expressed in 203 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_TSPAN15
ExpressionAtlasiO95858 baseline and differential
GenevisibleiO95858 HS

Organism-specific databases

HPAiHPA044657

Interactioni

Subunit structurei

Interacts with ADAM10; the interaction influences ADAM10 substrate specificity.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SYNE4Q8N2053EBI-7361096,EBI-7131783

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117099, 25 interactors
IntActiO95858, 5 interactors
MINTiO95858

Structurei

3D structure databases

ProteinModelPortaliO95858
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137851
HOGENOMiHOG000230655
HOVERGENiHBG106798
InParanoidiO95858
KOiK17297
OMAiYCARLSY
OrthoDBiEOG091G0CHZ
PhylomeDBiO95858
TreeFamiTF313002

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O95858-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRGDSEQVR YCARFSYLWL KFSLIIYSTV FWLIGALVLS VGIYAEVERQ
60 70 80 90 100
KYKTLESAFL APAIILILLG VVMFMVSFIG VLASLRDNLY LLQAFMYILG
110 120 130 140 150
ICLIMELIGG VVALTFRNQT IDFLNDNIRR GIENYYDDLD FKNIMDFVQK
160 170 180 190 200
KFKCCGGEDY RDWSKNQYHD CSAPGPLACG VPYTCCIRNT TEVVNTMCGY
210 220 230 240 250
KTIDKERFSV QDVIYVRGCT NAVIIWFMDN YTIMAGILLG ILLPQFLGVL
260 270 280 290
LTLLYITRVE DIIMEHSVTD GLLGPGAKPS VEAAGTGCCL CYPN
Length:294
Mass (Da):33,165
Last modified:May 1, 1999 - v1
Checksum:i71A6DC64D6CA6BAE
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C285H7C285_HUMAN
Tetraspanin-15
TSPAN15
160Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti236G → C in AAQ89293 (PubMed:12975309).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF120266 mRNA Translation: AAD17295.1
AY358934 mRNA Translation: AAQ89293.1
BC003157 mRNA Translation: AAH03157.1
BC004161 mRNA Translation: AAH04161.1
CCDSiCCDS7294.1
RefSeqiNP_036471.1, NM_012339.3
UniGeneiHs.499941

Genome annotation databases

EnsembliENST00000373290; ENSP00000362387; ENSG00000099282
GeneIDi23555
KEGGihsa:23555
UCSCiuc001jpo.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF120266 mRNA Translation: AAD17295.1
AY358934 mRNA Translation: AAQ89293.1
BC003157 mRNA Translation: AAH03157.1
BC004161 mRNA Translation: AAH04161.1
CCDSiCCDS7294.1
RefSeqiNP_036471.1, NM_012339.3
UniGeneiHs.499941

3D structure databases

ProteinModelPortaliO95858
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117099, 25 interactors
IntActiO95858, 5 interactors
MINTiO95858

Protein family/group databases

TCDBi8.A.40.1.17 the tetraspanin (tetraspanin) family

PTM databases

iPTMnetiO95858
PhosphoSitePlusiO95858
SwissPalmiO95858

Polymorphism and mutation databases

BioMutaiTSPAN15

Proteomic databases

EPDiO95858
MaxQBiO95858
PaxDbiO95858
PeptideAtlasiO95858
PRIDEiO95858
ProteomicsDBi51091

Protocols and materials databases

DNASUi23555
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373290; ENSP00000362387; ENSG00000099282
GeneIDi23555
KEGGihsa:23555
UCSCiuc001jpo.2 human

Organism-specific databases

CTDi23555
DisGeNETi23555
EuPathDBiHostDB:ENSG00000099282.9
GeneCardsiTSPAN15
HGNCiHGNC:23298 TSPAN15
HPAiHPA044657
MIMi613140 gene
neXtProtiNX_O95858
OpenTargetsiENSG00000099282
PharmGKBiPA128394634
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137851
HOGENOMiHOG000230655
HOVERGENiHBG106798
InParanoidiO95858
KOiK17297
OMAiYCARLSY
OrthoDBiEOG091G0CHZ
PhylomeDBiO95858
TreeFamiTF313002

Enzyme and pathway databases

SIGNORiO95858

Miscellaneous databases

ChiTaRSiTSPAN15 human
GenomeRNAii23555
PROiPR:O95858
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000099282 Expressed in 203 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_TSPAN15
ExpressionAtlasiO95858 baseline and differential
GenevisibleiO95858 HS

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTSN15_HUMAN
AccessioniPrimary (citable) accession number: O95858
Secondary accession number(s): Q6UW79
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: September 12, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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