UniProtKB - O95857 (TSN13_HUMAN)
Protein
Tetraspanin-13
Gene
TSPAN13
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- calcium channel regulator activity Source: Ensembl
GO - Biological processi
- regulation of calcium ion transmembrane transport Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | O95857 |
Names & Taxonomyi
Protein namesi | Recommended name: Tetraspanin-13Short name: Tspan-13 Alternative name(s): Tetraspan NET-6 Transmembrane 4 superfamily member 13 |
Gene namesi | Name:TSPAN13 Synonyms:NET6, TM4SF13 ORF Names:UNQ260/PRO296 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000106537.7 |
HGNCi | HGNC:21643, TSPAN13 |
MIMi | 613139, gene |
neXtProti | NX_O95857 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Other locations
- membrane Source: ProtInc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 19 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 20 – 40 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 41 – 44 | ExtracellularSequence analysis | 4 | |
Transmembranei | 45 – 65 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 66 – 72 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 73 – 93 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 94 – 167 | ExtracellularSequence analysisAdd BLAST | 74 | |
Transmembranei | 168 – 188 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 189 – 204 | CytoplasmicSequence analysisAdd BLAST | 16 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 27075 |
OpenTargetsi | ENSG00000106537 |
PharmGKBi | PA134868624 |
Miscellaneous databases
Pharosi | O95857, Tbio |
Polymorphism and mutation databases
BioMutai | TSPAN13 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000219258 | 1 – 204 | Tetraspanin-13Add BLAST | 204 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 113 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 137 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 143 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | O95857 |
jPOSTi | O95857 |
MassIVEi | O95857 |
PaxDbi | O95857 |
PeptideAtlasi | O95857 |
PRIDEi | O95857 |
ProteomicsDBi | 51090 |
PTM databases
GlyConnecti | 1798, 1 N-Linked glycan (1 site) |
GlyGeni | O95857, 4 sites |
iPTMneti | O95857 |
PhosphoSitePlusi | O95857 |
SwissPalmi | O95857 |
Expressioni
Gene expression databases
Bgeei | ENSG00000106537, Expressed in visceral pleura and 239 other tissues |
ExpressionAtlasi | O95857, baseline and differential |
Genevisiblei | O95857, HS |
Organism-specific databases
HPAi | ENSG00000106537, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 117984, 3 interactors |
STRINGi | 9606.ENSP00000262067 |
Miscellaneous databases
RNActi | O95857, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the tetraspanin (TM4SF) family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3882, Eukaryota |
GeneTreei | ENSGT00940000157010 |
HOGENOMi | CLU_088363_0_0_1 |
InParanoidi | O95857 |
OMAi | CPPCAPI |
OrthoDBi | 1203231at2759 |
PhylomeDBi | O95857 |
TreeFami | TF323367 |
Family and domain databases
InterProi | View protein in InterPro IPR000301, Tetraspanin IPR018499, Tetraspanin/Peripherin |
Pfami | View protein in Pfam PF00335, Tetraspanin, 1 hit |
PIRSFi | PIRSF002419, Tetraspanin, 1 hit |
PRINTSi | PR00259, TMFOUR |
i Sequence
Sequence statusi: Complete.
O95857-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVCGGFACSK NCLCALNLLY TLVSLLLIGI AAWGIGFGLI SSLRVVGVVI
60 70 80 90 100
AVGIFLFLIA LVGLIGAVKH HQVLLFFYMI ILLLVFIVQF SVSCACLALN
110 120 130 140 150
QEQQGQLLEV GWNNTASARN DIQRNLNCCG FRSVNPNDTC LASCVKSDHS
160 170 180 190 200
CSPCAPIIGE YAGEVLRFVG GIGLFFSFTE ILGVWLTYRY RNQKDPRANP
SAFL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF120265 mRNA Translation: AAD17294.1 AF100759 mRNA Translation: AAD43023.1 AY358995 mRNA Translation: AAQ89354.1 BC033863 mRNA Translation: AAH33863.1 |
CCDSi | CCDS5363.1 |
RefSeqi | NP_055214.1, NM_014399.3 |
Genome annotation databases
Ensembli | ENST00000262067; ENSP00000262067; ENSG00000106537 |
GeneIDi | 27075 |
KEGGi | hsa:27075 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF120265 mRNA Translation: AAD17294.1 AF100759 mRNA Translation: AAD43023.1 AY358995 mRNA Translation: AAQ89354.1 BC033863 mRNA Translation: AAH33863.1 |
CCDSi | CCDS5363.1 |
RefSeqi | NP_055214.1, NM_014399.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 117984, 3 interactors |
STRINGi | 9606.ENSP00000262067 |
PTM databases
GlyConnecti | 1798, 1 N-Linked glycan (1 site) |
GlyGeni | O95857, 4 sites |
iPTMneti | O95857 |
PhosphoSitePlusi | O95857 |
SwissPalmi | O95857 |
Polymorphism and mutation databases
BioMutai | TSPAN13 |
Proteomic databases
EPDi | O95857 |
jPOSTi | O95857 |
MassIVEi | O95857 |
PaxDbi | O95857 |
PeptideAtlasi | O95857 |
PRIDEi | O95857 |
ProteomicsDBi | 51090 |
Protocols and materials databases
Antibodypediai | 25268, 100 antibodies |
DNASUi | 27075 |
Genome annotation databases
Ensembli | ENST00000262067; ENSP00000262067; ENSG00000106537 |
GeneIDi | 27075 |
KEGGi | hsa:27075 |
Organism-specific databases
CTDi | 27075 |
DisGeNETi | 27075 |
EuPathDBi | HostDB:ENSG00000106537.7 |
GeneCardsi | TSPAN13 |
HGNCi | HGNC:21643, TSPAN13 |
HPAi | ENSG00000106537, Low tissue specificity |
MIMi | 613139, gene |
neXtProti | NX_O95857 |
OpenTargetsi | ENSG00000106537 |
PharmGKBi | PA134868624 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3882, Eukaryota |
GeneTreei | ENSGT00940000157010 |
HOGENOMi | CLU_088363_0_0_1 |
InParanoidi | O95857 |
OMAi | CPPCAPI |
OrthoDBi | 1203231at2759 |
PhylomeDBi | O95857 |
TreeFami | TF323367 |
Enzyme and pathway databases
PathwayCommonsi | O95857 |
Miscellaneous databases
BioGRID-ORCSi | 27075, 7 hits in 846 CRISPR screens |
ChiTaRSi | TSPAN13, human |
GeneWikii | TSPAN13 |
GenomeRNAii | 27075 |
Pharosi | O95857, Tbio |
PROi | PR:O95857 |
RNActi | O95857, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000106537, Expressed in visceral pleura and 239 other tissues |
ExpressionAtlasi | O95857, baseline and differential |
Genevisiblei | O95857, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000301, Tetraspanin IPR018499, Tetraspanin/Peripherin |
Pfami | View protein in Pfam PF00335, Tetraspanin, 1 hit |
PIRSFi | PIRSF002419, Tetraspanin, 1 hit |
PRINTSi | PR00259, TMFOUR |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TSN13_HUMAN | |
Accessioni | O95857Primary (citable) accession number: O95857 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families