TSPAN13

Functionⁱ

GO - Molecular functionⁱ

calcium channel regulator activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell surface receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of calcium ion transmembrane transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tetraspanin-13 Short name: Tspan-13 Alternative name(s): Tetraspan NET-6 Transmembrane 4 superfamily member 13
Gene namesⁱ	Name:TSPAN13 Synonyms:NET6, TM4SF13 ORF Names:UNQ260/PRO296
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000106537.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21643 TSPAN13
MIMⁱ	613139 gene
neXtProtⁱ	NX_O95857

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 19	CytoplasmicSequence analysisAdd BLAST	19
Transmembraneⁱ	20 – 40	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	41 – 44	ExtracellularSequence analysis	4
Transmembraneⁱ	45 – 65	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	66 – 72	CytoplasmicSequence analysis	7
Transmembraneⁱ	73 – 93	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	94 – 167	ExtracellularSequence analysisAdd BLAST	74
Transmembraneⁱ	168 – 188	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	189 – 204	CytoplasmicSequence analysisAdd BLAST	16

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	27075
Open Targets More...OpenTargetsⁱ	ENSG00000106537
PharmGKBⁱ	PA134868624

Polymorphism and mutation databases

BioMutaⁱ	TSPAN13

BioMutaⁱ

TSPAN13

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000219258	1 – 204	Tetraspanin-13Add BLAST		204

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	113	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	137	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	143	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	O95857
PaxDbⁱ	O95857
PeptideAtlas More...PeptideAtlasⁱ	O95857
PRIDEⁱ	O95857
ProteomicsDBⁱ	51090

PTM databases

GlyConnectⁱ	1798
iPTMnetⁱ	O95857
PhosphoSitePlusⁱ	O95857
SwissPalmⁱ	O95857

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000106537 Expressed in 228 organ(s), highest expression level in visceral pleura
CleanExⁱ	HS_TSPAN13
ExpressionAtlasⁱ	O95857 baseline and differential
Genevisibleⁱ	O95857 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA007426

HPAⁱ

HPA007426

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	117984, 3 interactors
STRINGⁱ	9606.ENSP00000262067

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O95857
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3882 Eukaryota ENOG4111IRY LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00500000044851
HOGENOMⁱ	HOG000005650
HOVERGENⁱ	HBG009195
InParanoidⁱ	O95857
KEGG Orthology (KO) More...KOⁱ	K17356
OMAⁱ	TEFVGVW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0PBF
PhylomeDBⁱ	O95857
TreeFamⁱ	TF323367

Family and domain databases

InterProⁱ	View protein in InterPro IPR000301 Tetraspanin IPR018499 Tetraspanin/Peripherin
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00335 Tetraspannin, 1 hit
PIRSFⁱ	PIRSF002419 Tetraspanin, 1 hit
PRINTSⁱ	PR00259 TMFOUR

Sequenceⁱ

Sequence statusⁱ: Complete.

O95857-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVCGGFACSK NCLCALNLLY TLVSLLLIGI AAWGIGFGLI SSLRVVGVVI 
        60         70         80         90        100
AVGIFLFLIA LVGLIGAVKH HQVLLFFYMI ILLLVFIVQF SVSCACLALN 
       110        120        130        140        150
QEQQGQLLEV GWNNTASARN DIQRNLNCCG FRSVNPNDTC LASCVKSDHS 
       160        170        180        190        200
CSPCAPIIGE YAGEVLRFVG GIGLFFSFTE ILGVWLTYRY RNQKDPRANP 

SAFL

Length:204

Mass (Da):22,147

Last modified:May 1, 1999 - v1

Checksum:ⁱ5928646BCD83C0D6

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF120265 mRNA Translation: AAD17294.1 AF100759 mRNA Translation: AAD43023.1 AY358995 mRNA Translation: AAQ89354.1 BC033863 mRNA Translation: AAH33863.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5363.1
NCBI Reference Sequences More...RefSeqⁱ	NP_055214.1, NM_014399.3
UniGeneⁱ	Hs.364544

Genome annotation databases

Ensemblⁱ	ENST00000262067; ENSP00000262067; ENSG00000106537
GeneIDⁱ	27075
KEGGⁱ	hsa:27075

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O95857	TM4SF13 protein		HUMAN		204	UniRef100_O95857
TSPAN13 isoform 1		PANTR		204
Uncharacterized protein		PANPA		204
Tetraspanin 13		GORGO		204

Protein	Similar proteins		Species	Score	Length	Source
O95857	Tetraspanin-13		MOUSE		204	UniRef90_Q9D8C2
Tetraspanin-13		BOVIN		204
Tetraspanin-13		RAT		204
Tetraspanin 13 (Fragment)		MUSPF		255
Tetraspanin 13		CANLF		254
+83

Protein	Similar proteins		Species	Score	Length	Source
O95857	Tetraspanin-13		MOUSE		204	UniRef50_Q9D8C2
Tetraspanin-13		RAT		204
Tetraspanin-13		BOVIN		204
Tetraspanin-31-B		XENLA		212
Tetraspanin-31		DANRE		212
+250

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF120265 mRNA Translation: AAD17294.1 AF100759 mRNA Translation: AAD43023.1 AY358995 mRNA Translation: AAQ89354.1 BC033863 mRNA Translation: AAH33863.1
CCDSⁱ	CCDS5363.1
RefSeqⁱ	NP_055214.1, NM_014399.3
UniGeneⁱ	Hs.364544

3D structure databases

ProteinModelPortalⁱ	O95857
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117984, 3 interactors
STRINGⁱ	9606.ENSP00000262067

PTM databases

GlyConnectⁱ	1798
iPTMnetⁱ	O95857
PhosphoSitePlusⁱ	O95857
SwissPalmⁱ	O95857

Polymorphism and mutation databases

BioMutaⁱ	TSPAN13

BioMutaⁱ

TSPAN13

Proteomic databases

EPDⁱ	O95857
PaxDbⁱ	O95857
PeptideAtlasⁱ	O95857
PRIDEⁱ	O95857
ProteomicsDBⁱ	51090

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	27075
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000262067; ENSP00000262067; ENSG00000106537
GeneIDⁱ	27075
KEGGⁱ	hsa:27075

Organism-specific databases

CTDⁱ	27075
DisGeNETⁱ	27075
EuPathDBⁱ	HostDB:ENSG00000106537.7
GeneCardsⁱ	TSPAN13
HGNCⁱ	HGNC:21643 TSPAN13
HPAⁱ	HPA007426
MIMⁱ	613139 gene
neXtProtⁱ	NX_O95857
OpenTargetsⁱ	ENSG00000106537
PharmGKBⁱ	PA134868624
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3882 Eukaryota ENOG4111IRY LUCA
GeneTreeⁱ	ENSGT00500000044851
HOGENOMⁱ	HOG000005650
HOVERGENⁱ	HBG009195
InParanoidⁱ	O95857
KOⁱ	K17356
OMAⁱ	TEFVGVW
OrthoDBⁱ	EOG091G0PBF
PhylomeDBⁱ	O95857
TreeFamⁱ	TF323367

Miscellaneous databases

ChiTaRSⁱ	TSPAN13 human
GeneWikiⁱ	TSPAN13
GenomeRNAiⁱ	27075
Protein Ontology More...PROⁱ	PR:O95857
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000106537 Expressed in 228 organ(s), highest expression level in visceral pleura
CleanExⁱ	HS_TSPAN13
ExpressionAtlasⁱ	O95857 baseline and differential
Genevisibleⁱ	O95857 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000301 Tetraspanin IPR018499 Tetraspanin/Peripherin
Pfamⁱ	View protein in Pfam PF00335 Tetraspannin, 1 hit
PIRSFⁱ	PIRSF002419 Tetraspanin, 1 hit
PRINTSⁱ	PR00259 TMFOUR
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TSN13_HUMAN
Accessionⁱ	O95857Primary (citable) accession number: O95857
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	May 1, 1999
	Last modified:	November 7, 2018
	This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

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Annotation systems

Supporting data

UniProtKB - O95857 (TSN13_HUMAN)

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Tetraspanin-13

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ