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Protein

Tetraspanin-13

Gene

TSPAN13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • calcium channel regulator activity Source: GO_Central

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-13
Short name:
Tspan-13
Alternative name(s):
Tetraspan NET-6
Transmembrane 4 superfamily member 13
Gene namesi
Name:TSPAN13
Synonyms:NET6, TM4SF13
ORF Names:UNQ260/PRO296
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000106537.7
HGNCiHGNC:21643 TSPAN13
MIMi613139 gene
neXtProtiNX_O95857

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Topological domaini41 – 44ExtracellularSequence analysis4
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Topological domaini66 – 72CytoplasmicSequence analysis7
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Topological domaini94 – 167ExtracellularSequence analysisAdd BLAST74
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Topological domaini189 – 204CytoplasmicSequence analysisAdd BLAST16

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi27075
OpenTargetsiENSG00000106537
PharmGKBiPA134868624

Polymorphism and mutation databases

BioMutaiTSPAN13

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192581 – 204Tetraspanin-13Add BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi113N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi137N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei143PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO95857
PaxDbiO95857
PeptideAtlasiO95857
PRIDEiO95857
ProteomicsDBi51090

PTM databases

GlyConnecti1798
iPTMnetiO95857
PhosphoSitePlusiO95857
SwissPalmiO95857

Expressioni

Gene expression databases

BgeeiENSG00000106537 Expressed in 228 organ(s), highest expression level in visceral pleura
CleanExiHS_TSPAN13
ExpressionAtlasiO95857 baseline and differential
GenevisibleiO95857 HS

Organism-specific databases

HPAiHPA007426

Interactioni

Protein-protein interaction databases

BioGridi117984, 3 interactors
STRINGi9606.ENSP00000262067

Structurei

3D structure databases

ProteinModelPortaliO95857
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00500000044851
HOGENOMiHOG000005650
HOVERGENiHBG009195
InParanoidiO95857
KOiK17356
OMAiTEFVGVW
OrthoDBiEOG091G0PBF
PhylomeDBiO95857
TreeFamiTF323367

Family and domain databases

InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR

Sequencei

Sequence statusi: Complete.

O95857-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVCGGFACSK NCLCALNLLY TLVSLLLIGI AAWGIGFGLI SSLRVVGVVI
60 70 80 90 100
AVGIFLFLIA LVGLIGAVKH HQVLLFFYMI ILLLVFIVQF SVSCACLALN
110 120 130 140 150
QEQQGQLLEV GWNNTASARN DIQRNLNCCG FRSVNPNDTC LASCVKSDHS
160 170 180 190 200
CSPCAPIIGE YAGEVLRFVG GIGLFFSFTE ILGVWLTYRY RNQKDPRANP

SAFL
Length:204
Mass (Da):22,147
Last modified:May 1, 1999 - v1
Checksum:i5928646BCD83C0D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF120265 mRNA Translation: AAD17294.1
AF100759 mRNA Translation: AAD43023.1
AY358995 mRNA Translation: AAQ89354.1
BC033863 mRNA Translation: AAH33863.1
CCDSiCCDS5363.1
RefSeqiNP_055214.1, NM_014399.3
UniGeneiHs.364544

Genome annotation databases

EnsembliENST00000262067; ENSP00000262067; ENSG00000106537
GeneIDi27075
KEGGihsa:27075

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF120265 mRNA Translation: AAD17294.1
AF100759 mRNA Translation: AAD43023.1
AY358995 mRNA Translation: AAQ89354.1
BC033863 mRNA Translation: AAH33863.1
CCDSiCCDS5363.1
RefSeqiNP_055214.1, NM_014399.3
UniGeneiHs.364544

3D structure databases

ProteinModelPortaliO95857
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117984, 3 interactors
STRINGi9606.ENSP00000262067

PTM databases

GlyConnecti1798
iPTMnetiO95857
PhosphoSitePlusiO95857
SwissPalmiO95857

Polymorphism and mutation databases

BioMutaiTSPAN13

Proteomic databases

EPDiO95857
PaxDbiO95857
PeptideAtlasiO95857
PRIDEiO95857
ProteomicsDBi51090

Protocols and materials databases

DNASUi27075
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262067; ENSP00000262067; ENSG00000106537
GeneIDi27075
KEGGihsa:27075

Organism-specific databases

CTDi27075
DisGeNETi27075
EuPathDBiHostDB:ENSG00000106537.7
GeneCardsiTSPAN13
HGNCiHGNC:21643 TSPAN13
HPAiHPA007426
MIMi613139 gene
neXtProtiNX_O95857
OpenTargetsiENSG00000106537
PharmGKBiPA134868624
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00500000044851
HOGENOMiHOG000005650
HOVERGENiHBG009195
InParanoidiO95857
KOiK17356
OMAiTEFVGVW
OrthoDBiEOG091G0PBF
PhylomeDBiO95857
TreeFamiTF323367

Miscellaneous databases

ChiTaRSiTSPAN13 human
GeneWikiiTSPAN13
GenomeRNAii27075
PROiPR:O95857
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106537 Expressed in 228 organ(s), highest expression level in visceral pleura
CleanExiHS_TSPAN13
ExpressionAtlasiO95857 baseline and differential
GenevisibleiO95857 HS

Family and domain databases

InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
ProtoNetiSearch...

Entry informationi

Entry nameiTSN13_HUMAN
AccessioniPrimary (citable) accession number: O95857
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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