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UniProtKB - O95848 (NUD14_HUMAN)
Protein
Uridine diphosphate glucose pyrophosphatase NUDT14
Gene
NUDT14
Organism
Homo sapiens (Human)
Status
Functioni
Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose.
Catalytic activityi
- UDP-sugar + H(2)O = UMP + alpha-D-aldose 1-phosphate. EC:3.6.1.45
Cofactori
pH dependencei
Optimum pH is 8.0-9.5.
GO - Molecular functioni
- ADP-ribose diphosphatase activity Source: Ensembl
- identical protein binding Source: IntAct
- metal ion binding Source: InterPro
- UDP-sugar diphosphatase activity Source: GO_Central
GO - Biological processi
- nucleoside phosphate metabolic process Source: GO_Central
- protein N-linked glycosylation via asparagine Source: Reactome
- ribose phosphate metabolic process Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Ligand | Magnesium |
Enzyme and pathway databases
BRENDAi | 3.6.1.45, 2681 |
PathwayCommonsi | O95848 |
Reactomei | R-HSA-480985, Synthesis of dolichyl-phosphate-glucose |
SignaLinki | O95848 |
Names & Taxonomyi
Protein namesi | Recommended name: Uridine diphosphate glucose pyrophosphatase NUDT14 (EC:3.6.1.45)Short name: UDPG pyrophosphatase Short name: UGPPase Alternative name(s): Nucleoside diphosphate-linked moiety X motif 14 Short name: Nudix motif 14 |
Gene namesi | Name:NUDT14 Synonyms:UGPP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20141, NUDT14 |
MIMi | 609219, gene |
neXtProti | NX_O95848 |
VEuPathDBi | HostDB:ENSG00000183828 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cytosol
- cytosol Source: Reactome
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000183828 |
PharmGKBi | PA134971372 |
Miscellaneous databases
Pharosi | O95848, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4105943 |
Genetic variation databases
BioMutai | NUDT14 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000057113 | 1 – 222 | Uridine diphosphate glucose pyrophosphatase NUDT14Add BLAST | 222 |
Proteomic databases
EPDi | O95848 |
jPOSTi | O95848 |
MassIVEi | O95848 |
MaxQBi | O95848 |
PaxDbi | O95848 |
PeptideAtlasi | O95848 |
PRIDEi | O95848 |
ProteomicsDBi | 51089 |
PTM databases
iPTMneti | O95848 |
PhosphoSitePlusi | O95848 |
Expressioni
Gene expression databases
Bgeei | ENSG00000183828, Expressed in muscle tissue and 189 other tissues |
ExpressionAtlasi | O95848, baseline and differential |
Genevisiblei | O95848, HS |
Organism-specific databases
HPAi | ENSG00000183828, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer.
1 PublicationBinary interactionsi
O95848
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 129152, 19 interactors |
IntActi | O95848, 12 interactors |
STRINGi | 9606.ENSP00000376349 |
Chemistry databases
BindingDBi | O95848 |
Miscellaneous databases
RNActi | O95848, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | O95848 |
SMRi | O95848 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O95848 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 38 – 206 | Nudix hydrolasePROSITE-ProRule annotationAdd BLAST | 169 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 111 – 129 | Nudix boxAdd BLAST | 19 |
Sequence similaritiesi
Belongs to the Nudix hydrolase family.Curated
Phylogenomic databases
eggNOGi | KOG4432, Eukaryota |
GeneTreei | ENSGT00940000154045 |
HOGENOMi | CLU_062658_1_0_1 |
InParanoidi | O95848 |
OMAi | YTYELCA |
OrthoDBi | 1164318at2759 |
PhylomeDBi | O95848 |
TreeFami | TF313661 |
Family and domain databases
InterProi | View protein in InterPro IPR004385, NDP_pyrophosphatase IPR015797, NUDIX_hydrolase-like_dom_sf IPR000086, NUDIX_hydrolase_dom |
Pfami | View protein in Pfam PF00293, NUDIX, 1 hit |
SUPFAMi | SSF55811, SSF55811, 1 hit |
TIGRFAMsi | TIGR00052, TIGR00052, 1 hit |
PROSITEi | View protein in PROSITE PS51462, NUDIX, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
O95848-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MERIEGASVG RCAASPYLRP LTLHYRQNGA QKSWDFMKTH DSVTVLLFNS
60 70 80 90 100
SRRSLVLVKQ FRPAVYAGEV ERRFPGSLAA VDQDGPRELQ PALPGSAGVT
110 120 130 140 150
VELCAGLVDQ PGLSLEEVAC KEAWEECGYH LAPSDLRRVA TYWSGVGLTG
160 170 180 190 200
SRQTMFYTEV TDAQRSGPGG GLVEEGELIE VVHLPLEGAQ AFADDPDIPK
210 220
TLGVIFGVSW FLSQVAPNLD LQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF8VU44 | F8VU44_HUMAN | Uridine diphosphate glucose pyropho... | NUDT14 | 96 | Annotation score: |
Sequence cautioni
The sequence AAD15563 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF111170 Genomic DNA Translation: AAD15563.1 Different initiation. AB087802 mRNA Translation: BAC65455.1 AL512355 Genomic DNA No translation available. BC041584 mRNA Translation: AAH41584.1 |
CCDSi | CCDS10000.1 |
RefSeqi | NP_803877.2, NM_177533.4 |
Genome annotation databases
Ensembli | ENST00000392568.7; ENSP00000376349.2; ENSG00000183828.15 |
GeneIDi | 256281 |
KEGGi | hsa:256281 |
MANE-Selecti | ENST00000392568.7; ENSP00000376349.2; NM_177533.5; NP_803877.2 |
UCSCi | uc010tyn.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF111170 Genomic DNA Translation: AAD15563.1 Different initiation. AB087802 mRNA Translation: BAC65455.1 AL512355 Genomic DNA No translation available. BC041584 mRNA Translation: AAH41584.1 |
CCDSi | CCDS10000.1 |
RefSeqi | NP_803877.2, NM_177533.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3Q91 | X-ray | 2.70 | A/B/C/D | 28-222 | [»] | |
AlphaFoldDBi | O95848 | |||||
SMRi | O95848 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 129152, 19 interactors |
IntActi | O95848, 12 interactors |
STRINGi | 9606.ENSP00000376349 |
Chemistry databases
BindingDBi | O95848 |
ChEMBLi | CHEMBL4105943 |
PTM databases
iPTMneti | O95848 |
PhosphoSitePlusi | O95848 |
Genetic variation databases
BioMutai | NUDT14 |
Proteomic databases
EPDi | O95848 |
jPOSTi | O95848 |
MassIVEi | O95848 |
MaxQBi | O95848 |
PaxDbi | O95848 |
PeptideAtlasi | O95848 |
PRIDEi | O95848 |
ProteomicsDBi | 51089 |
Protocols and materials databases
Antibodypediai | 49103, 73 antibodies from 17 providers |
DNASUi | 256281 |
Genome annotation databases
Ensembli | ENST00000392568.7; ENSP00000376349.2; ENSG00000183828.15 |
GeneIDi | 256281 |
KEGGi | hsa:256281 |
MANE-Selecti | ENST00000392568.7; ENSP00000376349.2; NM_177533.5; NP_803877.2 |
UCSCi | uc010tyn.4, human |
Organism-specific databases
CTDi | 256281 |
GeneCardsi | NUDT14 |
HGNCi | HGNC:20141, NUDT14 |
HPAi | ENSG00000183828, Low tissue specificity |
MIMi | 609219, gene |
neXtProti | NX_O95848 |
OpenTargetsi | ENSG00000183828 |
PharmGKBi | PA134971372 |
VEuPathDBi | HostDB:ENSG00000183828 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4432, Eukaryota |
GeneTreei | ENSGT00940000154045 |
HOGENOMi | CLU_062658_1_0_1 |
InParanoidi | O95848 |
OMAi | YTYELCA |
OrthoDBi | 1164318at2759 |
PhylomeDBi | O95848 |
TreeFami | TF313661 |
Enzyme and pathway databases
BRENDAi | 3.6.1.45, 2681 |
PathwayCommonsi | O95848 |
Reactomei | R-HSA-480985, Synthesis of dolichyl-phosphate-glucose |
SignaLinki | O95848 |
Miscellaneous databases
BioGRID-ORCSi | 256281, 10 hits in 1072 CRISPR screens |
EvolutionaryTracei | O95848 |
GenomeRNAii | 256281 |
Pharosi | O95848, Tbio |
PROi | PR:O95848 |
RNActi | O95848, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000183828, Expressed in muscle tissue and 189 other tissues |
ExpressionAtlasi | O95848, baseline and differential |
Genevisiblei | O95848, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004385, NDP_pyrophosphatase IPR015797, NUDIX_hydrolase-like_dom_sf IPR000086, NUDIX_hydrolase_dom |
Pfami | View protein in Pfam PF00293, NUDIX, 1 hit |
SUPFAMi | SSF55811, SSF55811, 1 hit |
TIGRFAMsi | TIGR00052, TIGR00052, 1 hit |
PROSITEi | View protein in PROSITE PS51462, NUDIX, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NUD14_HUMAN | |
Accessioni | O95848Primary (citable) accession number: O95848 Secondary accession number(s): Q86SJ8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 2004 |
Last sequence update: | March 1, 2004 | |
Last modified: | May 25, 2022 | |
This is version 163 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families