UniProtKB - O95847 (UCP4_HUMAN)
Protein
Mitochondrial uncoupling protein 4
Gene
SLC25A27
Organism
Homo sapiens (Human)
Status
Functioni
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. May play a role in thermoregulatory heat production and metabolism in brain.
GO - Biological processi
- cellular triglyceride homeostasis Source: Ensembl
- inner ear development Source: Ensembl
- negative regulation of apoptotic process Source: Ensembl
- negative regulation of mitochondrial calcium ion concentration Source: Ensembl
- negative regulation of mitochondrial membrane potential Source: Ensembl
- neuron death Source: Ensembl
- positive regulation of cell population proliferation Source: Ensembl
- proton transmembrane transport Source: Reactome
- regulation of glucose import Source: Ensembl
- response to cold Source: GO_Central
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
PathwayCommonsi | O95847 |
Reactomei | R-HSA-167826, The fatty acid cycling model R-HSA-167827, The proton buffering model |
Protein family/group databases
TCDBi | 2.A.29.24.3, the mitochondrial carrier (mc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Mitochondrial uncoupling protein 4Short name: UCP 4 Alternative name(s): Solute carrier family 25 member 27 |
Gene namesi | Name:SLC25A27 Synonyms:UCP4 ORF Names:UNQ772/PRO1566 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000153291.15 |
HGNCi | HGNC:21065, SLC25A27 |
MIMi | 613725, gene |
neXtProti | NX_O95847 |
Subcellular locationi
Mitochondrion
Mitochondrion
- mitochondrial inner membrane Source: Reactome
- mitochondrial membrane Source: GO_Central
- mitochondrion Source: GO_Central
Other locations
- apical part of cell Source: Ensembl
- integral component of membrane Source: UniProtKB-KW
- neuronal cell body Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 23 – 40 | Helical; Name=1Sequence analysisAdd BLAST | 18 | |
Transmembranei | 88 – 109 | Helical; Name=2Sequence analysisAdd BLAST | 22 | |
Transmembranei | 127 – 144 | Helical; Name=3Sequence analysisAdd BLAST | 18 | |
Transmembranei | 195 – 212 | Helical; Name=4Sequence analysisAdd BLAST | 18 | |
Transmembranei | 229 – 248 | Helical; Name=5Sequence analysisAdd BLAST | 20 | |
Transmembranei | 288 – 311 | Helical; Name=6Sequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePathology & Biotechi
Organism-specific databases
DisGeNETi | 9481 |
OpenTargetsi | ENSG00000153291 |
PharmGKBi | PA134970102 |
Miscellaneous databases
Pharosi | O95847, Tbio |
Polymorphism and mutation databases
BioMutai | SLC25A27 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000090676 | 1 – 323 | Mitochondrial uncoupling protein 4Add BLAST | 323 |
Proteomic databases
jPOSTi | O95847 |
MassIVEi | O95847 |
PaxDbi | O95847 |
PeptideAtlasi | O95847 |
PRIDEi | O95847 |
ProteomicsDBi | 24193 51088 [O95847-1] |
PTM databases
iPTMneti | O95847 |
PhosphoSitePlusi | O95847 |
Expressioni
Tissue specificityi
Found in adult and fetal brain. Present in most of the brain tissues, with low levels in spinal chord, corpus callosum and substantia nigra.
Gene expression databases
Bgeei | ENSG00000153291, Expressed in esophagus and 198 other tissues |
ExpressionAtlasi | O95847, baseline and differential |
Genevisiblei | O95847, HS |
Organism-specific databases
HPAi | ENSG00000153291, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 114866, 1 interactor |
IntActi | O95847, 2 interactors |
STRINGi | 9606.ENSP00000360398 |
Miscellaneous databases
RNActi | O95847, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 21 – 115 | Solcar 1Add BLAST | 95 | |
Repeati | 125 – 217 | Solcar 2Add BLAST | 93 | |
Repeati | 226 – 317 | Solcar 3Add BLAST | 92 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 5 – 8 | Poly-Glu | 4 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0753, Eukaryota |
GeneTreei | ENSGT00940000160098 |
HOGENOMi | CLU_015166_14_2_1 |
InParanoidi | O95847 |
OMAi | QMPDCHT |
OrthoDBi | 1013743at2759 |
PhylomeDBi | O95847 |
TreeFami | TF354328 |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O95847-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSVPEEEERL LPLTQRWPRA SKFLLSGCAA TVAELATFPL DLTKTRLQMQ
60 70 80 90 100
GEAALARLGD GARESAPYRG MVRTALGIIE EEGFLKLWQG VTPAIYRHVV
110 120 130 140 150
YSGGRMVTYE HLREVVFGKS EDEHYPLWKS VIGGMMAGVI GQFLANPTDL
160 170 180 190 200
VKVQMQMEGK RKLEGKPLRF RGVHHAFAKI LAEGGIRGLW AGWVPNIQRA
210 220 230 240 250
ALVNMGDLTT YDTVKHYLVL NTPLEDNIMT HGLSSLCSGL VASILGTPAD
260 270 280 290 300
VIKSRIMNQP RDKQGRGLLY KSSTDCLIQA VQGEGFMSLY KGFLPSWLRM
310 320
TPWSMVFWLT YEKIREMSGV SPF
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5VTS8 | Q5VTS8_HUMAN | Mitochondrial uncoupling protein 4 | SLC25A27 | 149 | Annotation score: | ||
S4R300 | S4R300_HUMAN | Mitochondrial uncoupling protein 4 | SLC25A27 | 98 | Annotation score: | ||
S4R3J2 | S4R3J2_HUMAN | Mitochondrial uncoupling protein 4 | SLC25A27 | 145 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_069101 | 145 | A → V1 PublicationCorresponds to variant dbSNP:rs17853162Ensembl. | 1 | |
Natural variantiVAR_050137 | 197 | I → T. Corresponds to variant dbSNP:rs35884480Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045916 | 236 – 323 | LCSGL…GVSPF → DLVGSHKAIQ in isoform 2. 1 PublicationAdd BLAST | 88 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF110532 mRNA Translation: AAD16995.1 AY358711 mRNA Translation: AAQ89951.1 AK291427 mRNA Translation: BAF84116.1 AL591242 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX04299.1 BC033091 mRNA Translation: AAH33091.1 |
CCDSi | CCDS43470.1 [O95847-1] CCDS56431.1 [O95847-2] |
RefSeqi | NP_001190980.1, NM_001204051.1 NP_001190981.1, NM_001204052.1 [O95847-2] NP_004268.3, NM_004277.4 [O95847-1] |
Genome annotation databases
Ensembli | ENST00000371347; ENSP00000360398; ENSG00000153291 [O95847-1] ENST00000411689; ENSP00000412024; ENSG00000153291 [O95847-2] |
GeneIDi | 9481 |
KEGGi | hsa:9481 |
UCSCi | uc003oyg.3, human [O95847-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF110532 mRNA Translation: AAD16995.1 AY358711 mRNA Translation: AAQ89951.1 AK291427 mRNA Translation: BAF84116.1 AL591242 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX04299.1 BC033091 mRNA Translation: AAH33091.1 |
CCDSi | CCDS43470.1 [O95847-1] CCDS56431.1 [O95847-2] |
RefSeqi | NP_001190980.1, NM_001204051.1 NP_001190981.1, NM_001204052.1 [O95847-2] NP_004268.3, NM_004277.4 [O95847-1] |
3D structure databases
SMRi | O95847 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114866, 1 interactor |
IntActi | O95847, 2 interactors |
STRINGi | 9606.ENSP00000360398 |
Protein family/group databases
TCDBi | 2.A.29.24.3, the mitochondrial carrier (mc) family |
PTM databases
iPTMneti | O95847 |
PhosphoSitePlusi | O95847 |
Polymorphism and mutation databases
BioMutai | SLC25A27 |
Proteomic databases
jPOSTi | O95847 |
MassIVEi | O95847 |
PaxDbi | O95847 |
PeptideAtlasi | O95847 |
PRIDEi | O95847 |
ProteomicsDBi | 24193 51088 [O95847-1] |
Protocols and materials databases
Antibodypediai | 4016, 80 antibodies |
DNASUi | 9481 |
Genome annotation databases
Ensembli | ENST00000371347; ENSP00000360398; ENSG00000153291 [O95847-1] ENST00000411689; ENSP00000412024; ENSG00000153291 [O95847-2] |
GeneIDi | 9481 |
KEGGi | hsa:9481 |
UCSCi | uc003oyg.3, human [O95847-1] |
Organism-specific databases
CTDi | 9481 |
DisGeNETi | 9481 |
EuPathDBi | HostDB:ENSG00000153291.15 |
GeneCardsi | SLC25A27 |
HGNCi | HGNC:21065, SLC25A27 |
HPAi | ENSG00000153291, Low tissue specificity |
MIMi | 613725, gene |
neXtProti | NX_O95847 |
OpenTargetsi | ENSG00000153291 |
PharmGKBi | PA134970102 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0753, Eukaryota |
GeneTreei | ENSGT00940000160098 |
HOGENOMi | CLU_015166_14_2_1 |
InParanoidi | O95847 |
OMAi | QMPDCHT |
OrthoDBi | 1013743at2759 |
PhylomeDBi | O95847 |
TreeFami | TF354328 |
Enzyme and pathway databases
PathwayCommonsi | O95847 |
Reactomei | R-HSA-167826, The fatty acid cycling model R-HSA-167827, The proton buffering model |
Miscellaneous databases
BioGRID-ORCSi | 9481, 5 hits in 847 CRISPR screens |
ChiTaRSi | SLC25A27, human |
GeneWikii | SLC25A27 |
GenomeRNAii | 9481 |
Pharosi | O95847, Tbio |
PROi | PR:O95847 |
RNActi | O95847, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000153291, Expressed in esophagus and 198 other tissues |
ExpressionAtlasi | O95847, baseline and differential |
Genevisiblei | O95847, HS |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UCP4_HUMAN | |
Accessioni | O95847Primary (citable) accession number: O95847 Secondary accession number(s): F5GWR4, Q5VTS9, Q8N518 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | May 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 159 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations