Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitochondrial uncoupling protein 4

Gene

SLC25A27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. May play a role in thermoregulatory heat production and metabolism in brain.

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-HSA-167826 The fatty acid cycling model
R-HSA-167827 The proton buffering model

Protein family/group databases

TCDBi2.A.29.24.3 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial uncoupling protein 4
Short name:
UCP 4
Alternative name(s):
Solute carrier family 25 member 27
Gene namesi
Name:SLC25A27
Synonyms:UCP4
ORF Names:UNQ772/PRO1566
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000153291.15
HGNCiHGNC:21065 SLC25A27
MIMi613725 gene
neXtProtiNX_O95847

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei23 – 40Helical; Name=1Sequence analysisAdd BLAST18
Transmembranei88 – 109Helical; Name=2Sequence analysisAdd BLAST22
Transmembranei127 – 144Helical; Name=3Sequence analysisAdd BLAST18
Transmembranei195 – 212Helical; Name=4Sequence analysisAdd BLAST18
Transmembranei229 – 248Helical; Name=5Sequence analysisAdd BLAST20
Transmembranei288 – 311Helical; Name=6Sequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9481
OpenTargetsiENSG00000153291
PharmGKBiPA134970102

Polymorphism and mutation databases

BioMutaiSLC25A27

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906761 – 323Mitochondrial uncoupling protein 4Add BLAST323

Proteomic databases

PaxDbiO95847
PeptideAtlasiO95847
PRIDEiO95847
ProteomicsDBi51088

PTM databases

iPTMnetiO95847
PhosphoSitePlusiO95847

Expressioni

Tissue specificityi

Found in adult and fetal brain. Present in most of the brain tissues, with low levels in spinal chord, corpus callosum and substantia nigra.

Gene expression databases

BgeeiENSG00000153291 Expressed in 182 organ(s), highest expression level in esophagus
CleanExiHS_SLC25A27
ExpressionAtlasiO95847 baseline and differential
GenevisibleiO95847 HS

Organism-specific databases

HPAiHPA069732

Interactioni

Protein-protein interaction databases

BioGridi114866, 1 interactor
IntActiO95847, 2 interactors
STRINGi9606.ENSP00000360398

Structurei

3D structure databases

ProteinModelPortaliO95847
SMRiO95847
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati21 – 115Solcar 1Add BLAST95
Repeati125 – 217Solcar 2Add BLAST93
Repeati226 – 317Solcar 3Add BLAST92

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 8Poly-Glu4

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0753 Eukaryota
ENOG410XRV1 LUCA
GeneTreeiENSGT00760000119170
HOGENOMiHOG000165140
HOVERGENiHBG009528
InParanoidiO95847
KOiK15112
OMAiQMPDCHT
OrthoDBiEOG091G0BQ7
PhylomeDBiO95847
TreeFamiTF354328

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR040062 Mitochondrial_carrier_protein
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PANTHERiPTHR24089 PTHR24089, 1 hit
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95847-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVPEEEERL LPLTQRWPRA SKFLLSGCAA TVAELATFPL DLTKTRLQMQ
60 70 80 90 100
GEAALARLGD GARESAPYRG MVRTALGIIE EEGFLKLWQG VTPAIYRHVV
110 120 130 140 150
YSGGRMVTYE HLREVVFGKS EDEHYPLWKS VIGGMMAGVI GQFLANPTDL
160 170 180 190 200
VKVQMQMEGK RKLEGKPLRF RGVHHAFAKI LAEGGIRGLW AGWVPNIQRA
210 220 230 240 250
ALVNMGDLTT YDTVKHYLVL NTPLEDNIMT HGLSSLCSGL VASILGTPAD
260 270 280 290 300
VIKSRIMNQP RDKQGRGLLY KSSTDCLIQA VQGEGFMSLY KGFLPSWLRM
310 320
TPWSMVFWLT YEKIREMSGV SPF
Length:323
Mass (Da):36,064
Last modified:May 1, 1999 - v1
Checksum:i4C54A56BB10333ED
GO
Isoform 2 (identifier: O95847-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     236-323: LCSGLVASIL...IREMSGVSPF → DLVGSHKAIQ

Note: No experimental confirmation available.
Show »
Length:245
Mass (Da):27,210
Checksum:iC734F03A6599D488
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5VTS8Q5VTS8_HUMAN
Mitochondrial uncoupling protein 4
SLC25A27
149Annotation score:
S4R300S4R300_HUMAN
Mitochondrial uncoupling protein 4
SLC25A27
98Annotation score:
S4R3J2S4R3J2_HUMAN
Mitochondrial uncoupling protein 4
SLC25A27
145Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_069101145A → V1 PublicationCorresponds to variant dbSNP:rs17853162Ensembl.1
Natural variantiVAR_050137197I → T. Corresponds to variant dbSNP:rs35884480Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_045916236 – 323LCSGL…GVSPF → DLVGSHKAIQ in isoform 2. 1 PublicationAdd BLAST88

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110532 mRNA Translation: AAD16995.1
AY358711 mRNA Translation: AAQ89951.1
AK291427 mRNA Translation: BAF84116.1
AL591242 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04299.1
BC033091 mRNA Translation: AAH33091.1
CCDSiCCDS43470.1 [O95847-1]
CCDS56431.1 [O95847-2]
RefSeqiNP_001190980.1, NM_001204051.1
NP_001190981.1, NM_001204052.1 [O95847-2]
NP_004268.3, NM_004277.4 [O95847-1]
UniGeneiHs.40510

Genome annotation databases

EnsembliENST00000371347; ENSP00000360398; ENSG00000153291 [O95847-1]
ENST00000411689; ENSP00000412024; ENSG00000153291 [O95847-2]
GeneIDi9481
KEGGihsa:9481
UCSCiuc003oyg.3 human [O95847-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110532 mRNA Translation: AAD16995.1
AY358711 mRNA Translation: AAQ89951.1
AK291427 mRNA Translation: BAF84116.1
AL591242 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04299.1
BC033091 mRNA Translation: AAH33091.1
CCDSiCCDS43470.1 [O95847-1]
CCDS56431.1 [O95847-2]
RefSeqiNP_001190980.1, NM_001204051.1
NP_001190981.1, NM_001204052.1 [O95847-2]
NP_004268.3, NM_004277.4 [O95847-1]
UniGeneiHs.40510

3D structure databases

ProteinModelPortaliO95847
SMRiO95847
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114866, 1 interactor
IntActiO95847, 2 interactors
STRINGi9606.ENSP00000360398

Protein family/group databases

TCDBi2.A.29.24.3 the mitochondrial carrier (mc) family

PTM databases

iPTMnetiO95847
PhosphoSitePlusiO95847

Polymorphism and mutation databases

BioMutaiSLC25A27

Proteomic databases

PaxDbiO95847
PeptideAtlasiO95847
PRIDEiO95847
ProteomicsDBi51088

Protocols and materials databases

DNASUi9481
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371347; ENSP00000360398; ENSG00000153291 [O95847-1]
ENST00000411689; ENSP00000412024; ENSG00000153291 [O95847-2]
GeneIDi9481
KEGGihsa:9481
UCSCiuc003oyg.3 human [O95847-1]

Organism-specific databases

CTDi9481
DisGeNETi9481
EuPathDBiHostDB:ENSG00000153291.15
GeneCardsiSLC25A27
HGNCiHGNC:21065 SLC25A27
HPAiHPA069732
MIMi613725 gene
neXtProtiNX_O95847
OpenTargetsiENSG00000153291
PharmGKBiPA134970102
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0753 Eukaryota
ENOG410XRV1 LUCA
GeneTreeiENSGT00760000119170
HOGENOMiHOG000165140
HOVERGENiHBG009528
InParanoidiO95847
KOiK15112
OMAiQMPDCHT
OrthoDBiEOG091G0BQ7
PhylomeDBiO95847
TreeFamiTF354328

Enzyme and pathway databases

ReactomeiR-HSA-167826 The fatty acid cycling model
R-HSA-167827 The proton buffering model

Miscellaneous databases

GeneWikiiSLC25A27
GenomeRNAii9481
PROiPR:O95847
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000153291 Expressed in 182 organ(s), highest expression level in esophagus
CleanExiHS_SLC25A27
ExpressionAtlasiO95847 baseline and differential
GenevisibleiO95847 HS

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR040062 Mitochondrial_carrier_protein
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PANTHERiPTHR24089 PTHR24089, 1 hit
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiUCP4_HUMAN
AccessioniPrimary (citable) accession number: O95847
Secondary accession number(s): F5GWR4, Q5VTS9, Q8N518
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again