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Protein

Glucagon-like peptide 2 receptor

Gene

GLP2R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  • glucagon receptor activity Source: GO_Central
  • G protein-coupled peptide receptor activity Source: GO_Central
  • G protein-coupled receptor activity Source: ProtInc
  • peptide hormone binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-418555 G alpha (s) signalling events
R-HSA-420092 Glucagon-type ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Glucagon-like peptide 2 receptor
Short name:
GLP-2 receptor
Short name:
GLP-2-R
Short name:
GLP-2R
Gene namesi
Name:GLP2R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000065325.12
HGNCiHGNC:4325 GLP2R
MIMi603659 gene
neXtProtiNX_O95838

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 173ExtracellularBy similarityAdd BLAST173
Transmembranei174 – 198Helical; Name=1By similarityAdd BLAST25
Topological domaini199 – 210CytoplasmicBy similarityAdd BLAST12
Transmembranei211 – 235Helical; Name=2By similarityAdd BLAST25
Topological domaini236 – 261ExtracellularBy similarityAdd BLAST26
Transmembranei262 – 285Helical; Name=3By similarityAdd BLAST24
Topological domaini286 – 299CytoplasmicBy similarityAdd BLAST14
Transmembranei300 – 321Helical; Name=4By similarityAdd BLAST22
Topological domaini322 – 339ExtracellularBy similarityAdd BLAST18
Transmembranei340 – 362Helical; Name=5By similarityAdd BLAST23
Topological domaini363 – 386CytoplasmicBy similarityAdd BLAST24
Transmembranei387 – 405Helical; Name=6By similarityAdd BLAST19
Topological domaini406 – 417ExtracellularBy similarityAdd BLAST12
Transmembranei418 – 438Helical; Name=7By similarityAdd BLAST21
Topological domaini439 – 550CytoplasmicBy similarityAdd BLAST112

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9340
OpenTargetsiENSG00000065325
PharmGKBiPA28726

Chemistry databases

ChEMBLiCHEMBL5844
DrugBankiDB00040 Glucagon recombinant
DB08900 Teduglutide
GuidetoPHARMACOLOGYi250

Polymorphism and mutation databases

BioMutaiGLP2R

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000128381 – 553Glucagon-like peptide 2 receptorAdd BLAST553

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi83 ↔ 105By similarity
Disulfide bondi96 ↔ 137By similarity
Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi113N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi118 ↔ 159By similarity
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi162N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO95838
PRIDEiO95838
ProteomicsDBi51084

PTM databases

iPTMnetiO95838
PhosphoSitePlusiO95838

Expressioni

Gene expression databases

BgeeiENSG00000065325 Expressed in 78 organ(s), highest expression level in muscle layer of sigmoid colon
CleanExiHS_GLP2R
ExpressionAtlasiO95838 baseline and differential
GenevisibleiO95838 HS

Organism-specific databases

HPAiCAB022690
HPA049244

Interactioni

Protein-protein interaction databases

MINTiO95838
STRINGi9606.ENSP00000262441

Chemistry databases

BindingDBiO95838

Structurei

3D structure databases

ProteinModelPortaliO95838
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
GeneTreeiENSGT00760000118800
HOGENOMiHOG000008250
HOVERGENiHBG008318
InParanoidiO95838
KOiK04582
OMAiDDQVEGF
OrthoDBiEOG091G0NF8
PhylomeDBiO95838
TreeFamiTF315710

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR039125 GLP2R
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PANTHERiPTHR12011:SF269 PTHR12011:SF269, 1 hit
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O95838-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLGSSRAGP GRGSAGLLPG VHELPMGIPA PWGTSPLSFH RKCSLWAPGR
60 70 80 90 100
PFLTLVLLVS IKQVTGSLLE ETTRKWAQYK QACLRDLLKE PSGIFCNGTF
110 120 130 140 150
DQYVCWPHSS PGNVSVPCPS YLPWWSEESS GRAYRHCLAQ GTWQTIENAT
160 170 180 190 200
DIWQDDSECS ENHSFKQNVD RYALLSTLQL MYTVGYSFSL ISLFLALTLL
210 220 230 240 250
LFLRKLHCTR NYIHMNLFAS FILRTLAVLV KDVVFYNSYS KRPDNENGWM
260 270 280 290 300
SYLSEMSTSC RSVQVLLHYF VGANYLWLLV EGLYLHTLLE PTVLPERRLW
310 320 330 340 350
PRYLLLGWAF PVLFVVPWGF ARAHLENTGC WTTNGNKKIW WIIRGPMMLC
360 370 380 390 400
VTVNFFIFLK ILKLLISKLK AHQMCFRDYK YRLAKSTLVL IPLLGVHEIL
410 420 430 440 450
FSFITDDQVE GFAKLIRLFI QLTLSSFHGF LVALQYGFAN GEVKAELRKY
460 470 480 490 500
WVRFLLARHS GCRACVLGKD FRFLGKCPKK LSEGDGAEKL RKLQPSLNSG
510 520 530 540 550
RLLHLAMRGL GELGAQPQQD HARWPRGSSL SECSEGDVTM ANTMEEILEE

SEI
Length:553
Mass (Da):63,001
Last modified:May 1, 1999 - v1
Checksum:iDA37379DF774A8F4
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L0P5I3L0P5_HUMAN
Glucagon-like peptide 2 receptor
GLP2R
373Annotation score:
E9PC86E9PC86_HUMAN
Glucagon-like peptide 2 receptor
GLP2R
118Annotation score:
H0Y6C2H0Y6C2_HUMAN
Glucagon-like peptide 2 receptor
GLP2R
93Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03396722H → L. Corresponds to variant dbSNP:rs8072568Ensembl.1
Natural variantiVAR_033968470D → N1 PublicationCorresponds to variant dbSNP:rs17681684Ensembl.1
Natural variantiVAR_033969523R → H. Corresponds to variant dbSNP:rs16958918Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF105367 mRNA Translation: AAD16895.1
BC096262 mRNA Translation: AAH96262.1
CCDSiCCDS11150.1
RefSeqiNP_004237.1, NM_004246.2
UniGeneiHs.248202

Genome annotation databases

EnsembliENST00000262441; ENSP00000262441; ENSG00000065325
GeneIDi9340
KEGGihsa:9340
UCSCiuc002gmd.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF105367 mRNA Translation: AAD16895.1
BC096262 mRNA Translation: AAH96262.1
CCDSiCCDS11150.1
RefSeqiNP_004237.1, NM_004246.2
UniGeneiHs.248202

3D structure databases

ProteinModelPortaliO95838
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiO95838
STRINGi9606.ENSP00000262441

Chemistry databases

BindingDBiO95838
ChEMBLiCHEMBL5844
DrugBankiDB00040 Glucagon recombinant
DB08900 Teduglutide
GuidetoPHARMACOLOGYi250

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO95838
PhosphoSitePlusiO95838

Polymorphism and mutation databases

BioMutaiGLP2R

Proteomic databases

PaxDbiO95838
PRIDEiO95838
ProteomicsDBi51084

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262441; ENSP00000262441; ENSG00000065325
GeneIDi9340
KEGGihsa:9340
UCSCiuc002gmd.2 human

Organism-specific databases

CTDi9340
DisGeNETi9340
EuPathDBiHostDB:ENSG00000065325.12
GeneCardsiGLP2R
HGNCiHGNC:4325 GLP2R
HPAiCAB022690
HPA049244
MIMi603659 gene
neXtProtiNX_O95838
OpenTargetsiENSG00000065325
PharmGKBiPA28726
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
GeneTreeiENSGT00760000118800
HOGENOMiHOG000008250
HOVERGENiHBG008318
InParanoidiO95838
KOiK04582
OMAiDDQVEGF
OrthoDBiEOG091G0NF8
PhylomeDBiO95838
TreeFamiTF315710

Enzyme and pathway databases

ReactomeiR-HSA-418555 G alpha (s) signalling events
R-HSA-420092 Glucagon-type ligand receptors

Miscellaneous databases

GeneWikiiGlucagon-like_peptide_2_receptor
GenomeRNAii9340
PROiPR:O95838
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000065325 Expressed in 78 organ(s), highest expression level in muscle layer of sigmoid colon
CleanExiHS_GLP2R
ExpressionAtlasiO95838 baseline and differential
GenevisibleiO95838 HS

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR039125 GLP2R
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PANTHERiPTHR12011:SF269 PTHR12011:SF269, 1 hit
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGLP2R_HUMAN
AccessioniPrimary (citable) accession number: O95838
Secondary accession number(s): Q4VAT3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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