UniProtKB - O95838 (GLP2R_HUMAN)
Protein
Glucagon-like peptide 2 receptor
Gene
GLP2R
Organism
Homo sapiens (Human)
Status
Functioni
This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
GO - Molecular functioni
- glucagon receptor activity Source: GO_Central
- G protein-coupled peptide receptor activity Source: GO_Central
- G protein-coupled receptor activity Source: ProtInc
- peptide hormone binding Source: GO_Central
GO - Biological processi
- adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: GO_Central
- cell surface receptor signaling pathway Source: InterPro
- G protein-coupled receptor signaling pathway Source: Reactome
- positive regulation of cell population proliferation Source: ProtInc
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | O95838 |
Reactomei | R-HSA-418555, G alpha (s) signalling events R-HSA-420092, Glucagon-type ligand receptors R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
Names & Taxonomyi
Protein namesi | Recommended name: Glucagon-like peptide 2 receptorShort name: GLP-2 receptor Short name: GLP-2-R Short name: GLP-2R |
Gene namesi | Name:GLP2R |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000065325.12 |
HGNCi | HGNC:4325, GLP2R |
MIMi | 603659, gene |
neXtProti | NX_O95838 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: ProtInc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 173 | ExtracellularBy similarityAdd BLAST | 173 | |
Transmembranei | 174 – 198 | Helical; Name=1By similarityAdd BLAST | 25 | |
Topological domaini | 199 – 210 | CytoplasmicBy similarityAdd BLAST | 12 | |
Transmembranei | 211 – 235 | Helical; Name=2By similarityAdd BLAST | 25 | |
Topological domaini | 236 – 261 | ExtracellularBy similarityAdd BLAST | 26 | |
Transmembranei | 262 – 285 | Helical; Name=3By similarityAdd BLAST | 24 | |
Topological domaini | 286 – 299 | CytoplasmicBy similarityAdd BLAST | 14 | |
Transmembranei | 300 – 321 | Helical; Name=4By similarityAdd BLAST | 22 | |
Topological domaini | 322 – 339 | ExtracellularBy similarityAdd BLAST | 18 | |
Transmembranei | 340 – 362 | Helical; Name=5By similarityAdd BLAST | 23 | |
Topological domaini | 363 – 386 | CytoplasmicBy similarityAdd BLAST | 24 | |
Transmembranei | 387 – 405 | Helical; Name=6By similarityAdd BLAST | 19 | |
Topological domaini | 406 – 417 | ExtracellularBy similarityAdd BLAST | 12 | |
Transmembranei | 418 – 438 | Helical; Name=7By similarityAdd BLAST | 21 | |
Topological domaini | 439 – 550 | CytoplasmicBy similarityAdd BLAST | 112 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 9340 |
OpenTargetsi | ENSG00000065325 |
PharmGKBi | PA28726 |
Miscellaneous databases
Pharosi | O95838, Tclin |
Chemistry databases
ChEMBLi | CHEMBL5844 |
DrugBanki | DB00040, Glucagon DB08900, Teduglutide |
DrugCentrali | O95838 |
GuidetoPHARMACOLOGYi | 250 |
Polymorphism and mutation databases
BioMutai | GLP2R |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000012838 | 1 – 553 | Glucagon-like peptide 2 receptorAdd BLAST | 553 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 83 ↔ 105 | By similarity | ||
Disulfide bondi | 96 ↔ 137 | By similarity | ||
Glycosylationi | 97 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 113 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 118 ↔ 159 | By similarity | ||
Glycosylationi | 148 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 162 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | O95838 |
PaxDbi | O95838 |
PeptideAtlasi | O95838 |
PRIDEi | O95838 |
ProteomicsDBi | 51084 |
PTM databases
GlyGeni | O95838, 4 sites |
iPTMneti | O95838 |
PhosphoSitePlusi | O95838 |
Expressioni
Gene expression databases
Bgeei | ENSG00000065325, Expressed in muscle layer of sigmoid colon and 93 other tissues |
ExpressionAtlasi | O95838, baseline and differential |
Genevisiblei | O95838, HS |
Organism-specific databases
HPAi | ENSG00000065325, Tissue enhanced (gallbladder) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 114746, 1 interactor |
IntActi | O95838, 1 interactor |
MINTi | O95838 |
STRINGi | 9606.ENSP00000262441 |
Chemistry databases
BindingDBi | O95838 |
Miscellaneous databases
RNActi | O95838, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 2 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4564, Eukaryota |
GeneTreei | ENSGT00940000158127 |
HOGENOMi | CLU_002753_4_0_1 |
InParanoidi | O95838 |
OMAi | FHRKCSL |
OrthoDBi | 651627at2759 |
PhylomeDBi | O95838 |
TreeFami | TF315710 |
Family and domain databases
Gene3Di | 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR039125, GLP2R IPR017981, GPCR_2-like IPR036445, GPCR_2_extracell_dom_sf IPR001879, GPCR_2_extracellular_dom IPR000832, GPCR_2_secretin-like IPR017983, GPCR_2_secretin-like_CS |
PANTHERi | PTHR45620:SF23, PTHR45620:SF23, 1 hit |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF02793, HRM, 1 hit |
PRINTSi | PR00249, GPCRSECRETIN |
SMARTi | View protein in SMART SM00008, HormR, 1 hit |
SUPFAMi | SSF111418, SSF111418, 1 hit |
PROSITEi | View protein in PROSITE PS00649, G_PROTEIN_RECEP_F2_1, 1 hit PS50227, G_PROTEIN_RECEP_F2_3, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
O95838-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKLGSSRAGP GRGSAGLLPG VHELPMGIPA PWGTSPLSFH RKCSLWAPGR
60 70 80 90 100
PFLTLVLLVS IKQVTGSLLE ETTRKWAQYK QACLRDLLKE PSGIFCNGTF
110 120 130 140 150
DQYVCWPHSS PGNVSVPCPS YLPWWSEESS GRAYRHCLAQ GTWQTIENAT
160 170 180 190 200
DIWQDDSECS ENHSFKQNVD RYALLSTLQL MYTVGYSFSL ISLFLALTLL
210 220 230 240 250
LFLRKLHCTR NYIHMNLFAS FILRTLAVLV KDVVFYNSYS KRPDNENGWM
260 270 280 290 300
SYLSEMSTSC RSVQVLLHYF VGANYLWLLV EGLYLHTLLE PTVLPERRLW
310 320 330 340 350
PRYLLLGWAF PVLFVVPWGF ARAHLENTGC WTTNGNKKIW WIIRGPMMLC
360 370 380 390 400
VTVNFFIFLK ILKLLISKLK AHQMCFRDYK YRLAKSTLVL IPLLGVHEIL
410 420 430 440 450
FSFITDDQVE GFAKLIRLFI QLTLSSFHGF LVALQYGFAN GEVKAELRKY
460 470 480 490 500
WVRFLLARHS GCRACVLGKD FRFLGKCPKK LSEGDGAEKL RKLQPSLNSG
510 520 530 540 550
RLLHLAMRGL GELGAQPQQD HARWPRGSSL SECSEGDVTM ANTMEEILEE
SEI
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketI3L0P5 | I3L0P5_HUMAN | Glucagon-like peptide 2 receptor | GLP2R | 373 | Annotation score: | ||
E9PC86 | E9PC86_HUMAN | Glucagon-like peptide 2 receptor | GLP2R | 118 | Annotation score: | ||
H0Y6C2 | H0Y6C2_HUMAN | Glucagon-like peptide 2 receptor | GLP2R | 93 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033967 | 22 | H → L. Corresponds to variant dbSNP:rs8072568EnsemblClinVar. | 1 | |
Natural variantiVAR_033968 | 470 | D → N1 PublicationCorresponds to variant dbSNP:rs17681684Ensembl. | 1 | |
Natural variantiVAR_033969 | 523 | R → H. Corresponds to variant dbSNP:rs16958918EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF105367 mRNA Translation: AAD16895.1 BC096262 mRNA Translation: AAH96262.1 |
CCDSi | CCDS11150.1 |
RefSeqi | NP_004237.1, NM_004246.2 |
Genome annotation databases
Ensembli | ENST00000262441; ENSP00000262441; ENSG00000065325 |
GeneIDi | 9340 |
KEGGi | hsa:9340 |
UCSCi | uc002gmd.2, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF105367 mRNA Translation: AAD16895.1 BC096262 mRNA Translation: AAH96262.1 |
CCDSi | CCDS11150.1 |
RefSeqi | NP_004237.1, NM_004246.2 |
3D structure databases
SMRi | O95838 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114746, 1 interactor |
IntActi | O95838, 1 interactor |
MINTi | O95838 |
STRINGi | 9606.ENSP00000262441 |
Chemistry databases
BindingDBi | O95838 |
ChEMBLi | CHEMBL5844 |
DrugBanki | DB00040, Glucagon DB08900, Teduglutide |
DrugCentrali | O95838 |
GuidetoPHARMACOLOGYi | 250 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | O95838, 4 sites |
iPTMneti | O95838 |
PhosphoSitePlusi | O95838 |
Polymorphism and mutation databases
BioMutai | GLP2R |
Proteomic databases
MassIVEi | O95838 |
PaxDbi | O95838 |
PeptideAtlasi | O95838 |
PRIDEi | O95838 |
ProteomicsDBi | 51084 |
Protocols and materials databases
Antibodypediai | 12679, 363 antibodies |
Genome annotation databases
Ensembli | ENST00000262441; ENSP00000262441; ENSG00000065325 |
GeneIDi | 9340 |
KEGGi | hsa:9340 |
UCSCi | uc002gmd.2, human |
Organism-specific databases
CTDi | 9340 |
DisGeNETi | 9340 |
EuPathDBi | HostDB:ENSG00000065325.12 |
GeneCardsi | GLP2R |
HGNCi | HGNC:4325, GLP2R |
HPAi | ENSG00000065325, Tissue enhanced (gallbladder) |
MIMi | 603659, gene |
neXtProti | NX_O95838 |
OpenTargetsi | ENSG00000065325 |
PharmGKBi | PA28726 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4564, Eukaryota |
GeneTreei | ENSGT00940000158127 |
HOGENOMi | CLU_002753_4_0_1 |
InParanoidi | O95838 |
OMAi | FHRKCSL |
OrthoDBi | 651627at2759 |
PhylomeDBi | O95838 |
TreeFami | TF315710 |
Enzyme and pathway databases
PathwayCommonsi | O95838 |
Reactomei | R-HSA-418555, G alpha (s) signalling events R-HSA-420092, Glucagon-type ligand receptors R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
Miscellaneous databases
BioGRID-ORCSi | 9340, 11 hits in 842 CRISPR screens |
GeneWikii | Glucagon-like_peptide_2_receptor |
GenomeRNAii | 9340 |
Pharosi | O95838, Tclin |
PROi | PR:O95838 |
RNActi | O95838, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000065325, Expressed in muscle layer of sigmoid colon and 93 other tissues |
ExpressionAtlasi | O95838, baseline and differential |
Genevisiblei | O95838, HS |
Family and domain databases
Gene3Di | 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR039125, GLP2R IPR017981, GPCR_2-like IPR036445, GPCR_2_extracell_dom_sf IPR001879, GPCR_2_extracellular_dom IPR000832, GPCR_2_secretin-like IPR017983, GPCR_2_secretin-like_CS |
PANTHERi | PTHR45620:SF23, PTHR45620:SF23, 1 hit |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF02793, HRM, 1 hit |
PRINTSi | PR00249, GPCRSECRETIN |
SMARTi | View protein in SMART SM00008, HormR, 1 hit |
SUPFAMi | SSF111418, SSF111418, 1 hit |
PROSITEi | View protein in PROSITE PS00649, G_PROTEIN_RECEP_F2_1, 1 hit PS50227, G_PROTEIN_RECEP_F2_3, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GLP2R_HUMAN | |
Accessioni | O95838Primary (citable) accession number: O95838 Secondary accession number(s): Q4VAT3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | May 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries