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UniProtKB - O95838 (GLP2R_HUMAN)

Entry version 155 (29 Sep 2021)
Sequence version 1 (01 May 1999)
Previous versions | rss
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Protein

Glucagon-like peptide 2 receptor

Gene

GLP2R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O95838

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-418555, G alpha (s) signalling events
R-HSA-420092, Glucagon-type ligand receptors
R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glucagon-like peptide 2 receptor
Short name:
GLP-2 receptor
Short name:
GLP-2-R
Short name:
GLP-2R
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GLP2R
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:4325, GLP2R

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603659, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O95838

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000065325

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 173ExtracellularBy similarityAdd BLAST173
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei174 – 198Helical; Name=1By similarityAdd BLAST25
Topological domaini199 – 210CytoplasmicBy similarityAdd BLAST12
Transmembranei211 – 235Helical; Name=2By similarityAdd BLAST25
Topological domaini236 – 261ExtracellularBy similarityAdd BLAST26
Transmembranei262 – 285Helical; Name=3By similarityAdd BLAST24
Topological domaini286 – 299CytoplasmicBy similarityAdd BLAST14
Transmembranei300 – 321Helical; Name=4By similarityAdd BLAST22
Topological domaini322 – 339ExtracellularBy similarityAdd BLAST18
Transmembranei340 – 362Helical; Name=5By similarityAdd BLAST23
Topological domaini363 – 386CytoplasmicBy similarityAdd BLAST24
Transmembranei387 – 405Helical; Name=6By similarityAdd BLAST19
Topological domaini406 – 417ExtracellularBy similarityAdd BLAST12
Transmembranei418 – 438Helical; Name=7By similarityAdd BLAST21
Topological domaini439 – 550CytoplasmicBy similarityAdd BLAST112

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		9340

Open Targets

More...OpenTargetsi		ENSG00000065325

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28726

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O95838, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5844

Drug and drug target database

More...DrugBanki		DB00040, Glucagon
DB08900, Teduglutide

DrugCentral

More...DrugCentrali		O95838

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		250

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GLP2R

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000128381 – 553Glucagon-like peptide 2 receptorAdd BLAST553

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi83 ↔ 105By similarity
Disulfide bondi96 ↔ 137By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi113N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi118 ↔ 159By similarity
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi162N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O95838

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O95838

PeptideAtlas

More...PeptideAtlasi		O95838

PRoteomics IDEntifications database

More...PRIDEi		O95838

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51084

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O95838, 4 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O95838

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O95838

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000065325, Expressed in muscle layer of sigmoid colon and 93 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O95838, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O95838, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000065325, Tissue enhanced (gallbladder)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114746, 2 interactors

Protein interaction database and analysis system

More...IntActi		O95838, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000262441

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		O95838

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O95838, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O95838

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4564, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158127

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002753_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O95838

Identification of Orthologs from Complete Genome Data

More...OMAi		STDIWRD

Database of Orthologous Groups

More...OrthoDBi		651627at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O95838

TreeFam database of animal gene trees

More...TreeFami		TF315710

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		4.10.1240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039125, GLP2R
IPR017981, GPCR_2-like
IPR036445, GPCR_2_extracell_dom_sf
IPR001879, GPCR_2_extracellular_dom
IPR000832, GPCR_2_secretin-like
IPR017983, GPCR_2_secretin-like_CS

The PANTHER Classification System

More...PANTHERi		PTHR45620:SF23, PTHR45620:SF23, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00002, 7tm_2, 1 hit
PF02793, HRM, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00249, GPCRSECRETIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00008, HormR, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF111418, SSF111418, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00649, G_PROTEIN_RECEP_F2_1, 1 hit
PS50227, G_PROTEIN_RECEP_F2_3, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O95838-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLGSSRAGP GRGSAGLLPG VHELPMGIPA PWGTSPLSFH RKCSLWAPGR 
        60         70         80         90        100
PFLTLVLLVS IKQVTGSLLE ETTRKWAQYK QACLRDLLKE PSGIFCNGTF 
       110        120        130        140        150
DQYVCWPHSS PGNVSVPCPS YLPWWSEESS GRAYRHCLAQ GTWQTIENAT 
       160        170        180        190        200
DIWQDDSECS ENHSFKQNVD RYALLSTLQL MYTVGYSFSL ISLFLALTLL 
       210        220        230        240        250
LFLRKLHCTR NYIHMNLFAS FILRTLAVLV KDVVFYNSYS KRPDNENGWM 
       260        270        280        290        300
SYLSEMSTSC RSVQVLLHYF VGANYLWLLV EGLYLHTLLE PTVLPERRLW 
       310        320        330        340        350
PRYLLLGWAF PVLFVVPWGF ARAHLENTGC WTTNGNKKIW WIIRGPMMLC 
       360        370        380        390        400
VTVNFFIFLK ILKLLISKLK AHQMCFRDYK YRLAKSTLVL IPLLGVHEIL 
       410        420        430        440        450
FSFITDDQVE GFAKLIRLFI QLTLSSFHGF LVALQYGFAN GEVKAELRKY 
       460        470        480        490        500
WVRFLLARHS GCRACVLGKD FRFLGKCPKK LSEGDGAEKL RKLQPSLNSG 
       510        520        530        540        550
RLLHLAMRGL GELGAQPQQD HARWPRGSSL SECSEGDVTM ANTMEEILEE 

SEI
Length:553
Mass (Da):63,001
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDA37379DF774A8F4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L0P5I3L0P5_HUMAN
Glucagon-like peptide 2 receptor
GLP2R
373Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PC86E9PC86_HUMAN
Glucagon-like peptide 2 receptor
GLP2R
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y6C2H0Y6C2_HUMAN
Glucagon-like peptide 2 receptor
GLP2R
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03396722H → L. Corresponds to variant dbSNP:rs8072568EnsemblClinVar.1
Natural variantiVAR_033968470D → N1 PublicationCorresponds to variant dbSNP:rs17681684Ensembl.1
Natural variantiVAR_033969523R → H. Corresponds to variant dbSNP:rs16958918EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF105367 mRNA Translation: AAD16895.1
BC096262 mRNA Translation: AAH96262.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11150.1

NCBI Reference Sequences

More...RefSeqi		NP_004237.1, NM_004246.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000262441; ENSP00000262441; ENSG00000065325

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9340

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9340

UCSC genome browser

More...UCSCi		uc002gmd.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF105367 mRNA Translation: AAD16895.1
BC096262 mRNA Translation: AAH96262.1
CCDSiCCDS11150.1
RefSeqiNP_004237.1, NM_004246.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
7D68electron microscopy3.00R1-490[»]
SMRiO95838
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114746, 2 interactors
IntActiO95838, 1 interactor
STRINGi9606.ENSP00000262441

Chemistry databases

BindingDBiO95838
ChEMBLiCHEMBL5844
DrugBankiDB00040, Glucagon
DB08900, Teduglutide
DrugCentraliO95838
GuidetoPHARMACOLOGYi250

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniO95838, 4 sites
iPTMnetiO95838
PhosphoSitePlusiO95838

Genetic variation databases

BioMutaiGLP2R

Proteomic databases

MassIVEiO95838
PaxDbiO95838
PeptideAtlasiO95838
PRIDEiO95838
ProteomicsDBi51084

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		12679, 373 antibodies

The DNASU plasmid repository

More...DNASUi		9340

Genome annotation databases

EnsembliENST00000262441; ENSP00000262441; ENSG00000065325
GeneIDi9340
KEGGihsa:9340
UCSCiuc002gmd.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9340
DisGeNETi9340

GeneCards: human genes, protein and diseases

More...GeneCardsi		GLP2R
HGNCiHGNC:4325, GLP2R
HPAiENSG00000065325, Tissue enhanced (gallbladder)
MIMi603659, gene
neXtProtiNX_O95838
OpenTargetsiENSG00000065325
PharmGKBiPA28726
VEuPathDBiHostDB:ENSG00000065325

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4564, Eukaryota
GeneTreeiENSGT00940000158127
HOGENOMiCLU_002753_4_0_1
InParanoidiO95838
OMAiSTDIWRD
OrthoDBi651627at2759
PhylomeDBiO95838
TreeFamiTF315710

Enzyme and pathway databases

PathwayCommonsiO95838
ReactomeiR-HSA-418555, G alpha (s) signalling events
R-HSA-420092, Glucagon-type ligand receptors
R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9340, 11 hits in 1009 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Glucagon-like_peptide_2_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9340
PharosiO95838, Tclin

Protein Ontology

More...PROi		PR:O95838
RNActiO95838, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000065325, Expressed in muscle layer of sigmoid colon and 93 other tissues
ExpressionAtlasiO95838, baseline and differential
GenevisibleiO95838, HS

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR039125, GLP2R
IPR017981, GPCR_2-like
IPR036445, GPCR_2_extracell_dom_sf
IPR001879, GPCR_2_extracellular_dom
IPR000832, GPCR_2_secretin-like
IPR017983, GPCR_2_secretin-like_CS
PANTHERiPTHR45620:SF23, PTHR45620:SF23, 1 hit
PfamiView protein in Pfam
PF00002, 7tm_2, 1 hit
PF02793, HRM, 1 hit
PRINTSiPR00249, GPCRSECRETIN
SMARTiView protein in SMART
SM00008, HormR, 1 hit
SUPFAMiSSF111418, SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649, G_PROTEIN_RECEP_F2_1, 1 hit
PS50227, G_PROTEIN_RECEP_F2_3, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGLP2R_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95838
Secondary accession number(s): Q4VAT3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: September 29, 2021
This is version 155 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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