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Protein

Guanine nucleotide-binding protein subunit alpha-14

Gene

GNA14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi49MagnesiumBy similarity1
Metal bindingi182MagnesiumBy similarity1
Binding sitei327GTP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi42 – 49GTPBy similarity8
Nucleotide bindingi176 – 182GTPBy similarity7
Nucleotide bindingi201 – 205GTPBy similarity5
Nucleotide bindingi270 – 273GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransducer
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-399997 Acetylcholine regulates insulin secretion
R-HSA-416476 G alpha (q) signalling events
R-HSA-418592 ADP signalling through P2Y purinoceptor 1
R-HSA-428930 Thromboxane signalling through TP receptor
R-HSA-434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs)

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit alpha-14
Short name:
G alpha-14
Short name:
G-protein subunit alpha-14
Gene namesi
Name:GNA14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000156049.6
HGNCiHGNC:4382 GNA14
MIMi604397 gene
neXtProtiNX_O95837

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi9630
MalaCardsiGNA14
OpenTargetsiENSG00000156049
Orphaneti2122 Kaposiform hemangioendothelioma
1063 Tufted angioma
PharmGKBiPA28767

Polymorphism and mutation databases

BioMutaiGNA14

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002037521 – 355Guanine nucleotide-binding protein subunit alpha-14Add BLAST355

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei179ADP-ribosylarginine; by cholera toxinBy similarity1

Keywords - PTMi

ADP-ribosylation

Proteomic databases

EPDiO95837
MaxQBiO95837
PaxDbiO95837
PeptideAtlasiO95837
PRIDEiO95837
ProteomicsDBi51083

PTM databases

iPTMnetiO95837
PhosphoSitePlusiO95837
SwissPalmiO95837

Expressioni

Gene expression databases

BgeeiENSG00000156049 Expressed in 159 organ(s), highest expression level in secondary oocyte
CleanExiHS_GNA14
GenevisibleiO95837 HS

Organism-specific databases

HPAiHPA048886

Interactioni

Subunit structurei

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

Binary interactionsi

WithEntry#Exp.IntActNotes
DNAL4O960153EBI-7951023,EBI-742362

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114989, 4 interactors
CORUMiO95837
IntActiO95837, 3 interactors
MINTiO95837
STRINGi9606.ENSP00000365807

Structurei

3D structure databases

ProteinModelPortaliO95837
SMRiO95837
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-alpha family. G(q) subfamily.Curated

Phylogenomic databases

eggNOGiKOG0085 Eukaryota
ENOG410XNVQ LUCA
GeneTreeiENSGT00760000118851
HOGENOMiHOG000038729
HOVERGENiHBG063184
InParanoidiO95837
KOiK04636
OMAiDRIAMPS
OrthoDBiEOG091G0VUT
PhylomeDBiO95837
TreeFamiTF300673

Family and domain databases

CDDicd00066 G-alpha, 1 hit
Gene3Di1.10.400.10, 1 hit
InterProiView protein in InterPro
IPR000654 Gprotein_alpha_Q
IPR001019 Gprotein_alpha_su
IPR011025 GproteinA_insert
IPR027417 P-loop_NTPase
PANTHERiPTHR10218 PTHR10218, 1 hit
PfamiView protein in Pfam
PF00503 G-alpha, 1 hit
PRINTSiPR00318 GPROTEINA
PR00442 GPROTEINAQ
SMARTiView protein in SMART
SM00275 G_alpha, 1 hit
SUPFAMiSSF47895 SSF47895, 1 hit
SSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

O95837-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGCCCLSAE EKESQRISAE IERQLRRDKK DARRELKLLL LGTGESGKST
60 70 80 90 100
FIKQMRIIHG SGYSDEDRKG FTKLVYQNIF TAMQAMIRAM DTLRIQYVCE
110 120 130 140 150
QNKENAQIIR EVEVDKVSML SREQVEAIKQ LWQDPGIQEC YDRRREYQLS
160 170 180 190 200
DSAKYYLTDI DRIATPSFVP TQQDVLRVRV PTTGIIEYPF DLENIIFRMV
210 220 230 240 250
DVGGQRSERR KWIHCFESVT SIIFLVALSE YDQVLAECDN ENRMEESKAL
260 270 280 290 300
FKTIITYPWF LNSSVILFLN KKDLLEEKIM YSHLISYFPE YTGPKQDVRA
310 320 330 340 350
ARDFILKLYQ DQNPDKEKVI YSHFTCATDT DNIRFVFAAV KDTILQLNLR

EFNLV
Length:355
Mass (Da):41,571
Last modified:May 1, 1999 - v1
Checksum:iEAB73A9876E9C47E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF105201 mRNA Translation: AAD17944.1
AF493903 mRNA Translation: AAM12617.1
AK312460 mRNA Translation: BAG35367.1
CH471089 Genomic DNA Translation: EAW62603.1
BC027886 mRNA Translation: AAH27886.1
CCDSiCCDS6657.1
RefSeqiNP_004288.1, NM_004297.3
UniGeneiHs.657795

Genome annotation databases

EnsembliENST00000341700; ENSP00000365807; ENSG00000156049
GeneIDi9630
KEGGihsa:9630
UCSCiuc004aku.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF105201 mRNA Translation: AAD17944.1
AF493903 mRNA Translation: AAM12617.1
AK312460 mRNA Translation: BAG35367.1
CH471089 Genomic DNA Translation: EAW62603.1
BC027886 mRNA Translation: AAH27886.1
CCDSiCCDS6657.1
RefSeqiNP_004288.1, NM_004297.3
UniGeneiHs.657795

3D structure databases

ProteinModelPortaliO95837
SMRiO95837
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114989, 4 interactors
CORUMiO95837
IntActiO95837, 3 interactors
MINTiO95837
STRINGi9606.ENSP00000365807

PTM databases

iPTMnetiO95837
PhosphoSitePlusiO95837
SwissPalmiO95837

Polymorphism and mutation databases

BioMutaiGNA14

Proteomic databases

EPDiO95837
MaxQBiO95837
PaxDbiO95837
PeptideAtlasiO95837
PRIDEiO95837
ProteomicsDBi51083

Protocols and materials databases

DNASUi9630
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341700; ENSP00000365807; ENSG00000156049
GeneIDi9630
KEGGihsa:9630
UCSCiuc004aku.4 human

Organism-specific databases

CTDi9630
DisGeNETi9630
EuPathDBiHostDB:ENSG00000156049.6
GeneCardsiGNA14
HGNCiHGNC:4382 GNA14
HPAiHPA048886
MalaCardsiGNA14
MIMi604397 gene
neXtProtiNX_O95837
OpenTargetsiENSG00000156049
Orphaneti2122 Kaposiform hemangioendothelioma
1063 Tufted angioma
PharmGKBiPA28767
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0085 Eukaryota
ENOG410XNVQ LUCA
GeneTreeiENSGT00760000118851
HOGENOMiHOG000038729
HOVERGENiHBG063184
InParanoidiO95837
KOiK04636
OMAiDRIAMPS
OrthoDBiEOG091G0VUT
PhylomeDBiO95837
TreeFamiTF300673

Enzyme and pathway databases

ReactomeiR-HSA-399997 Acetylcholine regulates insulin secretion
R-HSA-416476 G alpha (q) signalling events
R-HSA-418592 ADP signalling through P2Y purinoceptor 1
R-HSA-428930 Thromboxane signalling through TP receptor
R-HSA-434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs)

Miscellaneous databases

ChiTaRSiGNA14 human
GenomeRNAii9630
PROiPR:O95837
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000156049 Expressed in 159 organ(s), highest expression level in secondary oocyte
CleanExiHS_GNA14
GenevisibleiO95837 HS

Family and domain databases

CDDicd00066 G-alpha, 1 hit
Gene3Di1.10.400.10, 1 hit
InterProiView protein in InterPro
IPR000654 Gprotein_alpha_Q
IPR001019 Gprotein_alpha_su
IPR011025 GproteinA_insert
IPR027417 P-loop_NTPase
PANTHERiPTHR10218 PTHR10218, 1 hit
PfamiView protein in Pfam
PF00503 G-alpha, 1 hit
PRINTSiPR00318 GPROTEINA
PR00442 GPROTEINAQ
SMARTiView protein in SMART
SM00275 G_alpha, 1 hit
SUPFAMiSSF47895 SSF47895, 1 hit
SSF52540 SSF52540, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGNA14_HUMAN
AccessioniPrimary (citable) accession number: O95837
Secondary accession number(s): B1ALW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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