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Protein

Chloride intracellular channel protein 3

Gene

CLIC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Can insert into membranes and form chloride ion channels. May participate in cellular growth control.1 Publication

GO - Molecular functioni

  • chloride channel activity Source: UniProtKB
  • voltage-gated ion channel activity Source: UniProtKB-KW

GO - Biological processi

  • chloride transport Source: UniProtKB
  • regulation of ion transmembrane transport Source: UniProtKB-KW
  • signal transduction Source: ProtInc

Keywordsi

Molecular functionChloride channel, Ion channel, Voltage-gated channel
Biological processIon transport, Transport
LigandChloride

Protein family/group databases

TCDBi1.A.12.1.7 the intracellular chloride channel (clic) family

Names & Taxonomyi

Protein namesi
Recommended name:
Chloride intracellular channel protein 3
Gene namesi
Name:CLIC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000169583.12
HGNCiHGNC:2064 CLIC3
MIMi606533 gene
neXtProtiNX_O95833

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei24 – 44HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9022
OpenTargetsiENSG00000169583
PharmGKBiPA26590

Polymorphism and mutation databases

BioMutaiCLIC3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001442071 – 236Chloride intracellular channel protein 3Add BLAST236

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi22 ↔ 25In soluble form1 Publication
Modified residuei49PhosphoserineCombined sources1
Modified residuei159PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiO95833
MaxQBiO95833
PaxDbiO95833
PeptideAtlasiO95833
PRIDEiO95833
ProteomicsDBi51078

PTM databases

iPTMnetiO95833
PhosphoSitePlusiO95833

Expressioni

Tissue specificityi

Detected in placenta (at protein level). Widely expressed. High expression is found in placenta followed by lung and heart. Low expression in skeletal muscle, kidney and pancreas.2 Publications

Gene expression databases

BgeeiENSG00000169583 Expressed in 132 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_CLIC3
GenevisibleiO95833 HS

Organism-specific databases

HPAiHPA005963

Interactioni

Subunit structurei

Associated with the C-terminal of MAPK15.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi114489, 21 interactors
IntActiO95833, 26 interactors
STRINGi9606.ENSP00000419378

Structurei

Secondary structure

1236
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO95833
SMRiO95833
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95833

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 90GST N-terminalAdd BLAST79
Domaini91 – 235GST C-terminalAdd BLAST145

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 88Required for insertion into the membraneBy similarityAdd BLAST88

Domaini

Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity).By similarity

Sequence similaritiesi

Belongs to the chloride channel CLIC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410INGX Eukaryota
ENOG41128FW LUCA
GeneTreeiENSGT00550000074477
HOGENOMiHOG000231548
HOVERGENiHBG050994
InParanoidiO95833
KOiK05023
OMAiQDDALYQ
OrthoDBiEOG091G0IHT
PhylomeDBiO95833
TreeFamiTF315438

Family and domain databases

InterProiView protein in InterPro
IPR002946 CLIC
IPR030261 CLIC-3
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR040079 Glutathione_S-Trfase
IPR004045 Glutathione_S-Trfase_N
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR43920:SF3 PTHR43920:SF3, 1 hit
PfamiView protein in Pfam
PF13417 GST_N_3, 1 hit
PRINTSiPR01263 INTCLCHANNEL
SFLDiSFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

O95833-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAETKLQLFV KASEDGESVG HCPSCQRLFM VLLLKGVPFT LTTVDTRRSP
60 70 80 90 100
DVLKDFAPGS QLPILLYDSD AKTDTLQIED FLEETLGPPD FPSLAPRYRE
110 120 130 140 150
SNTAGNDVFH KFSAFIKNPV PAQDEALYQQ LLRALARLDS YLRAPLEHEL
160 170 180 190 200
AGEPQLRESR RRFLDGDRLT LADCSLLPKL HIVDTVCAHF RQAPIPAELR
210 220 230
GVRRYLDSAM QEKEFKYTCP HSAEILAAYR PAVHPR
Length:236
Mass (Da):26,648
Last modified:April 13, 2004 - v2
Checksum:iCA20E66195950886
GO

Sequence cautioni

The sequence AAD16450 differs from that shown. Reason: Frameshift at position 28.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02042438P → H. Corresponds to variant dbSNP:rs2292923Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL807752 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW88329.1
BC007012 mRNA Translation: AAH07012.2
AF102166 mRNA Translation: AAD16450.1 Frameshift.
CCDSiCCDS7021.1
RefSeqiNP_004660.2, NM_004669.2
XP_016870771.1, XM_017015282.1
UniGeneiHs.64746

Genome annotation databases

EnsembliENST00000494426; ENSP00000419378; ENSG00000169583
GeneIDi9022
KEGGihsa:9022
UCSCiuc004ckj.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL807752 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW88329.1
BC007012 mRNA Translation: AAH07012.2
AF102166 mRNA Translation: AAD16450.1 Frameshift.
CCDSiCCDS7021.1
RefSeqiNP_004660.2, NM_004669.2
XP_016870771.1, XM_017015282.1
UniGeneiHs.64746

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FY7X-ray1.95A/B1-230[»]
3KJYX-ray1.95A/B1-230[»]
ProteinModelPortaliO95833
SMRiO95833
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114489, 21 interactors
IntActiO95833, 26 interactors
STRINGi9606.ENSP00000419378

Protein family/group databases

TCDBi1.A.12.1.7 the intracellular chloride channel (clic) family

PTM databases

iPTMnetiO95833
PhosphoSitePlusiO95833

Polymorphism and mutation databases

BioMutaiCLIC3

Proteomic databases

EPDiO95833
MaxQBiO95833
PaxDbiO95833
PeptideAtlasiO95833
PRIDEiO95833
ProteomicsDBi51078

Protocols and materials databases

DNASUi9022
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000494426; ENSP00000419378; ENSG00000169583
GeneIDi9022
KEGGihsa:9022
UCSCiuc004ckj.2 human

Organism-specific databases

CTDi9022
DisGeNETi9022
EuPathDBiHostDB:ENSG00000169583.12
GeneCardsiCLIC3
HGNCiHGNC:2064 CLIC3
HPAiHPA005963
MIMi606533 gene
neXtProtiNX_O95833
OpenTargetsiENSG00000169583
PharmGKBiPA26590
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INGX Eukaryota
ENOG41128FW LUCA
GeneTreeiENSGT00550000074477
HOGENOMiHOG000231548
HOVERGENiHBG050994
InParanoidiO95833
KOiK05023
OMAiQDDALYQ
OrthoDBiEOG091G0IHT
PhylomeDBiO95833
TreeFamiTF315438

Miscellaneous databases

EvolutionaryTraceiO95833
GeneWikiiCLIC3
GenomeRNAii9022
PROiPR:O95833
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169583 Expressed in 132 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_CLIC3
GenevisibleiO95833 HS

Family and domain databases

InterProiView protein in InterPro
IPR002946 CLIC
IPR030261 CLIC-3
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR040079 Glutathione_S-Trfase
IPR004045 Glutathione_S-Trfase_N
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR43920:SF3 PTHR43920:SF3, 1 hit
PfamiView protein in Pfam
PF13417 GST_N_3, 1 hit
PRINTSiPR01263 INTCLCHANNEL
SFLDiSFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLIC3_HUMAN
AccessioniPrimary (citable) accession number: O95833
Secondary accession number(s): Q5SPZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 13, 2004
Last modified: November 7, 2018
This is version 166 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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