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Entry version 202 (31 Jul 2019)
Sequence version 1 (01 May 1999)
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Protein

Apoptosis-inducing factor 1, mitochondrial

Gene

AIFM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.4 Publications

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FAD1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.53 mM for NADH1 Publication
  2. KM=26 µM for cytochrome c1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei172FAD2 Publications1
    Binding sitei177FAD2 Publications1
    Binding sitei233FAD; via amide nitrogen and carbonyl oxygen2 Publications1
    Binding sitei285FAD2 Publications1
    Binding sitei438FAD2 Publications1
    Binding sitei483FAD; via carbonyl oxygen2 Publications1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi138 – 142FAD2 Publications5
    Nucleotide bindingi164 – 165FAD2 Publications2
    Nucleotide bindingi454 – 455FAD2 Publications2

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionDNA-binding, Oxidoreductase
    Biological processApoptosis
    LigandFAD, Flavoprotein, NAD

    Enzyme and pathway databases

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    O95831

    SignaLink: a signaling pathway resource with multi-layered regulatory networks

    More...
    SignaLinki
    O95831

    SIGNOR Signaling Network Open Resource

    More...
    SIGNORi
    O95831

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Apoptosis-inducing factor 1, mitochondrial (EC:1.1.1.-)
    Alternative name(s):
    Programmed cell death protein 8
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:AIFM1
    Synonyms:AIF, PDCD8
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:8768 AIFM1

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    300169 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_O95831

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm, Membrane, Mitochondrion, Mitochondrion inner membrane, Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Combined oxidative phosphorylation deficiency 6 (COXPD6)2 Publications
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionA mitochondrial disease resulting in a neurodegenerative disorder characterized by psychomotor delay, hypotonia, areflexia, muscle weakness and wasting. Some patients manifest prenatal ventriculomegaly and severe postnatal encephalomyopathy.
    Related information in OMIM
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_063827201Missing in COXPD6; higher DNA binding affinity, partially impaired flavin binding and association with increased parthanatos-linked cell death. 1 Publication1
    Natural variantiVAR_067334308G → E in COXPD6; with prenatal ventriculomegaly and severe postnatal encephalomyopathy. 1 Publication1
    Cowchock syndrome (COWCK)1 Publication
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionAn X-linked recessive neuromuscular disorder characterized by early childhood onset of a slowly progressive axonal sensorimotor neuropathy associated in some patients with sensorineural deafness and cognitive impairment.
    Related information in OMIM
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_069468493E → V in COWCK; increases affinity for NADH and electron transfer activity; increases affinity for DNA, resulting in increased apoptosis. 1 PublicationCorresponds to variant dbSNP:rs281864468EnsemblClinVar.1
    Deafness, X-linked, 5 (DFNX5)1 Publication
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionA form of hearing loss characterized by absent or severely abnormal auditory brainstem response, abnormal middle ear reflexes, abnormal speech discrimination, loss of outer hair cell function, and cochlear nerve hypoplasia. DFNX5 patients manifest auditory neuropathy with childhood onset, associated with distal sensory impairment affecting the peripheral nervous system.
    Related information in OMIM
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_076211260T → A in DFNX5. 1 PublicationCorresponds to variant dbSNP:rs863225432EnsemblClinVar.1
    Natural variantiVAR_076212344L → F in DFNX5; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs184474885EnsemblClinVar.1
    Natural variantiVAR_076213360G → R in DFNX5; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs724160026EnsemblClinVar.1
    Natural variantiVAR_076214422R → Q in DFNX5. 1 PublicationCorresponds to variant dbSNP:rs724160021EnsemblClinVar.1
    Natural variantiVAR_076215422R → W in DFNX5. 1 PublicationCorresponds to variant dbSNP:rs724160020EnsemblClinVar.1
    Natural variantiVAR_076216430R → C in DFNX5; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1223488720Ensembl.1
    Natural variantiVAR_076217451R → Q in DFNX5. 1 PublicationCorresponds to variant dbSNP:rs863225431EnsemblClinVar.1
    Natural variantiVAR_076218472A → V in DFNX5; unknown pathological significance. 1 Publication1
    Natural variantiVAR_076219475P → L in DFNX5; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs724160022EnsemblClinVar.1
    Natural variantiVAR_076220498V → M in DFNX5; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs724160023EnsemblClinVar.1
    Natural variantiVAR_076221591I → M in DFNX5; unknown pathological significance. 1 Publication1

    Keywords - Diseasei

    Charcot-Marie-Tooth disease, Deafness, Disease mutation, Mental retardation, Neurodegeneration, Neuropathy, Primary mitochondrial disease

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    9131

    GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

    More...
    GeneReviewsi
    AIFM1

    MalaCards human disease database

    More...
    MalaCardsi
    AIFM1
    MIMi300614 phenotype
    300816 phenotype
    310490 phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000156709

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    238329 Severe X-linked mitochondrial encephalomyopathy
    168448 Spondyloepimetaphyseal dysplasia, Bieganski type
    101078 X-linked Charcot-Marie-Tooth disease type 4
    139583 X-linked hereditary sensory and autonomic neuropathy with deafness

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA162376129

    Chemistry databases

    Drug and drug target database

    More...
    DrugBanki
    DB03147 Flavin adenine dinucleotide
    DB05282 MCC

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    AIFM1

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 54MitochondrionCombined sources2 PublicationsAdd BLAST54
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000040193555 – 101Removed in mature form1 PublicationAdd BLAST47
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000022030102 – 613Apoptosis-inducing factor 1, mitochondrialAdd BLAST512

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei105PhosphothreonineCombined sources1
    Modified residuei109N6-succinyllysineBy similarity1
    Modified residuei116PhosphoserineCombined sources1
    Modified residuei118PhosphoserineCombined sources1
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki255Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
    Modified residuei268PhosphoserineCombined sources1
    Modified residuei292PhosphoserineCombined sources1
    Modified residuei371PhosphoserineCombined sources1
    Modified residuei388N6-acetyllysineBy similarity1
    Modified residuei521PhosphothreonineCombined sources1
    Modified residuei524PhosphoserineCombined sources1
    Modified residuei530PhosphoserineCombined sources1
    Modified residuei593N6-acetyllysineBy similarity1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Under normal conditions, a 54-residue N-terminal segment is first proteolytically removed during or just after translocation into the mitochondrial intermembrane space (IMS) by the mitochondrial processing peptidase (MPP) to form the inner-membrane-anchored mature form (AIFmit). During apoptosis, it is further proteolytically processed at amino-acid position 101 leading to the generation of the mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis in a caspase-independent manner.1 Publication
    Ubiquitination by XIAP/BIRC4 does not lead to proteasomal degradation. Ubiquitination at Lys-255 by XIAP/BIRC4 blocks its ability to bind DNA and induce chromatin degradation, thereby inhibiting its ability to induce cell death.2 Publications

    Keywords - PTMi

    Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    O95831

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    O95831

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    O95831

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    O95831

    PeptideAtlas

    More...
    PeptideAtlasi
    O95831

    PRoteomics IDEntifications database

    More...
    PRIDEi
    O95831

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    51073 [O95831-1]
    51074 [O95831-2]
    51075 [O95831-3]
    51076 [O95831-4]
    61222
    61439

    2D gel databases

    REPRODUCTION-2DPAGE

    More...
    REPRODUCTION-2DPAGEi
    IPI00157908

    University College Dublin 2-DE Proteome Database

    More...
    UCD-2DPAGEi
    O95831

    PTM databases

    CarbonylDB database of protein carbonylation sites

    More...
    CarbonylDBi
    O95831

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    O95831

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    O95831

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    O95831

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Detected in muscle and skin fibroblasts (at protein level). Isoform 5 is frequently down-regulated in human cancers.2 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000156709 Expressed in 213 organ(s), highest expression level in apex of heart

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    O95831 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    O95831 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    CAB003764
    HPA030611

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Monomer (oxidized form). Homodimer (reduced form). Also dimerizes with isoform 3 preventing its release from mitochondria.

    Interacts with XIAP/BIRC4.

    Interacts (via N-terminus) with EIF3G (via C-terminus).

    Interacts with PRELID1.

    6 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    114579, 137 interactors

    CORUM comprehensive resource of mammalian protein complexes

    More...
    CORUMi
    O95831

    Database of interacting proteins

    More...
    DIPi
    DIP-32975N

    Protein interaction database and analysis system

    More...
    IntActi
    O95831, 243 interactors

    Molecular INTeraction database

    More...
    MINTi
    O95831

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000287295

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1613
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    O95831

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    O95831

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni134 – 483FAD-dependent oxidoreductaseBy similarityAdd BLAST350

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi446 – 451Nuclear localization signalSequence analysis6

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1346 Eukaryota
    COG0446 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000156455

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000124580

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    O95831

    KEGG Orthology (KO)

    More...
    KOi
    K04727

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    EGVNVMP

    Database of Orthologous Groups

    More...
    OrthoDBi
    1382017at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    O95831

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF314028

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.30.390.30, 1 hit
    3.50.50.60, 2 hits

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR029324 AIF_C
    IPR036188 FAD/NAD-bd_sf
    IPR023753 FAD/NAD-binding_dom
    IPR016156 FAD/NAD-linked_Rdtase_dimer_sf

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF14721 AIF_C, 1 hit
    PF07992 Pyr_redox_2, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF51905 SSF51905, 2 hits
    SSF55424 SSF55424, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: O95831-1) [UniParc]FASTAAdd to basket
    Also known as: AIF

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MFRCGGLAAG ALKQKLVPLV RTVCVRSPRQ RNRLPGNLFQ RWHVPLELQM
    60 70 80 90 100
    TRQMASSGAS GGKIDNSVLV LIVGLSTVGA GAYAYKTMKE DEKRYNERIS
    110 120 130 140 150
    GLGLTPEQKQ KKAALSASEG EEVPQDKAPS HVPFLLIGGG TAAFAAARSI
    160 170 180 190 200
    RARDPGARVL IVSEDPELPY MRPPLSKELW FSDDPNVTKT LRFKQWNGKE
    210 220 230 240 250
    RSIYFQPPSF YVSAQDLPHI ENGGVAVLTG KKVVQLDVRD NMVKLNDGSQ
    260 270 280 290 300
    ITYEKCLIAT GGTPRSLSAI DRAGAEVKSR TTLFRKIGDF RSLEKISREV
    310 320 330 340 350
    KSITIIGGGF LGSELACALG RKARALGTEV IQLFPEKGNM GKILPEYLSN
    360 370 380 390 400
    WTMEKVRREG VKVMPNAIVQ SVGVSSGKLL IKLKDGRKVE TDHIVAAVGL
    410 420 430 440 450
    EPNVELAKTG GLEIDSDFGG FRVNAELQAR SNIWVAGDAA CFYDIKLGRR
    460 470 480 490 500
    RVEHHDHAVV SGRLAGENMT GAAKPYWHQS MFWSDLGPDV GYEAIGLVDS
    510 520 530 540 550
    SLPTVGVFAK ATAQDNPKSA TEQSGTGIRS ESETESEASE ITIPPSTPAV
    560 570 580 590 600
    PQAPVQGEDY GKGVIFYLRD KVVVGIVLWN IFNRMPIARK IIKDGEQHED
    610
    LNEVAKLFNI HED
    Length:613
    Mass (Da):66,901
    Last modified:May 1, 1999 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA156762BC64E6340
    GO
    Isoform 2 (identifier: O95831-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         36-322: Missing.

    Show »
    Length:326
    Mass (Da):35,638
    Checksum:iA87ACDC0A0556040
    GO
    Isoform 3 (identifier: O95831-3) [UniParc]FASTAAdd to basket
    Also known as: AIF-exB, AIF2

    The sequence of this isoform differs from the canonical sequence as follows:
         36-82: GNLFQRWHVP...VGLSTVGAGA → VVQSHHLGSP...GATVTGAGVY

    Note: Brain-specific.
    Show »
    Length:609
    Mass (Da):66,295
    Checksum:i313ADD6FA4E5D61A
    GO
    Isoform 4 (identifier: O95831-4) [UniParc]FASTAAdd to basket
    Also known as: AIFsh2

    The sequence of this isoform differs from the canonical sequence as follows:
         323-324: AR → DI
         325-613: Missing.

    Note: Does not induce nuclear apoptosis.
    Show »
    Length:324
    Mass (Da):35,384
    Checksum:i259AA55812C2F07E
    GO
    Isoform 5 (identifier: O95831-5) [UniParc]FASTAAdd to basket
    Also known as: AIFsh

    The sequence of this isoform differs from the canonical sequence as follows:
         1-352: Missing.

    Note: Pro-apoptotic isoform, strongly down-regulated in many tumor cells, up-regulated by gamma-irradiation.
    Show »
    Length:261
    Mass (Da):28,404
    Checksum:iB05C9E9F3AA3F2E3
    GO
    Isoform 6 (identifier: O95831-6) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-87: Missing.
         323-324: AR → DI
         325-613: Missing.

    Show »
    Length:237
    Mass (Da):26,033
    Checksum:iC1DDF16F42339374
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    E9PMA0E9PMA0_HUMAN
    Apoptosis-inducing factor 1, mitoch...
    AIFM1
    274Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PMQ8E9PMQ8_HUMAN
    Apoptosis-inducing factor 1, mitoch...
    AIFM1
    89Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PRR0E9PRR0_HUMAN
    Apoptosis-inducing factor 1, mitoch...
    AIFM1
    43Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_063827201Missing in COXPD6; higher DNA binding affinity, partially impaired flavin binding and association with increased parthanatos-linked cell death. 1 Publication1
    Natural variantiVAR_072791243V → L Probable disease-associated mutation found in patient with severe myopathy; myopathic changes with partial type II fiber hypotrophy; reduced protein amount in muscle compared to controls. 1 Publication1
    Natural variantiVAR_076211260T → A in DFNX5. 1 PublicationCorresponds to variant dbSNP:rs863225432EnsemblClinVar.1
    Natural variantiVAR_067334308G → E in COXPD6; with prenatal ventriculomegaly and severe postnatal encephalomyopathy. 1 Publication1
    Natural variantiVAR_076212344L → F in DFNX5; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs184474885EnsemblClinVar.1
    Natural variantiVAR_076213360G → R in DFNX5; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs724160026EnsemblClinVar.1
    Natural variantiVAR_076214422R → Q in DFNX5. 1 PublicationCorresponds to variant dbSNP:rs724160021EnsemblClinVar.1
    Natural variantiVAR_076215422R → W in DFNX5. 1 PublicationCorresponds to variant dbSNP:rs724160020EnsemblClinVar.1
    Natural variantiVAR_076216430R → C in DFNX5; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1223488720Ensembl.1
    Natural variantiVAR_076217451R → Q in DFNX5. 1 PublicationCorresponds to variant dbSNP:rs863225431EnsemblClinVar.1
    Natural variantiVAR_076218472A → V in DFNX5; unknown pathological significance. 1 Publication1
    Natural variantiVAR_076219475P → L in DFNX5; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs724160022EnsemblClinVar.1
    Natural variantiVAR_069468493E → V in COWCK; increases affinity for NADH and electron transfer activity; increases affinity for DNA, resulting in increased apoptosis. 1 PublicationCorresponds to variant dbSNP:rs281864468EnsemblClinVar.1
    Natural variantiVAR_076220498V → M in DFNX5; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs724160023EnsemblClinVar.1
    Natural variantiVAR_076221591I → M in DFNX5; unknown pathological significance. 1 Publication1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0462481 – 352Missing in isoform 5. 1 PublicationAdd BLAST352
    Alternative sequenceiVSP_0476461 – 87Missing in isoform 6. 1 PublicationAdd BLAST87
    Alternative sequenceiVSP_00435736 – 322Missing in isoform 2. 1 PublicationAdd BLAST287
    Alternative sequenceiVSP_02295336 – 82GNLFQ…VGAGA → VVQSHHLGSPSRSLASTGAS GKDGSNLVYFLIVGATVTGA GVY in isoform 3. 3 PublicationsAdd BLAST47
    Alternative sequenceiVSP_043637323 – 324AR → DI in isoform 4 and isoform 6. 1 Publication2
    Alternative sequenceiVSP_043638325 – 613Missing in isoform 4 and isoform 6. 1 PublicationAdd BLAST289

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF100928 mRNA Translation: AAD16436.1
    DQ016496 mRNA Translation: AAY84737.1
    DQ016498 mRNA Translation: AAY84739.1
    DQ016500 mRNA Translation: AAY84741.1
    AL049703 mRNA Translation: CAB41267.1
    AL049704 mRNA Translation: CAB41268.1
    AK314446 mRNA Translation: BAG37055.1
    CR457379 mRNA Translation: CAG33660.1
    AL139234 Genomic DNA No translation available.
    CH471107 Genomic DNA Translation: EAX11811.1
    CH471107 Genomic DNA Translation: EAX11812.1
    CH471107 Genomic DNA Translation: EAX11810.1
    BC111065 mRNA Translation: AAI11066.1
    BC139738 mRNA Translation: AAI39739.1
    AF131759 mRNA Translation: AAD20036.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS14618.1 [O95831-1]
    CCDS14619.1 [O95831-3]
    CCDS48167.1 [O95831-4]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001124318.2, NM_001130846.3
    NP_001124319.1, NM_001130847.3 [O95831-4]
    NP_004199.1, NM_004208.3 [O95831-1]
    NP_665811.1, NM_145812.2 [O95831-3]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000287295; ENSP00000287295; ENSG00000156709 [O95831-1]
    ENST00000319908; ENSP00000315122; ENSG00000156709 [O95831-3]
    ENST00000346424; ENSP00000316320; ENSG00000156709 [O95831-2]
    ENST00000416073; ENSP00000402535; ENSG00000156709 [O95831-4]
    ENST00000535724; ENSP00000446113; ENSG00000156709 [O95831-4]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    9131

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:9131

    UCSC genome browser

    More...
    UCSCi
    uc004evg.4 human [O95831-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF100928 mRNA Translation: AAD16436.1
    DQ016496 mRNA Translation: AAY84737.1
    DQ016498 mRNA Translation: AAY84739.1
    DQ016500 mRNA Translation: AAY84741.1
    AL049703 mRNA Translation: CAB41267.1
    AL049704 mRNA Translation: CAB41268.1
    AK314446 mRNA Translation: BAG37055.1
    CR457379 mRNA Translation: CAG33660.1
    AL139234 Genomic DNA No translation available.
    CH471107 Genomic DNA Translation: EAX11811.1
    CH471107 Genomic DNA Translation: EAX11812.1
    CH471107 Genomic DNA Translation: EAX11810.1
    BC111065 mRNA Translation: AAI11066.1
    BC139738 mRNA Translation: AAI39739.1
    AF131759 mRNA Translation: AAD20036.1
    CCDSiCCDS14618.1 [O95831-1]
    CCDS14619.1 [O95831-3]
    CCDS48167.1 [O95831-4]
    RefSeqiNP_001124318.2, NM_001130846.3
    NP_001124319.1, NM_001130847.3 [O95831-4]
    NP_004199.1, NM_004208.3 [O95831-1]
    NP_665811.1, NM_145812.2 [O95831-3]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1M6IX-ray1.80A121-613[»]
    4BURX-ray2.88A/B/C/D103-613[»]
    4BV6X-ray1.80A121-613[»]
    4FDCX-ray2.40B103-613[»]
    4LIIX-ray1.88A100-611[»]
    5FMHX-ray1.80A104-613[»]
    5FS6X-ray1.90A/B103-613[»]
    5FS7X-ray1.85A/B103-613[»]
    5FS8X-ray1.40A103-613[»]
    5FS9X-ray1.75A/B103-613[»]
    5KVHX-ray2.27A/B78-613[»]
    5KVIX-ray2.00A78-613[»]
    SMRiO95831
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGridi114579, 137 interactors
    CORUMiO95831
    DIPiDIP-32975N
    IntActiO95831, 243 interactors
    MINTiO95831
    STRINGi9606.ENSP00000287295

    Chemistry databases

    DrugBankiDB03147 Flavin adenine dinucleotide
    DB05282 MCC

    PTM databases

    CarbonylDBiO95831
    iPTMnetiO95831
    PhosphoSitePlusiO95831
    SwissPalmiO95831

    Polymorphism and mutation databases

    BioMutaiAIFM1

    2D gel databases

    REPRODUCTION-2DPAGEiIPI00157908
    UCD-2DPAGEiO95831

    Proteomic databases

    EPDiO95831
    jPOSTiO95831
    MaxQBiO95831
    PaxDbiO95831
    PeptideAtlasiO95831
    PRIDEiO95831
    ProteomicsDBi51073 [O95831-1]
    51074 [O95831-2]
    51075 [O95831-3]
    51076 [O95831-4]
    61222
    61439

    Protocols and materials databases

    ABCD curated depository of sequenced antibodies

    More...
    ABCDi
    O95831

    The DNASU plasmid repository

    More...
    DNASUi
    51060
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000287295; ENSP00000287295; ENSG00000156709 [O95831-1]
    ENST00000319908; ENSP00000315122; ENSG00000156709 [O95831-3]
    ENST00000346424; ENSP00000316320; ENSG00000156709 [O95831-2]
    ENST00000416073; ENSP00000402535; ENSG00000156709 [O95831-4]
    ENST00000535724; ENSP00000446113; ENSG00000156709 [O95831-4]
    GeneIDi9131
    KEGGihsa:9131
    UCSCiuc004evg.4 human [O95831-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    9131
    DisGeNETi9131

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    AIFM1
    GeneReviewsiAIFM1
    HGNCiHGNC:8768 AIFM1
    HPAiCAB003764
    HPA030611
    MalaCardsiAIFM1
    MIMi300169 gene
    300614 phenotype
    300816 phenotype
    310490 phenotype
    neXtProtiNX_O95831
    OpenTargetsiENSG00000156709
    Orphaneti238329 Severe X-linked mitochondrial encephalomyopathy
    168448 Spondyloepimetaphyseal dysplasia, Bieganski type
    101078 X-linked Charcot-Marie-Tooth disease type 4
    139583 X-linked hereditary sensory and autonomic neuropathy with deafness
    PharmGKBiPA162376129

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1346 Eukaryota
    COG0446 LUCA
    GeneTreeiENSGT00940000156455
    HOGENOMiHOG000124580
    InParanoidiO95831
    KOiK04727
    OMAiEGVNVMP
    OrthoDBi1382017at2759
    PhylomeDBiO95831
    TreeFamiTF314028

    Enzyme and pathway databases

    SABIO-RKiO95831
    SignaLinkiO95831
    SIGNORiO95831

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    AIFM1 human
    EvolutionaryTraceiO95831

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    AIFM1

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    9131

    Protein Ontology

    More...
    PROi
    PR:O95831

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000156709 Expressed in 213 organ(s), highest expression level in apex of heart
    ExpressionAtlasiO95831 baseline and differential
    GenevisibleiO95831 HS

    Family and domain databases

    Gene3Di3.30.390.30, 1 hit
    3.50.50.60, 2 hits
    InterProiView protein in InterPro
    IPR029324 AIF_C
    IPR036188 FAD/NAD-bd_sf
    IPR023753 FAD/NAD-binding_dom
    IPR016156 FAD/NAD-linked_Rdtase_dimer_sf
    PfamiView protein in Pfam
    PF14721 AIF_C, 1 hit
    PF07992 Pyr_redox_2, 1 hit
    SUPFAMiSSF51905 SSF51905, 2 hits
    SSF55424 SSF55424, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAIFM1_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95831
    Secondary accession number(s): A4QPB4
    , B1ALN1, B2RB08, D3DTE9, Q1L6K4, Q1L6K6, Q2QKE4, Q5JUZ7, Q6I9X6, Q9Y3I3, Q9Y3I4
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: May 1, 1999
    Last modified: July 31, 2019
    This is version 202 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    4. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    5. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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