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Protein

Quinone oxidoreductase-like protein 1

Gene

CRYZL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • NADP binding Source: UniProtKB
  • NADPH:quinone reductase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Names & Taxonomyi

Protein namesi
Recommended name:
Quinone oxidoreductase-like protein 1 (EC:1.-.-.-)
Alternative name(s):
Protein 4P11
Quinone oxidoreductase homolog 1
Short name:
QOH-1
Zeta-crystallin homolog
Gene namesi
Name:CRYZL1
Synonyms:4P11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000205758.11
HGNCiHGNC:2420 CRYZL1
MIMi603920 gene
neXtProtiNX_O95825

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi9946
OpenTargetsiENSG00000205758
PharmGKBiPA26926

Polymorphism and mutation databases

BioMutaiCRYZL1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001609131 – 349Quinone oxidoreductase-like protein 1Add BLAST349

Proteomic databases

EPDiO95825
MaxQBiO95825
PaxDbiO95825
PeptideAtlasiO95825
PRIDEiO95825
ProteomicsDBi51072

PTM databases

iPTMnetiO95825
PhosphoSitePlusiO95825

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000205758 Expressed in 223 organ(s), highest expression level in testis
CleanExiHS_CRYZL1
ExpressionAtlasiO95825 baseline and differential
GenevisibleiO95825 HS

Organism-specific databases

HPAiCAB034129
HPA019120
HPA029399

Interactioni

Protein-protein interaction databases

BioGridi115271, 14 interactors
DIPiDIP-62115N
IntActiO95825, 4 interactors
STRINGi9606.ENSP00000370966

Structurei

3D structure databases

ProteinModelPortaliO95825
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1198 Eukaryota
COG0604 LUCA
GeneTreeiENSGT00390000013113
HOGENOMiHOG000293267
HOVERGENiHBG009484
InParanoidiO95825
OMAiVGGHWIT
OrthoDBiEOG091G08LX
PhylomeDBiO95825
TreeFamiTF328922

Family and domain databases

InterProiView protein in InterPro
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 16 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95825-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKGLYFQQSS TDEEITFVFQ EKEDLPVTED NFVKLQVKAC ALSQINTKLL
60 70 80 90 100
AEMKMKKDLF PVGREIAGIV LDVGSKVSFF QPDDEVVGIL PLDSEDPGLC
110 120 130 140 150
EVVRVHEHYL VHKPEKVTWT EAAGSIRDGV RAYTALHYLS HLSPGKSVLI
160 170 180 190 200
MDGASAFGTI AIQLAHHRGA KVISTACSLE DKQCLERFRP PIARVIDVSN
210 220 230 240 250
GKVHVAESCL EETGGLGVDI VLDAGVRLYS KDDEPAVKLQ LLPHKHDIIT
260 270 280 290 300
LLGVGGHWVT TEENLQLDPP DSHCLFLKGA TLAFLNDEVW NLSNVQQGKY
310 320 330 340
LCILKDVMEK LSTGVFRPQL DEPIPLYEAK VSMEAVQKNQ GRKKQVVQF
Length:349
Mass (Da):38,697
Last modified:October 3, 2006 - v2
Checksum:i7EC26B8852A5BD31
GO
Isoform 2 (identifier: O95825-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     193-198: ARVIDV → ENSTIA
     199-349: Missing.

Note: No experimental confirmation available.
Show »
Length:198
Mass (Da):21,928
Checksum:i55BE2194BCBEE6EB
GO

Computationally mapped potential isoform sequencesi

There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NHJ8A6NHJ8_HUMAN
Quinone oxidoreductase-like protein...
CRYZL1
325Annotation score:
A6NND8A6NND8_HUMAN
Quinone oxidoreductase-like protein...
CRYZL1
322Annotation score:
A6NMA8A6NMA8_HUMAN
Quinone oxidoreductase-like protein...
CRYZL1
334Annotation score:
C9JAL0C9JAL0_HUMAN
Quinone oxidoreductase-like protein...
CRYZL1
181Annotation score:
C9K0F7C9K0F7_HUMAN
Quinone oxidoreductase-like protein...
CRYZL1
158Annotation score:
H7C3I5H7C3I5_HUMAN
Quinone oxidoreductase-like protein...
CRYZL1
241Annotation score:
C9JZK8C9JZK8_HUMAN
Quinone oxidoreductase-like protein...
CRYZL1
197Annotation score:
C9JQD0C9JQD0_HUMAN
Quinone oxidoreductase-like protein...
CRYZL1
107Annotation score:
H7C3S0H7C3S0_HUMAN
Quinone oxidoreductase-like protein...
CRYZL1
96Annotation score:
H7C338H7C338_HUMAN
Quinone oxidoreductase-like protein...
CRYZL1
97Annotation score:
There are more potential isoformsShow all

Sequence cautioni

The sequence AAH13155 differs from that shown.Curated
The sequence BAA91605 differs from that shown. Reason: Frameshift at position 302.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti78S → P in BAA91605 (PubMed:14702039).Curated1
Sequence conflicti89I → T in BAA91605 (PubMed:14702039).Curated1
Sequence conflicti276F → L in AAD20219 (Ref. 1) Curated1
Sequence conflicti276F → L in AAD22381 (PubMed:10191096).Curated1
Sequence conflicti276F → L in AAH13155 (PubMed:10830953).Curated1
Sequence conflicti299K → E in BAA91605 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02783539A → T. Corresponds to variant dbSNP:rs13050238Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055792193 – 198ARVIDV → ENSTIA in isoform 2. 1 Publication6
Alternative sequenceiVSP_055793199 – 349Missing in isoform 2. 1 PublicationAdd BLAST151

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098798 mRNA Translation: AAD20219.1
AF029689 mRNA Translation: AAD22381.1
AK001293 mRNA Translation: BAA91605.1 Frameshift.
AK057604 mRNA Translation: BAG51939.1
AK315707 mRNA Translation: BAG38068.1
AP000304 Genomic DNA No translation available.
AP000305 Genomic DNA No translation available.
AP000306 Genomic DNA No translation available.
AP000307 Genomic DNA No translation available.
AP000308 Genomic DNA No translation available.
BC013155 mRNA Translation: AAH13155.1 Sequence problems.
BC033023 mRNA Translation: AAH33023.1
CCDSiCCDS13633.2 [O95825-1]
RefSeqiNP_665857.2, NM_145858.2 [O95825-1]
UniGeneiHs.352671

Genome annotation databases

EnsembliENST00000381554; ENSP00000370966; ENSG00000205758 [O95825-1]
ENST00000420072; ENSP00000416315; ENSG00000205758 [O95825-2]
GeneIDi9946
KEGGihsa:9946
UCSCiuc002yss.2 human [O95825-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098798 mRNA Translation: AAD20219.1
AF029689 mRNA Translation: AAD22381.1
AK001293 mRNA Translation: BAA91605.1 Frameshift.
AK057604 mRNA Translation: BAG51939.1
AK315707 mRNA Translation: BAG38068.1
AP000304 Genomic DNA No translation available.
AP000305 Genomic DNA No translation available.
AP000306 Genomic DNA No translation available.
AP000307 Genomic DNA No translation available.
AP000308 Genomic DNA No translation available.
BC013155 mRNA Translation: AAH13155.1 Sequence problems.
BC033023 mRNA Translation: AAH33023.1
CCDSiCCDS13633.2 [O95825-1]
RefSeqiNP_665857.2, NM_145858.2 [O95825-1]
UniGeneiHs.352671

3D structure databases

ProteinModelPortaliO95825
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115271, 14 interactors
DIPiDIP-62115N
IntActiO95825, 4 interactors
STRINGi9606.ENSP00000370966

PTM databases

iPTMnetiO95825
PhosphoSitePlusiO95825

Polymorphism and mutation databases

BioMutaiCRYZL1

Proteomic databases

EPDiO95825
MaxQBiO95825
PaxDbiO95825
PeptideAtlasiO95825
PRIDEiO95825
ProteomicsDBi51072

Protocols and materials databases

DNASUi9946
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381554; ENSP00000370966; ENSG00000205758 [O95825-1]
ENST00000420072; ENSP00000416315; ENSG00000205758 [O95825-2]
GeneIDi9946
KEGGihsa:9946
UCSCiuc002yss.2 human [O95825-1]

Organism-specific databases

CTDi9946
DisGeNETi9946
EuPathDBiHostDB:ENSG00000205758.11
GeneCardsiCRYZL1
HGNCiHGNC:2420 CRYZL1
HPAiCAB034129
HPA019120
HPA029399
MIMi603920 gene
neXtProtiNX_O95825
OpenTargetsiENSG00000205758
PharmGKBiPA26926
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1198 Eukaryota
COG0604 LUCA
GeneTreeiENSGT00390000013113
HOGENOMiHOG000293267
HOVERGENiHBG009484
InParanoidiO95825
OMAiVGGHWIT
OrthoDBiEOG091G08LX
PhylomeDBiO95825
TreeFamiTF328922

Miscellaneous databases

ChiTaRSiCRYZL1 human
GeneWikiiCRYZL1
GenomeRNAii9946
PROiPR:O95825
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000205758 Expressed in 223 organ(s), highest expression level in testis
CleanExiHS_CRYZL1
ExpressionAtlasiO95825 baseline and differential
GenevisibleiO95825 HS

Family and domain databases

InterProiView protein in InterPro
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQORL1_HUMAN
AccessioniPrimary (citable) accession number: O95825
Secondary accession number(s): B2RDX1
, B3KQ77, Q96DY0, Q9NVY7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 3, 2006
Last modified: September 12, 2018
This is version 165 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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