MAP4K4

Functionⁱ

Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322.2 Publications

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.1 Publication

Cofactorⁱ

Mg²⁺1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	54	ATPPROSITE-ProRule annotation		1
Active siteⁱ	153	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	31 – 39	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding
Source: UniProtKB
Inferred from direct assayⁱ
- 9890973
creatine kinase activity
Source: CACAO
Inferred from direct assayⁱ
- 23207904
microtubule binding
Source: ARUK-UCL
Inferred from direct assayⁱ
- 25490267
protein serine/threonine kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 9890973

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of protein kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
intracellular signal transduction
Source: UniProtKB
Inferred from direct assayⁱ
- 9890973
MAPK cascade
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of apoptotic process
Source: CACAO
Inferred from mutant phenotypeⁱ
- 21196414
negative regulation of cell-matrix adhesion
Source: ARUK-UCL
Non-traceable author statementⁱ
- 25490267
negative regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
negative regulation of neuron projection regeneration Source: Ensembl
neuron projection morphogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of adherens junction organization
Source: ARUK-UCL
Inferred from sequence or structural similarityⁱ
- 25490267
positive regulation of ARF protein signal transduction
Source: ARUK-UCL
Inferred from sequence or structural similarityⁱ
- 25490267
positive regulation of cell migration
Source: ARUK-UCL
Inferred from mutant phenotypeⁱ
- 24163766
positive regulation of focal adhesion assembly
Source: ARUK-UCL
Inferred from sequence or structural similarityⁱ
- 25490267
positive regulation of GTPase activity
Source: ARUK-UCL
Inferred from sequence or structural similarityⁱ
- 25490267
positive regulation of keratinocyte migration
Source: ARUK-UCL
Inferred from sequence or structural similarityⁱ
- 25490267
protein phosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 9890973
regulation of JNK cascade
Source: UniProtKB
Inferred from direct assayⁱ
- 14966141
signal transduction by protein phosphorylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
stress-activated protein kinase signaling cascade
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2559580 Oxidative Stress Induced Senescence
SignaLinkⁱ	O95819
SIGNORⁱ	O95819

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mitogen-activated protein kinase kinase kinase kinase 4 (EC:2.7.11.1) Alternative name(s): HPK/GCK-like kinase HGK MAPK/ERK kinase kinase kinase 4 Short name: MEK kinase kinase 4 Short name: MEKKK 4 Nck-interacting kinase
Gene namesⁱ	Name:MAP4K4 Synonyms:HGK, KIAA0687, NIK
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000071054.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6866 MAP4K4
MIMⁱ	604666 gene
neXtProtⁱ	NX_O95819

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9448
Open Targets More...OpenTargetsⁱ	ENSG00000071054
PharmGKBⁱ	PA30612

Chemistry databases

ChEMBLⁱ	CHEMBL6166
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2088

Polymorphism and mutation databases

BioMutaⁱ	MAP4K4

BioMutaⁱ

MAP4K4

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000086280	2 – 1239	Mitogen-activated protein kinase kinase kinase kinase 4Add BLAST		1238

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Modified residueⁱ	5	PhosphoserineCombined sources	1
Modified residueⁱ	324	PhosphoserineBy similarity	1
Modified residueⁱ	326	PhosphoserineBy similarity	1
Modified residueⁱ	629	PhosphoserineCombined sources	1
Modified residueⁱ	631	PhosphoserineCombined sources	1
Modified residueⁱ	639	PhosphoserineCombined sources	1
Modified residueⁱ	644	PhosphoserineCombined sources	1
Modified residueⁱ	656	PhosphoserineBy similarity	1
Modified residueⁱ	700	PhosphoserineCombined sources	1
Modified residueⁱ	712	PhosphoserineCombined sources	1
Modified residueⁱ	715	PhosphoserineCombined sources	1
Modified residueⁱ	791	PhosphoserineCombined sources	1
Modified residueⁱ	800	PhosphoserineCombined sources	1
Modified residueⁱ	801	PhosphoserineCombined sources	1
Modified residueⁱ	805	PhosphoserineCombined sources	1
Modified residueⁱ	823	PhosphoserineCombined sources	1
Modified residueⁱ	828	PhosphothreonineCombined sources	1
Modified residueⁱ	852	PhosphoserineCombined sources	1
Modified residueⁱ	855	PhosphoserineCombined sources	1
Modified residueⁱ	900	PhosphoserineCombined sources	1
Modified residueⁱ	913	PhosphoserineCombined sources	1
Isoform 21 Publication (identifier: O95819-2)
Modified residueⁱ	608	PhosphoserineCombined sources	1
Modified residueⁱ	625	PhosphoserineCombined sources	1
Isoform 6 (identifier: O95819-6)
Modified residueⁱ	608	PhosphoserineCombined sources	1
Modified residueⁱ	625	PhosphoserineCombined sources	1
Isoform 31 Publication (identifier: O95819-3)
Modified residueⁱ	716	PhosphoserineCombined sources	1
Modified residueⁱ	733	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	O95819
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O95819
PaxDbⁱ	O95819
PeptideAtlas More...PeptideAtlasⁱ	O95819
PRIDEⁱ	O95819
ProteomicsDBⁱ	51066 51067 [O95819-2] 51068 [O95819-3] 51069 [O95819-4] 51070 [O95819-5]

PTM databases

iPTMnetⁱ	O95819
PhosphoSitePlusⁱ	O95819

Expressionⁱ

Tissue specificityⁱ

Widely expressed. Isoform 5 is abundant in the brain. Isoform 4 is predominant in the liver, skeletal muscle and placenta.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000071054 Expressed in 229 organ(s), highest expression level in brain
CleanExⁱ	HS_MAP4K4
ExpressionAtlasⁱ	O95819 baseline and differential
Genevisibleⁱ	O95819 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA008476

HPAⁱ

HPA008476

Interactionⁱ

Subunit structureⁱ

Interacts with the SH3 domain of the adapter proteins Nck (By similarity). Interacts (via its CNH regulatory domain) with ATL1 (via the N-terminal region). Interacts with RAP2A (GTP-bound form preferentially).By similarity2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
GBP3	Q9H0R5	4	EBI-2511133,EBI-2798916

With

Entry

#Exp.

IntAct

Notes

GBP3

Q9H0R5

4

EBI-2511133,EBI-2798916

GO - Molecular functionⁱ

microtubule binding
Source: ARUK-UCL
Inferred from direct assayⁱ
- 25490267

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114838, 49 interactors
IntActⁱ	O95819, 23 interactors
Molecular INTeraction database More...MINTⁱ	O95819
STRINGⁱ	9606.ENSP00000314363

Chemistry databases

BindingDBⁱ

O95819

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	15 – 17	Combined sources	3
Turnⁱ	22 – 24	Combined sources	3
Beta strandⁱ	25 – 33	Combined sources	9
Beta strandⁱ	35 – 44	Combined sources	10
Turnⁱ	45 – 47	Combined sources	3
Beta strandⁱ	50 – 58	Combined sources	9
Turnⁱ	60 – 62	Combined sources	3
Helixⁱ	63 – 73	Combined sources	11
Helixⁱ	74 – 77	Combined sources	4
Beta strandⁱ	79 – 82	Combined sources	4
Beta strandⁱ	85 – 91	Combined sources	7
Beta strandⁱ	99 – 105	Combined sources	7
Helixⁱ	113 – 118	Combined sources	6
Helixⁱ	121 – 123	Combined sources	3
Helixⁱ	127 – 146	Combined sources	20
Helixⁱ	156 – 158	Combined sources	3
Beta strandⁱ	159 – 161	Combined sources	3
Beta strandⁱ	167 – 170	Combined sources	4
Helixⁱ	174 – 180	Combined sources	7
Beta strandⁱ	182 – 184	Combined sources	3
Helixⁱ	197 – 199	Combined sources	3
Beta strandⁱ	205 – 207	Combined sources	3
Helixⁱ	214 – 228	Combined sources	15
Turnⁱ	232 – 235	Combined sources	4
Helixⁱ	238 – 244	Combined sources	7
Turnⁱ	245 – 247	Combined sources	3
Helixⁱ	260 – 269	Combined sources	10
Helixⁱ	274 – 276	Combined sources	3
Helixⁱ	280 – 284	Combined sources	5
Helixⁱ	287 – 290	Combined sources	4
Helixⁱ	295 – 310	Combined sources	16

Show more details

3D structure databases

ProteinModelPortalⁱ	O95819
SMRⁱ	O95819
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	25 – 289	Protein kinasePROSITE-ProRule annotationAdd BLAST		265
Domainⁱ	926 – 1213	CNHPROSITE-ProRule annotationAdd BLAST		288

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	858 – 1212	Mediates interaction with RAP2A1 PublicationAdd BLAST		355

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0587 Eukaryota ENOG410YBF5 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150859
HOGENOMⁱ	HOG000290708
HOVERGENⁱ	HBG036506
InParanoidⁱ	O95819
KEGG Orthology (KO) More...KOⁱ	K04407
PhylomeDBⁱ	O95819
TreeFamⁱ	TF105138

Family and domain databases

InterProⁱ	View protein in InterPro IPR001180 CNH_dom IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00780 CNH, 1 hit PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00036 CNH, 1 hit SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50219 CNH, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (6+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 6 described isoforms and 12 potential isoforms that are computationally mapped.Show all Align All

Isoform 11 Publication (identifier: O95819-1) [UniParc]FASTA Add to basket

Also known as: Tumor-associated

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MANDSPAKSL VDIDLSSLRD PAGIFELVEV VGNGTYGQVY KGRHVKTGQL 
        60         70         80         90        100
AAIKVMDVTE DEEEEIKLEI NMLKKYSHHR NIATYYGAFI KKSPPGHDDQ 
       110        120        130        140        150
LWLVMEFCGA GSITDLVKNT KGNTLKEDWI AYISREILRG LAHLHIHHVI 
       160        170        180        190        200
HRDIKGQNVL LTENAEVKLV DFGVSAQLDR TVGRRNTFIG TPYWMAPEVI 
       210        220        230        240        250
ACDENPDATY DYRSDLWSCG ITAIEMAEGA PPLCDMHPMR ALFLIPRNPP 
       260        270        280        290        300
PRLKSKKWSK KFFSFIEGCL VKNYMQRPST EQLLKHPFIR DQPNERQVRI 
       310        320        330        340        350
QLKDHIDRTR KKRGEKDETE YEYSGSEEEE EEVPEQEGEP SSIVNVPGES 
       360        370        380        390        400
TLRRDFLRLQ QENKERSEAL RRQQLLQEQQ LREQEEYKRQ LLAERQKRIE 
       410        420        430        440        450
QQKEQRRRLE EQQRREREAR RQQEREQRRR EQEEKRRLEE LERRRKEEEE 
       460        470        480        490        500
RRRAEEEKRR VEREQEYIRR QLEEEQRHLE VLQQQLLQEQ AMLLECRWRE 
       510        520        530        540        550
MEEHRQAERL QRQLQQEQAY LLSLQHDHRR PHPQHSQQPP PPQQERSKPS 
       560        570        580        590        600
FHAPEPKAHY EPADRAREVE DRFRKTNHSS PEAQSKQTGR VLEPPVPSRS 
       610        620        630        640        650
ESFSNGNSES VHPALQRPAE PQVPVRTTSR SPVLSRRDSP LQGSGQQNSQ 
       660        670        680        690        700
AGQRNSTSIE PRLLWERVEK LVPRPGSGSS SGSSNSGSQP GSHPGSQSGS 
       710        720        730        740        750
GERFRVRSSS KSEGSPSQRL ENAVKKPEDK KEVFRPLKPA DLTALAKELR 
       760        770        780        790        800
AVEDVRPPHK VTDYSSSSEE SGTTDEEDDD VEQEGADEST SGPEDTRAAS 
       810        820        830        840        850
SLNLSNGETE SVKTMIVHDD VESEPAMTPS KEGTLIVRQT QSASSTLQKH 
       860        870        880        890        900
KSSSSFTPFI DPRLLQISPS SGTTVTSVVG FSCDGMRPEA IRQDPTRKGS 
       910        920        930        940        950
VVNVNPTNTR PQSDTPEIRK YKKRFNSEIL CAALWGVNLL VGTESGLMLL 
       960        970        980        990       1000
DRSGQGKVYP LINRRRFQQM DVLEGLNVLV TISGKKDKLR VYYLSWLRNK 
      1010       1020       1030       1040       1050
ILHNDPEVEK KQGWTTVGDL EGCVHYKVVK YERIKFLVIA LKSSVEVYAW 
      1060       1070       1080       1090       1100
APKPYHKFMA FKSFGELVHK PLLVDLTVEE GQRLKVIYGS CAGFHAVDVD 
      1110       1120       1130       1140       1150
SGSVYDIYLP THIQCSIKPH AIIILPNTDG MELLVCYEDE GVYVNTYGRI 
      1160       1170       1180       1190       1200
TKDVVLQWGE MPTSVAYIRS NQTMGWGEKA IEIRSVETGH LDGVFMHKRA 
      1210       1220       1230 
QRLKFLCERN DKVFFASVRS GGSSQVYFMT LGRTSLLSW

Length:1,239

Mass (Da):142,101

Last modified:March 28, 2003 - v2

Checksum:ⁱ8FBBE2F9ABEEC757

GO

Isoform 21 Publication (identifier: O95819-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     495-525: Missing.
     659-659: I → SI
     740-740: A → AGEV

« Hide

        10         20         30         40         50
MANDSPAKSL VDIDLSSLRD PAGIFELVEV VGNGTYGQVY KGRHVKTGQL 
        60         70         80         90        100
AAIKVMDVTE DEEEEIKLEI NMLKKYSHHR NIATYYGAFI KKSPPGHDDQ 
       110        120        130        140        150
LWLVMEFCGA GSITDLVKNT KGNTLKEDWI AYISREILRG LAHLHIHHVI 
       160        170        180        190        200
HRDIKGQNVL LTENAEVKLV DFGVSAQLDR TVGRRNTFIG TPYWMAPEVI 
       210        220        230        240        250
ACDENPDATY DYRSDLWSCG ITAIEMAEGA PPLCDMHPMR ALFLIPRNPP 
       260        270        280        290        300
PRLKSKKWSK KFFSFIEGCL VKNYMQRPST EQLLKHPFIR DQPNERQVRI 
       310        320        330        340        350
QLKDHIDRTR KKRGEKDETE YEYSGSEEEE EEVPEQEGEP SSIVNVPGES 
       360        370        380        390        400
TLRRDFLRLQ QENKERSEAL RRQQLLQEQQ LREQEEYKRQ LLAERQKRIE 
       410        420        430        440        450
QQKEQRRRLE EQQRREREAR RQQEREQRRR EQEEKRRLEE LERRRKEEEE 
       460        470        480        490        500
RRRAEEEKRR VEREQEYIRR QLEEEQRHLE VLQQQLLQEQ AMLLHDHRRP 
       510        520        530        540        550
HPQHSQQPPP PQQERSKPSF HAPEPKAHYE PADRAREVED RFRKTNHSSP 
       560        570        580        590        600
EAQSKQTGRV LEPPVPSRSE SFSNGNSESV HPALQRPAEP QVPVRTTSRS 
       610        620        630        640        650
PVLSRRDSPL QGSGQQNSQA GQRNSTSSIE PRLLWERVEK LVPRPGSGSS 
       660        670        680        690        700
SGSSNSGSQP GSHPGSQSGS GERFRVRSSS KSEGSPSQRL ENAVKKPEDK 
       710        720        730        740        750
KEVFRPLKPA GEVDLTALAK ELRAVEDVRP PHKVTDYSSS SEESGTTDEE 
       760        770        780        790        800
DDDVEQEGAD ESTSGPEDTR AASSLNLSNG ETESVKTMIV HDDVESEPAM 
       810        820        830        840        850
TPSKEGTLIV RQTQSASSTL QKHKSSSSFT PFIDPRLLQI SPSSGTTVTS 
       860        870        880        890        900
VVGFSCDGMR PEAIRQDPTR KGSVVNVNPT NTRPQSDTPE IRKYKKRFNS 
       910        920        930        940        950
EILCAALWGV NLLVGTESGL MLLDRSGQGK VYPLINRRRF QQMDVLEGLN 
       960        970        980        990       1000
VLVTISGKKD KLRVYYLSWL RNKILHNDPE VEKKQGWTTV GDLEGCVHYK 
      1010       1020       1030       1040       1050
VVKYERIKFL VIALKSSVEV YAWAPKPYHK FMAFKSFGEL VHKPLLVDLT 
      1060       1070       1080       1090       1100
VEEGQRLKVI YGSCAGFHAV DVDSGSVYDI YLPTHIQCSI KPHAIIILPN 
      1110       1120       1130       1140       1150
TDGMELLVCY EDEGVYVNTY GRITKDVVLQ WGEMPTSVAY IRSNQTMGWG 
      1160       1170       1180       1190       1200
EKAIEIRSVE TGHLDGVFMH KRAQRLKFLC ERNDKVFFAS VRSGGSSQVY 
      1210 
FMTLGRTSLL SW

Show »

Length:1,212

Mass (Da):138,505

Checksum:ⁱ29398FB628EE847F

GO

Isoform 31 Publication (identifier: O95819-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     623-623: V → VQWSHLASLK...SDSDEVPPRV
     659-659: I → SI
     740-740: A → AGEV

« Hide

        10         20         30         40         50
MANDSPAKSL VDIDLSSLRD PAGIFELVEV VGNGTYGQVY KGRHVKTGQL 
        60         70         80         90        100
AAIKVMDVTE DEEEEIKLEI NMLKKYSHHR NIATYYGAFI KKSPPGHDDQ 
       110        120        130        140        150
LWLVMEFCGA GSITDLVKNT KGNTLKEDWI AYISREILRG LAHLHIHHVI 
       160        170        180        190        200
HRDIKGQNVL LTENAEVKLV DFGVSAQLDR TVGRRNTFIG TPYWMAPEVI 
       210        220        230        240        250
ACDENPDATY DYRSDLWSCG ITAIEMAEGA PPLCDMHPMR ALFLIPRNPP 
       260        270        280        290        300
PRLKSKKWSK KFFSFIEGCL VKNYMQRPST EQLLKHPFIR DQPNERQVRI 
       310        320        330        340        350
QLKDHIDRTR KKRGEKDETE YEYSGSEEEE EEVPEQEGEP SSIVNVPGES 
       360        370        380        390        400
TLRRDFLRLQ QENKERSEAL RRQQLLQEQQ LREQEEYKRQ LLAERQKRIE 
       410        420        430        440        450
QQKEQRRRLE EQQRREREAR RQQEREQRRR EQEEKRRLEE LERRRKEEEE 
       460        470        480        490        500
RRRAEEEKRR VEREQEYIRR QLEEEQRHLE VLQQQLLQEQ AMLLECRWRE 
       510        520        530        540        550
MEEHRQAERL QRQLQQEQAY LLSLQHDHRR PHPQHSQQPP PPQQERSKPS 
       560        570        580        590        600
FHAPEPKAHY EPADRAREVE DRFRKTNHSS PEAQSKQTGR VLEPPVPSRS 
       610        620        630        640        650
ESFSNGNSES VHPALQRPAE PQVQWSHLAS LKNNVSPVSR SHSFSDPSPK 
       660        670        680        690        700
FAHHHLRSQD PCPPSRSEVL SQSSDSKSEA PDPTQKAWSR SDSDEVPPRV 
       710        720        730        740        750
PVRTTSRSPV LSRRDSPLQG SGQQNSQAGQ RNSTSSIEPR LLWERVEKLV 
       760        770        780        790        800
PRPGSGSSSG SSNSGSQPGS HPGSQSGSGE RFRVRSSSKS EGSPSQRLEN 
       810        820        830        840        850
AVKKPEDKKE VFRPLKPAGE VDLTALAKEL RAVEDVRPPH KVTDYSSSSE 
       860        870        880        890        900
ESGTTDEEDD DVEQEGADES TSGPEDTRAA SSLNLSNGET ESVKTMIVHD 
       910        920        930        940        950
DVESEPAMTP SKEGTLIVRQ TQSASSTLQK HKSSSSFTPF IDPRLLQISP 
       960        970        980        990       1000
SSGTTVTSVV GFSCDGMRPE AIRQDPTRKG SVVNVNPTNT RPQSDTPEIR 
      1010       1020       1030       1040       1050
KYKKRFNSEI LCAALWGVNL LVGTESGLML LDRSGQGKVY PLINRRRFQQ 
      1060       1070       1080       1090       1100
MDVLEGLNVL VTISGKKDKL RVYYLSWLRN KILHNDPEVE KKQGWTTVGD 
      1110       1120       1130       1140       1150
LEGCVHYKVV KYERIKFLVI ALKSSVEVYA WAPKPYHKFM AFKSFGELVH 
      1160       1170       1180       1190       1200
KPLLVDLTVE EGQRLKVIYG SCAGFHAVDV DSGSVYDIYL PTHIQCSIKP 
      1210       1220       1230       1240       1250
HAIIILPNTD GMELLVCYED EGVYVNTYGR ITKDVVLQWG EMPTSVAYIR 
      1260       1270       1280       1290       1300
SNQTMGWGEK AIEIRSVETG HLDGVFMHKR AQRLKFLCER NDKVFFASVR 
      1310       1320
SGGSSQVYFM TLGRTSLLSW

Show »

Length:1,320

Mass (Da):151,000

Checksum:ⁱ17890E0DC40169EC

GO

Isoform 41 Publication (identifier: O95819-4) [UniParc]FASTA Add to basket

Also known as: HGK-S1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     495-525: Missing.
     569-622: Missing.
     740-740: A → AGEV
     1112-1112: H → HVRKNPHSM

« Hide

        10         20         30         40         50
MANDSPAKSL VDIDLSSLRD PAGIFELVEV VGNGTYGQVY KGRHVKTGQL 
        60         70         80         90        100
AAIKVMDVTE DEEEEIKLEI NMLKKYSHHR NIATYYGAFI KKSPPGHDDQ 
       110        120        130        140        150
LWLVMEFCGA GSITDLVKNT KGNTLKEDWI AYISREILRG LAHLHIHHVI 
       160        170        180        190        200
HRDIKGQNVL LTENAEVKLV DFGVSAQLDR TVGRRNTFIG TPYWMAPEVI 
       210        220        230        240        250
ACDENPDATY DYRSDLWSCG ITAIEMAEGA PPLCDMHPMR ALFLIPRNPP 
       260        270        280        290        300
PRLKSKKWSK KFFSFIEGCL VKNYMQRPST EQLLKHPFIR DQPNERQVRI 
       310        320        330        340        350
QLKDHIDRTR KKRGEKDETE YEYSGSEEEE EEVPEQEGEP SSIVNVPGES 
       360        370        380        390        400
TLRRDFLRLQ QENKERSEAL RRQQLLQEQQ LREQEEYKRQ LLAERQKRIE 
       410        420        430        440        450
QQKEQRRRLE EQQRREREAR RQQEREQRRR EQEEKRRLEE LERRRKEEEE 
       460        470        480        490        500
RRRAEEEKRR VEREQEYIRR QLEEEQRHLE VLQQQLLQEQ AMLLHDHRRP 
       510        520        530        540        550
HPQHSQQPPP PQQERSKPSF HAPEPKAHYE PADRAREVPV RTTSRSPVLS 
       560        570        580        590        600
RRDSPLQGSG QQNSQAGQRN STSIEPRLLW ERVEKLVPRP GSGSSSGSSN 
       610        620        630        640        650
SGSQPGSHPG SQSGSGERFR VRSSSKSEGS PSQRLENAVK KPEDKKEVFR 
       660        670        680        690        700
PLKPAGEVDL TALAKELRAV EDVRPPHKVT DYSSSSEESG TTDEEDDDVE 
       710        720        730        740        750
QEGADESTSG PEDTRAASSL NLSNGETESV KTMIVHDDVE SEPAMTPSKE 
       760        770        780        790        800
GTLIVRQTQS ASSTLQKHKS SSSFTPFIDP RLLQISPSSG TTVTSVVGFS 
       810        820        830        840        850
CDGMRPEAIR QDPTRKGSVV NVNPTNTRPQ SDTPEIRKYK KRFNSEILCA 
       860        870        880        890        900
ALWGVNLLVG TESGLMLLDR SGQGKVYPLI NRRRFQQMDV LEGLNVLVTI 
       910        920        930        940        950
SGKKDKLRVY YLSWLRNKIL HNDPEVEKKQ GWTTVGDLEG CVHYKVVKYE 
       960        970        980        990       1000
RIKFLVIALK SSVEVYAWAP KPYHKFMAFK SFGELVHKPL LVDLTVEEGQ 
      1010       1020       1030       1040       1050
RLKVIYGSCA GFHAVDVDSG SVYDIYLPTH VRKNPHSMIQ CSIKPHAIII 
      1060       1070       1080       1090       1100
LPNTDGMELL VCYEDEGVYV NTYGRITKDV VLQWGEMPTS VAYIRSNQTM 
      1110       1120       1130       1140       1150
GWGEKAIEIR SVETGHLDGV FMHKRAQRLK FLCERNDKVF FASVRSGGSS 
      1160 
QVYFMTLGRT SLLSW

Show »

Length:1,165

Mass (Da):133,401

Checksum:ⁱ03D9E1A3D7F9415D

GO

Isoform 51 Publication (identifier: O95819-5) [UniParc]FASTA Add to basket

Also known as: HGK-L1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     495-525: Missing.
     569-622: Missing.
     623-623: V → VQWSHLASLK...SDSDEVPPRV
     740-740: A → AGEV
     1112-1112: H → HVRKNPHSM

« Hide

        10         20         30         40         50
MANDSPAKSL VDIDLSSLRD PAGIFELVEV VGNGTYGQVY KGRHVKTGQL 
        60         70         80         90        100
AAIKVMDVTE DEEEEIKLEI NMLKKYSHHR NIATYYGAFI KKSPPGHDDQ 
       110        120        130        140        150
LWLVMEFCGA GSITDLVKNT KGNTLKEDWI AYISREILRG LAHLHIHHVI 
       160        170        180        190        200
HRDIKGQNVL LTENAEVKLV DFGVSAQLDR TVGRRNTFIG TPYWMAPEVI 
       210        220        230        240        250
ACDENPDATY DYRSDLWSCG ITAIEMAEGA PPLCDMHPMR ALFLIPRNPP 
       260        270        280        290        300
PRLKSKKWSK KFFSFIEGCL VKNYMQRPST EQLLKHPFIR DQPNERQVRI 
       310        320        330        340        350
QLKDHIDRTR KKRGEKDETE YEYSGSEEEE EEVPEQEGEP SSIVNVPGES 
       360        370        380        390        400
TLRRDFLRLQ QENKERSEAL RRQQLLQEQQ LREQEEYKRQ LLAERQKRIE 
       410        420        430        440        450
QQKEQRRRLE EQQRREREAR RQQEREQRRR EQEEKRRLEE LERRRKEEEE 
       460        470        480        490        500
RRRAEEEKRR VEREQEYIRR QLEEEQRHLE VLQQQLLQEQ AMLLHDHRRP 
       510        520        530        540        550
HPQHSQQPPP PQQERSKPSF HAPEPKAHYE PADRAREVQW SHLASLKNNV 
       560        570        580        590        600
SPVSRSHSFS DPSPKFAHHH LRSQDPCPPS RSEVLSQSSD SKSEAPDPTQ 
       610        620        630        640        650
KAWSRSDSDE VPPRVPVRTT SRSPVLSRRD SPLQGSGQQN SQAGQRNSTS 
       660        670        680        690        700
IEPRLLWERV EKLVPRPGSG SSSGSSNSGS QPGSHPGSQS GSGERFRVRS 
       710        720        730        740        750
SSKSEGSPSQ RLENAVKKPE DKKEVFRPLK PAGEVDLTAL AKELRAVEDV 
       760        770        780        790        800
RPPHKVTDYS SSSEESGTTD EEDDDVEQEG ADESTSGPED TRAASSLNLS 
       810        820        830        840        850
NGETESVKTM IVHDDVESEP AMTPSKEGTL IVRQTQSASS TLQKHKSSSS 
       860        870        880        890        900
FTPFIDPRLL QISPSSGTTV TSVVGFSCDG MRPEAIRQDP TRKGSVVNVN 
       910        920        930        940        950
PTNTRPQSDT PEIRKYKKRF NSEILCAALW GVNLLVGTES GLMLLDRSGQ 
       960        970        980        990       1000
GKVYPLINRR RFQQMDVLEG LNVLVTISGK KDKLRVYYLS WLRNKILHND 
      1010       1020       1030       1040       1050
PEVEKKQGWT TVGDLEGCVH YKVVKYERIK FLVIALKSSV EVYAWAPKPY 
      1060       1070       1080       1090       1100
HKFMAFKSFG ELVHKPLLVD LTVEEGQRLK VIYGSCAGFH AVDVDSGSVY 
      1110       1120       1130       1140       1150
DIYLPTHVRK NPHSMIQCSI KPHAIIILPN TDGMELLVCY EDEGVYVNTY 
      1160       1170       1180       1190       1200
GRITKDVVLQ WGEMPTSVAY IRSNQTMGWG EKAIEIRSVE TGHLDGVFMH 
      1210       1220       1230       1240 
KRAQRLKFLC ERNDKVFFAS VRSGGSSQVY FMTLGRTSLL SW

Show »

Length:1,242

Mass (Da):141,929

Checksum:ⁱAF0219B2CA816B5B

GO

Isoform 6 (identifier: O95819-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     495-525: Missing.
     659-659: I → SI
     839-839: Q → QSTVDQKRASHHESNGFAGRIHLLPDLLQQSHSSSTSSTSSSPSSSQPTPTMSPQTPQDKLTANE

« Hide

        10         20         30         40         50
MANDSPAKSL VDIDLSSLRD PAGIFELVEV VGNGTYGQVY KGRHVKTGQL 
        60         70         80         90        100
AAIKVMDVTE DEEEEIKLEI NMLKKYSHHR NIATYYGAFI KKSPPGHDDQ 
       110        120        130        140        150
LWLVMEFCGA GSITDLVKNT KGNTLKEDWI AYISREILRG LAHLHIHHVI 
       160        170        180        190        200
HRDIKGQNVL LTENAEVKLV DFGVSAQLDR TVGRRNTFIG TPYWMAPEVI 
       210        220        230        240        250
ACDENPDATY DYRSDLWSCG ITAIEMAEGA PPLCDMHPMR ALFLIPRNPP 
       260        270        280        290        300
PRLKSKKWSK KFFSFIEGCL VKNYMQRPST EQLLKHPFIR DQPNERQVRI 
       310        320        330        340        350
QLKDHIDRTR KKRGEKDETE YEYSGSEEEE EEVPEQEGEP SSIVNVPGES 
       360        370        380        390        400
TLRRDFLRLQ QENKERSEAL RRQQLLQEQQ LREQEEYKRQ LLAERQKRIE 
       410        420        430        440        450
QQKEQRRRLE EQQRREREAR RQQEREQRRR EQEEKRRLEE LERRRKEEEE 
       460        470        480        490        500
RRRAEEEKRR VEREQEYIRR QLEEEQRHLE VLQQQLLQEQ AMLLHDHRRP 
       510        520        530        540        550
HPQHSQQPPP PQQERSKPSF HAPEPKAHYE PADRAREVED RFRKTNHSSP 
       560        570        580        590        600
EAQSKQTGRV LEPPVPSRSE SFSNGNSESV HPALQRPAEP QVPVRTTSRS 
       610        620        630        640        650
PVLSRRDSPL QGSGQQNSQA GQRNSTSSIE PRLLWERVEK LVPRPGSGSS 
       660        670        680        690        700
SGSSNSGSQP GSHPGSQSGS GERFRVRSSS KSEGSPSQRL ENAVKKPEDK 
       710        720        730        740        750
KEVFRPLKPA DLTALAKELR AVEDVRPPHK VTDYSSSSEE SGTTDEEDDD 
       760        770        780        790        800
VEQEGADEST SGPEDTRAAS SLNLSNGETE SVKTMIVHDD VESEPAMTPS 
       810        820        830        840        850
KEGTLIVRQS TVDQKRASHH ESNGFAGRIH LLPDLLQQSH SSSTSSTSSS 
       860        870        880        890        900
PSSSQPTPTM SPQTPQDKLT ANETQSASST LQKHKSSSSF TPFIDPRLLQ 
       910        920        930        940        950
ISPSSGTTVT SVVGFSCDGM RPEAIRQDPT RKGSVVNVNP TNTRPQSDTP 
       960        970        980        990       1000
EIRKYKKRFN SEILCAALWG VNLLVGTESG LMLLDRSGQG KVYPLINRRR 
      1010       1020       1030       1040       1050
FQQMDVLEGL NVLVTISGKK DKLRVYYLSW LRNKILHNDP EVEKKQGWTT 
      1060       1070       1080       1090       1100
VGDLEGCVHY KVVKYERIKF LVIALKSSVE VYAWAPKPYH KFMAFKSFGE 
      1110       1120       1130       1140       1150
LVHKPLLVDL TVEEGQRLKV IYGSCAGFHA VDVDSGSVYD IYLPTHIQCS 
      1160       1170       1180       1190       1200
IKPHAIIILP NTDGMELLVC YEDEGVYVNT YGRITKDVVL QWGEMPTSVA 
      1210       1220       1230       1240       1250
YIRSNQTMGW GEKAIEIRSV ETGHLDGVFM HKRAQRLKFL CERNDKVFFA 
      1260       1270 
SVRSGGSSQV YFMTLGRTSL LSW

Note: Gene prediction based on EST data.Combined sources

Show »

Length:1,273

Mass (Da):145,005

Checksum:ⁱ576DCE0A50E7E776

GO

Computationally mapped potential isoform sequencesⁱ

There are 12 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	E7EN19	E7EN19_HUMAN	Mitogen-activated protein kinase ki... Mitogen-activated protein kinase kinase kinase kinase 4	MAP4K4	1,272	Annotation score:
	A0A0D9SEY1	A0A0D9SEY1_HUMAN	Mitogen-activated protein kinase ki... Mitogen-activated protein kinase kinase kinase kinase 4, isoform CRA_a	MAP4K4 hCG_1640439	1,320	Annotation score:
	C9J840	C9J840_HUMAN	Mitogen-activated protein kinase ki... Mitogen-activated protein kinase kinase kinase kinase 4	MAP4K4	987	Annotation score:
	E7EX83	E7EX83_HUMAN	Mitogen-activated protein kinase ki... Mitogen-activated protein kinase kinase kinase kinase 4	MAP4K4	1,038	Annotation score:
	H7C360	H7C360_HUMAN	Mitogen-activated protein kinase ki... Mitogen-activated protein kinase kinase kinase kinase 4	MAP4K4	1,170	Annotation score:
	E7ENQ1	E7ENQ1_HUMAN	Mitogen-activated protein kinase ki... Mitogen-activated protein kinase kinase kinase kinase 4	MAP4K4	1,154	Annotation score:
	G5E948	G5E948_HUMAN	Mitogen-activated protein kinase ki... Mitogen-activated protein kinase kinase kinase kinase 4	MAP4K4	1,235	Annotation score:
	A0A0D9SG62	A0A0D9SG62_HUMAN	Mitogen-activated protein kinase ki... Mitogen-activated protein kinase kinase kinase kinase 4	MAP4K4	1,044	Annotation score:
	G3XAA2	G3XAA2_HUMAN	Mitogen-activated protein kinase ki... Mitogen-activated protein kinase kinase kinase kinase 4 (Mitogen-activated protein kinase kinase kinase kinase 4, isoform CRA_c)	MAP4K4 hCG_1640439	1,165	Annotation score:
	E7ETN6	E7ETN6_HUMAN	Mitogen-activated protein kinase ki... Mitogen-activated protein kinase kinase kinase kinase 4	MAP4K4	102	Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	839	Q → R in AAO32626 (PubMed:12612079).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_040746	712	S → T1 Publication	1
Isoform 31 Publication (identifier: O95819-3)
Natural variantⁱ	682	D → VCombined sources	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_007054	495 – 525	Missing in isoform 2, isoform 4, isoform 5 and isoform 6. 2 PublicationsCuratedAdd BLAST	31
Alternative sequenceⁱVSP_007055	569 – 622	Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST	54
Alternative sequenceⁱVSP_007056	623	V → VQWSHLASLKNNVSPVSRSH SFSDPSPKFAHHHLRSQDPC PPSRSEVLSQSSDSKSEAPD PTQKAWSRSDSDEVPPRV in isoform 3 and isoform 5. 2 Publications	1
Alternative sequenceⁱVSP_058855	659	I → SI in isoform 2, isoform 3 and isoform 6. 2 PublicationsCurated	1
Alternative sequenceⁱVSP_007057	740	A → AGEV in isoform 2, isoform 3, isoform 4 and isoform 5. 3 Publications	1
Alternative sequenceⁱVSP_058856	839	Q → QSTVDQKRASHHESNGFAGR IHLLPDLLQQSHSSSTSSTS SSPSSSQPTPTMSPQTPQDK LTANE in isoform 6. Curated	1
Alternative sequenceⁱVSP_007058	1112	H → HVRKNPHSM in isoform 4 and isoform 5. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF096300 mRNA Translation: AAD16137.1 AY212247 mRNA Translation: AAO32626.1 AC005035 Genomic DNA No translation available. CH471127 Genomic DNA Translation: EAX01810.1 AC007005 Genomic DNA No translation available. AB014587 mRNA Translation: BAA31662.1 AL137755 mRNA Translation: CAB70907.2 AB013385 mRNA Translation: BAA33714.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS56130.1 [O95819-1] CCDS74546.1 [O95819-6] CCDS82487.1 [O95819-4]
PIRⁱ	T46481
NCBI Reference Sequences More...RefSeqⁱ	NP_001229488.1, NM_001242559.1 [O95819-1] NP_004825.3, NM_004834.4 [O95819-4] NP_663719.2, NM_145686.3 [O95819-6] NP_663720.1, NM_145687.3 [O95819-2]
UniGeneⁱ	Hs.701013

Genome annotation databases

Ensemblⁱ	ENST00000347699; ENSP00000314363; ENSG00000071054 [O95819-1] ENST00000350878; ENSP00000343658; ENSG00000071054 [O95819-6] ENST00000634702; ENSP00000489579; ENSG00000071054 [O95819-4]
GeneIDⁱ	9448
KEGGⁱ	hsa:9448
UCSC genome browser More...UCSCⁱ	uc002tbf.4 human uc002tbg.4 human [O95819-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
O95819	MAP4K4 isoform 10		PANTR		1239	UniRef100_O95819
O95819-2	Epididymis secretory protein Li 31		HUMAN		1212	UniRef100_V9HWH3
UPI00024CA756		PANPA		1157
O95819-3	Uncharacterized protein MAP4K4 (Fragment)		HUMAN		1260	UniRef100_O95819-3
O95819-4	MAP4K4 isoform 9		PANTR		1165	UniRef100_H2QIG2
Uncharacterized protein		PANPA		1146
UPI000D500269		PANPA		1110
O95819-6	MAP4K4 isoform 2		PANTR		1273	UniRef100_A0A2I3T7Z9
Uncharacterized protein		PANPA		1254
UPI0004F0A112		PANPA		1218

Protein	Similar proteins		Species	Score	Length	Source
O95819	MAP4K4 isoform 10		PANTR		1239	UniRef90_O95819
Uncharacterized protein		MACFA		1251
Uncharacterized protein		MACNE		1251
Mitogen-activated protein kinase kinase kinase kinase 4 isoform 4		MACMU		1248
mitogen-activated protein kinase kinase kinase kinase 4 isoform X6		DIPOR		1244
+120
O95819-2	Mitogen-activated protein kinase kinase kinase kinase 4 (Fragment)		HUMAN		1170	UniRef90_H7C360
MAP4K4 isoform 13 (Fragment)		PANTR		1170
mitogen-activated protein kinase kinase kinase kinase 4 isoform X8		BALAS		1213
mitogen-activated protein kinase kinase kinase kinase 4 isoform X11		DIPOR		1213
Mitogen-activated protein kinase kinase kinase kinase 4 isoform 3		MACMU		1212
+125
O95819-3	Uncharacterized protein MAP4K4 (Fragment)		HUMAN		1260	UniRef90_O95819-3
Uncharacterized protein		ALLMI		1349
mitogen-activated protein kinase kinase kinase kinase 4 isoform X9		MESAU		1328
Uncharacterized protein		PROCO		1327
Mitogen-activated protein kinase kinase kinase kinase 4 isoform 5		MACMU		1326
+221
O95819-4	MAP4K4 isoform 9		PANTR		1165	UniRef90_H2QIG2
Uncharacterized protein		PANPA		1146
Uncharacterized protein		PROCO		1166
Mitogen-activated protein kinase kinase kinase kinase 4		HUMAN		1165
Uncharacterized protein		MACMU		1165
+73
O95819-6	Mitogen-activated protein kinase kinase kinase kinase 4		MUSPF		1215	UniRef90_M3YLC5
mitogen-activated protein kinase kinase kinase kinase 4 isoform X3		DIPOR		1279
Mitogen-activated protein kinase kinase kinase kinase 4 isoform 2		CALJA		1276
Uncharacterized protein		RHIBE		1275
Mitogen-activated protein kinase kinase kinase kinase 4 isoform 2		HETGA		1274
+243

Protein	Similar proteins		Species	Score	Length	Source
O95819	MAP4K4 isoform 10		PANTR		1239	UniRef50_O95819
Uncharacterized protein		MACFA		1251
Uncharacterized protein		MACNE		1251
Mitogen-activated protein kinase kinase kinase kinase 4 isoform 4		MACMU		1248
mitogen-activated protein kinase kinase kinase kinase 4 isoform X6		DIPOR		1244
+1448
O95819-3	Uncharacterized protein MAP4K4 (Fragment)		HUMAN		1260	UniRef50_O95819-3
Uncharacterized protein		ALLMI		1349
mitogen-activated protein kinase kinase kinase kinase 4 isoform X9		MESAU		1328
Uncharacterized protein		PROCO		1327
Mitogen-activated protein kinase kinase kinase kinase 4 isoform 5		MACMU		1326
+778
O95819-4	Mitogen-activated protein kinase kinase kinase kinase 4		DANRE		1068	UniRef50_A0A0R4ICI1
RNA binding protein fox-1 homolog		bluefin notho		384
Mitogen-activated protein kinase kinase kinase kinase 4 (Fragment)		Nothobranchius korthausae		1221
RNA binding protein fox-1 homolog		Iconisemion striatum		384
RFOX3		blackstripe livebearer		134
+153
O95819-5	Mitogen-activated protein kinase kinase kinase kinase 4		MOUSE		1233	UniRef50_O95819-5
Uncharacterized protein		CIOSA		1239
Uncharacterized protein		CHICK		1230
Mitogen-activated protein kinase kinase kinase kinase 4 isoform B		ALLMI		1230
Uncharacterized protein		LEPOC		1233
+359

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF096300 mRNA Translation: AAD16137.1 AY212247 mRNA Translation: AAO32626.1 AC005035 Genomic DNA No translation available. CH471127 Genomic DNA Translation: EAX01810.1 AC007005 Genomic DNA No translation available. AB014587 mRNA Translation: BAA31662.1 AL137755 mRNA Translation: CAB70907.2 AB013385 mRNA Translation: BAA33714.1
CCDSⁱ	CCDS56130.1 [O95819-1] CCDS74546.1 [O95819-6] CCDS82487.1 [O95819-4]
PIRⁱ	T46481
RefSeqⁱ	NP_001229488.1, NM_001242559.1 [O95819-1] NP_004825.3, NM_004834.4 [O95819-4] NP_663719.2, NM_145686.3 [O95819-6] NP_663720.1, NM_145687.3 [O95819-2]
UniGeneⁱ	Hs.701013

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4OBO	X-ray	2.10	A/B	2-328	[»]
	4OBP	X-ray	2.27	A/B	2-328	[»]
	4OBQ	X-ray	2.19	A/B	2-328	[»]
	4RVT	X-ray	2.40	A/B	1-325	[»]
	4U3Y	X-ray	1.45	A/B	2-328	[»]
	4U3Z	X-ray	2.09	A/B	2-328	[»]
	4U40	X-ray	2.30	A/B	2-328	[»]
	4U41	X-ray	2.20	A/B	2-328	[»]
	4U42	X-ray	2.50	A/B	2-328	[»]
	4U43	X-ray	2.18	A/B	2-328	[»]
	4U44	X-ray	2.43	A/B	2-328	[»]
	4U45	X-ray	2.58	A/B	2-328	[»]
	4ZK5	X-ray	2.89	A/B	2-328	[»]
	4ZP5	X-ray	2.29	A/B	1-309	[»]
	5DI1	X-ray	2.90	A/B	1-310	[»]
	5J95	X-ray	2.50	A/B	2-313	[»]
	5W5Q	X-ray	2.33	A/B	2-328	[»]
ProteinModelPortalⁱ	O95819
SMRⁱ	O95819
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114838, 49 interactors
IntActⁱ	O95819, 23 interactors
MINTⁱ	O95819
STRINGⁱ	9606.ENSP00000314363

Chemistry databases

BindingDBⁱ	O95819
ChEMBLⁱ	CHEMBL6166
GuidetoPHARMACOLOGYⁱ	2088

PTM databases

iPTMnetⁱ	O95819
PhosphoSitePlusⁱ	O95819

Polymorphism and mutation databases

BioMutaⁱ	MAP4K4

BioMutaⁱ

MAP4K4

Proteomic databases

EPDⁱ	O95819
MaxQBⁱ	O95819
PaxDbⁱ	O95819
PeptideAtlasⁱ	O95819
PRIDEⁱ	O95819
ProteomicsDBⁱ	51066 51067 [O95819-2] 51068 [O95819-3] 51069 [O95819-4] 51070 [O95819-5]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000347699; ENSP00000314363; ENSG00000071054 [O95819-1] ENST00000350878; ENSP00000343658; ENSG00000071054 [O95819-6] ENST00000634702; ENSP00000489579; ENSG00000071054 [O95819-4]
GeneIDⁱ	9448
KEGGⁱ	hsa:9448
UCSCⁱ	uc002tbf.4 human uc002tbg.4 human [O95819-1]

Organism-specific databases

CTDⁱ	9448
DisGeNETⁱ	9448
EuPathDBⁱ	HostDB:ENSG00000071054.16
GeneCardsⁱ	MAP4K4
HGNCⁱ	HGNC:6866 MAP4K4
HPAⁱ	HPA008476
MIMⁱ	604666 gene
neXtProtⁱ	NX_O95819
OpenTargetsⁱ	ENSG00000071054
PharmGKBⁱ	PA30612
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0587 Eukaryota ENOG410YBF5 LUCA
GeneTreeⁱ	ENSGT00930000150859
HOGENOMⁱ	HOG000290708
HOVERGENⁱ	HBG036506
InParanoidⁱ	O95819
KOⁱ	K04407
PhylomeDBⁱ	O95819
TreeFamⁱ	TF105138

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2559580 Oxidative Stress Induced Senescence
SignaLinkⁱ	O95819
SIGNORⁱ	O95819

Miscellaneous databases

ChiTaRSⁱ	MAP4K4 human
GeneWikiⁱ	MAP4K4
GenomeRNAiⁱ	9448
Protein Ontology More...PROⁱ	PR:O95819
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000071054 Expressed in 229 organ(s), highest expression level in brain
CleanExⁱ	HS_MAP4K4
ExpressionAtlasⁱ	O95819 baseline and differential
Genevisibleⁱ	O95819 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR001180 CNH_dom IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF00780 CNH, 1 hit PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00036 CNH, 1 hit SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50219 CNH, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	M4K4_HUMAN
Accessionⁱ	O95819Primary (citable) accession number: O95819 Secondary accession number(s): E7ESS2, O75172, Q9NST7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 28, 2003
	Last sequence update:	March 28, 2003
	Last modified:	November 7, 2018
	This is version 186 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

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UniProtKB - O95819 (M4K4_HUMAN)

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Mitogen-activated protein kinase kinase kinase kinase 4

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ