UniProtKB - O95819 (M4K4_HUMAN)
Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4
Functioni
Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322.
2 PublicationsCatalytic activityi
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 54 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 153 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 31 – 39 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB
- creatine kinase activity Source: CACAO
- microtubule binding Source: ARUK-UCL
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: UniProtKB
- protein serine kinase activity Source: RHEA
GO - Biological processi
- intracellular signal transduction Source: UniProtKB
- MAPK cascade Source: GO_Central
- negative regulation of apoptotic process Source: CACAO
- negative regulation of cell-matrix adhesion Source: ARUK-UCL
- neuron projection morphogenesis Source: GO_Central
- positive regulation of ARF protein signal transduction Source: ARUK-UCL
- positive regulation of cell migration Source: ARUK-UCL
- positive regulation of focal adhesion assembly Source: ARUK-UCL
- positive regulation of focal adhesion disassembly Source: ARUK-UCL
- positive regulation of GTPase activity Source: ARUK-UCL
- positive regulation of keratinocyte migration Source: ARUK-UCL
- protein phosphorylation Source: UniProtKB
- regulation of JNK cascade Source: UniProtKB
- regulation of MAPK cascade Source: GO_Central
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | O95819 |
Reactomei | R-HSA-2559580, Oxidative Stress Induced Senescence |
SignaLinki | O95819 |
SIGNORi | O95819 |
Names & Taxonomyi
Protein namesi | Recommended name: Mitogen-activated protein kinase kinase kinase kinase 4 (EC:2.7.11.1)Alternative name(s): HPK/GCK-like kinase HGK MAPK/ERK kinase kinase kinase 4 Short name: MEK kinase kinase 4 Short name: MEKKK 4 Nck-interacting kinase |
Gene namesi | Name:MAP4K4 Synonyms:HGK, KIAA0687, NIK |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6866, MAP4K4 |
MIMi | 604666, gene |
neXtProti | NX_O95819 |
VEuPathDBi | HostDB:ENSG00000071054 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Other locations
- cytoplasm Source: UniProtKB
- focal adhesion Source: ARUK-UCL
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 9448 |
OpenTargetsi | ENSG00000071054 |
PharmGKBi | PA30612 |
Miscellaneous databases
Pharosi | O95819, Tchem |
Chemistry databases
ChEMBLi | CHEMBL6166 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | O95819 |
GuidetoPHARMACOLOGYi | 2088 |
Genetic variation databases
BioMutai | MAP4K4 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000086280 | 2 – 1239 | Mitogen-activated protein kinase kinase kinase kinase 4Add BLAST | 1238 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | ||
Modified residuei | 5 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 324 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 326 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 629 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 631 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 639 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 644 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 656 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 700 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 712 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 715 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 791 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 800 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 801 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 805 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 823 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 828 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 852 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 855 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 900 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 913 | PhosphoserineCombined sources | 1 | ||
Isoform 21 Publication (identifier: O95819-2) | |||||
Modified residuei | 608 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 625 | PhosphoserineCombined sources | 1 | ||
Isoform 6 (identifier: O95819-6) | |||||
Modified residuei | 608 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 625 | PhosphoserineCombined sources | 1 | ||
Isoform 31 Publication (identifier: O95819-3) | |||||
Modified residuei | 716 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 733 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
CPTACi | CPTAC-1049 CPTAC-866 |
EPDi | O95819 |
jPOSTi | O95819 |
MassIVEi | O95819 |
MaxQBi | O95819 |
PaxDbi | O95819 |
PeptideAtlasi | O95819 |
PRIDEi | O95819 |
ProteomicsDBi | 18046 51066 [O95819-1] 51067 [O95819-2] 51068 [O95819-3] 51069 [O95819-4] 51070 [O95819-5] |
PTM databases
GlyGeni | O95819, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | O95819 |
MetOSitei | O95819 |
PhosphoSitePlusi | O95819 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000071054, Expressed in brain and 239 other tissues |
ExpressionAtlasi | O95819, baseline and differential |
Genevisiblei | O95819, HS |
Organism-specific databases
HPAi | ENSG00000071054, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Interacts with the SH3 domain of the adapter proteins Nck (By similarity).
Interacts (via its CNH regulatory domain) with ATL1 (via the N-terminal region).
Interacts with RAP2A (GTP-bound form preferentially).
By similarity2 PublicationsBinary interactionsi
GO - Molecular functioni
- microtubule binding Source: ARUK-UCL
Protein-protein interaction databases
BioGRIDi | 114838, 161 interactors |
IntActi | O95819, 46 interactors |
MINTi | O95819 |
STRINGi | 9606.ENSP00000343658 |
Chemistry databases
BindingDBi | O95819 |
Miscellaneous databases
RNActi | O95819, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O95819 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 289 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 265 | |
Domaini | 926 – 1213 | CNHPROSITE-ProRule annotationAdd BLAST | 288 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 306 – 349 | DisorderedSequence analysisAdd BLAST | 44 | |
Regioni | 421 – 462 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 517 – 811 | DisorderedSequence analysisAdd BLAST | 295 | |
Regioni | 858 – 1212 | Mediates interaction with RAP2A1 PublicationAdd BLAST | 355 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 306 – 320 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 321 – 337 | Acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 550 – 579 | Basic and acidic residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 598 – 612 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 622 – 660 | Polar residuesSequence analysisAdd BLAST | 39 | |
Compositional biasi | 676 – 719 | Polar residuesSequence analysisAdd BLAST | 44 | |
Compositional biasi | 722 – 737 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 770 – 789 | Acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 793 – 811 | Polar residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0587, Eukaryota |
GeneTreei | ENSGT00940000155063 |
InParanoidi | O95819 |
OMAi | RHENATK |
OrthoDBi | 533537at2759 |
PhylomeDBi | O95819 |
TreeFami | TF105138 |
Family and domain databases
InterProi | View protein in InterPro IPR001180, CNH_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00780, CNH, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00036, CNH, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50219, CNH, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MANDSPAKSL VDIDLSSLRD PAGIFELVEV VGNGTYGQVY KGRHVKTGQL
60 70 80 90 100
AAIKVMDVTE DEEEEIKLEI NMLKKYSHHR NIATYYGAFI KKSPPGHDDQ
110 120 130 140 150
LWLVMEFCGA GSITDLVKNT KGNTLKEDWI AYISREILRG LAHLHIHHVI
160 170 180 190 200
HRDIKGQNVL LTENAEVKLV DFGVSAQLDR TVGRRNTFIG TPYWMAPEVI
210 220 230 240 250
ACDENPDATY DYRSDLWSCG ITAIEMAEGA PPLCDMHPMR ALFLIPRNPP
260 270 280 290 300
PRLKSKKWSK KFFSFIEGCL VKNYMQRPST EQLLKHPFIR DQPNERQVRI
310 320 330 340 350
QLKDHIDRTR KKRGEKDETE YEYSGSEEEE EEVPEQEGEP SSIVNVPGES
360 370 380 390 400
TLRRDFLRLQ QENKERSEAL RRQQLLQEQQ LREQEEYKRQ LLAERQKRIE
410 420 430 440 450
QQKEQRRRLE EQQRREREAR RQQEREQRRR EQEEKRRLEE LERRRKEEEE
460 470 480 490 500
RRRAEEEKRR VEREQEYIRR QLEEEQRHLE VLQQQLLQEQ AMLLECRWRE
510 520 530 540 550
MEEHRQAERL QRQLQQEQAY LLSLQHDHRR PHPQHSQQPP PPQQERSKPS
560 570 580 590 600
FHAPEPKAHY EPADRAREVE DRFRKTNHSS PEAQSKQTGR VLEPPVPSRS
610 620 630 640 650
ESFSNGNSES VHPALQRPAE PQVPVRTTSR SPVLSRRDSP LQGSGQQNSQ
660 670 680 690 700
AGQRNSTSIE PRLLWERVEK LVPRPGSGSS SGSSNSGSQP GSHPGSQSGS
710 720 730 740 750
GERFRVRSSS KSEGSPSQRL ENAVKKPEDK KEVFRPLKPA DLTALAKELR
760 770 780 790 800
AVEDVRPPHK VTDYSSSSEE SGTTDEEDDD VEQEGADEST SGPEDTRAAS
810 820 830 840 850
SLNLSNGETE SVKTMIVHDD VESEPAMTPS KEGTLIVRQT QSASSTLQKH
860 870 880 890 900
KSSSSFTPFI DPRLLQISPS SGTTVTSVVG FSCDGMRPEA IRQDPTRKGS
910 920 930 940 950
VVNVNPTNTR PQSDTPEIRK YKKRFNSEIL CAALWGVNLL VGTESGLMLL
960 970 980 990 1000
DRSGQGKVYP LINRRRFQQM DVLEGLNVLV TISGKKDKLR VYYLSWLRNK
1010 1020 1030 1040 1050
ILHNDPEVEK KQGWTTVGDL EGCVHYKVVK YERIKFLVIA LKSSVEVYAW
1060 1070 1080 1090 1100
APKPYHKFMA FKSFGELVHK PLLVDLTVEE GQRLKVIYGS CAGFHAVDVD
1110 1120 1130 1140 1150
SGSVYDIYLP THIQCSIKPH AIIILPNTDG MELLVCYEDE GVYVNTYGRI
1160 1170 1180 1190 1200
TKDVVLQWGE MPTSVAYIRS NQTMGWGEKA IEIRSVETGH LDGVFMHKRA
1210 1220 1230
QRLKFLCERN DKVFFASVRS GGSSQVYFMT LGRTSLLSW
The sequence of this isoform differs from the canonical sequence as follows:
495-525: Missing.
569-622: Missing.
623-623: V → VQWSHLASLK...SDSDEVPPRV
740-740: A → AGEV
1112-1112: H → HVRKNPHSM
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7EN19 | E7EN19_HUMAN | Mitogen-activated protein kinase ki... | MAP4K4 | 1,272 | Annotation score: | ||
E7ENQ1 | E7ENQ1_HUMAN | Mitogen-activated protein kinase ki... | MAP4K4 | 1,154 | Annotation score: | ||
E7EX83 | E7EX83_HUMAN | Mitogen-activated protein kinase ki... | MAP4K4 | 1,038 | Annotation score: | ||
G5E948 | G5E948_HUMAN | Mitogen-activated protein kinase ki... | MAP4K4 | 1,235 | Annotation score: | ||
A0A0D9SG62 | A0A0D9SG62_HUMAN | Mitogen-activated protein kinase ki... | MAP4K4 | 1,044 | Annotation score: | ||
G3XAA2 | G3XAA2_HUMAN | Mitogen-activated protein kinase ki... | MAP4K4 hCG_1640439 | 1,165 | Annotation score: | ||
A0A0D9SEY1 | A0A0D9SEY1_HUMAN | Mitogen-activated protein kinase ki... | MAP4K4 hCG_1640439 | 1,320 | Annotation score: | ||
C9J840 | C9J840_HUMAN | Mitogen-activated protein kinase ki... | MAP4K4 | 987 | Annotation score: | ||
H7C360 | H7C360_HUMAN | Mitogen-activated protein kinase ki... | MAP4K4 | 1,170 | Annotation score: | ||
H7C0P6 | H7C0P6_HUMAN | Mitogen-activated protein kinase ki... | MAP4K4 | 1,056 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 839 | Q → R in AAO32626 (PubMed:12612079).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Natural variantiVAR_040746 | 712 | S → T1 Publication | 1 | ||
Isoform 31 Publication (identifier: O95819-3) | |||||
Natural variantiVAR_082893 | 682 | D → VCombined sources | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_007054 | 495 – 525 | Missing in isoform 2, isoform 4, isoform 5 and isoform 6. 2 PublicationsCuratedAdd BLAST | 31 | |
Alternative sequenceiVSP_007055 | 569 – 622 | Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST | 54 | |
Alternative sequenceiVSP_007056 | 623 | V → VQWSHLASLKNNVSPVSRSH SFSDPSPKFAHHHLRSQDPC PPSRSEVLSQSSDSKSEAPD PTQKAWSRSDSDEVPPRV in isoform 3 and isoform 5. 2 Publications | 1 | |
Alternative sequenceiVSP_058855 | 659 | I → SI in isoform 2, isoform 3 and isoform 6. 2 PublicationsCurated | 1 | |
Alternative sequenceiVSP_007057 | 740 | A → AGEV in isoform 2, isoform 3, isoform 4 and isoform 5. 3 Publications | 1 | |
Alternative sequenceiVSP_058856 | 839 | Q → QSTVDQKRASHHESNGFAGR IHLLPDLLQQSHSSSTSSTS SSPSSSQPTPTMSPQTPQDK LTANE in isoform 6. Curated | 1 | |
Alternative sequenceiVSP_007058 | 1112 | H → HVRKNPHSM in isoform 4 and isoform 5. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF096300 mRNA Translation: AAD16137.1 AY212247 mRNA Translation: AAO32626.1 AC005035 Genomic DNA No translation available. CH471127 Genomic DNA Translation: EAX01810.1 AC007005 Genomic DNA No translation available. AB014587 mRNA Translation: BAA31662.1 AL137755 mRNA Translation: CAB70907.2 AB013385 mRNA Translation: BAA33714.1 |
CCDSi | CCDS56130.1 [O95819-1] CCDS74546.1 [O95819-6] CCDS82487.1 [O95819-4] |
PIRi | T46481 |
RefSeqi | NP_001229488.1, NM_001242559.1 [O95819-1] NP_004825.3, NM_004834.4 [O95819-4] NP_663719.2, NM_145686.3 [O95819-6] NP_663720.1, NM_145687.3 [O95819-2] |
Genome annotation databases
Ensembli | ENST00000347699; ENSP00000314363; ENSG00000071054 ENST00000350878; ENSP00000343658; ENSG00000071054 [O95819-6] ENST00000634702; ENSP00000489579; ENSG00000071054 [O95819-4] |
GeneIDi | 9448 |
KEGGi | hsa:9448 |
UCSCi | uc002tbf.4, human uc002tbg.4, human [O95819-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF096300 mRNA Translation: AAD16137.1 AY212247 mRNA Translation: AAO32626.1 AC005035 Genomic DNA No translation available. CH471127 Genomic DNA Translation: EAX01810.1 AC007005 Genomic DNA No translation available. AB014587 mRNA Translation: BAA31662.1 AL137755 mRNA Translation: CAB70907.2 AB013385 mRNA Translation: BAA33714.1 |
CCDSi | CCDS56130.1 [O95819-1] CCDS74546.1 [O95819-6] CCDS82487.1 [O95819-4] |
PIRi | T46481 |
RefSeqi | NP_001229488.1, NM_001242559.1 [O95819-1] NP_004825.3, NM_004834.4 [O95819-4] NP_663719.2, NM_145686.3 [O95819-6] NP_663720.1, NM_145687.3 [O95819-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4OBO | X-ray | 2.10 | A/B | 2-328 | [»] | |
4OBP | X-ray | 2.27 | A/B | 2-328 | [»] | |
4OBQ | X-ray | 2.19 | A/B | 2-328 | [»] | |
4RVT | X-ray | 2.40 | A/B | 1-325 | [»] | |
4U3Y | X-ray | 1.45 | A/B | 2-328 | [»] | |
4U3Z | X-ray | 2.09 | A/B | 2-328 | [»] | |
4U40 | X-ray | 2.30 | A/B | 2-328 | [»] | |
4U41 | X-ray | 2.20 | A/B | 2-328 | [»] | |
4U42 | X-ray | 2.50 | A/B | 2-328 | [»] | |
4U43 | X-ray | 2.18 | A/B | 2-328 | [»] | |
4U44 | X-ray | 2.43 | A/B | 2-328 | [»] | |
4U45 | X-ray | 2.58 | A/B | 2-328 | [»] | |
4ZK5 | X-ray | 2.89 | A/B | 2-328 | [»] | |
4ZP5 | X-ray | 2.29 | A/B | 1-309 | [»] | |
5DI1 | X-ray | 2.90 | A/B | 1-310 | [»] | |
5J95 | X-ray | 2.50 | A/B | 2-313 | [»] | |
5W5Q | X-ray | 2.33 | A/B | 2-328 | [»] | |
SMRi | O95819 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114838, 161 interactors |
IntActi | O95819, 46 interactors |
MINTi | O95819 |
STRINGi | 9606.ENSP00000343658 |
Chemistry databases
BindingDBi | O95819 |
ChEMBLi | CHEMBL6166 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | O95819 |
GuidetoPHARMACOLOGYi | 2088 |
PTM databases
GlyGeni | O95819, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | O95819 |
MetOSitei | O95819 |
PhosphoSitePlusi | O95819 |
Genetic variation databases
BioMutai | MAP4K4 |
Proteomic databases
CPTACi | CPTAC-1049 CPTAC-866 |
EPDi | O95819 |
jPOSTi | O95819 |
MassIVEi | O95819 |
MaxQBi | O95819 |
PaxDbi | O95819 |
PeptideAtlasi | O95819 |
PRIDEi | O95819 |
ProteomicsDBi | 18046 51066 [O95819-1] 51067 [O95819-2] 51068 [O95819-3] 51069 [O95819-4] 51070 [O95819-5] |
Protocols and materials databases
Antibodypediai | 2062, 672 antibodies from 38 providers |
DNASUi | 9448 |
Genome annotation databases
Ensembli | ENST00000347699; ENSP00000314363; ENSG00000071054 ENST00000350878; ENSP00000343658; ENSG00000071054 [O95819-6] ENST00000634702; ENSP00000489579; ENSG00000071054 [O95819-4] |
GeneIDi | 9448 |
KEGGi | hsa:9448 |
UCSCi | uc002tbf.4, human uc002tbg.4, human [O95819-1] |
Organism-specific databases
CTDi | 9448 |
DisGeNETi | 9448 |
GeneCardsi | MAP4K4 |
HGNCi | HGNC:6866, MAP4K4 |
HPAi | ENSG00000071054, Tissue enhanced (brain) |
MIMi | 604666, gene |
neXtProti | NX_O95819 |
OpenTargetsi | ENSG00000071054 |
PharmGKBi | PA30612 |
VEuPathDBi | HostDB:ENSG00000071054 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0587, Eukaryota |
GeneTreei | ENSGT00940000155063 |
InParanoidi | O95819 |
OMAi | RHENATK |
OrthoDBi | 533537at2759 |
PhylomeDBi | O95819 |
TreeFami | TF105138 |
Enzyme and pathway databases
PathwayCommonsi | O95819 |
Reactomei | R-HSA-2559580, Oxidative Stress Induced Senescence |
SignaLinki | O95819 |
SIGNORi | O95819 |
Miscellaneous databases
BioGRID-ORCSi | 9448, 13 hits in 1094 CRISPR screens |
ChiTaRSi | MAP4K4, human |
GeneWikii | MAP4K4 |
GenomeRNAii | 9448 |
Pharosi | O95819, Tchem |
PROi | PR:O95819 |
RNActi | O95819, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000071054, Expressed in brain and 239 other tissues |
ExpressionAtlasi | O95819, baseline and differential |
Genevisiblei | O95819, HS |
Family and domain databases
InterProi | View protein in InterPro IPR001180, CNH_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00780, CNH, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00036, CNH, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50219, CNH, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | M4K4_HUMAN | |
Accessioni | O95819Primary (citable) accession number: O95819 Secondary accession number(s): E7ESS2, O75172, Q9NST7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 28, 2003 |
Last sequence update: | March 28, 2003 | |
Last modified: | February 23, 2022 | |
This is version 208 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families