Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

BAG family molecular chaperone regulator 3

Gene

BAG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:9873016, PubMed:27474739). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920).5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • adenyl-nucleotide exchange factor activity Source: UniProtKB
  • cadherin binding Source: BHF-UCL
  • chaperone binding Source: ARUK-UCL
  • dynein intermediate chain binding Source: ARUK-UCL
  • protein-containing complex binding Source: Ensembl
  • protein transporter activity Source: ARUK-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone
Biological processApoptosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3371453 Regulation of HSF1-mediated heat shock response

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
O95817

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O95817

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
BAG family molecular chaperone regulator 3
Short name:
BAG-3
Alternative name(s):
Bcl-2-associated athanogene 3
Bcl-2-binding protein Bis
Docking protein CAIR-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BAG3
Synonyms:BIS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000151929.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:939 BAG3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603883 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95817

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Myopathy, myofibrillar, 6 (MFM6)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of myofibrillar myopathy, a group of chronic neuromuscular disorders characterized at ultrastructural level by disintegration of the sarcomeric Z disk and myofibrils, and replacement of the normal myofibrillar markings by small dense granules, or larger hyaline masses, or amorphous material. MFM6 is characterized by early-onset of severe, progressive, diffuse muscle weakness associated with cardiomyopathy, severe respiratory insufficiency during adolescence, and a rigid spine in some patients.
See also OMIM:612954
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_063089209P → L in MFM6; interferes with the differentiation of skeletal muscle cells; does not cause functional alterations in cardiomyocyte cells. 3 PublicationsCorresponds to variant dbSNP:rs121918312EnsemblClinVar.1
Cardiomyopathy, dilated 1HH (CMD1HH)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
See also OMIM:613881
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06547971R → W in CMD1HH. 1 PublicationCorresponds to variant dbSNP:rs387906874EnsemblClinVar.1
Natural variantiVAR_066781218R → W in CMD1HH; interferes with the assembly of Z-disks; increases stress-induced apoptosis. 1 PublicationCorresponds to variant dbSNP:rs397514506EnsemblClinVar.1
Natural variantiVAR_066785455E → K in CMD1HH. 1 PublicationCorresponds to variant dbSNP:rs397516881EnsemblClinVar.1
Natural variantiVAR_066786462L → P in CMD1HH; interferes with the assembly of Z-disks; increases stress-induced apoptosis. 1 PublicationCorresponds to variant dbSNP:rs397514507EnsemblClinVar.1
Natural variantiVAR_066787468V → M in CMD1HH. 1 Publication1
Natural variantiVAR_065480477R → H in CMD1HH. 1 PublicationCorresponds to variant dbSNP:rs387906876EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi480 – 481RR → AA: Significant loss of interaction with HSPA8. 1 Publication2

Keywords - Diseasei

Cardiomyopathy, Disease mutation, Myofibrillar myopathy

Organism-specific databases

DisGeNET

More...
DisGeNETi
9531

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
BAG3

MalaCards human disease database

More...
MalaCardsi
BAG3
MIMi612954 phenotype
613881 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000151929

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
154 Familial isolated dilated cardiomyopathy
199340 Muscular dystrophy, Selcen type

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25239

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BAG3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000888682 – 575BAG family molecular chaperone regulator 3Add BLAST574

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei136PhosphoserineBy similarity1
Modified residuei139Omega-N-methylarginineBy similarity1
Modified residuei173PhosphoserineCombined sources1
Modified residuei198PhosphoserineCombined sources1
Modified residuei261Omega-N-methylarginineBy similarity1
Modified residuei269PhosphoserineCombined sources1
Modified residuei274PhosphoserineCombined sources1
Modified residuei275PhosphoserineCombined sources1
Modified residuei279PhosphoserineCombined sources1
Modified residuei285PhosphothreonineCombined sources1
Modified residuei289PhosphoserineCombined sources1
Modified residuei291PhosphoserineCombined sources1
Modified residuei377PhosphoserineCombined sources1
Modified residuei385PhosphoserineCombined sources1
Modified residuei386PhosphoserineCombined sources1
Modified residuei406PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki445Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki445Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O95817

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O95817

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O95817

PeptideAtlas

More...
PeptideAtlasi
O95817

PRoteomics IDEntifications database

More...
PRIDEi
O95817

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51065

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O95817

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O95817

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
O95817

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000151929 Expressed in 232 organ(s), highest expression level in deltoid

CleanEx database of gene expression profiles

More...
CleanExi
HS_BAG3

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O95817 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O95817 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA018493
HPA020586

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to the ATPase domain of HSP70/HSC70 chaperones (PubMed:9873016). Interacts with BCL2 (PubMed:10597216). Interacts with phospholipase C-gamma proteins (PubMed:10980614). Interacts with DNAJB6 (PubMed:22366786). Interacts (via BAG domain) with HSF1; this interaction occurs in normal and heat-shocked cells promoting HSF1 nucleocytoplasmic shuttling (PubMed:26159920). Interacts with HSPA8 (via NBD) (PubMed:27474739, PubMed:24318877). Interacts with HSPA1A (via NBD) and HSPA1B (via NBD) (PubMed:24318877). Interacts (via WW domain 1) with SYNPO2 (via PPPY motif) (PubMed:23434281). Interacts with HSPB8 (PubMed:28144995).9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114907, 489 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
O95817

Database of interacting proteins

More...
DIPi
DIP-41273N

Protein interaction database and analysis system

More...
IntActi
O95817, 135 interactors

Molecular INTeraction database

More...
MINTi
O95817

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000358081

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O95817

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O95817

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 54WW 1PROSITE-ProRule annotationAdd BLAST35
Domaini124 – 154WW 2PROSITE-ProRule annotationAdd BLAST31
Domaini421 – 498BAGPROSITE-ProRule annotationAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi180 – 187Poly-Ser8

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0940 Eukaryota
KOG4361 Eukaryota
COG5021 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159204

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000050234

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG003419

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O95817

KEGG Orthology (KO)

More...
KOi
K09557

Identification of Orthologs from Complete Genome Data

More...
OMAi
QTGWPFF

Database of Orthologous Groups

More...
OrthoDBi
EOG091G08LY

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O95817

TreeFam database of animal gene trees

More...
TreeFami
TF102013

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00201 WW, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.58.120, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039773 BAG_chaperone_regulator
IPR036533 BAG_dom_sf
IPR003103 BAG_domain
IPR001202 WW_dom
IPR036020 WW_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12329 PTHR12329, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02179 BAG, 1 hit
PF00397 WW, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00264 BAG, 1 hit
SM00456 WW, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51045 SSF51045, 1 hit
SSF63491 SSF63491, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51035 BAG, 1 hit
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O95817-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAATHSPMM QVASGNGDRD PLPPGWEIKI DPQTGWPFFV DHNSRTTTWN
60 70 80 90 100
DPRVPSEGPK ETPSSANGPS REGSRLPPAR EGHPVYPQLR PGYIPIPVLH
110 120 130 140 150
EGAENRQVHP FHVYPQPGMQ RFRTEAAAAA PQRSQSPLRG MPETTQPDKQ
160 170 180 190 200
CGQVAAAAAA QPPASHGPER SQSPAASDCS SSSSSASLPS SGRSSLGSHQ
210 220 230 240 250
LPRGYISIPV IHEQNVTRPA AQPSFHQAQK THYPAQQGEY QTHQPVYHKI
260 270 280 290 300
QGDDWEPRPL RAASPFRSSV QGASSREGSP ARSSTPLHSP SPIRVHTVVD
310 320 330 340 350
RPQQPMTHRE TAPVSQPENK PESKPGPVGP ELPPGHIPIQ VIRKEVDSKP
360 370 380 390 400
VSQKPPPPSE KVEVKVPPAP VPCPPPSPGP SAVPSSPKSV ATEERAAPST
410 420 430 440 450
APAEATPPKP GEAEAPPKHP GVLKVEAILE KVQGLEQAVD NFEGKKTDKK
460 470 480 490 500
YLMIEEYLTK ELLALDSVDP EGRADVRQAR RDGVRKVQTI LEKLEQKAID
510 520 530 540 550
VPGQVQVYEL QPSNLEADQP LQAIMEMGAV AADKGKKNAG NAEDPHTETQ
560 570
QPEATAAATS NPSSMTDTPG NPAAP
Length:575
Mass (Da):61,595
Last modified:January 11, 2001 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA6328A44F37A406A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JFK9C9JFK9_HUMAN
BAG family molecular chaperone regu...
BAG3
325Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti227Q → K in AAD16122 (PubMed:9873016).Curated1
Sequence conflicti237Q → R in AAD16122 (PubMed:9873016).Curated1
Sequence conflicti304Missing in CAB70824 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04834471R → Q1 PublicationCorresponds to variant dbSNP:rs35434411EnsemblClinVar.1
Natural variantiVAR_06547971R → W in CMD1HH. 1 PublicationCorresponds to variant dbSNP:rs387906874EnsemblClinVar.1
Natural variantiVAR_06677777P → L1 PublicationCorresponds to variant dbSNP:rs141355480EnsemblClinVar.1
Natural variantiVAR_06677894I → F1 PublicationCorresponds to variant dbSNP:rs145393807EnsemblClinVar.1
Natural variantiVAR_066779115P → S1 PublicationCorresponds to variant dbSNP:rs774241343Ensembl.1
Natural variantiVAR_048345151C → R2 PublicationsCorresponds to variant dbSNP:rs2234962EnsemblClinVar.1
Natural variantiVAR_066780155A → T1 PublicationCorresponds to variant dbSNP:rs61756328EnsemblClinVar.1
Natural variantiVAR_063089209P → L in MFM6; interferes with the differentiation of skeletal muscle cells; does not cause functional alterations in cardiomyocyte cells. 3 PublicationsCorresponds to variant dbSNP:rs121918312EnsemblClinVar.1
Natural variantiVAR_066781218R → W in CMD1HH; interferes with the assembly of Z-disks; increases stress-induced apoptosis. 1 PublicationCorresponds to variant dbSNP:rs397514506EnsemblClinVar.1
Natural variantiVAR_066782258R → W Polymorphism; no functional consequences. 2 PublicationsCorresponds to variant dbSNP:rs117671123EnsemblClinVar.1
Natural variantiVAR_066783300D → N1 PublicationCorresponds to variant dbSNP:rs78439745EnsemblClinVar.1
Natural variantiVAR_066784380P → S1 PublicationCorresponds to variant dbSNP:rs144692954EnsemblClinVar.1
Natural variantiVAR_048346405A → V. Corresponds to variant dbSNP:rs11199064EnsemblClinVar.1
Natural variantiVAR_048347407P → L2 PublicationsCorresponds to variant dbSNP:rs3858340EnsemblClinVar.1
Natural variantiVAR_066785455E → K in CMD1HH. 1 PublicationCorresponds to variant dbSNP:rs397516881EnsemblClinVar.1
Natural variantiVAR_066786462L → P in CMD1HH; interferes with the assembly of Z-disks; increases stress-induced apoptosis. 1 PublicationCorresponds to variant dbSNP:rs397514507EnsemblClinVar.1
Natural variantiVAR_066787468V → M in CMD1HH. 1 Publication1
Natural variantiVAR_065480477R → H in CMD1HH. 1 PublicationCorresponds to variant dbSNP:rs387906876EnsemblClinVar.1
Natural variantiVAR_066788553E → D1 PublicationCorresponds to variant dbSNP:rs763530097EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF095193 mRNA Translation: AAD16122.2
AF127139 mRNA Translation: AAF26839.1
AF071218 mRNA Translation: AAF69592.2
AK291333 mRNA Translation: BAF84022.1
AL137582 mRNA Translation: CAB70824.1
BC006418 mRNA Translation: AAH06418.1
BC014656 mRNA Translation: AAH14656.1
BC107786 mRNA Translation: AAI07787.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7615.1

NCBI Reference Sequences

More...
RefSeqi
NP_004272.2, NM_004281.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.523309

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000369085; ENSP00000358081; ENSG00000151929

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9531

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9531

UCSC genome browser

More...
UCSCi
uc001lem.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095193 mRNA Translation: AAD16122.2
AF127139 mRNA Translation: AAF26839.1
AF071218 mRNA Translation: AAF69592.2
AK291333 mRNA Translation: BAF84022.1
AL137582 mRNA Translation: CAB70824.1
BC006418 mRNA Translation: AAH06418.1
BC014656 mRNA Translation: AAH14656.1
BC107786 mRNA Translation: AAI07787.1
CCDSiCCDS7615.1
RefSeqiNP_004272.2, NM_004281.3
UniGeneiHs.523309

3D structure databases

ProteinModelPortaliO95817
SMRiO95817
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114907, 489 interactors
CORUMiO95817
DIPiDIP-41273N
IntActiO95817, 135 interactors
MINTiO95817
STRINGi9606.ENSP00000358081

PTM databases

iPTMnetiO95817
PhosphoSitePlusiO95817

Polymorphism and mutation databases

BioMutaiBAG3

Proteomic databases

EPDiO95817
MaxQBiO95817
PaxDbiO95817
PeptideAtlasiO95817
PRIDEiO95817
ProteomicsDBi51065

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9531
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369085; ENSP00000358081; ENSG00000151929
GeneIDi9531
KEGGihsa:9531
UCSCiuc001lem.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9531
DisGeNETi9531
EuPathDBiHostDB:ENSG00000151929.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BAG3
GeneReviewsiBAG3
HGNCiHGNC:939 BAG3
HPAiHPA018493
HPA020586
MalaCardsiBAG3
MIMi603883 gene
612954 phenotype
613881 phenotype
neXtProtiNX_O95817
OpenTargetsiENSG00000151929
Orphaneti154 Familial isolated dilated cardiomyopathy
199340 Muscular dystrophy, Selcen type
PharmGKBiPA25239

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0940 Eukaryota
KOG4361 Eukaryota
COG5021 LUCA
GeneTreeiENSGT00940000159204
HOGENOMiHOG000050234
HOVERGENiHBG003419
InParanoidiO95817
KOiK09557
OMAiQTGWPFF
OrthoDBiEOG091G08LY
PhylomeDBiO95817
TreeFamiTF102013

Enzyme and pathway databases

ReactomeiR-HSA-3371453 Regulation of HSF1-mediated heat shock response
SignaLinkiO95817
SIGNORiO95817

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
BAG3 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
BAG3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9531
PMAP-CutDBiO95817

Protein Ontology

More...
PROi
PR:O95817

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000151929 Expressed in 232 organ(s), highest expression level in deltoid
CleanExiHS_BAG3
ExpressionAtlasiO95817 baseline and differential
GenevisibleiO95817 HS

Family and domain databases

CDDicd00201 WW, 1 hit
Gene3Di1.20.58.120, 1 hit
InterProiView protein in InterPro
IPR039773 BAG_chaperone_regulator
IPR036533 BAG_dom_sf
IPR003103 BAG_domain
IPR001202 WW_dom
IPR036020 WW_dom_sf
PANTHERiPTHR12329 PTHR12329, 1 hit
PfamiView protein in Pfam
PF02179 BAG, 1 hit
PF00397 WW, 1 hit
SMARTiView protein in SMART
SM00264 BAG, 1 hit
SM00456 WW, 1 hit
SUPFAMiSSF51045 SSF51045, 1 hit
SSF63491 SSF63491, 1 hit
PROSITEiView protein in PROSITE
PS51035 BAG, 1 hit
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBAG3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95817
Secondary accession number(s): A8K5L8
, Q3B763, Q9NT20, Q9P120
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2001
Last modified: December 5, 2018
This is version 189 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again