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Protein

BAG family molecular chaperone regulator 2

Gene

BAG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release (PubMed:24318877, PubMed:9873016).2 Publications

GO - Molecular functioni

  • adenyl-nucleotide exchange factor activity Source: UniProtKB
  • chaperone binding Source: ARUK-UCL
  • heat shock protein binding Source: Ensembl
  • identical protein binding Source: IntAct
  • ion channel binding Source: ARUK-UCL
  • tau protein binding Source: Ensembl
  • ubiquitin protein ligase binding Source: Ensembl

GO - Biological processi

  • negative regulation of protein binding Source: ARUK-UCL
  • negative regulation of protein ubiquitination Source: ARUK-UCL
  • negative regulation of ubiquitin protein ligase activity Source: ARUK-UCL
  • positive regulation of proteasomal protein catabolic process Source: ARUK-UCL
  • positive regulation of protein processing Source: ARUK-UCL
  • protein folding Source: ProtInc
  • protein metabolic process Source: MGI
  • protein stabilization Source: ARUK-UCL
  • regulation of cellular response to heat Source: Reactome

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-HSA-3371453 Regulation of HSF1-mediated heat shock response
SIGNORiO95816

Names & Taxonomyi

Protein namesi
Recommended name:
BAG family molecular chaperone regulator 2
Short name:
BAG-2
Alternative name(s):
Bcl-2-associated athanogene 2
Gene namesi
Name:BAG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112208.11
HGNCiHGNC:938 BAG2
MIMi603882 gene
neXtProtiNX_O95816

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi9532
OpenTargetsiENSG00000112208
PharmGKBiPA25238

Polymorphism and mutation databases

BioMutaiBAG2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000888662 – 211BAG family molecular chaperone regulator 2Add BLAST210

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei20PhosphoserineCombined sources1
Modified residuei31PhosphoserineCombined sources1
Modified residuei73PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO95816
MaxQBiO95816
PaxDbiO95816
PeptideAtlasiO95816
PRIDEiO95816
ProteomicsDBi51064
TopDownProteomicsiO95816-1 [O95816-1]

PTM databases

iPTMnetiO95816
PhosphoSitePlusiO95816
SwissPalmiO95816

Expressioni

Gene expression databases

BgeeiENSG00000112208
CleanExiHS_BAG2
GenevisibleiO95816 HS

Organism-specific databases

HPAiHPA018862
HPA019918

Interactioni

Subunit structurei

Binds to the ATPase domain of HSP/HSC70 chaperones (PubMed:9873016). May interact with NWD1 (PubMed:24681825). Interacts with HSPA1A (via NBD), HSPA1B (via NBD) and HSPA8 (PubMed:24318877).3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • chaperone binding Source: ARUK-UCL
  • heat shock protein binding Source: Ensembl
  • identical protein binding Source: IntAct
  • ion channel binding Source: ARUK-UCL
  • tau protein binding Source: Ensembl
  • ubiquitin protein ligase binding Source: Ensembl

Protein-protein interaction databases

BioGridi114908, 116 interactors
IntActiO95816, 170 interactors
MINTiO95816
STRINGi9606.ENSP00000359727

Structurei

3D structure databases

ProteinModelPortaliO95816
SMRiO95816
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini109 – 189BAGPROSITE-ProRule annotationAdd BLAST81

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili20 – 61Sequence analysisAdd BLAST42

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3633 Eukaryota
ENOG410XRW0 LUCA
GeneTreeiENSGT00390000017590
HOGENOMiHOG000073529
HOVERGENiHBG004808
InParanoidiO95816
KOiK09556
OMAiQLEMRVE
OrthoDBiEOG091G0G1G
PhylomeDBiO95816
TreeFamiTF102012

Family and domain databases

InterProiView protein in InterPro
IPR037689 BAG2
IPR003103 BAG_domain
PANTHERiPTHR12334 PTHR12334, 1 hit
SMARTiView protein in SMART
SM00264 BAG, 1 hit
PROSITEiView protein in PROSITE
PS51035 BAG, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95816-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQAKINAKA NEGRFCRSSS MADRSSRLLE SLDQLELRVE ALREAATAVE
60 70 80 90 100
QEKEILLEMI HSIQNSQDMR QISDGEREEL NLTANRLMGR TLTVEVSVET
110 120 130 140 150
IRNPQQQESL KHATRIIDEV VNKFLDDLGN AKSHLMSLYS ACSSEVPHGP
160 170 180 190 200
VDQKFQSIVI GCALEDQKKI KRRLETLLRN IENSDKAIKL LEHSKGAGSK
210
TLQQNAESRF N
Length:211
Mass (Da):23,772
Last modified:May 1, 1999 - v1
Checksum:iCAF631F4578FCCA3
GO
Isoform 2 (identifier: O95816-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: MAQAKINAKANEGRFCRSSSMADRSSRLLESLDQLELR → MPHMW

Note: No experimental confirmation available.
Show »
Length:178
Mass (Da):20,189
Checksum:i548BFD3AB88A93DB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti180N → D in CAG38527 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0564621 – 38MAQAK…QLELR → MPHMW in isoform 2. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095192 mRNA Translation: AAD16121.1
AL050287 mRNA Translation: CAB43388.1
AK301934 mRNA Translation: BAG63354.1
CR533496 mRNA Translation: CAG38527.1
AL031321 Genomic DNA No translation available.
AL136311 Genomic DNA No translation available.
BC125039 mRNA Translation: AAI25040.1
CCDSiCCDS4961.1 [O95816-1]
PIRiT08764
RefSeqiNP_004273.1, NM_004282.3 [O95816-1]
XP_005249547.1, XM_005249490.3 [O95816-2]
XP_011513300.1, XM_011514998.2 [O95816-2]
XP_011513301.1, XM_011514999.2 [O95816-2]
UniGeneiHs.745046

Genome annotation databases

EnsembliENST00000370693; ENSP00000359727; ENSG00000112208 [O95816-1]
GeneIDi9532
KEGGihsa:9532
UCSCiuc003pdr.4 human [O95816-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiBAG2_HUMAN
AccessioniPrimary (citable) accession number: O95816
Secondary accession number(s): B4DXE2, Q08AS9, Q6FID0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: July 18, 2018
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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