BAG2

Functionⁱ

Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release (PubMed:24318877, PubMed:9873016).2 Publications

GO - Molecular functionⁱ

adenyl-nucleotide exchange factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 24318877
chaperone binding
Source: ARUK-UCL
Inferred from physical interactionⁱ
- 16207813
heat shock protein binding Source: Ensembl
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
ion channel binding
Source: ARUK-UCL
Inferred from physical interactionⁱ
- 16207813
tau protein binding Source: Ensembl
ubiquitin protein ligase binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of protein binding
Source: ARUK-UCL
Inferred from direct assayⁱ
- 16207813
negative regulation of protein ubiquitination
Source: ARUK-UCL
Inferred from direct assayⁱ
- 24383081
- 25006867
negative regulation of ubiquitin protein ligase activity
Source: ARUK-UCL
Inferred from direct assayⁱ
- 16207813
positive regulation of proteasomal protein catabolic process
Source: ARUK-UCL
Inferred from sequence or structural similarityⁱ
- 19228967
positive regulation of protein processing
Source: ARUK-UCL
Inferred from mutant phenotypeⁱ
- 16207813
protein folding
Source: ProtInc
Traceable author statementⁱ
- 9873016
protein metabolic process
Source: MGI
Inferred from direct assayⁱ
- 9873015
protein stabilization
Source: ARUK-UCL
Inferred from direct assayⁱ
regulation of cellular response to heat Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chaperone

Molecular function

Chaperone

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3371453 Regulation of HSF1-mediated heat shock response
SIGNORⁱ	O95816

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: BAG family molecular chaperone regulator 2 Short name: BAG-2 Alternative name(s): Bcl-2-associated athanogene 2
Gene namesⁱ	Name:BAG2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000112208.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:938 BAG2
MIMⁱ	603882 gene
neXtProtⁱ	NX_O95816

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9532
Open Targets More...OpenTargetsⁱ	ENSG00000112208
PharmGKBⁱ	PA25238

Polymorphism and mutation databases

BioMutaⁱ	BAG2

BioMutaⁱ

BAG2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000088866	2 – 211	BAG family molecular chaperone regulator 2Add BLAST		210

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Modified residueⁱ	20	PhosphoserineCombined sources	1
Modified residueⁱ	31	PhosphoserineCombined sources	1
Modified residueⁱ	73	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	O95816
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O95816
PaxDbⁱ	O95816
PeptideAtlas More...PeptideAtlasⁱ	O95816
PRIDEⁱ	O95816
ProteomicsDBⁱ	51064
TopDownProteomicsⁱ	O95816-1 [O95816-1]

PTM databases

iPTMnetⁱ	O95816
PhosphoSitePlusⁱ	O95816
SwissPalmⁱ	O95816

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000112208 Expressed in 195 organ(s), highest expression level in cauda epididymis
CleanExⁱ	HS_BAG2
Genevisibleⁱ	O95816 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA018862 HPA019918

HPAⁱ

HPA018862
HPA019918

Interactionⁱ

Subunit structureⁱ

Binds to the ATPase domain of HSP/HSC70 chaperones (PubMed:9873016). May interact with NWD1 (PubMed:24681825). Interacts with HSPA1A (via NBD), HSPA1B (via NBD) and HSPA8 (PubMed:24318877).3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		3	EBI-355275,EBI-355275
	A8K1F4	2	EBI-355275,EBI-9357094
	Q96BE0	2	EBI-355275,EBI-9356686
DAPK1	P53355	3	EBI-355275,EBI-358616
DNAJC7	Q99615	2	EBI-355275,EBI-357552
EBNA-LP	Q8AZK7	3	EBI-355275,EBI-1185167	From Epstein-Barr virus (strain B95-8).
HSPA8	P11142	7	EBI-355275,EBI-351896
LRRK2	Q5S007	3	EBI-355275,EBI-5323863
SGTA	O43765	2	EBI-355275,EBI-347996
STUB1	Q9UNE7	4	EBI-355275,EBI-357085

GO - Molecular functionⁱ

chaperone binding
Source: ARUK-UCL
Inferred from physical interactionⁱ
- 16207813
heat shock protein binding Source: Ensembl
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
ion channel binding
Source: ARUK-UCL
Inferred from physical interactionⁱ
- 16207813
tau protein binding Source: Ensembl
ubiquitin protein ligase binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114908, 118 interactors
IntActⁱ	O95816, 158 interactors
Molecular INTeraction database More...MINTⁱ	O95816
STRINGⁱ	9606.ENSP00000359727

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O95816
SMRⁱ	O95816
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	109 – 189	BAGPROSITE-ProRule annotationAdd BLAST		81

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	20 – 61	Sequence analysisAdd BLAST		42

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG3633 Eukaryota ENOG410XRW0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000017590
HOGENOMⁱ	HOG000073529
HOVERGENⁱ	HBG004808
InParanoidⁱ	O95816
KEGG Orthology (KO) More...KOⁱ	K09556
OMAⁱ	IKIMDHQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0G1G
PhylomeDBⁱ	O95816
TreeFamⁱ	TF102012

Family and domain databases

InterProⁱ	View protein in InterPro IPR037689 BAG2 IPR003103 BAG_domain
PANTHERⁱ	PTHR12334 PTHR12334, 1 hit
SMARTⁱ	View protein in SMART SM00264 BAG, 1 hit
PROSITEⁱ	View protein in PROSITE PS51035 BAG, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: O95816-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQAKINAKA NEGRFCRSSS MADRSSRLLE SLDQLELRVE ALREAATAVE 
        60         70         80         90        100
QEKEILLEMI HSIQNSQDMR QISDGEREEL NLTANRLMGR TLTVEVSVET 
       110        120        130        140        150
IRNPQQQESL KHATRIIDEV VNKFLDDLGN AKSHLMSLYS ACSSEVPHGP 
       160        170        180        190        200
VDQKFQSIVI GCALEDQKKI KRRLETLLRN IENSDKAIKL LEHSKGAGSK 
       210 
TLQQNAESRF N

Length:211

Mass (Da):23,772

Last modified:May 1, 1999 - v1

Checksum:ⁱCAF631F4578FCCA3

GO

Isoform 2 (identifier: O95816-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-38: MAQAKINAKANEGRFCRSSSMADRSSRLLESLDQLELR → MPHMW

« Hide

        10         20         30         40         50
MPHMWVEALR EAATAVEQEK EILLEMIHSI QNSQDMRQIS DGEREELNLT 
        60         70         80         90        100
ANRLMGRTLT VEVSVETIRN PQQQESLKHA TRIIDEVVNK FLDDLGNAKS 
       110        120        130        140        150
HLMSLYSACS SEVPHGPVDQ KFQSIVIGCA LEDQKKIKRR LETLLRNIEN 
       160        170 
SDKAIKLLEH SKGAGSKTLQ QNAESRFN

Note: No experimental confirmation available.

Show »

Length:178

Mass (Da):20,189

Checksum:ⁱ548BFD3AB88A93DB

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	180	N → D in CAG38527 (Ref. 4) Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056462	1 – 38	MAQAK…QLELR → MPHMW in isoform 2. 1 PublicationAdd BLAST		38

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF095192 mRNA Translation: AAD16121.1 AL050287 mRNA Translation: CAB43388.1 AK301934 mRNA Translation: BAG63354.1 CR533496 mRNA Translation: CAG38527.1 AL031321 Genomic DNA No translation available. AL136311 Genomic DNA No translation available. BC125039 mRNA Translation: AAI25040.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4961.1 [O95816-1]
PIRⁱ	T08764
NCBI Reference Sequences More...RefSeqⁱ	NP_004273.1, NM_004282.3 [O95816-1] XP_005249547.1, XM_005249490.3 [O95816-2] XP_011513300.1, XM_011514998.2 [O95816-2] XP_011513301.1, XM_011514999.2 [O95816-2]
UniGeneⁱ	Hs.745046

Genome annotation databases

Ensemblⁱ	ENST00000370693; ENSP00000359727; ENSG00000112208 [O95816-1]
GeneIDⁱ	9532
KEGGⁱ	hsa:9532
UCSC genome browser More...UCSCⁱ	uc003pdr.4 human [O95816-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
O95816	BAG2 isoform 1		PANTR		211	UniRef100_O95816
BCL2 associated athanogene 2		GORGO		211
Uncharacterized protein		PANPA		211
O95816-2	BAG2 isoform 2		PANTR		178	UniRef100_A0A2J8P1A8
BCL2 associated athanogene 2		GORGO		178

Protein	Similar proteins		Species	Score	Length	Source
O95816	BAG family molecular chaperone regulator 2		BOVIN		211	UniRef90_O95816
BAG2 isoform 1		PANTR		211
BCL2 associated athanogene 2		GORGO		211
Uncharacterized protein		PANPA		211
BCL2 associated athanogene 2		LOXAF		212
+72
O95816-2	BCL2 associated athanogene 2		AILME		179	UniRef90_G1LJS7
BAG family molecular chaperone regulator 2		URSMA		220
BAG2 isoform 2		PANTR		178
BCL2 associated athanogene 2		GORGO		178
BCL2 associated athanogene 2		SHEEP		178
+9

Protein	Similar proteins		Species	Score	Length	Source
O95816	BAG family molecular chaperone regulator 2		BOVIN		211	UniRef50_O95816
BAG family molecular chaperone regulator 2	)	MOUSE		210
BAG2 isoform 1		PANTR		211
BCL2 associated athanogene 2		GORGO		211
Uncharacterized protein		PANPA		211
+222

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF095192 mRNA Translation: AAD16121.1 AL050287 mRNA Translation: CAB43388.1 AK301934 mRNA Translation: BAG63354.1 CR533496 mRNA Translation: CAG38527.1 AL031321 Genomic DNA No translation available. AL136311 Genomic DNA No translation available. BC125039 mRNA Translation: AAI25040.1
CCDSⁱ	CCDS4961.1 [O95816-1]
PIRⁱ	T08764
RefSeqⁱ	NP_004273.1, NM_004282.3 [O95816-1] XP_005249547.1, XM_005249490.3 [O95816-2] XP_011513300.1, XM_011514998.2 [O95816-2] XP_011513301.1, XM_011514999.2 [O95816-2]
UniGeneⁱ	Hs.745046

3D structure databases

ProteinModelPortalⁱ	O95816
SMRⁱ	O95816
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114908, 118 interactors
IntActⁱ	O95816, 158 interactors
MINTⁱ	O95816
STRINGⁱ	9606.ENSP00000359727

PTM databases

iPTMnetⁱ	O95816
PhosphoSitePlusⁱ	O95816
SwissPalmⁱ	O95816

Polymorphism and mutation databases

BioMutaⁱ	BAG2

BioMutaⁱ

BAG2

Proteomic databases

EPDⁱ	O95816
MaxQBⁱ	O95816
PaxDbⁱ	O95816
PeptideAtlasⁱ	O95816
PRIDEⁱ	O95816
ProteomicsDBⁱ	51064
TopDownProteomicsⁱ	O95816-1 [O95816-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9532
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000370693; ENSP00000359727; ENSG00000112208 [O95816-1]
GeneIDⁱ	9532
KEGGⁱ	hsa:9532
UCSCⁱ	uc003pdr.4 human [O95816-1]

Organism-specific databases

CTDⁱ	9532
DisGeNETⁱ	9532
EuPathDBⁱ	HostDB:ENSG00000112208.11
GeneCardsⁱ	BAG2
HGNCⁱ	HGNC:938 BAG2
HPAⁱ	HPA018862 HPA019918
MIMⁱ	603882 gene
neXtProtⁱ	NX_O95816
OpenTargetsⁱ	ENSG00000112208
PharmGKBⁱ	PA25238
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3633 Eukaryota ENOG410XRW0 LUCA
GeneTreeⁱ	ENSGT00390000017590
HOGENOMⁱ	HOG000073529
HOVERGENⁱ	HBG004808
InParanoidⁱ	O95816
KOⁱ	K09556
OMAⁱ	IKIMDHQ
OrthoDBⁱ	EOG091G0G1G
PhylomeDBⁱ	O95816
TreeFamⁱ	TF102012

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3371453 Regulation of HSF1-mediated heat shock response
SIGNORⁱ	O95816

Miscellaneous databases

ChiTaRSⁱ	BAG2 human
GeneWikiⁱ	BAG2
GenomeRNAiⁱ	9532
Protein Ontology More...PROⁱ	PR:O95816
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000112208 Expressed in 195 organ(s), highest expression level in cauda epididymis
CleanExⁱ	HS_BAG2
Genevisibleⁱ	O95816 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR037689 BAG2 IPR003103 BAG_domain
PANTHERⁱ	PTHR12334 PTHR12334, 1 hit
SMARTⁱ	View protein in SMART SM00264 BAG, 1 hit
PROSITEⁱ	View protein in PROSITE PS51035 BAG, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BAG2_HUMAN
Accessionⁱ	O95816Primary (citable) accession number: O95816 Secondary accession number(s): B4DXE2, Q08AS9, Q6FID0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
	Last sequence update:	May 1, 1999
	Last modified:	November 7, 2018
	This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O95816 (BAG2_HUMAN)

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BAG family molecular chaperone regulator 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytosol

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ