UniProtKB - O95816 (BAG2_HUMAN)
Protein
BAG family molecular chaperone regulator 2
Gene
BAG2
Organism
Homo sapiens (Human)
Status
Functioni
Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release (PubMed:24318877, PubMed:9873016).2 Publications
GO - Molecular functioni
- adenyl-nucleotide exchange factor activity Source: UniProtKB
- chaperone binding Source: ARUK-UCL
- heat shock protein binding Source: Ensembl
- identical protein binding Source: IntAct
- ion channel binding Source: ARUK-UCL
- tau protein binding Source: ARUK-UCL
- ubiquitin protein ligase binding Source: Ensembl
GO - Biological processi
- negative regulation of protein binding Source: ARUK-UCL
- negative regulation of protein ubiquitination Source: ARUK-UCL
- negative regulation of ubiquitin protein ligase activity Source: ARUK-UCL
- positive regulation of proteasomal protein catabolic process Source: ARUK-UCL
- positive regulation of protein processing Source: ARUK-UCL
- protein folding Source: ProtInc
- protein metabolic process Source: MGI
- protein stabilization Source: ARUK-UCL
- regulation of cellular response to heat Source: Reactome
Keywordsi
Molecular function | Chaperone |
Enzyme and pathway databases
PathwayCommonsi | O95816 |
Reactomei | R-HSA-3371453, Regulation of HSF1-mediated heat shock response |
SIGNORi | O95816 |
Names & Taxonomyi
Protein namesi | Recommended name: BAG family molecular chaperone regulator 2Short name: BAG-2 Alternative name(s): Bcl-2-associated athanogene 2 |
Gene namesi | Name:BAG2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000112208.11 |
HGNCi | HGNC:938, BAG2 |
MIMi | 603882, gene |
neXtProti | NX_O95816 |
Subcellular locationi
Cytoskeleton
- dendritic microtubule Source: Ensembl
Cytosol
- cytosol Source: Reactome
Other locations
- axon Source: ARUK-UCL
- chaperone complex Source: ARUK-UCL
- dendrite Source: ARUK-UCL
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 9532 |
OpenTargetsi | ENSG00000112208 |
PharmGKBi | PA25238 |
Miscellaneous databases
Pharosi | O95816, Tbio |
Polymorphism and mutation databases
BioMutai | BAG2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000088866 | 2 – 211 | BAG family molecular chaperone regulator 2Add BLAST | 210 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 20 | PhosphoserineCombined sources | 1 | |
Modified residuei | 31 | PhosphoserineCombined sources | 1 | |
Modified residuei | 73 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | O95816 |
jPOSTi | O95816 |
MassIVEi | O95816 |
MaxQBi | O95816 |
PaxDbi | O95816 |
PeptideAtlasi | O95816 |
PRIDEi | O95816 |
ProteomicsDBi | 51064 [O95816-1] 5430 |
TopDownProteomicsi | O95816-1 [O95816-1] |
PTM databases
iPTMneti | O95816 |
MetOSitei | O95816 |
PhosphoSitePlusi | O95816 |
SwissPalmi | O95816 |
Expressioni
Gene expression databases
Bgeei | ENSG00000112208, Expressed in cauda epididymis and 208 other tissues |
Genevisiblei | O95816, HS |
Organism-specific databases
HPAi | ENSG00000112208, Tissue enhanced (smooth muscle, urinary bladder) |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsO95816
GO - Molecular functioni
- chaperone binding Source: ARUK-UCL
- heat shock protein binding Source: Ensembl
- identical protein binding Source: IntAct
- ion channel binding Source: ARUK-UCL
- tau protein binding Source: ARUK-UCL
- ubiquitin protein ligase binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 114908, 182 interactors |
IntActi | O95816, 203 interactors |
MINTi | O95816 |
STRINGi | 9606.ENSP00000359727 |
Miscellaneous databases
RNActi | O95816, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 109 – 189 | BAGPROSITE-ProRule annotationAdd BLAST | 81 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 20 – 61 | Sequence analysisAdd BLAST | 42 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG3633, Eukaryota |
GeneTreei | ENSGT00390000017590 |
HOGENOMi | CLU_072417_2_0_1 |
InParanoidi | O95816 |
OMAi | EMIHNIQ |
OrthoDBi | 1268987at2759 |
PhylomeDBi | O95816 |
TreeFami | TF102012 |
Family and domain databases
InterProi | View protein in InterPro IPR037689, BAG2 IPR003103, BAG_domain |
PANTHERi | PTHR12334, PTHR12334, 1 hit |
SMARTi | View protein in SMART SM00264, BAG, 1 hit |
PROSITEi | View protein in PROSITE PS51035, BAG, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: O95816-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAQAKINAKA NEGRFCRSSS MADRSSRLLE SLDQLELRVE ALREAATAVE
60 70 80 90 100
QEKEILLEMI HSIQNSQDMR QISDGEREEL NLTANRLMGR TLTVEVSVET
110 120 130 140 150
IRNPQQQESL KHATRIIDEV VNKFLDDLGN AKSHLMSLYS ACSSEVPHGP
160 170 180 190 200
VDQKFQSIVI GCALEDQKKI KRRLETLLRN IENSDKAIKL LEHSKGAGSK
210
TLQQNAESRF N
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 180 | N → D in CAG38527 (Ref. 4) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056462 | 1 – 38 | MAQAK…QLELR → MPHMW in isoform 2. 1 PublicationAdd BLAST | 38 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF095192 mRNA Translation: AAD16121.1 AL050287 mRNA Translation: CAB43388.1 AK301934 mRNA Translation: BAG63354.1 CR533496 mRNA Translation: CAG38527.1 AL031321 Genomic DNA No translation available. AL136311 Genomic DNA No translation available. BC125039 mRNA Translation: AAI25040.1 |
CCDSi | CCDS4961.1 [O95816-1] |
PIRi | T08764 |
RefSeqi | NP_004273.1, NM_004282.3 [O95816-1] XP_005249547.1, XM_005249490.3 [O95816-2] XP_011513300.1, XM_011514998.2 [O95816-2] XP_011513301.1, XM_011514999.2 [O95816-2] |
Genome annotation databases
Ensembli | ENST00000370693; ENSP00000359727; ENSG00000112208 [O95816-1] |
GeneIDi | 9532 |
KEGGi | hsa:9532 |
UCSCi | uc003pdr.4, human [O95816-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF095192 mRNA Translation: AAD16121.1 AL050287 mRNA Translation: CAB43388.1 AK301934 mRNA Translation: BAG63354.1 CR533496 mRNA Translation: CAG38527.1 AL031321 Genomic DNA No translation available. AL136311 Genomic DNA No translation available. BC125039 mRNA Translation: AAI25040.1 |
CCDSi | CCDS4961.1 [O95816-1] |
PIRi | T08764 |
RefSeqi | NP_004273.1, NM_004282.3 [O95816-1] XP_005249547.1, XM_005249490.3 [O95816-2] XP_011513300.1, XM_011514998.2 [O95816-2] XP_011513301.1, XM_011514999.2 [O95816-2] |
3D structure databases
SMRi | O95816 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114908, 182 interactors |
IntActi | O95816, 203 interactors |
MINTi | O95816 |
STRINGi | 9606.ENSP00000359727 |
PTM databases
iPTMneti | O95816 |
MetOSitei | O95816 |
PhosphoSitePlusi | O95816 |
SwissPalmi | O95816 |
Polymorphism and mutation databases
BioMutai | BAG2 |
Proteomic databases
EPDi | O95816 |
jPOSTi | O95816 |
MassIVEi | O95816 |
MaxQBi | O95816 |
PaxDbi | O95816 |
PeptideAtlasi | O95816 |
PRIDEi | O95816 |
ProteomicsDBi | 51064 [O95816-1] 5430 |
TopDownProteomicsi | O95816-1 [O95816-1] |
Protocols and materials databases
Antibodypediai | 17541, 305 antibodies |
DNASUi | 9532 |
Genome annotation databases
Ensembli | ENST00000370693; ENSP00000359727; ENSG00000112208 [O95816-1] |
GeneIDi | 9532 |
KEGGi | hsa:9532 |
UCSCi | uc003pdr.4, human [O95816-1] |
Organism-specific databases
CTDi | 9532 |
DisGeNETi | 9532 |
EuPathDBi | HostDB:ENSG00000112208.11 |
GeneCardsi | BAG2 |
HGNCi | HGNC:938, BAG2 |
HPAi | ENSG00000112208, Tissue enhanced (smooth muscle, urinary bladder) |
MIMi | 603882, gene |
neXtProti | NX_O95816 |
OpenTargetsi | ENSG00000112208 |
PharmGKBi | PA25238 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3633, Eukaryota |
GeneTreei | ENSGT00390000017590 |
HOGENOMi | CLU_072417_2_0_1 |
InParanoidi | O95816 |
OMAi | EMIHNIQ |
OrthoDBi | 1268987at2759 |
PhylomeDBi | O95816 |
TreeFami | TF102012 |
Enzyme and pathway databases
PathwayCommonsi | O95816 |
Reactomei | R-HSA-3371453, Regulation of HSF1-mediated heat shock response |
SIGNORi | O95816 |
Miscellaneous databases
BioGRID-ORCSi | 9532, 10 hits in 842 CRISPR screens |
ChiTaRSi | BAG2, human |
GeneWikii | BAG2 |
GenomeRNAii | 9532 |
Pharosi | O95816, Tbio |
PROi | PR:O95816 |
RNActi | O95816, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000112208, Expressed in cauda epididymis and 208 other tissues |
Genevisiblei | O95816, HS |
Family and domain databases
InterProi | View protein in InterPro IPR037689, BAG2 IPR003103, BAG_domain |
PANTHERi | PTHR12334, PTHR12334, 1 hit |
SMARTi | View protein in SMART SM00264, BAG, 1 hit |
PROSITEi | View protein in PROSITE PS51035, BAG, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BAG2_HUMAN | |
Accessioni | O95816Primary (citable) accession number: O95816 Secondary accession number(s): B4DXE2, Q08AS9, Q6FID0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | May 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 182 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot