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Protein

Cerberus

Gene

CER1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak (By similarity).By similarity

GO - Molecular functioni

  • BMP binding Source: BHF-UCL
  • cytokine activity Source: UniProtKB-KW
  • morphogen activity Source: BHF-UCL
  • protein homodimerization activity Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-HSA-1181150 Signaling by NODAL
R-HSA-1433617 Regulation of signaling by NODAL
R-HSA-201451 Signaling by BMP

Names & Taxonomyi

Protein namesi
Recommended name:
Cerberus
Alternative name(s):
Cerberus-related protein
DAN domain family member 4
Gene namesi
Name:CER1
Synonyms:DAND4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000147869.4
HGNCiHGNC:1862 CER1
MIMi603777 gene
neXtProtiNX_O95813

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi9350
OpenTargetsiENSG00000147869
PharmGKBiPA26417

Polymorphism and mutation databases

BioMutaiCER1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 171 PublicationAdd BLAST17
ChainiPRO_000000671118 – 267CerberusAdd BLAST250

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi26N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi162 ↔ 209PROSITE-ProRule annotation
Disulfide bondi176 ↔ 223PROSITE-ProRule annotation
Disulfide bondi186 ↔ 239PROSITE-ProRule annotation
Disulfide bondi190 ↔ 241PROSITE-ProRule annotation
Glycosylationi222N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO95813
PeptideAtlasiO95813
PRIDEiO95813
ProteomicsDBi51063

PTM databases

iPTMnetiO95813
PhosphoSitePlusiO95813

Expressioni

Gene expression databases

BgeeiENSG00000147869 Expressed in 24 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_CER1
GenevisibleiO95813 HS

Organism-specific databases

HPAiHPA019917

Interactioni

Subunit structurei

Forms monomers and predominantly dimers.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114753, 14 interactors
STRINGi9606.ENSP00000370297

Structurei

3D structure databases

ProteinModelPortaliO95813
SMRiO95813
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini162 – 246CTCKPROSITE-ProRule annotationAdd BLAST85

Sequence similaritiesi

Belongs to the DAN family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IGR5 Eukaryota
ENOG410YX4Y LUCA
GeneTreeiENSGT00530000063926
HOGENOMiHOG000231309
HOVERGENiHBG050902
InParanoidiO95813
KOiK01645
OMAiCFGKCGS
OrthoDBiEOG091G0IOA
PhylomeDBiO95813
TreeFamiTF106445

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR016860 Cerberus
IPR006207 Cys_knot_C
IPR029034 Cystine-knot_cytokine
IPR004133 DAN
PANTHERiPTHR15273 PTHR15273, 1 hit
PfamiView protein in Pfam
PF03045 DAN, 1 hit
PIRSFiPIRSF027807 Cerberus, 1 hit
SMARTiView protein in SMART
SM00041 CT, 1 hit
PROSITEiView protein in PROSITE
PS01225 CTCK_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95813-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHLLLFQLLV LLPLGKTTRH QDGRQNQSSL SPVLLPRNQR ELPTGNHEEA
60 70 80 90 100
EEKPDLFVAV PHLVATSPAG EGQRQREKML SRFGRFWKKP EREMHPSRDS
110 120 130 140 150
DSEPFPPGTQ SLIQPIDGMK MEKSPLREEA KKFWHHFMFR KTPASQGVIL
160 170 180 190 200
PIKSHEVHWE TCRTVPFSQT ITHEGCEKVV VQNNLCFGKC GSVHFPGAAQ
210 220 230 240 250
HSHTSCSHCL PAKFTTMHLP LNCTELSSVI KVVMLVEECQ CKVKTEHEDG
260
HILHAGSQDS FIPGVSA
Length:267
Mass (Da):30,084
Last modified:May 1, 1999 - v1
Checksum:iC9FB048CD8558ED7
GO

Sequence cautioni

The sequence AAH69503 differs from that shown. Reason: Erroneous termination at position 266. Translated as Ser.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57F → L in AAH69503 (PubMed:15489334).Curated1
Sequence conflicti221L → V in AAH69405 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02159119R → W1 PublicationCorresponds to variant dbSNP:rs10115703Ensembl.1
Natural variantiVAR_02159265A → G1 PublicationCorresponds to variant dbSNP:rs3747532Ensembl.1
Natural variantiVAR_021593179V → I1 PublicationCorresponds to variant dbSNP:rs7036635Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090189 Genomic DNA Translation: AAD19879.1
AF400435 mRNA Translation: AAK92484.1
AL390732 Genomic DNA No translation available.
BC069371 mRNA Translation: AAH69371.1
BC069405 mRNA Translation: AAH69405.1
BC069491 mRNA Translation: AAH69491.1
BC069503 mRNA Translation: AAH69503.1 Sequence problems.
CCDSiCCDS6476.1
RefSeqiNP_005445.1, NM_005454.2
UniGeneiHs.248204

Genome annotation databases

EnsembliENST00000380911; ENSP00000370297; ENSG00000147869
GeneIDi9350
KEGGihsa:9350
UCSCiuc003zlj.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCER1_HUMAN
AccessioniPrimary (citable) accession number: O95813
Secondary accession number(s): Q6ISJ1
, Q6ISJ6, Q6ISQ2, Q6ISS1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: May 1, 1999
Last modified: September 12, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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