UniProtKB - O95810 (CAVN2_HUMAN)
Protein
Caveolae-associated protein 2
Gene
CAVIN2
Organism
Homo sapiens (Human)
Status
Functioni
Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity).By similarity1 Publication
Miscellaneous
Binds phosphatidylserine (PS) in a calcium-independent manner. PS-binding is inhibited by phosphotidic acid and phosphatidylinositol. Does not bind phosphatidylcholine.
GO - Molecular functioni
- phosphatidylserine binding Source: UniProtKB
- phospholipid binding Source: ProtInc
- protein kinase C binding Source: GO_Central
GO - Biological processi
- plasma membrane tubulation Source: UniProtKB
Keywordsi
Ligand | Lipid-binding |
Enzyme and pathway databases
PathwayCommonsi | O95810 |
Names & Taxonomyi
Protein namesi | Recommended name: Caveolae-associated protein 2ImportedAlternative name(s): Cavin-2 PS-p68 Phosphatidylserine-binding protein Serum deprivation-response protein |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000168497.4 |
HGNCi | HGNC:10690, CAVIN2 |
MIMi | 606728, gene |
neXtProti | NX_O95810 |
Subcellular locationi
Cytosol
- cytosol Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- caveola Source: UniProtKB
- plasma membrane Source: HPA
Other locations
- cytoplasm Source: MGI
- membrane raft Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 86 | L → E: Loss of localization in caveolae; when associated with E-93 or E-100. 1 Publication | 1 | |
Mutagenesisi | 93 | I → E: Loss of localization in caveolae; when associated with E-86 or E-100. 1 Publication | 1 | |
Mutagenesisi | 100 | L → E: Loss of localization in caveolae; when associated with E-86 or E-93. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 8436 |
OpenTargetsi | ENSG00000168497 |
PharmGKBi | PA35615 |
Miscellaneous databases
Pharosi | O95810, Tbio |
Polymorphism and mutation databases
BioMutai | CAVIN2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000238918 | 2 – 425 | Caveolae-associated protein 2Add BLAST | 424 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylglycine1 Publication | 1 | |
Modified residuei | 27 | PhosphoserineBy similarity | 1 | |
Modified residuei | 35 | PhosphoserineCombined sources | 1 | |
Modified residuei | 37 | PhosphoserineBy similarity | 1 | |
Modified residuei | 51 | PhosphoserineBy similarity | 1 | |
Modified residuei | 196 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 199 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 203 | PhosphoserineCombined sources | 1 | |
Modified residuei | 204 | PhosphoserineCombined sources | 1 | |
Modified residuei | 218 | PhosphoserineCombined sources | 1 | |
Modified residuei | 283 | PhosphoserineBy similarity | 1 | |
Modified residuei | 284 | PhosphoserineBy similarity | 1 | |
Modified residuei | 287 | PhosphoserineCombined sources | 1 | |
Modified residuei | 288 | PhosphoserineCombined sources | 1 | |
Modified residuei | 293 | PhosphoserineCombined sources | 1 | |
Modified residuei | 332 | PhosphoserineBy similarity | 1 | |
Modified residuei | 341 | PhosphoserineBy similarity | 1 | |
Modified residuei | 366 | PhosphoserineBy similarity | 1 | |
Modified residuei | 370 | PhosphoserineBy similarity | 1 | |
Modified residuei | 375 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 395 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 403 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Phosphorylated on Ser residues.1 Publication
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | O95810 |
jPOSTi | O95810 |
MassIVEi | O95810 |
MaxQBi | O95810 |
PaxDbi | O95810 |
PeptideAtlasi | O95810 |
PRIDEi | O95810 |
ProteomicsDBi | 51062 |
TopDownProteomicsi | O95810 |
2D gel databases
OGPi | O95810 |
PTM databases
CarbonylDBi | O95810 |
iPTMneti | O95810 |
PhosphoSitePlusi | O95810 |
SwissPalmi | O95810 |
Expressioni
Tissue specificityi
Highly expressed in heart and lung, and expressed at lower levels in brain, kidney, liver, pancreas, placenta, and skeletal muscle.1 Publication
Inductioni
Up-regulated in asyncronously growing fibroblasts following serum deprivation but not following contact inhibition. Down-regulated during synchronous cell cycle re-entry.1 Publication
Gene expression databases
Bgeei | ENSG00000168497, Expressed in upper lobe of lung and 217 other tissues |
Genevisiblei | O95810, HS |
Organism-specific databases
HPAi | ENSG00000168497, Low tissue specificity |
Interactioni
Subunit structurei
Component of the CAVIN complex composed of CAVIN1, CAVIN2, CAVIN3 and CAVIN4. Binds to PRKCA in the presence of phosphatidylserine (By similarity).
Interacts with CAVIN4; this augments the transactivation of NPPA by CAVIN4 (PubMed:18332105, PubMed:24567387).
Interacts with CAVIN1 (PubMed:19525939, PubMed:24567387).
Interacts with CAV3 (PubMed:24567387).
By similarity3 PublicationsBinary interactionsi
Hide detailsO95810
GO - Molecular functioni
- protein kinase C binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 114016, 16 interactors |
DIPi | DIP-56943N |
IntActi | O95810, 19 interactors |
MINTi | O95810 |
STRINGi | 9606.ENSP00000305675 |
Miscellaneous databases
RNActi | O95810, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2 – 168 | Interaction with CAVIN1By similarityAdd BLAST | 167 | |
Regioni | 62 – 100 | Leucine-zipper1 PublicationAdd BLAST | 39 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 61 – 82 | Sequence analysisAdd BLAST | 22 | |
Coiled coili | 125 – 154 | Sequence analysisAdd BLAST | 30 | |
Coiled coili | 210 – 268 | Sequence analysisAdd BLAST | 59 |
Domaini
The leucine-zipper domain is essential for its localization in the caveolae.1 Publication
Sequence similaritiesi
Belongs to the CAVIN family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QQCA, Eukaryota |
GeneTreei | ENSGT00950000182910 |
HOGENOMi | CLU_039470_1_0_1 |
InParanoidi | O95810 |
OMAi | TKSEDMP |
OrthoDBi | 858587at2759 |
PhylomeDBi | O95810 |
TreeFami | TF331031 |
Family and domain databases
InterProi | View protein in InterPro IPR033298, Cavin2 IPR026752, Cavin_fam |
PANTHERi | PTHR15240, PTHR15240, 1 hit PTHR15240:SF1, PTHR15240:SF1, 1 hit |
Pfami | View protein in Pfam PF15237, PTRF_SDPR, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
O95810-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGEDAAQAEK FQHPGSDMRQ EKPSSPSPMP SSTPSPSLNL GNTEEAIRDN
60 70 80 90 100
SQVNAVTVLT LLDKLVNMLD AVQENQHKME QRQISLEGSV KGIQNDLTKL
110 120 130 140 150
SKYQASTSNT VSKLLEKSRK VSAHTRAVKE RMDRQCAQVK RLENNHAQLL
160 170 180 190 200
RRNHFKVLIF QEENEIPASV FVKQPVSGAV EGKEELPDEN KSLEETLHTV
210 220 230 240 250
DLSSDDDLPH DEEALEDSAE EKVEESRAEK IKRSSLKKVD SLKKAFSRQN
260 270 280 290 300
IEKKMNKLGT KIVSVERREK IKKSLTSNHQ KISSGKSSPF KVSPLTFGRK
310 320 330 340 350
KVREGESHAE NETKSEDLPS SEQMPNDQEE ESFAEGHSEA SLASALVEGE
360 370 380 390 400
IAEEAAEKAT SRGSNSGMDS NIDLTIVEDE EEESVALEQA QKVRYEGSYA
410 420
LTSEEAERSD GDPVQPAVLQ VHQTS
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034422 | 130 | E → D. Corresponds to variant dbSNP:rs35012125Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF085481 mRNA Translation: AAD17795.1 AC098872 Genomic DNA Translation: AAY24078.1 BC016475 mRNA Translation: AAH16475.1 |
CCDSi | CCDS2313.1 |
RefSeqi | NP_004648.1, NM_004657.5 |
Genome annotation databases
Ensembli | ENST00000304141; ENSP00000305675; ENSG00000168497 |
GeneIDi | 8436 |
KEGGi | hsa:8436 |
UCSCi | uc002utb.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF085481 mRNA Translation: AAD17795.1 AC098872 Genomic DNA Translation: AAY24078.1 BC016475 mRNA Translation: AAH16475.1 |
CCDSi | CCDS2313.1 |
RefSeqi | NP_004648.1, NM_004657.5 |
3D structure databases
SMRi | O95810 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114016, 16 interactors |
DIPi | DIP-56943N |
IntActi | O95810, 19 interactors |
MINTi | O95810 |
STRINGi | 9606.ENSP00000305675 |
PTM databases
CarbonylDBi | O95810 |
iPTMneti | O95810 |
PhosphoSitePlusi | O95810 |
SwissPalmi | O95810 |
Polymorphism and mutation databases
BioMutai | CAVIN2 |
2D gel databases
OGPi | O95810 |
Proteomic databases
EPDi | O95810 |
jPOSTi | O95810 |
MassIVEi | O95810 |
MaxQBi | O95810 |
PaxDbi | O95810 |
PeptideAtlasi | O95810 |
PRIDEi | O95810 |
ProteomicsDBi | 51062 |
TopDownProteomicsi | O95810 |
Protocols and materials databases
Antibodypediai | 34051, 123 antibodies |
DNASUi | 8436 |
Genome annotation databases
Ensembli | ENST00000304141; ENSP00000305675; ENSG00000168497 |
GeneIDi | 8436 |
KEGGi | hsa:8436 |
UCSCi | uc002utb.4, human |
Organism-specific databases
CTDi | 8436 |
DisGeNETi | 8436 |
EuPathDBi | HostDB:ENSG00000168497.4 |
GeneCardsi | CAVIN2 |
HGNCi | HGNC:10690, CAVIN2 |
HPAi | ENSG00000168497, Low tissue specificity |
MIMi | 606728, gene |
neXtProti | NX_O95810 |
OpenTargetsi | ENSG00000168497 |
PharmGKBi | PA35615 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQCA, Eukaryota |
GeneTreei | ENSGT00950000182910 |
HOGENOMi | CLU_039470_1_0_1 |
InParanoidi | O95810 |
OMAi | TKSEDMP |
OrthoDBi | 858587at2759 |
PhylomeDBi | O95810 |
TreeFami | TF331031 |
Enzyme and pathway databases
PathwayCommonsi | O95810 |
Miscellaneous databases
BioGRID-ORCSi | 8436, 1 hit in 839 CRISPR screens |
ChiTaRSi | SDPR, human |
GeneWikii | SDPR |
GenomeRNAii | 8436 |
Pharosi | O95810, Tbio |
PROi | PR:O95810 |
RNActi | O95810, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000168497, Expressed in upper lobe of lung and 217 other tissues |
Genevisiblei | O95810, HS |
Family and domain databases
InterProi | View protein in InterPro IPR033298, Cavin2 IPR026752, Cavin_fam |
PANTHERi | PTHR15240, PTHR15240, 1 hit PTHR15240:SF1, PTHR15240:SF1, 1 hit |
Pfami | View protein in Pfam PF15237, PTRF_SDPR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CAVN2_HUMAN | |
Accessioni | O95810Primary (citable) accession number: O95810 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2006 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 150 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations