CAVIN2

Functionⁱ

Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity).By similarity1 Publication

Miscellaneous

Binds phosphatidylserine (PS) in a calcium-independent manner. PS-binding is inhibited by phosphotidic acid and phosphatidylinositol. Does not bind phosphatidylcholine.

GO - Molecular functionⁱ

phosphatidylserine binding
Source: UniProtKB
Inferred from direct assayⁱ
- 10191091
- 2390065
phospholipid binding
Source: ProtInc
Traceable author statementⁱ
- 10191091
protein kinase C binding Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

plasma membrane tubulation
Source: UniProtKB
Inferred from direct assayⁱ
- 19525939

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Lipid-binding

Ligand

Lipid-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Caveolae-associated protein 2Imported Alternative name(s): Cavin-2 PS-p68 Phosphatidylserine-binding protein Serum deprivation-response protein
Gene namesⁱ	Name:CAVIN2Imported Synonyms:SDPRImported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000168497.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10690 CAVIN2
MIMⁱ	606728 gene
neXtProtⁱ	NX_O95810

Keywords - Cellular componentⁱ

Cytoplasm, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	86	L → E: Loss of localization in caveolae; when associated with E-93 or E-100. 1 Publication	1
Mutagenesisⁱ	93	I → E: Loss of localization in caveolae; when associated with E-86 or E-100. 1 Publication	1
Mutagenesisⁱ	100	L → E: Loss of localization in caveolae; when associated with E-86 or E-93. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8436
Open Targets More...OpenTargetsⁱ	ENSG00000168497
PharmGKBⁱ	PA35615

Polymorphism and mutation databases

BioMutaⁱ	SDPR

BioMutaⁱ

SDPR

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed1 Publication
ChainⁱPRO_0000238918	2 – 425	Caveolae-associated protein 2Add BLAST		424

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylglycine1 Publication	1
Modified residueⁱ	27	PhosphoserineBy similarity	1
Modified residueⁱ	35	PhosphoserineCombined sources	1
Modified residueⁱ	37	PhosphoserineBy similarity	1
Modified residueⁱ	51	PhosphoserineBy similarity	1
Modified residueⁱ	196	PhosphothreonineCombined sources	1
Modified residueⁱ	199	PhosphothreonineCombined sources	1
Modified residueⁱ	203	PhosphoserineCombined sources	1
Modified residueⁱ	204	PhosphoserineCombined sources	1
Modified residueⁱ	218	PhosphoserineCombined sources	1
Modified residueⁱ	283	PhosphoserineBy similarity	1
Modified residueⁱ	284	PhosphoserineBy similarity	1
Modified residueⁱ	287	PhosphoserineCombined sources	1
Modified residueⁱ	288	PhosphoserineCombined sources	1
Modified residueⁱ	293	PhosphoserineCombined sources	1
Modified residueⁱ	332	PhosphoserineBy similarity	1
Modified residueⁱ	341	PhosphoserineBy similarity	1
Modified residueⁱ	366	PhosphoserineBy similarity	1
Modified residueⁱ	370	PhosphoserineBy similarity	1
Modified residueⁱ	375	PhosphothreonineBy similarity	1
Modified residueⁱ	395	PhosphotyrosineBy similarity	1
Modified residueⁱ	403	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Phosphorylated on Ser residues.1 Publication

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	O95810
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O95810
PaxDbⁱ	O95810
PeptideAtlas More...PeptideAtlasⁱ	O95810
PRIDEⁱ	O95810
ProteomicsDBⁱ	51062
TopDownProteomicsⁱ	O95810

2D gel databases

USC-OGP 2-DE database More...OGPⁱ	O95810

OGPⁱ

O95810

PTM databases

CarbonylDBⁱ	O95810
iPTMnetⁱ	O95810
PhosphoSitePlusⁱ	O95810
SwissPalmⁱ	O95810

Expressionⁱ

Tissue specificityⁱ

Highly expressed in heart and lung, and expressed at lower levels in brain, kidney, liver, pancreas, placenta, and skeletal muscle.1 Publication

Inductionⁱ

Up-regulated in asyncronously growing fibroblasts following serum deprivation but not following contact inhibition. Down-regulated during synchronous cell cycle re-entry.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000168497 Expressed in 204 organ(s), highest expression level in upper lobe of lung
CleanExⁱ	HS_SDPR
Genevisibleⁱ	O95810 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA039325 HPA062122

HPAⁱ

HPA039325
HPA062122

Interactionⁱ

Subunit structureⁱ

Component of the CAVIN complex composed of CAVIN1, CAVIN2, CAVIN3 and CAVIN4. Binds to PRKCA in the presence of phosphatidylserine (By similarity). Interacts with CAVIN4; this augments the transactivation of NPPA by CAVIN4 (PubMed:18332105, PubMed:24567387). Interacts with CAVIN1 (PubMed:19525939, PubMed:24567387). Interacts with CAV3 (PubMed:24567387).By similarity3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
A1CF	Q9NQ94-2	3	EBI-742141,EBI-10311892
CAV1	Q03135	6	EBI-742141,EBI-603614
CAVIN1	Q6NZI2	6	EBI-742141,EBI-2559016
PLEK	P08567	4	EBI-742141,EBI-2565501

GO - Molecular functionⁱ

protein kinase C binding Source: GO_Central

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114016, 7 interactors
Database of interacting proteins More...DIPⁱ	DIP-56943N
IntActⁱ	O95810, 16 interactors
Molecular INTeraction database More...MINTⁱ	O95810
STRINGⁱ	9606.ENSP00000305675

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O95810
SMRⁱ	O95810
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	2 – 168	Interaction with CAVIN1By similarityAdd BLAST		167
Regionⁱ	62 – 100	Leucine-zipper1 PublicationAdd BLAST		39

Coiled coil

Feature key	Position(s)	DescriptionActions	Length
Coiled coilⁱ	61 – 82	Sequence analysisAdd BLAST	22
Coiled coilⁱ	125 – 154	Sequence analysisAdd BLAST	30
Coiled coilⁱ	210 – 268	Sequence analysisAdd BLAST	59

Domainⁱ

The leucine-zipper domain is essential for its localization in the caveolae.1 Publication

Sequence similaritiesⁱ

Belongs to the CAVIN family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IEZA Eukaryota ENOG410XP8W LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063058
HOGENOMⁱ	HOG000293135
HOVERGENⁱ	HBG056807
InParanoidⁱ	O95810
OMAⁱ	ERMDRQC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09Y1
PhylomeDBⁱ	O95810
TreeFamⁱ	TF331031

Family and domain databases

InterProⁱ	View protein in InterPro IPR033298 Cavin2 IPR026752 Cavin_fam
PANTHERⁱ	PTHR15240 PTHR15240, 1 hit PTHR15240:SF1 PTHR15240:SF1, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15237 PTRF_SDPR, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

O95810-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGEDAAQAEK FQHPGSDMRQ EKPSSPSPMP SSTPSPSLNL GNTEEAIRDN 
        60         70         80         90        100
SQVNAVTVLT LLDKLVNMLD AVQENQHKME QRQISLEGSV KGIQNDLTKL 
       110        120        130        140        150
SKYQASTSNT VSKLLEKSRK VSAHTRAVKE RMDRQCAQVK RLENNHAQLL 
       160        170        180        190        200
RRNHFKVLIF QEENEIPASV FVKQPVSGAV EGKEELPDEN KSLEETLHTV 
       210        220        230        240        250
DLSSDDDLPH DEEALEDSAE EKVEESRAEK IKRSSLKKVD SLKKAFSRQN 
       260        270        280        290        300
IEKKMNKLGT KIVSVERREK IKKSLTSNHQ KISSGKSSPF KVSPLTFGRK 
       310        320        330        340        350
KVREGESHAE NETKSEDLPS SEQMPNDQEE ESFAEGHSEA SLASALVEGE 
       360        370        380        390        400
IAEEAAEKAT SRGSNSGMDS NIDLTIVEDE EEESVALEQA QKVRYEGSYA 
       410        420 
LTSEEAERSD GDPVQPAVLQ VHQTS

Length:425

Mass (Da):47,173

Last modified:January 23, 2007 - v3

Checksum:ⁱ0631CBF4BED537F9

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_034422	130	E → D. Corresponds to variant dbSNP:rs35012125Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF085481 mRNA Translation: AAD17795.1 AC098872 Genomic DNA Translation: AAY24078.1 BC016475 mRNA Translation: AAH16475.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2313.1
NCBI Reference Sequences More...RefSeqⁱ	NP_004648.1, NM_004657.5
UniGeneⁱ	Hs.26530

Genome annotation databases

Ensemblⁱ	ENST00000304141; ENSP00000305675; ENSG00000168497
GeneIDⁱ	8436
KEGGⁱ	hsa:8436
UCSC genome browser More...UCSCⁱ	uc002utb.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O95810	Uncharacterized protein		AOTNA		427	UniRef90_O95810
cDNA FLJ78516		HUMAN		425
Caveolae associated protein 2		MACMU		425
Uncharacterized protein		CERAT		425
Uncharacterized protein		MACFA		425
+21

Protein	Similar proteins		Species	Score	Length	Source
O95810	Uncharacterized protein		AOTNA		427	UniRef50_O95810
CAVIN2 isoform 1		PANTR		425
Uncharacterized protein		NOMLE		425
Uncharacterized protein		MACFA		425
Uncharacterized protein		MANLE		425
+123

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF085481 mRNA Translation: AAD17795.1 AC098872 Genomic DNA Translation: AAY24078.1 BC016475 mRNA Translation: AAH16475.1
CCDSⁱ	CCDS2313.1
RefSeqⁱ	NP_004648.1, NM_004657.5
UniGeneⁱ	Hs.26530

3D structure databases

ProteinModelPortalⁱ	O95810
SMRⁱ	O95810
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114016, 7 interactors
DIPⁱ	DIP-56943N
IntActⁱ	O95810, 16 interactors
MINTⁱ	O95810
STRINGⁱ	9606.ENSP00000305675

PTM databases

CarbonylDBⁱ	O95810
iPTMnetⁱ	O95810
PhosphoSitePlusⁱ	O95810
SwissPalmⁱ	O95810

Polymorphism and mutation databases

BioMutaⁱ	SDPR

BioMutaⁱ

SDPR

2D gel databases

OGPⁱ	O95810

OGPⁱ

O95810

Proteomic databases

EPDⁱ	O95810
MaxQBⁱ	O95810
PaxDbⁱ	O95810
PeptideAtlasⁱ	O95810
PRIDEⁱ	O95810
ProteomicsDBⁱ	51062
TopDownProteomicsⁱ	O95810

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	8436
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000304141; ENSP00000305675; ENSG00000168497
GeneIDⁱ	8436
KEGGⁱ	hsa:8436
UCSCⁱ	uc002utb.4 human

Organism-specific databases

CTDⁱ	8436
DisGeNETⁱ	8436
EuPathDBⁱ	HostDB:ENSG00000168497.4
GeneCardsⁱ	CAVIN2
HGNCⁱ	HGNC:10690 CAVIN2
HPAⁱ	HPA039325 HPA062122
MIMⁱ	606728 gene
neXtProtⁱ	NX_O95810
OpenTargetsⁱ	ENSG00000168497
PharmGKBⁱ	PA35615
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IEZA Eukaryota ENOG410XP8W LUCA
GeneTreeⁱ	ENSGT00530000063058
HOGENOMⁱ	HOG000293135
HOVERGENⁱ	HBG056807
InParanoidⁱ	O95810
OMAⁱ	ERMDRQC
OrthoDBⁱ	EOG091G09Y1
PhylomeDBⁱ	O95810
TreeFamⁱ	TF331031

Miscellaneous databases

GeneWikiⁱ	SDPR
GenomeRNAiⁱ	8436
Protein Ontology More...PROⁱ	PR:O95810
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000168497 Expressed in 204 organ(s), highest expression level in upper lobe of lung
CleanExⁱ	HS_SDPR
Genevisibleⁱ	O95810 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR033298 Cavin2 IPR026752 Cavin_fam
PANTHERⁱ	PTHR15240 PTHR15240, 1 hit PTHR15240:SF1 PTHR15240:SF1, 1 hit
Pfamⁱ	View protein in Pfam PF15237 PTRF_SDPR, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CAVN2_HUMAN
Accessionⁱ	O95810Primary (citable) accession number: O95810
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
	Last sequence update:	January 23, 2007
	Last modified:	September 12, 2018
	This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

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UniProtKB - O95810 (CAVN2_HUMAN)

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Caveolae-associated protein 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Other locations

Cytoskeleton

Cytosol

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ