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UniProtKB - O95810 (CAVN2_HUMAN)

Protein

Caveolae-associated protein 2

Gene

CAVIN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity).By similarity1 Publication

Miscellaneous

Binds phosphatidylserine (PS) in a calcium-independent manner. PS-binding is inhibited by phosphotidic acid and phosphatidylinositol. Does not bind phosphatidylcholine.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • phosphatidylserine binding Source: UniProtKB
  • phospholipid binding Source: ProtInc
  • protein kinase C binding Source: GO_Central
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandLipid-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Caveolae-associated protein 2Imported
Alternative name(s):
Cavin-2
PS-p68
Phosphatidylserine-binding protein
Serum deprivation-response protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CAVIN2Imported
Synonyms:SDPRImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000168497.4

Human Gene Nomenclature Database

More...HGNCi		HGNC:10690 CAVIN2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606728 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O95810

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi86L → E: Loss of localization in caveolae; when associated with E-93 or E-100. 1 Publication1
Mutagenesisi93I → E: Loss of localization in caveolae; when associated with E-86 or E-100. 1 Publication1
Mutagenesisi100L → E: Loss of localization in caveolae; when associated with E-86 or E-93. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		8436

Open Targets

More...OpenTargetsi		ENSG00000168497

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35615

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CAVIN2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002389182 – 425Caveolae-associated protein 2Add BLAST424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylglycine1 Publication1
Modified residuei27PhosphoserineBy similarity1
Modified residuei35PhosphoserineCombined sources1
Modified residuei37PhosphoserineBy similarity1
Modified residuei51PhosphoserineBy similarity1
Modified residuei196PhosphothreonineCombined sources1
Modified residuei199PhosphothreonineCombined sources1
Modified residuei203PhosphoserineCombined sources1
Modified residuei204PhosphoserineCombined sources1
Modified residuei218PhosphoserineCombined sources1
Modified residuei283PhosphoserineBy similarity1
Modified residuei284PhosphoserineBy similarity1
Modified residuei287PhosphoserineCombined sources1
Modified residuei288PhosphoserineCombined sources1
Modified residuei293PhosphoserineCombined sources1
Modified residuei332PhosphoserineBy similarity1
Modified residuei341PhosphoserineBy similarity1
Modified residuei366PhosphoserineBy similarity1
Modified residuei370PhosphoserineBy similarity1
Modified residuei375PhosphothreonineBy similarity1
Modified residuei395PhosphotyrosineBy similarity1
Modified residuei403PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on Ser residues.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O95810

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O95810

MaxQB - The MaxQuant DataBase

More...MaxQBi		O95810

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O95810

PeptideAtlas

More...PeptideAtlasi		O95810

PRoteomics IDEntifications database

More...PRIDEi		O95810

ProteomicsDB human proteome resource

More...ProteomicsDBi		51062

Consortium for Top Down Proteomics

More...TopDownProteomicsi		O95810

2D gel databases

USC-OGP 2-DE database

More...OGPi		O95810

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		O95810

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O95810

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O95810

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O95810

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in heart and lung, and expressed at lower levels in brain, kidney, liver, pancreas, placenta, and skeletal muscle.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in asyncronously growing fibroblasts following serum deprivation but not following contact inhibition. Down-regulated during synchronous cell cycle re-entry.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000168497 Expressed in 204 organ(s), highest expression level in upper lobe of lung

CleanEx database of gene expression profiles

More...CleanExi		HS_SDPR

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O95810 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA039325
HPA062122

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the CAVIN complex composed of CAVIN1, CAVIN2, CAVIN3 and CAVIN4. Binds to PRKCA in the presence of phosphatidylserine (By similarity). Interacts with CAVIN4; this augments the transactivation of NPPA by CAVIN4 (PubMed:18332105, PubMed:24567387). Interacts with CAVIN1 (PubMed:19525939, PubMed:24567387). Interacts with CAV3 (PubMed:24567387).By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		114016, 7 interactors

Database of interacting proteins

More...DIPi		DIP-56943N

Protein interaction database and analysis system

More...IntActi		O95810, 16 interactors

Molecular INTeraction database

More...MINTi		O95810

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000305675

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		O95810

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O95810

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 168Interaction with CAVIN1By similarityAdd BLAST167
Regioni62 – 100Leucine-zipper1 PublicationAdd BLAST39

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili61 – 82Sequence analysisAdd BLAST22
Coiled coili125 – 154Sequence analysisAdd BLAST30
Coiled coili210 – 268Sequence analysisAdd BLAST59

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The leucine-zipper domain is essential for its localization in the caveolae.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CAVIN family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IEZA Eukaryota
ENOG410XP8W LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154218

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000293135

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG056807

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O95810

Identification of Orthologs from Complete Genome Data

More...OMAi		GSDMRQE

Database of Orthologous Groups

More...OrthoDBi		858587at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O95810

TreeFam database of animal gene trees

More...TreeFami		TF331031

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR033298 Cavin2
IPR026752 Cavin_fam

The PANTHER Classification System

More...PANTHERi		PTHR15240 PTHR15240, 1 hit
PTHR15240:SF1 PTHR15240:SF1, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15237 PTRF_SDPR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

O95810-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGEDAAQAEK FQHPGSDMRQ EKPSSPSPMP SSTPSPSLNL GNTEEAIRDN 
        60         70         80         90        100
SQVNAVTVLT LLDKLVNMLD AVQENQHKME QRQISLEGSV KGIQNDLTKL 
       110        120        130        140        150
SKYQASTSNT VSKLLEKSRK VSAHTRAVKE RMDRQCAQVK RLENNHAQLL 
       160        170        180        190        200
RRNHFKVLIF QEENEIPASV FVKQPVSGAV EGKEELPDEN KSLEETLHTV 
       210        220        230        240        250
DLSSDDDLPH DEEALEDSAE EKVEESRAEK IKRSSLKKVD SLKKAFSRQN 
       260        270        280        290        300
IEKKMNKLGT KIVSVERREK IKKSLTSNHQ KISSGKSSPF KVSPLTFGRK 
       310        320        330        340        350
KVREGESHAE NETKSEDLPS SEQMPNDQEE ESFAEGHSEA SLASALVEGE 
       360        370        380        390        400
IAEEAAEKAT SRGSNSGMDS NIDLTIVEDE EEESVALEQA QKVRYEGSYA 
       410        420 
LTSEEAERSD GDPVQPAVLQ VHQTS
Length:425
Mass (Da):47,173
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0631CBF4BED537F9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034422130E → D. Corresponds to variant dbSNP:rs35012125Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF085481 mRNA Translation: AAD17795.1
AC098872 Genomic DNA Translation: AAY24078.1
BC016475 mRNA Translation: AAH16475.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2313.1

NCBI Reference Sequences

More...RefSeqi		NP_004648.1, NM_004657.5

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.26530

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000304141; ENSP00000305675; ENSG00000168497

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8436

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8436

UCSC genome browser

More...UCSCi		uc002utb.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085481 mRNA Translation: AAD17795.1
AC098872 Genomic DNA Translation: AAY24078.1
BC016475 mRNA Translation: AAH16475.1
CCDSiCCDS2313.1
RefSeqiNP_004648.1, NM_004657.5
UniGeneiHs.26530

3D structure databases

ProteinModelPortaliO95810
SMRiO95810
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114016, 7 interactors
DIPiDIP-56943N
IntActiO95810, 16 interactors
MINTiO95810
STRINGi9606.ENSP00000305675

PTM databases

CarbonylDBiO95810
iPTMnetiO95810
PhosphoSitePlusiO95810
SwissPalmiO95810

Polymorphism and mutation databases

BioMutaiCAVIN2

2D gel databases

OGPiO95810

Proteomic databases

EPDiO95810
jPOSTiO95810
MaxQBiO95810
PaxDbiO95810
PeptideAtlasiO95810
PRIDEiO95810
ProteomicsDBi51062
TopDownProteomicsiO95810

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		8436
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304141; ENSP00000305675; ENSG00000168497
GeneIDi8436
KEGGihsa:8436
UCSCiuc002utb.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8436
DisGeNETi8436
EuPathDBiHostDB:ENSG00000168497.4

GeneCards: human genes, protein and diseases

More...GeneCardsi		CAVIN2
HGNCiHGNC:10690 CAVIN2
HPAiHPA039325
HPA062122
MIMi606728 gene
neXtProtiNX_O95810
OpenTargetsiENSG00000168497
PharmGKBiPA35615

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IEZA Eukaryota
ENOG410XP8W LUCA
GeneTreeiENSGT00940000154218
HOGENOMiHOG000293135
HOVERGENiHBG056807
InParanoidiO95810
OMAiGSDMRQE
OrthoDBi858587at2759
PhylomeDBiO95810
TreeFamiTF331031

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SDPR

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8436

Protein Ontology

More...PROi		PR:O95810

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000168497 Expressed in 204 organ(s), highest expression level in upper lobe of lung
CleanExiHS_SDPR
GenevisibleiO95810 HS

Family and domain databases

InterProiView protein in InterPro
IPR033298 Cavin2
IPR026752 Cavin_fam
PANTHERiPTHR15240 PTHR15240, 1 hit
PTHR15240:SF1 PTHR15240:SF1, 1 hit
PfamiView protein in Pfam
PF15237 PTRF_SDPR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAVN2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95810
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: January 23, 2007
Last modified: January 16, 2019
This is version 137 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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