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Protein

Caveolae-associated protein 2

Gene

CAVIN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity).By similarity1 Publication

Miscellaneous

Binds phosphatidylserine (PS) in a calcium-independent manner. PS-binding is inhibited by phosphotidic acid and phosphatidylinositol. Does not bind phosphatidylcholine.

GO - Molecular functioni

  • phosphatidylserine binding Source: UniProtKB
  • phospholipid binding Source: ProtInc
  • protein kinase C binding Source: GO_Central

GO - Biological processi

Keywordsi

LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Caveolae-associated protein 2Imported
Alternative name(s):
Cavin-2
PS-p68
Phosphatidylserine-binding protein
Serum deprivation-response protein
Gene namesi
Name:CAVIN2Imported
Synonyms:SDPRImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000168497.4
HGNCiHGNC:10690 CAVIN2
MIMi606728 gene
neXtProtiNX_O95810

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi86L → E: Loss of localization in caveolae; when associated with E-93 or E-100. 1 Publication1
Mutagenesisi93I → E: Loss of localization in caveolae; when associated with E-86 or E-100. 1 Publication1
Mutagenesisi100L → E: Loss of localization in caveolae; when associated with E-86 or E-93. 1 Publication1

Organism-specific databases

DisGeNETi8436
OpenTargetsiENSG00000168497
PharmGKBiPA35615

Polymorphism and mutation databases

BioMutaiSDPR

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002389182 – 425Caveolae-associated protein 2Add BLAST424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycine1 Publication1
Modified residuei27PhosphoserineBy similarity1
Modified residuei35PhosphoserineCombined sources1
Modified residuei37PhosphoserineBy similarity1
Modified residuei51PhosphoserineBy similarity1
Modified residuei196PhosphothreonineCombined sources1
Modified residuei199PhosphothreonineCombined sources1
Modified residuei203PhosphoserineCombined sources1
Modified residuei204PhosphoserineCombined sources1
Modified residuei218PhosphoserineCombined sources1
Modified residuei283PhosphoserineBy similarity1
Modified residuei284PhosphoserineBy similarity1
Modified residuei287PhosphoserineCombined sources1
Modified residuei288PhosphoserineCombined sources1
Modified residuei293PhosphoserineCombined sources1
Modified residuei332PhosphoserineBy similarity1
Modified residuei341PhosphoserineBy similarity1
Modified residuei366PhosphoserineBy similarity1
Modified residuei370PhosphoserineBy similarity1
Modified residuei375PhosphothreonineBy similarity1
Modified residuei395PhosphotyrosineBy similarity1
Modified residuei403PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated on Ser residues.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO95810
MaxQBiO95810
PaxDbiO95810
PeptideAtlasiO95810
PRIDEiO95810
ProteomicsDBi51062
TopDownProteomicsiO95810

2D gel databases

OGPiO95810

PTM databases

CarbonylDBiO95810
iPTMnetiO95810
PhosphoSitePlusiO95810
SwissPalmiO95810

Expressioni

Tissue specificityi

Highly expressed in heart and lung, and expressed at lower levels in brain, kidney, liver, pancreas, placenta, and skeletal muscle.1 Publication

Inductioni

Up-regulated in asyncronously growing fibroblasts following serum deprivation but not following contact inhibition. Down-regulated during synchronous cell cycle re-entry.1 Publication

Gene expression databases

BgeeiENSG00000168497 Expressed in 204 organ(s), highest expression level in upper lobe of lung
CleanExiHS_SDPR
GenevisibleiO95810 HS

Organism-specific databases

HPAiHPA039325
HPA062122

Interactioni

Subunit structurei

Component of the CAVIN complex composed of CAVIN1, CAVIN2, CAVIN3 and CAVIN4. Binds to PRKCA in the presence of phosphatidylserine (By similarity). Interacts with CAVIN4; this augments the transactivation of NPPA by CAVIN4 (PubMed:18332105, PubMed:24567387). Interacts with CAVIN1 (PubMed:19525939, PubMed:24567387). Interacts with CAV3 (PubMed:24567387).By similarity3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114016, 7 interactors
DIPiDIP-56943N
IntActiO95810, 16 interactors
MINTiO95810
STRINGi9606.ENSP00000305675

Structurei

3D structure databases

ProteinModelPortaliO95810
SMRiO95810
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 168Interaction with CAVIN1By similarityAdd BLAST167
Regioni62 – 100Leucine-zipper1 PublicationAdd BLAST39

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili61 – 82Sequence analysisAdd BLAST22
Coiled coili125 – 154Sequence analysisAdd BLAST30
Coiled coili210 – 268Sequence analysisAdd BLAST59

Domaini

The leucine-zipper domain is essential for its localization in the caveolae.1 Publication

Sequence similaritiesi

Belongs to the CAVIN family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEZA Eukaryota
ENOG410XP8W LUCA
GeneTreeiENSGT00530000063058
HOGENOMiHOG000293135
HOVERGENiHBG056807
InParanoidiO95810
OMAiERMDRQC
OrthoDBiEOG091G09Y1
PhylomeDBiO95810
TreeFamiTF331031

Family and domain databases

InterProiView protein in InterPro
IPR033298 Cavin2
IPR026752 Cavin_fam
PANTHERiPTHR15240 PTHR15240, 1 hit
PTHR15240:SF1 PTHR15240:SF1, 1 hit
PfamiView protein in Pfam
PF15237 PTRF_SDPR, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95810-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGEDAAQAEK FQHPGSDMRQ EKPSSPSPMP SSTPSPSLNL GNTEEAIRDN
60 70 80 90 100
SQVNAVTVLT LLDKLVNMLD AVQENQHKME QRQISLEGSV KGIQNDLTKL
110 120 130 140 150
SKYQASTSNT VSKLLEKSRK VSAHTRAVKE RMDRQCAQVK RLENNHAQLL
160 170 180 190 200
RRNHFKVLIF QEENEIPASV FVKQPVSGAV EGKEELPDEN KSLEETLHTV
210 220 230 240 250
DLSSDDDLPH DEEALEDSAE EKVEESRAEK IKRSSLKKVD SLKKAFSRQN
260 270 280 290 300
IEKKMNKLGT KIVSVERREK IKKSLTSNHQ KISSGKSSPF KVSPLTFGRK
310 320 330 340 350
KVREGESHAE NETKSEDLPS SEQMPNDQEE ESFAEGHSEA SLASALVEGE
360 370 380 390 400
IAEEAAEKAT SRGSNSGMDS NIDLTIVEDE EEESVALEQA QKVRYEGSYA
410 420
LTSEEAERSD GDPVQPAVLQ VHQTS
Length:425
Mass (Da):47,173
Last modified:January 23, 2007 - v3
Checksum:i0631CBF4BED537F9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034422130E → D. Corresponds to variant dbSNP:rs35012125Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085481 mRNA Translation: AAD17795.1
AC098872 Genomic DNA Translation: AAY24078.1
BC016475 mRNA Translation: AAH16475.1
CCDSiCCDS2313.1
RefSeqiNP_004648.1, NM_004657.5
UniGeneiHs.26530

Genome annotation databases

EnsembliENST00000304141; ENSP00000305675; ENSG00000168497
GeneIDi8436
KEGGihsa:8436
UCSCiuc002utb.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085481 mRNA Translation: AAD17795.1
AC098872 Genomic DNA Translation: AAY24078.1
BC016475 mRNA Translation: AAH16475.1
CCDSiCCDS2313.1
RefSeqiNP_004648.1, NM_004657.5
UniGeneiHs.26530

3D structure databases

ProteinModelPortaliO95810
SMRiO95810
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114016, 7 interactors
DIPiDIP-56943N
IntActiO95810, 16 interactors
MINTiO95810
STRINGi9606.ENSP00000305675

PTM databases

CarbonylDBiO95810
iPTMnetiO95810
PhosphoSitePlusiO95810
SwissPalmiO95810

Polymorphism and mutation databases

BioMutaiSDPR

2D gel databases

OGPiO95810

Proteomic databases

EPDiO95810
MaxQBiO95810
PaxDbiO95810
PeptideAtlasiO95810
PRIDEiO95810
ProteomicsDBi51062
TopDownProteomicsiO95810

Protocols and materials databases

DNASUi8436
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304141; ENSP00000305675; ENSG00000168497
GeneIDi8436
KEGGihsa:8436
UCSCiuc002utb.4 human

Organism-specific databases

CTDi8436
DisGeNETi8436
EuPathDBiHostDB:ENSG00000168497.4
GeneCardsiCAVIN2
HGNCiHGNC:10690 CAVIN2
HPAiHPA039325
HPA062122
MIMi606728 gene
neXtProtiNX_O95810
OpenTargetsiENSG00000168497
PharmGKBiPA35615
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEZA Eukaryota
ENOG410XP8W LUCA
GeneTreeiENSGT00530000063058
HOGENOMiHOG000293135
HOVERGENiHBG056807
InParanoidiO95810
OMAiERMDRQC
OrthoDBiEOG091G09Y1
PhylomeDBiO95810
TreeFamiTF331031

Miscellaneous databases

GeneWikiiSDPR
GenomeRNAii8436
PROiPR:O95810
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168497 Expressed in 204 organ(s), highest expression level in upper lobe of lung
CleanExiHS_SDPR
GenevisibleiO95810 HS

Family and domain databases

InterProiView protein in InterPro
IPR033298 Cavin2
IPR026752 Cavin_fam
PANTHERiPTHR15240 PTHR15240, 1 hit
PTHR15240:SF1 PTHR15240:SF1, 1 hit
PfamiView protein in Pfam
PF15237 PTRF_SDPR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCAVN2_HUMAN
AccessioniPrimary (citable) accession number: O95810
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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