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Protein

Transmembrane protein 50A

Gene

TMEM50A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • late endosome to vacuole transport via multivesicular body sorting pathway Source: GO_Central

Protein family/group databases

TCDBi9.B.199.1.1 the 4 tms pf05225 (pf0225) family

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 50A
Alternative name(s):
Small membrane protein 1
Gene namesi
Name:TMEM50A
Synonyms:SMP1
ORF Names:UNQ386/PRO718
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000183726.10
HGNCiHGNC:30590 TMEM50A
MIMi605348 gene
neXtProtiNX_O95807

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei26 – 46HelicalSequence analysisAdd BLAST21
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Transmembranei126 – 146HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000183726
PharmGKBiPA142670766

Polymorphism and mutation databases

BioMutaiTMEM50A

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001741812 – 157Transmembrane protein 50AAdd BLAST156

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei2PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO95807
PaxDbiO95807
PeptideAtlasiO95807
PRIDEiO95807
ProteomicsDBi51061

PTM databases

iPTMnetiO95807
PhosphoSitePlusiO95807
SwissPalmiO95807

Expressioni

Gene expression databases

BgeeiENSG00000183726 Expressed in 230 organ(s), highest expression level in saliva-secreting gland
CleanExiHS_TMEM50A
ExpressionAtlasiO95807 baseline and differential
GenevisibleiO95807 HS

Organism-specific databases

HPAiHPA065192

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LEPROTO152434EBI-12903814,EBI-15672507

Protein-protein interaction databases

BioGridi117120, 3 interactors
CORUMiO95807
IntActiO95807, 8 interactors
STRINGi9606.ENSP00000363478

Structurei

3D structure databases

ProteinModelPortaliO95807
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0220 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3393 Eukaryota
ENOG410YCSG LUCA
GeneTreeiENSGT00390000007434
HOVERGENiHBG000997
InParanoidiO95807
OMAiEDFNHSY
OrthoDBiEOG091G0QWW
PhylomeDBiO95807
TreeFamiTF300282

Family and domain databases

InterProiView protein in InterPro
IPR007919 UPF0220
PANTHERiPTHR13180 PTHR13180, 1 hit
PfamiView protein in Pfam
PF05255 UPF0220, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95807-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGFLEGLRC SECIDWGEKR NTIASIAAGV LFFTGWWIII DAAVIYPTMK
60 70 80 90 100
DFNHSYHACG VIATIAFLMI NAVSNGQVRG DSYSEGCLGQ TGARIWLFVG
110 120 130 140 150
FMLAFGSLIA SMWILFGGYV AKEKDIVYPG IAVFFQNAFI FFGGLVFKFG

RTEDLWQ
Length:157
Mass (Da):17,400
Last modified:May 1, 1999 - v1
Checksum:i8CDF83AA23EBB1FA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01312158A → V1 PublicationCorresponds to variant dbSNP:rs3093647Ensembl.1
Natural variantiVAR_007851141F → L. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081282 mRNA Translation: AAD17754.1
AL136627 mRNA Translation: CAB66562.1
AY358650 mRNA Translation: AAQ89013.1
AF458851 Genomic DNA Translation: AAL51108.1
BC007341 mRNA Translation: AAH07341.1
CCDSiCCDS264.1
RefSeqiNP_055128.1, NM_014313.3
XP_011539461.1, XM_011541159.1
UniGeneiHs.705699

Genome annotation databases

EnsembliENST00000374358; ENSP00000363478; ENSG00000183726
GeneIDi23585
KEGGihsa:23585

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081282 mRNA Translation: AAD17754.1
AL136627 mRNA Translation: CAB66562.1
AY358650 mRNA Translation: AAQ89013.1
AF458851 Genomic DNA Translation: AAL51108.1
BC007341 mRNA Translation: AAH07341.1
CCDSiCCDS264.1
RefSeqiNP_055128.1, NM_014313.3
XP_011539461.1, XM_011541159.1
UniGeneiHs.705699

3D structure databases

ProteinModelPortaliO95807
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117120, 3 interactors
CORUMiO95807
IntActiO95807, 8 interactors
STRINGi9606.ENSP00000363478

Protein family/group databases

TCDBi9.B.199.1.1 the 4 tms pf05225 (pf0225) family

PTM databases

iPTMnetiO95807
PhosphoSitePlusiO95807
SwissPalmiO95807

Polymorphism and mutation databases

BioMutaiTMEM50A

Proteomic databases

EPDiO95807
PaxDbiO95807
PeptideAtlasiO95807
PRIDEiO95807
ProteomicsDBi51061

Protocols and materials databases

DNASUi23585
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374358; ENSP00000363478; ENSG00000183726
GeneIDi23585
KEGGihsa:23585

Organism-specific databases

CTDi23585
EuPathDBiHostDB:ENSG00000183726.10
GeneCardsiTMEM50A
HGNCiHGNC:30590 TMEM50A
HPAiHPA065192
MIMi605348 gene
neXtProtiNX_O95807
OpenTargetsiENSG00000183726
PharmGKBiPA142670766
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3393 Eukaryota
ENOG410YCSG LUCA
GeneTreeiENSGT00390000007434
HOVERGENiHBG000997
InParanoidiO95807
OMAiEDFNHSY
OrthoDBiEOG091G0QWW
PhylomeDBiO95807
TreeFamiTF300282

Miscellaneous databases

ChiTaRSiTMEM50A human
GeneWikiiTMEM50A
GenomeRNAii23585
PROiPR:O95807
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183726 Expressed in 230 organ(s), highest expression level in saliva-secreting gland
CleanExiHS_TMEM50A
ExpressionAtlasiO95807 baseline and differential
GenevisibleiO95807 HS

Family and domain databases

InterProiView protein in InterPro
IPR007919 UPF0220
PANTHERiPTHR13180 PTHR13180, 1 hit
PfamiView protein in Pfam
PF05255 UPF0220, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTM50A_HUMAN
AccessioniPrimary (citable) accession number: O95807
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
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Main funding by: National Institutes of Health

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