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Protein

Probable G-protein coupled receptor 75

Gene

GPR75

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor.1 PublicationBy similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 75
Gene namesi
Name:GPR75
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000119737.5
HGNCiHGNC:4526 GPR75
MIMi606704 gene
neXtProtiNX_O95800

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 46ExtracellularSequence analysisAdd BLAST46
Transmembranei47 – 67Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini68 – 86CytoplasmicSequence analysisAdd BLAST19
Transmembranei87 – 107Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini108 – 120ExtracellularSequence analysisAdd BLAST13
Transmembranei121 – 141Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini142 – 160CytoplasmicSequence analysisAdd BLAST19
Transmembranei161 – 181Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini182 – 205ExtracellularSequence analysisAdd BLAST24
Transmembranei206 – 226Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini227 – 318CytoplasmicSequence analysisAdd BLAST92
Transmembranei319 – 339Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini340 – 350ExtracellularSequence analysisAdd BLAST11
Transmembranei351 – 371Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini372 – 540CytoplasmicSequence analysisAdd BLAST169

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10936
OpenTargetsiENSG00000119737
PharmGKBiPA28919

Chemistry databases

GuidetoPHARMACOLOGYi115

Polymorphism and mutation databases

BioMutaiGPR75

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695831 – 540Probable G-protein coupled receptor 75Add BLAST540

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi12N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi25N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO95800
PRIDEiO95800
ProteomicsDBi51057

PTM databases

iPTMnetiO95800
PhosphoSitePlusiO95800

Expressioni

Tissue specificityi

Expressed at high levels in brain and spinal cord and at detectable levels in retinal pigment epithelium. In situ hybridization of adult eye sections localized transcripts only to the perivascular cells, surrounding retinal arterioles, in the ganglion cell/nerve fiber layer. Also expressed by islet cells (at protein level).3 Publications

Gene expression databases

BgeeiENSG00000119737 Expressed in 96 organ(s), highest expression level in corpus callosum
GenevisibleiO95800 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000378195

Structurei

3D structure databases

ProteinModelPortaliO95800
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi61 – 121Phe-richAdd BLAST61

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJVJ Eukaryota
ENOG410ZQWK LUCA
GeneTreeiENSGT00390000007723
HOGENOMiHOG000059632
HOVERGENiHBG051818
InParanoidiO95800
KOiK08417
OMAiNKSSHHE
OrthoDBiEOG091G07SG
PhylomeDBiO95800
TreeFamiTF331523

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O95800-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSTGHLQDA PNATSLHVPH SQEGNSTSLQ EGLQDLIHTA TLVTCTFLLA
60 70 80 90 100
VIFCLGSYGN FIVFLSFFDP AFRKFRTNFD FMILNLSFCD LFICGVTAPM
110 120 130 140 150
FTFVLFFSSA SSIPDAFCFT FHLTSSGFII MSLKTVAVIA LHRLRMVLGK
160 170 180 190 200
QPNRTASFPC TVLLTLLLWA TSFTLATLAT LKTSKSHLCL PMSSLIAGKG
210 220 230 240 250
KAILSLYVVD FTFCVAVVSV SYIMIAQTLR KNAQVRKCPP VITVDASRPQ
260 270 280 290 300
PFMGVPVQGG GDPIQCAMPA LYRNQNYNKL QHVQTRGYTK SPNQLVTPAA
310 320 330 340 350
SRLQLVSAIN LSTAKDSKAV VTCVIIVLSV LVCCLPLGIS LVQVVLSSNG
360 370 380 390 400
SFILYQFELF GFTLIFFKSG LNPFIYSRNS AGLRRKVLWC LQYIGLGFFC
410 420 430 440 450
CKQKTRLRAM GKGNLEVNRN KSSHHETNSA YMLSPKPQKK FVDQACGPSH
460 470 480 490 500
SKESMVSPKI SAGHQHCGQS SSTPINTRIE PYYSIYNSSP SQEESSPCNL
510 520 530 540
QPVNSFGFAN SYIAMHYHTT NDLVQEYDST SAKQIPVPSV
Length:540
Mass (Da):59,359
Last modified:May 1, 1999 - v1
Checksum:iB5BE87BB384190EE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti175L → P in AAH67475 (PubMed:15489334).Curated1
Sequence conflicti278N → D in AAH67475 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07125878N → K Found in a patient with age-related macular degeneration; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs72799238Ensembl.1
Natural variantiVAR_07125999P → L Found in a patient with age-related macular degeneration; unknown pathological significance. 1 Publication1
Natural variantiVAR_071260108S → T Found in a patient with age-related macular degeneration; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs763005023Ensembl.1
Natural variantiVAR_033471116A → T1 PublicationCorresponds to variant dbSNP:rs34000641Ensembl.1
Natural variantiVAR_071261135T → P Found in a patient with age-related macular degeneration; unknown pathological significance. 1 Publication1
Natural variantiVAR_033472160C → G. Corresponds to variant dbSNP:rs35349235Ensembl.1
Natural variantiVAR_033473433L → V. Corresponds to variant dbSNP:rs3731969Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072693 mRNA Translation: AAD19849.1
AF101472 Genomic DNA Translation: AAD22770.1
AK314885 mRNA Translation: BAG37399.1
AC008068 Genomic DNA Translation: AAY15018.1
CH471053 Genomic DNA Translation: EAX00162.1
BC067475 mRNA Translation: AAH67475.1
BC067476 mRNA Translation: AAH67476.1
CCDSiCCDS1849.1
RefSeqiNP_006785.1, NM_006794.3
UniGeneiHs.40763

Genome annotation databases

EnsembliENST00000394705; ENSP00000378195; ENSG00000119737
GeneIDi10936
KEGGihsa:10936
UCSCiuc002rxo.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072693 mRNA Translation: AAD19849.1
AF101472 Genomic DNA Translation: AAD22770.1
AK314885 mRNA Translation: BAG37399.1
AC008068 Genomic DNA Translation: AAY15018.1
CH471053 Genomic DNA Translation: EAX00162.1
BC067475 mRNA Translation: AAH67475.1
BC067476 mRNA Translation: AAH67476.1
CCDSiCCDS1849.1
RefSeqiNP_006785.1, NM_006794.3
UniGeneiHs.40763

3D structure databases

ProteinModelPortaliO95800
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000378195

Chemistry databases

GuidetoPHARMACOLOGYi115

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO95800
PhosphoSitePlusiO95800

Polymorphism and mutation databases

BioMutaiGPR75

Proteomic databases

PaxDbiO95800
PRIDEiO95800
ProteomicsDBi51057

Protocols and materials databases

DNASUi10936
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394705; ENSP00000378195; ENSG00000119737
GeneIDi10936
KEGGihsa:10936
UCSCiuc002rxo.4 human

Organism-specific databases

CTDi10936
DisGeNETi10936
EuPathDBiHostDB:ENSG00000119737.5
GeneCardsiGPR75
HGNCiHGNC:4526 GPR75
MIMi606704 gene
neXtProtiNX_O95800
OpenTargetsiENSG00000119737
PharmGKBiPA28919
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJVJ Eukaryota
ENOG410ZQWK LUCA
GeneTreeiENSGT00390000007723
HOGENOMiHOG000059632
HOVERGENiHBG051818
InParanoidiO95800
KOiK08417
OMAiNKSSHHE
OrthoDBiEOG091G07SG
PhylomeDBiO95800
TreeFamiTF331523

Miscellaneous databases

GeneWikiiGPR75
GenomeRNAii10936
PROiPR:O95800
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000119737 Expressed in 96 organ(s), highest expression level in corpus callosum
GenevisibleiO95800 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPR75_HUMAN
AccessioniPrimary (citable) accession number: O95800
Secondary accession number(s): B2RC02, Q6NWR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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