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Protein

Double-stranded RNA-binding protein Staufen homolog 1

Gene

STAU1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.

GO - Molecular functioni

  • double-stranded RNA binding Source: ProtInc
  • protein phosphatase 1 binding Source: Ensembl
  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Double-stranded RNA-binding protein Staufen homolog 1
Gene namesi
Name:STAU1
Synonyms:STAU
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000124214.19
HGNCiHGNC:11370 STAU1
MIMi601716 gene
neXtProtiNX_O95793

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

DisGeNETi6780
OpenTargetsiENSG00000124214
PharmGKBiPA36188

Polymorphism and mutation databases

BioMutaiSTAU1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000722432 – 577Double-stranded RNA-binding protein Staufen homolog 1Add BLAST576

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei108Asymmetric dimethylarginineCombined sources1
Modified residuei115Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei115Omega-N-methylarginine; alternateCombined sources1
Modified residuei176PhosphoserineCombined sources1
Modified residuei278PhosphoserineCombined sources1
Modified residuei390PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiO95793
MaxQBiO95793
PaxDbiO95793
PeptideAtlasiO95793
PRIDEiO95793
ProteomicsDBi51054
51055 [O95793-2]
51056 [O95793-3]

PTM databases

iPTMnetiO95793
PhosphoSitePlusiO95793

Expressioni

Tissue specificityi

Widely expressed. Expressed in brain, pancreas, heart, skeletal muscles, liver, lung, kidney and placenta.

Gene expression databases

BgeeiENSG00000124214 Expressed in 240 organ(s), highest expression level in oviduct epithelium
CleanExiHS_STAU1
ExpressionAtlasiO95793 baseline and differential
GenevisibleiO95793 HS

Organism-specific databases

HPAiCAB020839
HPA049892

Interactioni

Subunit structurei

Binds tubulin. Binds with low affinity single-stranded RNA or DNA homopolymers. Interacts with CASC3 in an RNA-dependent manner (By similarity). Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Interacts with the influenza virus nonstructural protein NS1.By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112657, 374 interactors
CORUMiO95793
IntActiO95793, 98 interactors
MINTiO95793
STRINGi9606.ENSP00000360922

Structurei

Secondary structure

1577
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO95793
SMRiO95793
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 162DRBM 1PROSITE-ProRule annotationAdd BLAST91
Domaini184 – 251DRBM 2PROSITE-ProRule annotationAdd BLAST68
Domaini286 – 354DRBM 3PROSITE-ProRule annotationAdd BLAST69

Domaini

One of the DRDB could be involved in RER binding.
The C-terminal contains the tubulin binding domain (TBD).By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3732 Eukaryota
ENOG410XSCK LUCA
GeneTreeiENSGT00900000140998
HOGENOMiHOG000231025
HOVERGENiHBG005013
InParanoidiO95793
KOiK17597
OMAiTPIKKPG
OrthoDBiEOG091G07A0
PhylomeDBiO95793
TreeFamiTF350296

Family and domain databases

CDDicd00048 DSRM, 2 hits
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR032478 Staufen_C
PfamiView protein in Pfam
PF00035 dsrm, 3 hits
PF16482 Staufen_C, 1 hit
SMARTiView protein in SMART
SM00358 DSRM, 3 hits
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 3 hits

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform Long (identifier: O95793-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSQVQVQVQN PSAALSGSQI LNKNQSLLSQ PLMSIPSTTS SLPSENAGRP
60 70 80 90 100
IQNSALPSAS ITSTSAAAES ITPTVELNAL CMKLGKKPMY KPVDPYSRMQ
110 120 130 140 150
STYNYNMRGG AYPPRYFYPF PVPPLLYQVE LSVGGQQFNG KGKTRQAAKH
160 170 180 190 200
DAAAKALRIL QNEPLPERLE VNGRESEEEN LNKSEISQVF EIALKRNLPV
210 220 230 240 250
NFEVARESGP PHMKNFVTKV SVGEFVGEGE GKSKKISKKN AAIAVLEELK
260 270 280 290 300
KLPPLPAVER VKPRIKKKTK PIVKPQTSPE YGQGINPISR LAQIQQAKKE
310 320 330 340 350
KEPEYTLLTE RGLPRRREFV MQVKVGNHTA EGTGTNKKVA KRNAAENMLE
360 370 380 390 400
ILGFKVPQAQ PTKPALKSEE KTPIKKPGDG RKVTFFEPGS GDENGTSNKE
410 420 430 440 450
DEFRMPYLSH QQLPAGILPM VPEVAQAVGV SQGHHTKDFT RAAPNPAKAT
460 470 480 490 500
VTAMIARELL YGGTSPTAET ILKNNISSGH VPHGPLTRPS EQLDYLSRVQ
510 520 530 540 550
GFQVEYKDFP KNNKNEFVSL INCSSQPPLI SHGIGKDVES CHDMAALNIL
560 570
KLLSELDQQS TEMPRTGNGP MSVCGRC
Length:577
Mass (Da):63,182
Last modified:March 7, 2006 - v2
Checksum:i0977CEF40FD99517
GO
Isoform Short (identifier: O95793-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: Missing.

Show »
Length:496
Mass (Da):54,934
Checksum:i509B6CF2B928C02C
GO
Isoform 3 (identifier: O95793-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: Missing.
     203-203: E → ESFPLKQ

Show »
Length:502
Mass (Da):55,635
Checksum:i3AA2A672D9D87081
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JW30Q5JW30_HUMAN
Double-stranded RNA-binding protein...
STAU1
494Annotation score:
A0A087X1A5A0A087X1A5_HUMAN
Double-stranded RNA-binding protein...
STAU1
493Annotation score:
Q5JW28Q5JW28_HUMAN
Double-stranded RNA-binding protein...
STAU1
199Annotation score:
F6UDC6F6UDC6_HUMAN
Double-stranded RNA-binding protein...
STAU1
129Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti359A → R (PubMed:10022909).Curated1
Sequence conflicti359A → R (PubMed:10325410).Curated1
Sequence conflicti360 – 392QPTKP…PGSGD → SHQTRTQVRGEDTHKETRGW KKSNLFLNLALGM (PubMed:10325410).CuratedAdd BLAST33

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0044341 – 81Missing in isoform Short and isoform 3. 5 PublicationsAdd BLAST81
Alternative sequenceiVSP_043701203E → ESFPLKQ in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061939 mRNA Translation: AAD17531.1
AF061941 mRNA Translation: AAD17533.1
AF061938 mRNA Translation: AAD17530.1
AF061940 mRNA Translation: AAD17532.1
AJ132258 mRNA Translation: CAB40082.1
AY529074 mRNA Translation: AAS76636.1
AY546099 mRNA Translation: AAS76637.1
AL136601 mRNA Translation: CAB66536.1
AK292859 mRNA Translation: BAF85548.1
AL133174 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75669.1
CH471077 Genomic DNA Translation: EAW75671.1
CH471077 Genomic DNA Translation: EAW75672.1
CH471077 Genomic DNA Translation: EAW75673.1
CH471077 Genomic DNA Translation: EAW75674.1
BC050432 mRNA Translation: AAH50432.1
BC095397 mRNA Translation: AAH95397.1
CCDSiCCDS13414.1 [O95793-1]
CCDS13415.1 [O95793-2]
CCDS33481.1 [O95793-3]
RefSeqiNP_001032405.1, NM_001037328.2 [O95793-3]
NP_001306063.1, NM_001319134.1 [O95793-3]
NP_001306064.1, NM_001319135.1 [O95793-1]
NP_001309856.1, NM_001322927.1 [O95793-3]
NP_001309858.1, NM_001322929.1 [O95793-1]
NP_001309859.1, NM_001322930.1 [O95793-1]
NP_004593.2, NM_004602.3 [O95793-2]
NP_059346.2, NM_017452.3 [O95793-2]
NP_059347.2, NM_017453.3 [O95793-1]
NP_059348.2, NM_017454.3 [O95793-2]
XP_005260584.1, XM_005260527.1 [O95793-3]
UniGeneiHs.596704

Genome annotation databases

EnsembliENST00000340954; ENSP00000345425; ENSG00000124214 [O95793-2]
ENST00000347458; ENSP00000323443; ENSG00000124214 [O95793-2]
ENST00000360426; ENSP00000353604; ENSG00000124214 [O95793-2]
ENST00000371802; ENSP00000360867; ENSG00000124214 [O95793-3]
ENST00000371828; ENSP00000360893; ENSG00000124214 [O95793-3]
ENST00000371856; ENSP00000360922; ENSG00000124214 [O95793-1]
GeneIDi6780
KEGGihsa:6780
UCSCiuc002xua.4 human [O95793-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061939 mRNA Translation: AAD17531.1
AF061941 mRNA Translation: AAD17533.1
AF061938 mRNA Translation: AAD17530.1
AF061940 mRNA Translation: AAD17532.1
AJ132258 mRNA Translation: CAB40082.1
AY529074 mRNA Translation: AAS76636.1
AY546099 mRNA Translation: AAS76637.1
AL136601 mRNA Translation: CAB66536.1
AK292859 mRNA Translation: BAF85548.1
AL133174 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75669.1
CH471077 Genomic DNA Translation: EAW75671.1
CH471077 Genomic DNA Translation: EAW75672.1
CH471077 Genomic DNA Translation: EAW75673.1
CH471077 Genomic DNA Translation: EAW75674.1
BC050432 mRNA Translation: AAH50432.1
BC095397 mRNA Translation: AAH95397.1
CCDSiCCDS13414.1 [O95793-1]
CCDS13415.1 [O95793-2]
CCDS33481.1 [O95793-3]
RefSeqiNP_001032405.1, NM_001037328.2 [O95793-3]
NP_001306063.1, NM_001319134.1 [O95793-3]
NP_001306064.1, NM_001319135.1 [O95793-1]
NP_001309856.1, NM_001322927.1 [O95793-3]
NP_001309858.1, NM_001322929.1 [O95793-1]
NP_001309859.1, NM_001322930.1 [O95793-1]
NP_004593.2, NM_004602.3 [O95793-2]
NP_059346.2, NM_017452.3 [O95793-2]
NP_059347.2, NM_017453.3 [O95793-1]
NP_059348.2, NM_017454.3 [O95793-2]
XP_005260584.1, XM_005260527.1 [O95793-3]
UniGeneiHs.596704

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DKKX-ray1.70A448-557[»]
ProteinModelPortaliO95793
SMRiO95793
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112657, 374 interactors
CORUMiO95793
IntActiO95793, 98 interactors
MINTiO95793
STRINGi9606.ENSP00000360922

PTM databases

iPTMnetiO95793
PhosphoSitePlusiO95793

Polymorphism and mutation databases

BioMutaiSTAU1

Proteomic databases

EPDiO95793
MaxQBiO95793
PaxDbiO95793
PeptideAtlasiO95793
PRIDEiO95793
ProteomicsDBi51054
51055 [O95793-2]
51056 [O95793-3]

Protocols and materials databases

DNASUi6780
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340954; ENSP00000345425; ENSG00000124214 [O95793-2]
ENST00000347458; ENSP00000323443; ENSG00000124214 [O95793-2]
ENST00000360426; ENSP00000353604; ENSG00000124214 [O95793-2]
ENST00000371802; ENSP00000360867; ENSG00000124214 [O95793-3]
ENST00000371828; ENSP00000360893; ENSG00000124214 [O95793-3]
ENST00000371856; ENSP00000360922; ENSG00000124214 [O95793-1]
GeneIDi6780
KEGGihsa:6780
UCSCiuc002xua.4 human [O95793-1]

Organism-specific databases

CTDi6780
DisGeNETi6780
EuPathDBiHostDB:ENSG00000124214.19
GeneCardsiSTAU1
HGNCiHGNC:11370 STAU1
HPAiCAB020839
HPA049892
MIMi601716 gene
neXtProtiNX_O95793
OpenTargetsiENSG00000124214
PharmGKBiPA36188
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3732 Eukaryota
ENOG410XSCK LUCA
GeneTreeiENSGT00900000140998
HOGENOMiHOG000231025
HOVERGENiHBG005013
InParanoidiO95793
KOiK17597
OMAiTPIKKPG
OrthoDBiEOG091G07A0
PhylomeDBiO95793
TreeFamiTF350296

Miscellaneous databases

ChiTaRSiSTAU1 human
GeneWikiiSTAU1
GenomeRNAii6780
PROiPR:O95793
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124214 Expressed in 240 organ(s), highest expression level in oviduct epithelium
CleanExiHS_STAU1
ExpressionAtlasiO95793 baseline and differential
GenevisibleiO95793 HS

Family and domain databases

CDDicd00048 DSRM, 2 hits
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR032478 Staufen_C
PfamiView protein in Pfam
PF00035 dsrm, 3 hits
PF16482 Staufen_C, 1 hit
SMARTiView protein in SMART
SM00358 DSRM, 3 hits
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSTAU1_HUMAN
AccessioniPrimary (citable) accession number: O95793
Secondary accession number(s): A8K9Z4
, E1P5Y1, E1P608, Q5JW29, Q6GTM4, Q9H5B4, Q9H5B5, Q9Y3Q2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: March 7, 2006
Last modified: October 10, 2018
This is version 186 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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