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Protein

Double-stranded RNA-binding protein Staufen homolog 1

Gene

STAU1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.
(Microbial infection) Plays a role in virus particles production of many viruses including of HIV-1, HERV-K, ebola virus and influenza virus. Acts by interacting with various viral proteins involved in particle budding process.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • double-stranded RNA binding Source: ProtInc
  • protein phosphatase 1 binding Source: Ensembl
  • RNA binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processHost-virus interaction

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Double-stranded RNA-binding protein Staufen homolog 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STAU1
Synonyms:STAU
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000124214.19

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11370 STAU1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601716 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95793

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6780

Open Targets

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OpenTargetsi
ENSG00000124214

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36188

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
STAU1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000722432 – 577Double-stranded RNA-binding protein Staufen homolog 1Add BLAST576

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei108Asymmetric dimethylarginineCombined sources1
Modified residuei115Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei115Omega-N-methylarginine; alternateCombined sources1
Modified residuei176PhosphoserineCombined sources1
Modified residuei278PhosphoserineCombined sources1
Modified residuei390PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O95793

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O95793

MaxQB - The MaxQuant DataBase

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MaxQBi
O95793

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O95793

PeptideAtlas

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PeptideAtlasi
O95793

PRoteomics IDEntifications database

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PRIDEi
O95793

ProteomicsDB human proteome resource

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ProteomicsDBi
51054
51055 [O95793-2]
51056 [O95793-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O95793

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O95793

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expressed in brain, pancreas, heart, skeletal muscles, liver, lung, kidney and placenta.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000124214 Expressed in 240 organ(s), highest expression level in oviduct epithelium

CleanEx database of gene expression profiles

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CleanExi
HS_STAU1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O95793 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O95793 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB020839
HPA049892

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds tubulin. Binds with low affinity single-stranded RNA or DNA homopolymers. Interacts with CASC3 in an RNA-dependent manner (By similarity). Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1.By similarity1 Publication
(Microbial infection) Interacts with HERV-K rec and gag proteins.1 Publication
(Microbial infection) Interacts with HIV-1 GAG polyprotein.1 Publication
(Microbial infection) Interacts with influenza virus NS1 protein.1 Publication
(Microbial infection) Interacts with Ebola virus NP, VP30 and VP35.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112657, 381 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
O95793

Protein interaction database and analysis system

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IntActi
O95793, 99 interactors

Molecular INTeraction database

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MINTi
O95793

STRING: functional protein association networks

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STRINGi
9606.ENSP00000360922

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1577
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DKKX-ray1.70A448-557[»]
6HTUX-ray2.89A/B/C182-360[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O95793

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O95793

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini72 – 162DRBM 1PROSITE-ProRule annotationAdd BLAST91
Domaini184 – 251DRBM 2PROSITE-ProRule annotationAdd BLAST68
Domaini286 – 354DRBM 3PROSITE-ProRule annotationAdd BLAST69

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

One of the DRDB could be involved in RER binding.
The C-terminal contains the tubulin binding domain (TBD).By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3732 Eukaryota
ENOG410XSCK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157304

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231025

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG005013

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O95793

KEGG Orthology (KO)

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KOi
K17597

Identification of Orthologs from Complete Genome Data

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OMAi
QGIQVEY

Database of Orthologous Groups

More...
OrthoDBi
823092at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O95793

TreeFam database of animal gene trees

More...
TreeFami
TF350296

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00048 DSRM, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR014720 dsRBD_dom
IPR032478 Staufen_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00035 dsrm, 3 hits
PF16482 Staufen_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00358 DSRM, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50137 DS_RBD, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform Long (identifier: O95793-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSQVQVQVQN PSAALSGSQI LNKNQSLLSQ PLMSIPSTTS SLPSENAGRP
60 70 80 90 100
IQNSALPSAS ITSTSAAAES ITPTVELNAL CMKLGKKPMY KPVDPYSRMQ
110 120 130 140 150
STYNYNMRGG AYPPRYFYPF PVPPLLYQVE LSVGGQQFNG KGKTRQAAKH
160 170 180 190 200
DAAAKALRIL QNEPLPERLE VNGRESEEEN LNKSEISQVF EIALKRNLPV
210 220 230 240 250
NFEVARESGP PHMKNFVTKV SVGEFVGEGE GKSKKISKKN AAIAVLEELK
260 270 280 290 300
KLPPLPAVER VKPRIKKKTK PIVKPQTSPE YGQGINPISR LAQIQQAKKE
310 320 330 340 350
KEPEYTLLTE RGLPRRREFV MQVKVGNHTA EGTGTNKKVA KRNAAENMLE
360 370 380 390 400
ILGFKVPQAQ PTKPALKSEE KTPIKKPGDG RKVTFFEPGS GDENGTSNKE
410 420 430 440 450
DEFRMPYLSH QQLPAGILPM VPEVAQAVGV SQGHHTKDFT RAAPNPAKAT
460 470 480 490 500
VTAMIARELL YGGTSPTAET ILKNNISSGH VPHGPLTRPS EQLDYLSRVQ
510 520 530 540 550
GFQVEYKDFP KNNKNEFVSL INCSSQPPLI SHGIGKDVES CHDMAALNIL
560 570
KLLSELDQQS TEMPRTGNGP MSVCGRC
Length:577
Mass (Da):63,182
Last modified:March 7, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0977CEF40FD99517
GO
Isoform Short (identifier: O95793-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: Missing.

Show »
Length:496
Mass (Da):54,934
Checksum:i509B6CF2B928C02C
GO
Isoform 3 (identifier: O95793-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: Missing.
     203-203: E → ESFPLKQ

Show »
Length:502
Mass (Da):55,635
Checksum:i3AA2A672D9D87081
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JW30Q5JW30_HUMAN
Double-stranded RNA-binding protein...
STAU1
494Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X1A5A0A087X1A5_HUMAN
Double-stranded RNA-binding protein...
STAU1
493Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JW28Q5JW28_HUMAN
Double-stranded RNA-binding protein...
STAU1
199Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6UDC6F6UDC6_HUMAN
Double-stranded RNA-binding protein...
STAU1
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti359A → R (PubMed:10022909).Curated1
Sequence conflicti359A → R (PubMed:10325410).Curated1
Sequence conflicti360 – 392QPTKP…PGSGD → SHQTRTQVRGEDTHKETRGW KKSNLFLNLALGM (PubMed:10325410).CuratedAdd BLAST33

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0044341 – 81Missing in isoform Short and isoform 3. 5 PublicationsAdd BLAST81
Alternative sequenceiVSP_043701203E → ESFPLKQ in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF061939 mRNA Translation: AAD17531.1
AF061941 mRNA Translation: AAD17533.1
AF061938 mRNA Translation: AAD17530.1
AF061940 mRNA Translation: AAD17532.1
AJ132258 mRNA Translation: CAB40082.1
AY529074 mRNA Translation: AAS76636.1
AY546099 mRNA Translation: AAS76637.1
AL136601 mRNA Translation: CAB66536.1
AK292859 mRNA Translation: BAF85548.1
AL133174 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75669.1
CH471077 Genomic DNA Translation: EAW75671.1
CH471077 Genomic DNA Translation: EAW75672.1
CH471077 Genomic DNA Translation: EAW75673.1
CH471077 Genomic DNA Translation: EAW75674.1
BC050432 mRNA Translation: AAH50432.1
BC095397 mRNA Translation: AAH95397.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13414.1 [O95793-1]
CCDS13415.1 [O95793-2]
CCDS33481.1 [O95793-3]

NCBI Reference Sequences

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RefSeqi
NP_001032405.1, NM_001037328.2 [O95793-3]
NP_001306063.1, NM_001319134.1 [O95793-3]
NP_001306064.1, NM_001319135.1 [O95793-1]
NP_001309856.1, NM_001322927.1 [O95793-3]
NP_001309858.1, NM_001322929.1 [O95793-1]
NP_001309859.1, NM_001322930.1 [O95793-1]
NP_004593.2, NM_004602.3 [O95793-2]
NP_059346.2, NM_017452.3 [O95793-2]
NP_059347.2, NM_017453.3 [O95793-1]
NP_059348.2, NM_017454.3 [O95793-2]
XP_005260584.1, XM_005260527.1 [O95793-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.596704

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000340954; ENSP00000345425; ENSG00000124214 [O95793-2]
ENST00000347458; ENSP00000323443; ENSG00000124214 [O95793-2]
ENST00000360426; ENSP00000353604; ENSG00000124214 [O95793-2]
ENST00000371802; ENSP00000360867; ENSG00000124214 [O95793-3]
ENST00000371828; ENSP00000360893; ENSG00000124214 [O95793-3]
ENST00000371856; ENSP00000360922; ENSG00000124214 [O95793-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6780

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6780

UCSC genome browser

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UCSCi
uc002xua.4 human [O95793-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061939 mRNA Translation: AAD17531.1
AF061941 mRNA Translation: AAD17533.1
AF061938 mRNA Translation: AAD17530.1
AF061940 mRNA Translation: AAD17532.1
AJ132258 mRNA Translation: CAB40082.1
AY529074 mRNA Translation: AAS76636.1
AY546099 mRNA Translation: AAS76637.1
AL136601 mRNA Translation: CAB66536.1
AK292859 mRNA Translation: BAF85548.1
AL133174 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75669.1
CH471077 Genomic DNA Translation: EAW75671.1
CH471077 Genomic DNA Translation: EAW75672.1
CH471077 Genomic DNA Translation: EAW75673.1
CH471077 Genomic DNA Translation: EAW75674.1
BC050432 mRNA Translation: AAH50432.1
BC095397 mRNA Translation: AAH95397.1
CCDSiCCDS13414.1 [O95793-1]
CCDS13415.1 [O95793-2]
CCDS33481.1 [O95793-3]
RefSeqiNP_001032405.1, NM_001037328.2 [O95793-3]
NP_001306063.1, NM_001319134.1 [O95793-3]
NP_001306064.1, NM_001319135.1 [O95793-1]
NP_001309856.1, NM_001322927.1 [O95793-3]
NP_001309858.1, NM_001322929.1 [O95793-1]
NP_001309859.1, NM_001322930.1 [O95793-1]
NP_004593.2, NM_004602.3 [O95793-2]
NP_059346.2, NM_017452.3 [O95793-2]
NP_059347.2, NM_017453.3 [O95793-1]
NP_059348.2, NM_017454.3 [O95793-2]
XP_005260584.1, XM_005260527.1 [O95793-3]
UniGeneiHs.596704

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DKKX-ray1.70A448-557[»]
6HTUX-ray2.89A/B/C182-360[»]
ProteinModelPortaliO95793
SMRiO95793
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112657, 381 interactors
CORUMiO95793
IntActiO95793, 99 interactors
MINTiO95793
STRINGi9606.ENSP00000360922

PTM databases

iPTMnetiO95793
PhosphoSitePlusiO95793

Polymorphism and mutation databases

BioMutaiSTAU1

Proteomic databases

EPDiO95793
jPOSTiO95793
MaxQBiO95793
PaxDbiO95793
PeptideAtlasiO95793
PRIDEiO95793
ProteomicsDBi51054
51055 [O95793-2]
51056 [O95793-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
6780
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340954; ENSP00000345425; ENSG00000124214 [O95793-2]
ENST00000347458; ENSP00000323443; ENSG00000124214 [O95793-2]
ENST00000360426; ENSP00000353604; ENSG00000124214 [O95793-2]
ENST00000371802; ENSP00000360867; ENSG00000124214 [O95793-3]
ENST00000371828; ENSP00000360893; ENSG00000124214 [O95793-3]
ENST00000371856; ENSP00000360922; ENSG00000124214 [O95793-1]
GeneIDi6780
KEGGihsa:6780
UCSCiuc002xua.4 human [O95793-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6780
DisGeNETi6780
EuPathDBiHostDB:ENSG00000124214.19

GeneCards: human genes, protein and diseases

More...
GeneCardsi
STAU1
HGNCiHGNC:11370 STAU1
HPAiCAB020839
HPA049892
MIMi601716 gene
neXtProtiNX_O95793
OpenTargetsiENSG00000124214
PharmGKBiPA36188

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3732 Eukaryota
ENOG410XSCK LUCA
GeneTreeiENSGT00940000157304
HOGENOMiHOG000231025
HOVERGENiHBG005013
InParanoidiO95793
KOiK17597
OMAiQGIQVEY
OrthoDBi823092at2759
PhylomeDBiO95793
TreeFamiTF350296

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
STAU1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
STAU1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6780

Protein Ontology

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PROi
PR:O95793

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000124214 Expressed in 240 organ(s), highest expression level in oviduct epithelium
CleanExiHS_STAU1
ExpressionAtlasiO95793 baseline and differential
GenevisibleiO95793 HS

Family and domain databases

CDDicd00048 DSRM, 2 hits
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR032478 Staufen_C
PfamiView protein in Pfam
PF00035 dsrm, 3 hits
PF16482 Staufen_C, 1 hit
SMARTiView protein in SMART
SM00358 DSRM, 3 hits
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTAU1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95793
Secondary accession number(s): A8K9Z4
, E1P5Y1, E1P608, Q5JW29, Q6GTM4, Q9H5B4, Q9H5B5, Q9Y3Q2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: March 7, 2006
Last modified: January 16, 2019
This is version 189 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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