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Entry version 146 (08 May 2019)
Sequence version 2 (01 May 2007)
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Protein

Protein Wiz

Gene

WIZ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri267 – 289C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri304 – 326C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri353 – 375C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri416 – 439C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri701 – 723C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri769 – 791C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri870 – 892C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1043 – 1065C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1227 – 1249C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1397 – 1419C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1596 – 1622C2H2-type 11PROSITE-ProRule annotationAdd BLAST27

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein Wiz
Alternative name(s):
Widely-interspaced zinc finger-containing protein
Zinc finger protein 803
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WIZ
Synonyms:ZNF803
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30917 WIZ

neXtProt; the human protein knowledge platform

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neXtProti
NX_O95785

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000011451

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162409232

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
WIZ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002860541 – 1651Protein WizAdd BLAST1651

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki883Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki939Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki955Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki967Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki988Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei996PhosphoserineCombined sources1
Modified residuei998PhosphothreonineCombined sources1
Cross-linki1000Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1005Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1006PhosphoserineCombined sources1
Modified residuei1012PhosphoserineCombined sources1
Modified residuei1017PhosphoserineCombined sources1
Modified residuei1025PhosphoserineCombined sources1
Cross-linki1056Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1079PhosphoserineCombined sources1
Modified residuei1106PhosphoserineCombined sources1
Cross-linki1108Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1112Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1122PhosphoserineCombined sources1
Modified residuei1127PhosphoserineCombined sources1
Modified residuei1134PhosphoserineCombined sources1
Cross-linki1138Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1139Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1146PhosphoserineCombined sources1
Modified residuei1151PhosphoserineCombined sources1
Modified residuei1162N6,N6,N6-trimethyllysine; by EHMT2; alternate1 Publication1
Modified residuei1162N6,N6-dimethyllysine; by EHMT2; alternate1 Publication1
Cross-linki1177Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1240Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1263PhosphoserineCombined sources1
Cross-linki1282Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1309PhosphoserineCombined sources1
Modified residuei1314PhosphoserineCombined sources1
Cross-linki1343Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1356Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1370Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1372Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1382Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1448Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1464Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1477Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1480PhosphoserineCombined sources1
Modified residuei1517PhosphoserineCombined sources1
Cross-linki1523Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki1523Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki1534Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1560Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1630Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 3 (identifier: O95785-3)
Cross-linki11Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki29Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki39Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki258Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki313Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 4 (identifier: O95785-4)
Cross-linki14Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki32Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki42Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O95785

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O95785

MaxQB - The MaxQuant DataBase

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MaxQBi
O95785

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O95785

PeptideAtlas

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PeptideAtlasi
O95785

PRoteomics IDEntifications database

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PRIDEi
O95785

ProteomicsDB human proteome resource

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ProteomicsDBi
51045
51046 [O95785-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O95785

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O95785

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000011451 Expressed in 207 organ(s), highest expression level in right testis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O95785 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O95785 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA022923
HPA023774

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with EHMT1, EHMT2, CTBP1 and CTBP2 (By similarity). Part of a complex containing at least CDYL, REST, WIZ, SETB1, EHMT1 and EHMT2.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
121845, 73 interactors

Protein interaction database and analysis system

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IntActi
O95785, 51 interactors

Molecular INTeraction database

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MINTi
O95785

STRING: functional protein association networks

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STRINGi
9606.ENSP00000263381

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1030 – 1034Interaction with CTBP1 and CTBP2 1By similarity5
Regioni1214 – 1218Interaction with CTBP1 and CTBP2 2By similarity5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi567 – 576Poly-Glu10
Compositional biasi624 – 629Poly-Gln6
Compositional biasi753 – 757Poly-Lys5
Compositional biasi1096 – 1178Pro-richAdd BLAST83

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C2H2-type zinc finger 11 mediates interaction with EHMT1 and EHMT2.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri267 – 289C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri304 – 326C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri353 – 375C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri416 – 439C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri701 – 723C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri769 – 791C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri870 – 892C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1043 – 1065C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1227 – 1249C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1397 – 1419C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1596 – 1622C2H2-type 11PROSITE-ProRule annotationAdd BLAST27

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

Ensembl GeneTree

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GeneTreei
ENSGT00940000159979

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000065754

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O95785

Database of Orthologous Groups

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OrthoDBi
434804at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O95785

TreeFam database of animal gene trees

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TreeFami
TF333705

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 11 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57667 SSF57667, 3 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95785-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGSLAGSLA APDRPQGPER LPGPAPRENI EGGAEAAEGE GGIFRSTRYL
60 70 80 90 100
PVTKEGPRDI LDGRGGISGT PDGRGPWEHP LVQEAGEGIL SERRFEDSVI
110 120 130 140 150
VRTMKPHAEL EGSRRFLHHR GEPRLLEKHA QGRPRFDWLQ DEDEQGSPQD
160 170 180 190 200
AGLHLDLPAQ PPPLAPFRRV FVPVEDTPKT LDMAVVGGRE DLEDLEGLAQ
210 220 230 240 250
PSEWGLPTSA SEVATQTWTV NSEASVERLQ PLLPPIRTGP YLCELLEEVA
260 270 280 290 300
EGVASPDEDE DEEPAVFPCI ECSIYFKQKE HLLEHMSQHR RAPGQEPPAD
310 320 330 340 350
LAPLACGECG WAFADPTALE QHRQLHQASR EKIIEEIQKL KQVPGDEGRE
360 370 380 390 400
ARLQCPKCVF GTNSSRAYVQ HAKLHMREPP GQTTKEPFGG SSGAGSPSPE
410 420 430 440 450
ASALLYQPYG AAVGLSACVF CGFPAPSESL LREHVRLVHA HPHWEEDGEA
460 470 480 490 500
YEEDPASQPG TSQDAHACFP DTAVDYFGKA EPSLAPMWRE NPAGYDPSLA
510 520 530 540 550
FGPGCQQLSI RDFPLSKPLL HGTGQRPLGR LAFPSTLAST PYSLQLGRNK
560 570 580 590 600
STVHPQGLGE RRRPWSEEEE EEEEEEDVVL TSEMDFSPEN GVFSPLATPS
610 620 630 640 650
LIPQAALELK QAFREALQAV EATQGQQQQL RGMVPIVLVA KLGPQVMAAA
660 670 680 690 700
RVPPRLQPEE LGLAGAHPLD FLLLDAPLGG PLGLDTLLDG DPAMALKHEE
710 720 730 740 750
RKCPYCPDRF HNGIGLANHV RGHLNRVGVS YNVRHFISAE EVKAIERRFS
760 770 780 790 800
FQKKKKKVAN FDPGTFSLMR CDFCGAGFDT RAGLSSHARA HLRDFGITNW
810 820 830 840 850
ELTVSPINIL QELLATSAAE QPPSPLGREP GGPPGSFLTS RRPRLPLTVP
860 870 880 890 900
FPPTWAEDPG PAYGDAQSLT TCEVCGACFE TRKGLSSHAR SHLRQLGVAE
910 920 930 940 950
SESSGAPIDL LYELVKQKGL PDAHLGLPPG LAKKSSSLKE VVAGAPRPGL
960 970 980 990 1000
LSLAKPLDAP AVNKAIKSPP GFSAKGLGHP PSSPLLKKTP LALAGSPTPK
1010 1020 1030 1040 1050
NPEDKSPQLS LSPRPASPKA QWPQSEDEGP LNLTSGPEPA RDIRCEFCGE
1060 1070 1080 1090 1100
FFENRKGLSS HARSHLRQMG VTEWYVNGSP IDTLREILKR RTQSRPGGPP
1110 1120 1130 1140 1150
NPPGPSPKAL AKMMGGAGPG SSLEARSPSD LHISPLAKKL PPPPGSPLGH
1160 1170 1180 1190 1200
SPTASPPPTA RKMFPGLAAP SLPKKLKPEQ IRVEIKREML PGALHGELHP
1210 1220 1230 1240 1250
SEGPWGAPRE DMTPLNLSSR AEPVRDIRCE FCGEFFENRK GLSSHARSHL
1260 1270 1280 1290 1300
RQMGVTEWSV NGSPIDTLRE ILKKKSKPCL IKKEPPAGDL APALAEDGPP
1310 1320 1330 1340 1350
TVAPGPVQSP LPLSPLAGRP GKPGAGPAQV PRELSLTPIT GAKPSATGYL
1360 1370 1380 1390 1400
GSVAAKRPLQ EDRLLPAEVK AKTYIQTELP FKAKTLHEKT SHSSTEACCE
1410 1420 1430 1440 1450
LCGLYFENRK ALASHARAHL RQFGVTEWCV NGSPIETLSE WIKHRPQKVG
1460 1470 1480 1490 1500
AYRSYIQGGR PFTKKFRSAG HGRDSDKRPS LGLAPGGLAV VGRSAGGEPG
1510 1520 1530 1540 1550
PEAGRAADGG ERPLAASPPG TVKAEEHQRQ NINKFERRQA RPPDASAARG
1560 1570 1580 1590 1600
GEDTNDLQQK LEEVRQPPPR VRPVPSLVPR PPQTSLVKFV GNIYTLKCRF
1610 1620 1630 1640 1650
CEVEFQGPLS IQEEWVRHLQ RHILEMNFSK ADPPPEESQA PQAQTAAAEA

P
Length:1,651
Mass (Da):178,674
Last modified:May 1, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9DB0485964578310
GO
Isoform 2 (identifier: O95785-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-757: Missing.
     867-1034: Missing.

Show »
Length:794
Mass (Da):85,380
Checksum:i19284DFA21E8DF0D
GO
Isoform 3 (identifier: O95785-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: MEGSLAGSLA...AEGEGGIFRS → MDLGSPSLPK...GSKQELQDLK
     47-865: Missing.
     1034-1034: T → TLDSDGGREL...DVEPSPLNLS

Note: No experimental confirmation available.Combined sources
Show »
Length:965
Mass (Da):102,978
Checksum:iB41B51E8CAA3FB9F
GO
Isoform 4 (identifier: O95785-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: MEGSLAGSLA...EGGIFRSTRY → MVAMDLGSPS...GSKQELQDLK
     50-865: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:835
Mass (Da):89,356
Checksum:iC686BA9551332063
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QXA7M0QXA7_HUMAN
Protein Wiz
WIZ
968Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B9EGQ5B9EGQ5_HUMAN
Protein Wiz
WIZ
832Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YFV2A0A2R8YFV2_HUMAN
Protein Wiz
WIZ
1,699Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXF8M0QXF8_HUMAN
Protein Wiz
WIZ
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IS05A0A3B3IS05_HUMAN
Protein Wiz
WIZ
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB55234 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1373T → A in BAD18551 (PubMed:15057824).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0572071 – 49MEGSL…RSTRY → MVAMDLGSPSLPKKSLPVPG ALEQVASRLSSKVAAEVPHG SKQELQDLK in isoform 4. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_0545091 – 46MEGSL…GIFRS → MDLGSPSLPKKSLPVPGALE QVASRLSSKVAAEVPHGSKQ ELQDLK in isoform 3. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_05451047 – 865Missing in isoform 3. 1 PublicationAdd BLAST819
Alternative sequenceiVSP_05720850 – 865Missing in isoform 4. 1 PublicationAdd BLAST816
Alternative sequenceiVSP_02495169 – 757Missing in isoform 2. 1 PublicationAdd BLAST689
Alternative sequenceiVSP_024952867 – 1034Missing in isoform 2. 1 PublicationAdd BLAST168
Alternative sequenceiVSP_0545111034T → TLDSDGGRELDCQLCGAWFE TRKGLSSHARAHLRHLGVSD PDAKGSPIDVLHGLIRRDGV QIRLPPRRGALAHPGRPPPT SAALSLLPPPPPAKKAKLKA AGMASPWGKQDLSAAAAAGI FWASDVEPSPLNLS in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK027615 mRNA Translation: BAB55234.1 Different initiation.
AK122890 mRNA Translation: BAG53783.1
AK131404 mRNA Translation: BAD18551.1
AC006128 Genomic DNA Translation: AAC97985.1
AC007059 Genomic DNA Translation: AAD19817.1
AC007059 Genomic DNA Translation: AAD19818.1
AC011492 Genomic DNA No translation available.
BC002329 mRNA Translation: AAH02329.2
BC007551 mRNA Translation: AAH07551.1
BC062360 mRNA Translation: AAH62360.1
BC098445 mRNA Translation: AAH98445.1
BC144332 mRNA Translation: AAI44333.1
AL390184 mRNA Translation: CAB99102.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42516.1 [O95785-2]
CCDS82308.1 [O95785-4]

Protein sequence database of the Protein Information Resource

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PIRi
T51885

NCBI Reference Sequences

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RefSeqi
NP_001317324.1, NM_001330395.1 [O95785-4]
NP_067064.2, NM_021241.2 [O95785-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000263381; ENSP00000263381; ENSG00000011451 [O95785-2]
ENST00000545156; ENSP00000445824; ENSG00000011451 [O95785-3]
ENST00000599686; ENSP00000469534; ENSG00000011451 [O95785-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
58525

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:58525

UCSC genome browser

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UCSCi
uc002nba.5 human [O95785-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027615 mRNA Translation: BAB55234.1 Different initiation.
AK122890 mRNA Translation: BAG53783.1
AK131404 mRNA Translation: BAD18551.1
AC006128 Genomic DNA Translation: AAC97985.1
AC007059 Genomic DNA Translation: AAD19817.1
AC007059 Genomic DNA Translation: AAD19818.1
AC011492 Genomic DNA No translation available.
BC002329 mRNA Translation: AAH02329.2
BC007551 mRNA Translation: AAH07551.1
BC062360 mRNA Translation: AAH62360.1
BC098445 mRNA Translation: AAH98445.1
BC144332 mRNA Translation: AAI44333.1
AL390184 mRNA Translation: CAB99102.1
CCDSiCCDS42516.1 [O95785-2]
CCDS82308.1 [O95785-4]
PIRiT51885
RefSeqiNP_001317324.1, NM_001330395.1 [O95785-4]
NP_067064.2, NM_021241.2 [O95785-2]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi121845, 73 interactors
IntActiO95785, 51 interactors
MINTiO95785
STRINGi9606.ENSP00000263381

PTM databases

iPTMnetiO95785
PhosphoSitePlusiO95785

Polymorphism and mutation databases

BioMutaiWIZ

Proteomic databases

EPDiO95785
jPOSTiO95785
MaxQBiO95785
PaxDbiO95785
PeptideAtlasiO95785
PRIDEiO95785
ProteomicsDBi51045
51046 [O95785-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263381; ENSP00000263381; ENSG00000011451 [O95785-2]
ENST00000545156; ENSP00000445824; ENSG00000011451 [O95785-3]
ENST00000599686; ENSP00000469534; ENSG00000011451 [O95785-4]
GeneIDi58525
KEGGihsa:58525
UCSCiuc002nba.5 human [O95785-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
58525

GeneCards: human genes, protein and diseases

More...
GeneCardsi
WIZ
HGNCiHGNC:30917 WIZ
HPAiHPA022923
HPA023774
neXtProtiNX_O95785
OpenTargetsiENSG00000011451
PharmGKBiPA162409232

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000159979
HOGENOMiHOG000065754
InParanoidiO95785
OrthoDBi434804at2759
PhylomeDBiO95785
TreeFamiTF333705

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
WIZ human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
58525

Protein Ontology

More...
PROi
PR:O95785

Gene expression databases

BgeeiENSG00000011451 Expressed in 207 organ(s), highest expression level in right testis
ExpressionAtlasiO95785 baseline and differential
GenevisibleiO95785 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 11 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWIZ_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95785
Secondary accession number(s): B3KVH1
, B7ZM82, M0QY21, Q4G0E0, Q6P6B0, Q6ZN24, Q7LDY6, Q7LDZ1, Q96IG5, Q96SQ6, Q9BUR8, Q9NPT1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: May 8, 2019
This is version 146 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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