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UniProtKB - O95782 (AP2A1_HUMAN)

Entry version 195 (02 Jun 2021)
Sequence version 3 (03 Nov 2009)
Previous versions | rss
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Protein

AP-2 complex subunit alpha-1

Gene

AP2A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497).

The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity).

By similarity4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processEndocytosis, Protein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O95782

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-167590, Nef Mediated CD4 Down-regulation
R-HSA-177504, Retrograde neurotrophin signalling
R-HSA-182218, Nef Mediated CD8 Down-regulation
R-HSA-2132295, MHC class II antigen presentation
R-HSA-3928665, EPH-ephrin mediated repulsion of cells
R-HSA-416993, Trafficking of GluR2-containing AMPA receptors
R-HSA-437239, Recycling pathway of L1
R-HSA-5099900, WNT5A-dependent internalization of FZD4
R-HSA-5140745, WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828, Clathrin-mediated endocytosis
R-HSA-8866427, VLDLR internalisation and degradation
R-HSA-8964038, LDL clearance
R-HSA-9679191, Potential therapeutics for SARS

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O95782

Protein family/group databases

Transport Classification Database

More...TCDBi		9.B.278.1.4, the organellar-targeting adaptor protein complex (o-apc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AP-2 complex subunit alpha-1
Alternative name(s):
100 kDa coated vesicle protein A
Adaptor protein complex AP-2 subunit alpha-1
Adaptor-related protein complex 2 subunit alpha-1
Alpha-adaptin A
Alpha1-adaptin
Clathrin assembly protein complex 2 alpha-A large chain
Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AP2A1
Synonyms:ADTAA, CLAPA1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:561, AP2A1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601026, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O95782

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000196961.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Coated pit, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		160

Open Targets

More...OpenTargetsi		ENSG00000196961

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24852

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O95782, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4295687

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		AP2A1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001937301 – 977AP-2 complex subunit alpha-1Add BLAST977

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei626PhosphoserineCombined sources1
Modified residuei652PhosphoserineCombined sources1
Modified residuei653PhosphothreonineCombined sources1
Modified residuei655PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O95782

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O95782

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O95782

MaxQB - The MaxQuant DataBase

More...MaxQBi		O95782

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O95782

PeptideAtlas

More...PeptideAtlasi		O95782

PRoteomics IDEntifications database

More...PRIDEi		O95782

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51043 [O95782-1]
51044 [O95782-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O95782

MetOSite database of methionine sulfoxide sites

More...MetOSitei		O95782

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O95782

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O95782

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the brain (at protein level) (PubMed:23676497). Isoform A: Expressed in forebrain, skeletal muscle, spinal cord, cerebellum, salivary gland, heart and colon. Isoform B: Widely expressed in tissues and also in breast cancer and in prostate carcinoma cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000196961, Expressed in right adrenal gland and 204 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O95782, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O95782, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000196961, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).

Interacts with SGIP1 (By similarity).

Interacts with HIP1 and RAB11FIP2 (PubMed:11532990, PubMed:12364336).

Interacts with SLC12A5 (By similarity).

Interacts with clathrin (By similarity).

Interacts with RFTN1 (PubMed:27022195).

Interacts with KIAA1107 (PubMed:29262337).

Interacts with PICALM (PubMed:16262731). Together with AP2B1 and AP2M1, it interacts with ADAM10; this interaction facilitates ADAM10 endocytosis from the plasma membrane during long-term potentiation in hippocampal neurons (PubMed:23676497).

Interacts with ABCB11; this interaction regulates cell membrane expresion of ABCB11 through its internalization in a clathrin-dependent manner and its subsequent degradation (PubMed:22262466).

By similarity7 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		106669, 206 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-5149, AP-2 Adaptor complex, alpha1 variant

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O95782

Database of interacting proteins

More...DIPi		DIP-33164N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		O95782

Protein interaction database and analysis system

More...IntActi		O95782, 109 interactors

Molecular INTeraction database

More...MINTi		O95782

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000351926

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O95782, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O95782

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni615 – 675DisorderedSequence analysisAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi615 – 636Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi640 – 657Polar residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the adaptor complexes large subunit family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1077, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182838

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003824_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O95782

Identification of Orthologs from Complete Genome Data

More...OMAi		HNELFNC

Database of Orthologous Groups

More...OrthoDBi		751651at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O95782

TreeFam database of animal gene trees

More...TreeFami		TF300308

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.10.10, 1 hit
3.30.310.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR017104, AP2_complex_asu
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR002553, Clathrin/coatomer_adapt-like_N
IPR003164, Clathrin_a-adaptin_app_sub_C
IPR008152, Clathrin_a/b/g-adaptin_app_Ig
IPR013041, Clathrin_app_Ig-like_sf
IPR009028, Coatomer/calthrin_app_sub_C
IPR012295, TBP_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01602, Adaptin_N, 1 hit
PF02296, Alpha_adaptin_C, 1 hit
PF02883, Alpha_adaptinC2, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF037091, AP2_complex_alpha, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00809, Alpha_adaptinC2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit
SSF49348, SSF49348, 1 hit
SSF55711, SSF55711, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform A (identifier: O95782-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPAVSKGDGM RGLAVFISDI RNCKSKEAEI KRINKELANI RSKFKGDKAL 
        60         70         80         90        100
DGYSKKKYVC KLLFIFLLGH DIDFGHMEAV NLLSSNKYTE KQIGYLFISV 
       110        120        130        140        150
LVNSNSELIR LINNAIKNDL ASRNPTFMCL ALHCIANVGS REMGEAFAAD 
       160        170        180        190        200
IPRILVAGDS MDSVKQSAAL CLLRLYKASP DLVPMGEWTA RVVHLLNDQH 
       210        220        230        240        250
MGVVTAAVSL ITCLCKKNPD DFKTCVSLAV SRLSRIVSSA STDLQDYTYY 
       260        270        280        290        300
FVPAPWLSVK LLRLLQCYPP PEDAAVKGRL VECLETVLNK AQEPPKSKKV 
       310        320        330        340        350
QHSNAKNAIL FETISLIIHY DSEPNLLVRA CNQLGQFLQH RETNLRYLAL 
       360        370        380        390        400
ESMCTLASSE FSHEAVKTHI DTVINALKTE RDVSVRQRAA DLLYAMCDRS 
       410        420        430        440        450
NAKQIVSEML RYLETADYAI REEIVLKVAI LAEKYAVDYS WYVDTILNLI 
       460        470        480        490        500
RIAGDYVSEE VWYRVLQIVT NRDDVQGYAA KTVFEALQAP ACHENMVKVG 
       510        520        530        540        550
GYILGEFGNL IAGDPRSSPP VQFSLLHSKF HLCSVATRAL LLSTYIKFIN 
       560        570        580        590        600
LFPETKATIQ GVLRAGSQLR NADVELQQRA VEYLTLSSVA STDVLATVLE 
       610        620        630        640        650
EMPPFPERES SILAKLKRKK GPGAGSALDD GRRDPSSNDI NGGMEPTPST 
       660        670        680        690        700
VSTPSPSADL LGLRAAPPPA APPASAGAGN LLVDVFDGPA AQPSLGPTPE 
       710        720        730        740        750
EAFLSELEPP APESPMALLA DPAPAADPGP EDIGPPIPEA DELLNKFVCK 
       760        770        780        790        800
NNGVLFENQL LQIGVKSEFR QNLGRMYLFY GNKTSVQFQN FSPTVVHPGD 
       810        820        830        840        850
LQTQLAVQTK RVAAQVDGGA QVQQVLNIEC LRDFLTPPLL SVRFRYGGAP 
       860        870        880        890        900
QALTLKLPVT INKFFQPTEM AAQDFFQRWK QLSLPQQEAQ KIFKANHPMD 
       910        920        930        940        950
AEVTKAKLLG FGSALLDNVD PNPENFVGAG IIQTKALQVG CLLRLEPNAQ 
       960        970 
AQMYRLTLRT SKEPVSRHLC ELLAQQF
Length:977
Mass (Da):107,546
Last modified:November 3, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD9FB569E7EDDF6ED
GO
Isoform B (identifier: O95782-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     706-727: Missing.

Show »
Length:955
Mass (Da):105,361
Checksum:iFCE1AEC87453B17F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R2D9M0R2D9_HUMAN
AP-2 complex subunit alpha-1
AP2A1
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD15564 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti804Q → H in AAL11039 (PubMed:12036598).Curated1
Sequence conflicti804Q → H in AAL11040 (PubMed:12036598).Curated1
Sequence conflicti924 – 977ENFVG…LAQQF → GDREDTRVWGMPGTFLRPFV FLFLFICCCLHSGGLGGVPL PPFPPQAQRGEGPGKWMSPP LPPHPVVAPPTPSPSRGCVL L in AAH14214 (PubMed:15489334).CuratedAdd BLAST54

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_060544270P → L1 PublicationCorresponds to variant dbSNP:rs17851121Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_000161706 – 727Missing in isoform B. 2 PublicationsAdd BLAST22

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF289221 Genomic DNA Translation: AAL11039.1
AF289221 Genomic DNA Translation: AAL11040.1
AL136925 mRNA Translation: CAB66859.1
AC006942 Genomic DNA Translation: AAD15564.1 Sequence problems.
AC011495 Genomic DNA No translation available.
AC098783 Genomic DNA No translation available.
BC014214 mRNA Translation: AAH14214.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS46148.1 [O95782-1]
CCDS46149.1 [O95782-2]

NCBI Reference Sequences

More...RefSeqi		NP_055018.2, NM_014203.2 [O95782-1]
NP_570603.2, NM_130787.2 [O95782-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000354293; ENSP00000346246; ENSG00000196961 [O95782-2]
ENST00000359032; ENSP00000351926; ENSG00000196961 [O95782-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		160

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:160

UCSC genome browser

More...UCSCi		uc002ppn.4, human [O95782-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF289221 Genomic DNA Translation: AAL11039.1
AF289221 Genomic DNA Translation: AAL11040.1
AL136925 mRNA Translation: CAB66859.1
AC006942 Genomic DNA Translation: AAD15564.1 Sequence problems.
AC011495 Genomic DNA No translation available.
AC098783 Genomic DNA No translation available.
BC014214 mRNA Translation: AAH14214.1
CCDSiCCDS46148.1 [O95782-1]
CCDS46149.1 [O95782-2]
RefSeqiNP_055018.2, NM_014203.2 [O95782-1]
NP_570603.2, NM_130787.2 [O95782-2]

3D structure databases

SMRiO95782
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi106669, 206 interactors
ComplexPortaliCPX-5149, AP-2 Adaptor complex, alpha1 variant
CORUMiO95782
DIPiDIP-33164N
ELMiO95782
IntActiO95782, 109 interactors
MINTiO95782
STRINGi9606.ENSP00000351926

Chemistry databases

ChEMBLiCHEMBL4295687

Protein family/group databases

TCDBi9.B.278.1.4, the organellar-targeting adaptor protein complex (o-apc) family

PTM databases

iPTMnetiO95782
MetOSiteiO95782
PhosphoSitePlusiO95782
SwissPalmiO95782

Genetic variation databases

BioMutaiAP2A1

Proteomic databases

EPDiO95782
jPOSTiO95782
MassIVEiO95782
MaxQBiO95782
PaxDbiO95782
PeptideAtlasiO95782
PRIDEiO95782
ProteomicsDBi51043 [O95782-1]
51044 [O95782-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3805, 295 antibodies

The DNASU plasmid repository

More...DNASUi		160

Genome annotation databases

EnsembliENST00000354293; ENSP00000346246; ENSG00000196961 [O95782-2]
ENST00000359032; ENSP00000351926; ENSG00000196961 [O95782-1]
GeneIDi160
KEGGihsa:160
UCSCiuc002ppn.4, human [O95782-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		160
DisGeNETi160

GeneCards: human genes, protein and diseases

More...GeneCardsi		AP2A1
HGNCiHGNC:561, AP2A1
HPAiENSG00000196961, Low tissue specificity
MIMi601026, gene
neXtProtiNX_O95782
OpenTargetsiENSG00000196961
PharmGKBiPA24852
VEuPathDBiHostDB:ENSG00000196961.12

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1077, Eukaryota
GeneTreeiENSGT00950000182838
HOGENOMiCLU_003824_1_0_1
InParanoidiO95782
OMAiHNELFNC
OrthoDBi751651at2759
PhylomeDBiO95782
TreeFamiTF300308

Enzyme and pathway databases

PathwayCommonsiO95782
ReactomeiR-HSA-167590, Nef Mediated CD4 Down-regulation
R-HSA-177504, Retrograde neurotrophin signalling
R-HSA-182218, Nef Mediated CD8 Down-regulation
R-HSA-2132295, MHC class II antigen presentation
R-HSA-3928665, EPH-ephrin mediated repulsion of cells
R-HSA-416993, Trafficking of GluR2-containing AMPA receptors
R-HSA-437239, Recycling pathway of L1
R-HSA-5099900, WNT5A-dependent internalization of FZD4
R-HSA-5140745, WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828, Clathrin-mediated endocytosis
R-HSA-8866427, VLDLR internalisation and degradation
R-HSA-8964038, LDL clearance
R-HSA-9679191, Potential therapeutics for SARS
SignaLinkiO95782

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		160, 40 hits in 995 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		AP2A1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Adaptor-related_protein_complex_2,_alpha_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		160
PharosiO95782, Tbio

Protein Ontology

More...PROi		PR:O95782
RNActiO95782, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000196961, Expressed in right adrenal gland and 204 other tissues
ExpressionAtlasiO95782, baseline and differential
GenevisibleiO95782, HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
3.30.310.10, 1 hit
InterProiView protein in InterPro
IPR017104, AP2_complex_asu
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR002553, Clathrin/coatomer_adapt-like_N
IPR003164, Clathrin_a-adaptin_app_sub_C
IPR008152, Clathrin_a/b/g-adaptin_app_Ig
IPR013041, Clathrin_app_Ig-like_sf
IPR009028, Coatomer/calthrin_app_sub_C
IPR012295, TBP_dom_sf
PfamiView protein in Pfam
PF01602, Adaptin_N, 1 hit
PF02296, Alpha_adaptin_C, 1 hit
PF02883, Alpha_adaptinC2, 1 hit
PIRSFiPIRSF037091, AP2_complex_alpha, 1 hit
SMARTiView protein in SMART
SM00809, Alpha_adaptinC2, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
SSF49348, SSF49348, 1 hit
SSF55711, SSF55711, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAP2A1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95782
Secondary accession number(s): Q96CI7
, Q96PP6, Q96PP7, Q9H070
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 3, 2009
Last modified: June 2, 2021
This is version 195 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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