AP2A1

Functionⁱ

Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity).By similarity3 Publications

GO - Molecular functionⁱ

clathrin adaptor activity Source: InterPro
low-density lipoprotein particle receptor binding
Source: ARUK-UCL
Inferred from physical interactionⁱ
- 26005850
protein-containing complex binding Source: Ensembl
protein C-terminus binding Source: Ensembl
protein kinase binding Source: ParkinsonsUK-UCL

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
clathrin-dependent endocytosis
Source: BHF-UCL
Traceable author statementⁱ
- 12121421
endocytosis
Source: UniProtKB
Non-traceable author statementⁱ
- 12036598
ephrin receptor signaling pathway Source: Reactome
Golgi to endosome transport
Source: UniProtKB
Non-traceable author statementⁱ
- 12036598
intracellular protein transport
Source: UniProtKB
Non-traceable author statementⁱ
- 12036598
low-density lipoprotein particle clearance Source: Reactome
low-density lipoprotein particle receptor catabolic process Source: Reactome
membrane organization Source: Reactome
negative regulation of hyaluronan biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 24251095
positive regulation of neuron projection development Source: Ensembl
positive regulation of receptor-mediated endocytosis Source: Ensembl
regulation of defense response to virus by virus Source: Reactome
Wnt signaling pathway, planar cell polarity pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Endocytosis, Protein transport, Transport

Biological process

Endocytosis, Protein transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-167590 Nef Mediated CD4 Down-regulation R-HSA-177504 Retrograde neurotrophin signalling R-HSA-182218 Nef Mediated CD8 Down-regulation R-HSA-2132295 MHC class II antigen presentation R-HSA-3928665 EPH-ephrin mediated repulsion of cells R-HSA-416993 Trafficking of GluR2-containing AMPA receptors R-HSA-437239 Recycling pathway of L1 R-HSA-5099900 WNT5A-dependent internalization of FZD4 R-HSA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828 Clathrin-mediated endocytosis R-HSA-8866427 VLDLR internalisation and degradation R-HSA-8964038 LDL clearance
SignaLinkⁱ	O95782

Reactomeⁱ

R-HSA-167590 Nef Mediated CD4 Down-regulation
R-HSA-177504 Retrograde neurotrophin signalling
R-HSA-182218 Nef Mediated CD8 Down-regulation
R-HSA-2132295 MHC class II antigen presentation
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
R-HSA-416993 Trafficking of GluR2-containing AMPA receptors
R-HSA-437239 Recycling pathway of L1
R-HSA-5099900 WNT5A-dependent internalization of FZD4
R-HSA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-8866427 VLDLR internalisation and degradation
R-HSA-8964038 LDL clearance

SignaLinkⁱ

O95782

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: AP-2 complex subunit alpha-1 Alternative name(s): 100 kDa coated vesicle protein A Adaptor protein complex AP-2 subunit alpha-1 Adaptor-related protein complex 2 subunit alpha-1 Alpha-adaptin A Alpha1-adaptin Clathrin assembly protein complex 2 alpha-A large chain Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit
Gene namesⁱ	Name:AP2A1 Synonyms:ADTAA, CLAPA1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000196961.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:561 AP2A1
MIMⁱ	601026 gene
neXtProtⁱ	NX_O95782

Keywords - Cellular componentⁱ

Cell membrane, Coated pit, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	160
Open Targets More...OpenTargetsⁱ	ENSG00000196961
PharmGKBⁱ	PA24852

Polymorphism and mutation databases

BioMutaⁱ	AP2A1

BioMutaⁱ

AP2A1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000193730	1 – 977	AP-2 complex subunit alpha-1Add BLAST		977

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	626	PhosphoserineCombined sources	1
Modified residueⁱ	652	PhosphoserineCombined sources	1
Modified residueⁱ	653	PhosphothreonineCombined sources	1
Modified residueⁱ	655	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	O95782
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O95782
PaxDbⁱ	O95782
PeptideAtlas More...PeptideAtlasⁱ	O95782
PRIDEⁱ	O95782
ProteomicsDBⁱ	51043 51044 [O95782-2]

PTM databases

iPTMnetⁱ	O95782
PhosphoSitePlusⁱ	O95782
SwissPalmⁱ	O95782

Expressionⁱ

Tissue specificityⁱ

Isoform A expressed in forebrain, skeletal muscle, spinal cord, cerebellum, salivary gland, heart and colon. Isoform B is widely expressed in tissues and also in breast cancer and in prostate carcinoma cells.

Gene expression databases

Bgeeⁱ	ENSG00000196961 Expressed in 189 organ(s), highest expression level in right adrenal gland
CleanExⁱ	HS_AP2A1
ExpressionAtlasⁱ	O95782 baseline and differential
Genevisibleⁱ	O95782 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB004306

HPAⁱ

CAB004306

Interactionⁱ

Subunit structureⁱ

Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1). Interacts with SGIP1 (By similarity). Interacts with HIP1 and RAB11FIP2 (PubMed:12364336, PubMed:11532990). Interacts with SLC12A5 (By similarity). Interacts with clathrin (By similarity). Interacts with RFTN1 (PubMed:27022195). Interacts with KIAA1107 (PubMed:29262337).By similarity4 Publications

GO - Molecular functionⁱ

clathrin adaptor activity Source: InterPro
low-density lipoprotein particle receptor binding
Source: ARUK-UCL
Inferred from physical interactionⁱ
- 26005850
protein C-terminus binding Source: Ensembl
protein kinase binding Source: ParkinsonsUK-UCL

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	106669, 130 interactors
CORUMⁱ	O95782
Database of interacting proteins More...DIPⁱ	DIP-33164N
ELMⁱ	O95782
IntActⁱ	O95782, 73 interactors
Molecular INTeraction database More...MINTⁱ	O95782
STRINGⁱ	9606.ENSP00000351926

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O95782
SMRⁱ	O95782
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the adaptor complexes large subunit family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1077 Eukaryota ENOG410XNQE LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074757
HOGENOMⁱ	HOG000170596
HOVERGENⁱ	HBG050518
InParanoidⁱ	O95782
KEGG Orthology (KO) More...KOⁱ	K11824
OMAⁱ	HNELFNC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01JZ
PhylomeDBⁱ	O95782
TreeFamⁱ	TF300308

Family and domain databases

Gene3Dⁱ	1.25.10.10, 1 hit 3.30.310.10, 1 hit
InterProⁱ	View protein in InterPro IPR017104 AP2_complex_asu IPR011989 ARM-like IPR016024 ARM-type_fold IPR002553 Clathrin/coatomer_adapt-like_N IPR003164 Clathrin_a-adaptin_app_sub_C IPR008152 Clathrin_a/b/g-adaptin_app_Ig IPR013041 Clathrin_app_Ig-like_sf IPR009028 Coatomer/calthrin_app_sub_C IPR012295 TBP_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01602 Adaptin_N, 1 hit PF02296 Alpha_adaptin_C, 1 hit PF02883 Alpha_adaptinC2, 1 hit
PIRSFⁱ	PIRSF037091 AP2_complex_alpha, 1 hit
SMARTⁱ	View protein in SMART SM00809 Alpha_adaptinC2, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 1 hit SSF49348 SSF49348, 1 hit SSF55711 SSF55711, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform A (identifier: O95782-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPAVSKGDGM RGLAVFISDI RNCKSKEAEI KRINKELANI RSKFKGDKAL 
        60         70         80         90        100
DGYSKKKYVC KLLFIFLLGH DIDFGHMEAV NLLSSNKYTE KQIGYLFISV 
       110        120        130        140        150
LVNSNSELIR LINNAIKNDL ASRNPTFMCL ALHCIANVGS REMGEAFAAD 
       160        170        180        190        200
IPRILVAGDS MDSVKQSAAL CLLRLYKASP DLVPMGEWTA RVVHLLNDQH 
       210        220        230        240        250
MGVVTAAVSL ITCLCKKNPD DFKTCVSLAV SRLSRIVSSA STDLQDYTYY 
       260        270        280        290        300
FVPAPWLSVK LLRLLQCYPP PEDAAVKGRL VECLETVLNK AQEPPKSKKV 
       310        320        330        340        350
QHSNAKNAIL FETISLIIHY DSEPNLLVRA CNQLGQFLQH RETNLRYLAL 
       360        370        380        390        400
ESMCTLASSE FSHEAVKTHI DTVINALKTE RDVSVRQRAA DLLYAMCDRS 
       410        420        430        440        450
NAKQIVSEML RYLETADYAI REEIVLKVAI LAEKYAVDYS WYVDTILNLI 
       460        470        480        490        500
RIAGDYVSEE VWYRVLQIVT NRDDVQGYAA KTVFEALQAP ACHENMVKVG 
       510        520        530        540        550
GYILGEFGNL IAGDPRSSPP VQFSLLHSKF HLCSVATRAL LLSTYIKFIN 
       560        570        580        590        600
LFPETKATIQ GVLRAGSQLR NADVELQQRA VEYLTLSSVA STDVLATVLE 
       610        620        630        640        650
EMPPFPERES SILAKLKRKK GPGAGSALDD GRRDPSSNDI NGGMEPTPST 
       660        670        680        690        700
VSTPSPSADL LGLRAAPPPA APPASAGAGN LLVDVFDGPA AQPSLGPTPE 
       710        720        730        740        750
EAFLSELEPP APESPMALLA DPAPAADPGP EDIGPPIPEA DELLNKFVCK 
       760        770        780        790        800
NNGVLFENQL LQIGVKSEFR QNLGRMYLFY GNKTSVQFQN FSPTVVHPGD 
       810        820        830        840        850
LQTQLAVQTK RVAAQVDGGA QVQQVLNIEC LRDFLTPPLL SVRFRYGGAP 
       860        870        880        890        900
QALTLKLPVT INKFFQPTEM AAQDFFQRWK QLSLPQQEAQ KIFKANHPMD 
       910        920        930        940        950
AEVTKAKLLG FGSALLDNVD PNPENFVGAG IIQTKALQVG CLLRLEPNAQ 
       960        970 
AQMYRLTLRT SKEPVSRHLC ELLAQQF

Length:977

Mass (Da):107,546

Last modified:November 3, 2009 - v3

Checksum:ⁱD9FB569E7EDDF6ED

GO

Isoform B (identifier: O95782-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
706-727: Missing.

« Hide

        10         20         30         40         50
MPAVSKGDGM RGLAVFISDI RNCKSKEAEI KRINKELANI RSKFKGDKAL 
        60         70         80         90        100
DGYSKKKYVC KLLFIFLLGH DIDFGHMEAV NLLSSNKYTE KQIGYLFISV 
       110        120        130        140        150
LVNSNSELIR LINNAIKNDL ASRNPTFMCL ALHCIANVGS REMGEAFAAD 
       160        170        180        190        200
IPRILVAGDS MDSVKQSAAL CLLRLYKASP DLVPMGEWTA RVVHLLNDQH 
       210        220        230        240        250
MGVVTAAVSL ITCLCKKNPD DFKTCVSLAV SRLSRIVSSA STDLQDYTYY 
       260        270        280        290        300
FVPAPWLSVK LLRLLQCYPP PEDAAVKGRL VECLETVLNK AQEPPKSKKV 
       310        320        330        340        350
QHSNAKNAIL FETISLIIHY DSEPNLLVRA CNQLGQFLQH RETNLRYLAL 
       360        370        380        390        400
ESMCTLASSE FSHEAVKTHI DTVINALKTE RDVSVRQRAA DLLYAMCDRS 
       410        420        430        440        450
NAKQIVSEML RYLETADYAI REEIVLKVAI LAEKYAVDYS WYVDTILNLI 
       460        470        480        490        500
RIAGDYVSEE VWYRVLQIVT NRDDVQGYAA KTVFEALQAP ACHENMVKVG 
       510        520        530        540        550
GYILGEFGNL IAGDPRSSPP VQFSLLHSKF HLCSVATRAL LLSTYIKFIN 
       560        570        580        590        600
LFPETKATIQ GVLRAGSQLR NADVELQQRA VEYLTLSSVA STDVLATVLE 
       610        620        630        640        650
EMPPFPERES SILAKLKRKK GPGAGSALDD GRRDPSSNDI NGGMEPTPST 
       660        670        680        690        700
VSTPSPSADL LGLRAAPPPA APPASAGAGN LLVDVFDGPA AQPSLGPTPE 
       710        720        730        740        750
EAFLSPGPED IGPPIPEADE LLNKFVCKNN GVLFENQLLQ IGVKSEFRQN 
       760        770        780        790        800
LGRMYLFYGN KTSVQFQNFS PTVVHPGDLQ TQLAVQTKRV AAQVDGGAQV 
       810        820        830        840        850
QQVLNIECLR DFLTPPLLSV RFRYGGAPQA LTLKLPVTIN KFFQPTEMAA 
       860        870        880        890        900
QDFFQRWKQL SLPQQEAQKI FKANHPMDAE VTKAKLLGFG SALLDNVDPN 
       910        920        930        940        950
PENFVGAGII QTKALQVGCL LRLEPNAQAQ MYRLTLRTSK EPVSRHLCEL 

LAQQF

Show »

Length:955

Mass (Da):105,361

Checksum:ⁱFCE1AEC87453B17F

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	M0R2D9	M0R2D9_HUMAN		AP-2 complex subunit alpha-1 AP-2 complex subunit alpha-1	AP2A1	57	Annotation score:

Sequence cautionⁱ

The sequence AAD15564 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	804	Q → H in AAL11039 (PubMed:12036598).Curated	1
Sequence conflictⁱ	804	Q → H in AAL11040 (PubMed:12036598).Curated	1
Sequence conflictⁱ	924 – 977	ENFVG…LAQQF → GDREDTRVWGMPGTFLRPFV FLFLFICCCLHSGGLGGVPL PPFPPQAQRGEGPGKWMSPP LPPHPVVAPPTPSPSRGCVL L in AAH14214 (PubMed:15489334).CuratedAdd BLAST	54

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_060544	270	P → L1 PublicationCorresponds to variant dbSNP:rs17851121Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_000161	706 – 727	Missing in isoform B. 2 PublicationsAdd BLAST		22

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF289221 Genomic DNA Translation: AAL11039.1 AF289221 Genomic DNA Translation: AAL11040.1 AL136925 mRNA Translation: CAB66859.1 AC006942 Genomic DNA Translation: AAD15564.1 Sequence problems. AC011495 Genomic DNA No translation available. AC098783 Genomic DNA No translation available. BC014214 mRNA Translation: AAH14214.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS46148.1 [O95782-1] CCDS46149.1 [O95782-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_055018.2, NM_014203.2 [O95782-1] NP_570603.2, NM_130787.2 [O95782-2]
UniGeneⁱ	Hs.467125

Genome annotation databases

Ensemblⁱ	ENST00000354293; ENSP00000346246; ENSG00000196961 [O95782-2] ENST00000359032; ENSP00000351926; ENSG00000196961 [O95782-1]
GeneIDⁱ	160
KEGGⁱ	hsa:160
UCSC genome browser More...UCSCⁱ	uc002ppn.4 human [O95782-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O95782	AP-2 complex subunit alpha		PANTR		977	UniRef100_O95782
AP-2 complex subunit alpha		PANPA		977
O95782-2	AP-2 complex subunit alpha		PANTR		955	UniRef100_O95782-2
AP-2 complex subunit alpha		PANPA		955

Protein	Similar proteins		Species	Score	Length	Source
O95782	AP-2 complex subunit alpha-1		MOUSE		977	UniRef90_O95782
AP-2 complex subunit alpha		PANTR		977
AP-2 complex subunit alpha		PANPA		977
AP-2 complex subunit alpha-1 isoform X1		BALAS		983
AP-2 complex subunit alpha		Cebus capucinus imitator		982
+113
O95782-2	AP-2 complex subunit alpha		PANTR		955	UniRef90_O95782-2
AP-2 complex subunit alpha		PANPA		955
AP-2 complex subunit alpha		DELLE		1023
AP-2 complex subunit alpha		AILME		973
AP-2 complex subunit alpha		Yangtze finless porpoise		961
+117

Protein	Similar proteins		Species	Score	Length	Source
O95782	AP-2 complex subunit alpha-1		MOUSE		977	UniRef50_O95782
AP-2 complex subunit alpha		ANOGA		934
AP-2 complex subunit alpha		DROME		940
AP-2 complex subunit alpha		DROPS		939
AP-2 complex subunit alpha		PANTR		977
+1077

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF289221 Genomic DNA Translation: AAL11039.1 AF289221 Genomic DNA Translation: AAL11040.1 AL136925 mRNA Translation: CAB66859.1 AC006942 Genomic DNA Translation: AAD15564.1 Sequence problems. AC011495 Genomic DNA No translation available. AC098783 Genomic DNA No translation available. BC014214 mRNA Translation: AAH14214.1
CCDSⁱ	CCDS46148.1 [O95782-1] CCDS46149.1 [O95782-2]
RefSeqⁱ	NP_055018.2, NM_014203.2 [O95782-1] NP_570603.2, NM_130787.2 [O95782-2]
UniGeneⁱ	Hs.467125

3D structure databases

ProteinModelPortalⁱ	O95782
SMRⁱ	O95782
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106669, 130 interactors
CORUMⁱ	O95782
DIPⁱ	DIP-33164N
ELMⁱ	O95782
IntActⁱ	O95782, 73 interactors
MINTⁱ	O95782
STRINGⁱ	9606.ENSP00000351926

PTM databases

iPTMnetⁱ	O95782
PhosphoSitePlusⁱ	O95782
SwissPalmⁱ	O95782

Polymorphism and mutation databases

BioMutaⁱ	AP2A1

BioMutaⁱ

AP2A1

Proteomic databases

EPDⁱ	O95782
MaxQBⁱ	O95782
PaxDbⁱ	O95782
PeptideAtlasⁱ	O95782
PRIDEⁱ	O95782
ProteomicsDBⁱ	51043 51044 [O95782-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	160
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000354293; ENSP00000346246; ENSG00000196961 [O95782-2] ENST00000359032; ENSP00000351926; ENSG00000196961 [O95782-1]
GeneIDⁱ	160
KEGGⁱ	hsa:160
UCSCⁱ	uc002ppn.4 human [O95782-1]

Organism-specific databases

CTDⁱ	160
DisGeNETⁱ	160
EuPathDBⁱ	HostDB:ENSG00000196961.12
GeneCardsⁱ	AP2A1
HGNCⁱ	HGNC:561 AP2A1
HPAⁱ	CAB004306
MIMⁱ	601026 gene
neXtProtⁱ	NX_O95782
OpenTargetsⁱ	ENSG00000196961
PharmGKBⁱ	PA24852
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1077 Eukaryota ENOG410XNQE LUCA
GeneTreeⁱ	ENSGT00550000074757
HOGENOMⁱ	HOG000170596
HOVERGENⁱ	HBG050518
InParanoidⁱ	O95782
KOⁱ	K11824
OMAⁱ	HNELFNC
OrthoDBⁱ	EOG091G01JZ
PhylomeDBⁱ	O95782
TreeFamⁱ	TF300308

Enzyme and pathway databases

Reactomeⁱ	R-HSA-167590 Nef Mediated CD4 Down-regulation R-HSA-177504 Retrograde neurotrophin signalling R-HSA-182218 Nef Mediated CD8 Down-regulation R-HSA-2132295 MHC class II antigen presentation R-HSA-3928665 EPH-ephrin mediated repulsion of cells R-HSA-416993 Trafficking of GluR2-containing AMPA receptors R-HSA-437239 Recycling pathway of L1 R-HSA-5099900 WNT5A-dependent internalization of FZD4 R-HSA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828 Clathrin-mediated endocytosis R-HSA-8866427 VLDLR internalisation and degradation R-HSA-8964038 LDL clearance
SignaLinkⁱ	O95782

Reactomeⁱ

R-HSA-167590 Nef Mediated CD4 Down-regulation
R-HSA-177504 Retrograde neurotrophin signalling
R-HSA-182218 Nef Mediated CD8 Down-regulation
R-HSA-2132295 MHC class II antigen presentation
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
R-HSA-416993 Trafficking of GluR2-containing AMPA receptors
R-HSA-437239 Recycling pathway of L1
R-HSA-5099900 WNT5A-dependent internalization of FZD4
R-HSA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-8866427 VLDLR internalisation and degradation
R-HSA-8964038 LDL clearance

SignaLinkⁱ

O95782

Miscellaneous databases

ChiTaRSⁱ	AP2A1 human
GeneWikiⁱ	Adaptor-related_protein_complex_2,_alpha_1
GenomeRNAiⁱ	160
Protein Ontology More...PROⁱ	PR:O95782
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000196961 Expressed in 189 organ(s), highest expression level in right adrenal gland
CleanExⁱ	HS_AP2A1
ExpressionAtlasⁱ	O95782 baseline and differential
Genevisibleⁱ	O95782 HS

Family and domain databases

Gene3Dⁱ	1.25.10.10, 1 hit 3.30.310.10, 1 hit
InterProⁱ	View protein in InterPro IPR017104 AP2_complex_asu IPR011989 ARM-like IPR016024 ARM-type_fold IPR002553 Clathrin/coatomer_adapt-like_N IPR003164 Clathrin_a-adaptin_app_sub_C IPR008152 Clathrin_a/b/g-adaptin_app_Ig IPR013041 Clathrin_app_Ig-like_sf IPR009028 Coatomer/calthrin_app_sub_C IPR012295 TBP_dom_sf
Pfamⁱ	View protein in Pfam PF01602 Adaptin_N, 1 hit PF02296 Alpha_adaptin_C, 1 hit PF02883 Alpha_adaptinC2, 1 hit
PIRSFⁱ	PIRSF037091 AP2_complex_alpha, 1 hit
SMARTⁱ	View protein in SMART SM00809 Alpha_adaptinC2, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 1 hit SSF49348 SSF49348, 1 hit SSF55711 SSF55711, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AP2A1_HUMAN
Accessionⁱ	O95782Primary (citable) accession number: O95782 Secondary accession number(s): Q96CI7 , Q96PP6, Q96PP7, Q9H070
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
	Last sequence update:	November 3, 2009
	Last modified:	September 12, 2018
	This is version 175 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM

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UniProtKB - O95782 (AP2A1_HUMAN)

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AP-2 complex subunit alpha-1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ