STARD3NL

Functionⁱ

Tethering protein that creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263).1 Publication

GO - Molecular functionⁱ

cholesterol binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15718238
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 15718238

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

C21-steroid hormone biosynthetic process Source: Reactome
vesicle tethering to endoplasmic reticulum
Source: UniProtKB
Inferred from direct assayⁱ
- 24105263

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-196108 Pregnenolone biosynthesis

Reactomeⁱ

R-HSA-196108 Pregnenolone biosynthesis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: STARD3 N-terminal-like protein1 Publication Alternative name(s): MLN64 N-terminal domain homolog
Gene namesⁱ	Name:STARD3NL1 PublicationImported Synonyms:MENTHO1 Publication ORF Names:UNQ855/PRO1864
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000010270.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19169 STARD3NL
MIMⁱ	611759 gene
neXtProtⁱ	NX_O95772

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 53	Cytoplasmic1 PublicationAdd BLAST	53
Transmembraneⁱ	54 – 74	HelicalPROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	75 – 97	ExtracellularSequence analysisAdd BLAST	23
Transmembraneⁱ	98 – 118	HelicalPROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	119 – 122	CytoplasmicSequence analysis	4
Transmembraneⁱ	123 – 143	HelicalPROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	144 – 150	ExtracellularSequence analysis	7
Transmembraneⁱ	151 – 171	HelicalPROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	172 – 234	Cytoplasmic1 PublicationAdd BLAST	63

Keywords - Cellular componentⁱ

Endosome, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	83930
Open Targets More...OpenTargetsⁱ	ENSG00000010270
PharmGKBⁱ	PA134990065

Polymorphism and mutation databases

BioMutaⁱ	STARD3NL

BioMutaⁱ

STARD3NL

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000021666	1 – 234	STARD3 N-terminal-like proteinAdd BLAST		234

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources	1
Modified residueⁱ	15	PhosphoserineCombined sources	1
Modified residueⁱ	21	PhosphoserineCombined sources	1
Modified residueⁱ	27	PhosphoserineCombined sources	1
Modified residueⁱ	193	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	O95772
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O95772
PaxDbⁱ	O95772
PeptideAtlas More...PeptideAtlasⁱ	O95772
PRIDEⁱ	O95772
ProteomicsDBⁱ	51038 51039 [O95772-2]

PTM databases

iPTMnetⁱ	O95772
PhosphoSitePlusⁱ	O95772
SwissPalmⁱ	O95772

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000010270 Expressed in 194 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_STARD3NL
ExpressionAtlasⁱ	O95772 baseline and differential
Genevisibleⁱ	O95772 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA019204

HPAⁱ

HPA019204

Interactionⁱ

Subunit structureⁱ

Homodimer (PubMed:16709157). Interacts (via the MENTAL domain) with STARD3NL (PubMed:16709157). Interacts (via FFAT motif) with VAPA. Interacts (via FFAT motif) with VAPB (PubMed:24105263).2 Publications

GO - Molecular functionⁱ

protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 15718238

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	123815, 7 interactors
IntActⁱ	O95772, 5 interactors
STRINGⁱ	9606.ENSP00000009041

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O95772
SMRⁱ	O95772
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	48 – 218	MENTALPROSITE-ProRule annotationAdd BLAST		171

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	208 – 213	FFAT1 Publication		6

Domainⁱ

The FFAT motif mediates interaction with VAPA and VAPB.By similarity

The MENTAL domain anchors the protein in endosome membranes and exposes the START domain in the cytosol (By similarity). It binds cholesterol and mediates homotypic as well as heterotypic interactions between STARD3 and STARD3NL (PubMed:15718238, PubMed:16709157).By similarity2 Publications

Sequence similaritiesⁱ

Belongs to the STARD3 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IPP0 Eukaryota ENOG4110JA9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063139
HOGENOMⁱ	HOG000252985
HOVERGENⁱ	HBG052455
InParanoidⁱ	O95772
OMAⁱ	WWAIAFT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06RM
PhylomeDBⁱ	O95772
TreeFamⁱ	TF313869

Family and domain databases

InterProⁱ	View protein in InterPro IPR019498 MENTAL
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10457 MENTAL, 1 hit
PROSITEⁱ	View protein in PROSITE PS51439 MENTAL, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative initiation. Align Add to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O95772-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNHLPEDMEN ALTGSQSSHA SLRNIHSINP TQLMARIESY EGREKKGISD 
        60         70         80         90        100
VRRTFCLFVT FDLLFVTLLW IIELNVNGGI ENTLEKEVMQ YDYYSSYFDI 
       110        120        130        140        150
FLLAVFRFKV LILAYAVCRL RHWWAIALTT AVTSAFLLAK VILSKLFSQG 
       160        170        180        190        200
AFGYVLPIIS FILAWIETWF LDFKVLPQEA EEENRLLIVQ DASERAALIP 
       210        220        230 
GGLSDGQFYS PPESEAGSEE AEEKQDSEKP LLEL

Length:234

Mass (Da):26,655

Last modified:May 1, 1999 - v1

Checksum:ⁱAFB7DAE381983FB0

GO

Isoform 2 (identifier: O95772-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-7: Missing.

« Hide

        10         20         30         40         50
MENALTGSQS SHASLRNIHS INPTQLMARI ESYEGREKKG ISDVRRTFCL 
        60         70         80         90        100
FVTFDLLFVT LLWIIELNVN GGIENTLEKE VMQYDYYSSY FDIFLLAVFR 
       110        120        130        140        150
FKVLILAYAV CRLRHWWAIA LTTAVTSAFL LAKVILSKLF SQGAFGYVLP 
       160        170        180        190        200
IISFILAWIE TWFLDFKVLP QEAEEENRLL IVQDASERAA LIPGGLSDGQ 
       210        220 
FYSPPESEAG SEEAEEKQDS EKPLLEL

Show »

Length:227

Mass (Da):25,818

Checksum:ⁱ1313F76EC5C9CA91

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JKL2	C9JKL2_HUMAN	STARD3 N-terminal-like protein STARD3 N-terminal-like protein	STARD3NL	216	Annotation score:
C9JPX5	C9JPX5_HUMAN	STARD3 N-terminal-like protein STARD3 N-terminal-like protein	STARD3NL	206	Annotation score:
C9J3F5	C9J3F5_HUMAN	STARD3 N-terminal-like protein STARD3 N-terminal-like protein	STARD3NL	184	Annotation score:
C9JJ39	C9JJ39_HUMAN	STARD3 N-terminal-like protein STARD3 N-terminal-like protein	STARD3NL	172	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_018819	1 – 7	Missing in isoform 2. Curated		7

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ492267 mRNA Translation: CAD37353.1 AY358645 mRNA Translation: AAQ89008.1 AK315404 mRNA Translation: BAG37796.1 AC006033 Genomic DNA Translation: AAS07552.1 CH236951 Genomic DNA Translation: EAL23983.1 CH471073 Genomic DNA Translation: EAW94088.1 BC003074 mRNA Translation: AAH03074.1 BC005959 mRNA Translation: AAH05959.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5455.1 [O95772-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_114405.1, NM_032016.3 [O95772-1] XP_005249937.1, XM_005249880.1 [O95772-1] XP_011513874.1, XM_011515572.1 [O95772-1] XP_016868181.1, XM_017012692.1 [O95772-1] XP_016868182.1, XM_017012693.1 [O95772-1] XP_016868183.1, XM_017012694.1
UniGeneⁱ	Hs.309753 Hs.744885

Genome annotation databases

Ensemblⁱ	ENST00000009041; ENSP00000009041; ENSG00000010270 [O95772-1] ENST00000396013; ENSP00000379334; ENSG00000010270 [O95772-1]
GeneIDⁱ	83930
KEGGⁱ	hsa:83930
UCSC genome browser More...UCSCⁱ	uc003tfr.4 human [O95772-1]

Keywords - Coding sequence diversityⁱ

Alternative initiation

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O95772	STARD3 N-terminal like, isoform CRA_a		HUMAN		234	UniRef100_O95772
STARD3 N-terminal like		PANTR		234
MLN64 N-terminal domain homolog		MACMU		234
Uncharacterized protein		RHIBE		234
Uncharacterized protein		COLAP		234
+16

Protein	Similar proteins		Species	Score	Length	Source
O95772	STARD3 N-terminal-like protein		MOUSE		235	UniRef90_O95772
STARD3 N-terminal like, isoform CRA_a		HUMAN		234
STARD3 N-terminal like		PANTR		234
MLN64 N-terminal domain homolog		MACMU		234
Uncharacterized protein		RHIBE		234
+31

Protein	Similar proteins		Species	Score	Length	Source
O95772	STARD3 N-terminal-like protein		MOUSE		235	UniRef50_O95772
STARD3 N-terminal like, isoform CRA_a		HUMAN		234
STARD3 N-terminal like		PANTR		234
MLN64 N-terminal domain homolog		MACMU		234
Uncharacterized protein		RHIBE		234
+243

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ492267 mRNA Translation: CAD37353.1 AY358645 mRNA Translation: AAQ89008.1 AK315404 mRNA Translation: BAG37796.1 AC006033 Genomic DNA Translation: AAS07552.1 CH236951 Genomic DNA Translation: EAL23983.1 CH471073 Genomic DNA Translation: EAW94088.1 BC003074 mRNA Translation: AAH03074.1 BC005959 mRNA Translation: AAH05959.1
CCDSⁱ	CCDS5455.1 [O95772-1]
RefSeqⁱ	NP_114405.1, NM_032016.3 [O95772-1] XP_005249937.1, XM_005249880.1 [O95772-1] XP_011513874.1, XM_011515572.1 [O95772-1] XP_016868181.1, XM_017012692.1 [O95772-1] XP_016868182.1, XM_017012693.1 [O95772-1] XP_016868183.1, XM_017012694.1
UniGeneⁱ	Hs.309753 Hs.744885

3D structure databases

ProteinModelPortalⁱ	O95772
SMRⁱ	O95772
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	123815, 7 interactors
IntActⁱ	O95772, 5 interactors
STRINGⁱ	9606.ENSP00000009041

PTM databases

iPTMnetⁱ	O95772
PhosphoSitePlusⁱ	O95772
SwissPalmⁱ	O95772

Polymorphism and mutation databases

BioMutaⁱ	STARD3NL

BioMutaⁱ

STARD3NL

Proteomic databases

EPDⁱ	O95772
MaxQBⁱ	O95772
PaxDbⁱ	O95772
PeptideAtlasⁱ	O95772
PRIDEⁱ	O95772
ProteomicsDBⁱ	51038 51039 [O95772-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	83930
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000009041; ENSP00000009041; ENSG00000010270 [O95772-1] ENST00000396013; ENSP00000379334; ENSG00000010270 [O95772-1]
GeneIDⁱ	83930
KEGGⁱ	hsa:83930
UCSCⁱ	uc003tfr.4 human [O95772-1]

Organism-specific databases

CTDⁱ	83930
DisGeNETⁱ	83930
EuPathDBⁱ	HostDB:ENSG00000010270.13
GeneCardsⁱ	STARD3NL
HGNCⁱ	HGNC:19169 STARD3NL
HPAⁱ	HPA019204
MIMⁱ	611759 gene
neXtProtⁱ	NX_O95772
OpenTargetsⁱ	ENSG00000010270
PharmGKBⁱ	PA134990065
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IPP0 Eukaryota ENOG4110JA9 LUCA
GeneTreeⁱ	ENSGT00530000063139
HOGENOMⁱ	HOG000252985
HOVERGENⁱ	HBG052455
InParanoidⁱ	O95772
OMAⁱ	WWAIAFT
OrthoDBⁱ	EOG091G06RM
PhylomeDBⁱ	O95772
TreeFamⁱ	TF313869

Enzyme and pathway databases

Reactomeⁱ	R-HSA-196108 Pregnenolone biosynthesis

Reactomeⁱ

R-HSA-196108 Pregnenolone biosynthesis

Miscellaneous databases

ChiTaRSⁱ	STARD3NL human
GeneWikiⁱ	STARD3NL
GenomeRNAiⁱ	83930
Protein Ontology More...PROⁱ	PR:O95772
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000010270 Expressed in 194 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_STARD3NL
ExpressionAtlasⁱ	O95772 baseline and differential
Genevisibleⁱ	O95772 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR019498 MENTAL
Pfamⁱ	View protein in Pfam PF10457 MENTAL, 1 hit
PROSITEⁱ	View protein in PROSITE PS51439 MENTAL, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	STR3N_HUMAN
Accessionⁱ	O95772Primary (citable) accession number: O95772 Secondary accession number(s): A4D1X0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
	Last sequence update:	May 1, 1999
	Last modified:	October 10, 2018
	This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM
SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O95772 (STR3N_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

STARD3 N-terminal-like protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Cytosol

Endosome

Lysosome

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ