UniProtKB - O95772 (STR3N_HUMAN)
Protein
STARD3 N-terminal-like protein
Gene
STARD3NL
Organism
Homo sapiens (Human)
Status
Functioni
Tethering protein that creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263).1 Publication
GO - Molecular functioni
- cholesterol binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
GO - Biological processi
- C21-steroid hormone biosynthetic process Source: Reactome
- vesicle tethering to endoplasmic reticulum Source: UniProtKB
Enzyme and pathway databases
Reactomei | R-HSA-196108 Pregnenolone biosynthesis |
Names & Taxonomyi
Protein namesi | Recommended name: STARD3 N-terminal-like protein1 PublicationAlternative name(s): MLN64 N-terminal domain homolog |
Gene namesi | ORF Names:UNQ855/PRO1864 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000010270.13 |
HGNCi | HGNC:19169 STARD3NL |
MIMi | 611759 gene |
neXtProti | NX_O95772 |
Subcellular locationi
Endosome
- Late endosome membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Note: Localizes to contact sites between the endoplasmic reticulum and late endosomes: associates with the endoplasmic reticulum membrane via interaction with VAPA and VAPB.1 Publication
Cytosol
- cytosol Source: Reactome
Endosome
- late endosome membrane Source: UniProtKB
Lysosome
- lysosomal membrane Source: UniProtKB
Other locations
- endoplasmic reticulum-endosome membrane contact site Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
- intracellular membrane-bounded organelle Source: HPA
- membrane Source: UniProtKB
- organelle membrane contact site Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 53 | Cytoplasmic1 PublicationAdd BLAST | 53 | |
Transmembranei | 54 – 74 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 75 – 97 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 98 – 118 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 119 – 122 | CytoplasmicSequence analysis | 4 | |
Transmembranei | 123 – 143 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 144 – 150 | ExtracellularSequence analysis | 7 | |
Transmembranei | 151 – 171 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 172 – 234 | Cytoplasmic1 PublicationAdd BLAST | 63 |
Keywords - Cellular componenti
Endosome, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 83930 |
OpenTargetsi | ENSG00000010270 |
PharmGKBi | PA134990065 |
Polymorphism and mutation databases
BioMutai | STARD3NL |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000021666 | 1 – 234 | STARD3 N-terminal-like proteinAdd BLAST | 234 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 15 | PhosphoserineCombined sources | 1 | |
Modified residuei | 21 | PhosphoserineCombined sources | 1 | |
Modified residuei | 27 | PhosphoserineCombined sources | 1 | |
Modified residuei | 193 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | O95772 |
jPOSTi | O95772 |
MaxQBi | O95772 |
PaxDbi | O95772 |
PeptideAtlasi | O95772 |
PRIDEi | O95772 |
ProteomicsDBi | 51038 51039 [O95772-2] |
PTM databases
iPTMneti | O95772 |
PhosphoSitePlusi | O95772 |
SwissPalmi | O95772 |
Expressioni
Gene expression databases
Bgeei | ENSG00000010270 Expressed in 194 organ(s), highest expression level in secondary oocyte |
ExpressionAtlasi | O95772 baseline and differential |
Genevisiblei | O95772 HS |
Organism-specific databases
HPAi | HPA019204 |
Interactioni
Subunit structurei
Homodimer (PubMed:16709157). Interacts (via the MENTAL domain) with STARD3NL (PubMed:16709157). Interacts (via FFAT motif) with VAPA. Interacts (via FFAT motif) with VAPB (PubMed:24105263).2 Publications
GO - Molecular functioni
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGridi | 123815, 7 interactors |
IntActi | O95772, 6 interactors |
MINTi | O95772 |
STRINGi | 9606.ENSP00000009041 |
Structurei
3D structure databases
ProteinModelPortali | O95772 |
SMRi | O95772 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 48 – 218 | MENTALPROSITE-ProRule annotationAdd BLAST | 171 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 208 – 213 | FFAT1 Publication | 6 |
Domaini
The FFAT motif mediates interaction with VAPA and VAPB.By similarity
The MENTAL domain anchors the protein in endosome membranes and exposes the START domain in the cytosol (By similarity). It binds cholesterol and mediates homotypic as well as heterotypic interactions between STARD3 and STARD3NL (PubMed:15718238, PubMed:16709157).By similarity2 Publications
Sequence similaritiesi
Belongs to the STARD3 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IPP0 Eukaryota ENOG4110JA9 LUCA |
GeneTreei | ENSGT00940000155476 |
HOGENOMi | HOG000252985 |
HOVERGENi | HBG052455 |
InParanoidi | O95772 |
OMAi | WWAIAFT |
OrthoDBi | 1437203at2759 |
PhylomeDBi | O95772 |
TreeFami | TF313869 |
Family and domain databases
InterProi | View protein in InterPro IPR019498 MENTAL |
Pfami | View protein in Pfam PF10457 MENTAL, 1 hit |
PROSITEi | View protein in PROSITE PS51439 MENTAL, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative initiation. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O95772-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MNHLPEDMEN ALTGSQSSHA SLRNIHSINP TQLMARIESY EGREKKGISD
60 70 80 90 100
VRRTFCLFVT FDLLFVTLLW IIELNVNGGI ENTLEKEVMQ YDYYSSYFDI
110 120 130 140 150
FLLAVFRFKV LILAYAVCRL RHWWAIALTT AVTSAFLLAK VILSKLFSQG
160 170 180 190 200
AFGYVLPIIS FILAWIETWF LDFKVLPQEA EEENRLLIVQ DASERAALIP
210 220 230
GGLSDGQFYS PPESEAGSEE AEEKQDSEKP LLEL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JKL2 | C9JKL2_HUMAN | STARD3 N-terminal-like protein | STARD3NL | 216 | Annotation score: | ||
C9JPX5 | C9JPX5_HUMAN | STARD3 N-terminal-like protein | STARD3NL | 206 | Annotation score: | ||
C9J3F5 | C9J3F5_HUMAN | STARD3 N-terminal-like protein | STARD3NL | 184 | Annotation score: | ||
C9JJ39 | C9JJ39_HUMAN | STARD3 N-terminal-like protein | STARD3NL | 172 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_018819 | 1 – 7 | Missing in isoform 2. Curated | 7 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ492267 mRNA Translation: CAD37353.1 AY358645 mRNA Translation: AAQ89008.1 AK315404 mRNA Translation: BAG37796.1 AC006033 Genomic DNA Translation: AAS07552.1 CH236951 Genomic DNA Translation: EAL23983.1 CH471073 Genomic DNA Translation: EAW94088.1 BC003074 mRNA Translation: AAH03074.1 BC005959 mRNA Translation: AAH05959.1 |
CCDSi | CCDS5455.1 [O95772-1] |
RefSeqi | NP_114405.1, NM_032016.3 [O95772-1] XP_005249937.1, XM_005249880.1 XP_011513874.1, XM_011515572.1 [O95772-1] XP_016868181.1, XM_017012692.1 XP_016868182.1, XM_017012693.1 [O95772-1] XP_016868183.1, XM_017012694.1 |
UniGenei | Hs.309753 Hs.744885 |
Genome annotation databases
Ensembli | ENST00000009041; ENSP00000009041; ENSG00000010270 [O95772-1] ENST00000396013; ENSP00000379334; ENSG00000010270 [O95772-1] |
GeneIDi | 83930 |
KEGGi | hsa:83930 |
UCSCi | uc003tfr.4 human [O95772-1] |
Keywords - Coding sequence diversityi
Alternative initiationSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ492267 mRNA Translation: CAD37353.1 AY358645 mRNA Translation: AAQ89008.1 AK315404 mRNA Translation: BAG37796.1 AC006033 Genomic DNA Translation: AAS07552.1 CH236951 Genomic DNA Translation: EAL23983.1 CH471073 Genomic DNA Translation: EAW94088.1 BC003074 mRNA Translation: AAH03074.1 BC005959 mRNA Translation: AAH05959.1 |
CCDSi | CCDS5455.1 [O95772-1] |
RefSeqi | NP_114405.1, NM_032016.3 [O95772-1] XP_005249937.1, XM_005249880.1 XP_011513874.1, XM_011515572.1 [O95772-1] XP_016868181.1, XM_017012692.1 XP_016868182.1, XM_017012693.1 [O95772-1] XP_016868183.1, XM_017012694.1 |
UniGenei | Hs.309753 Hs.744885 |
3D structure databases
ProteinModelPortali | O95772 |
SMRi | O95772 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 123815, 7 interactors |
IntActi | O95772, 6 interactors |
MINTi | O95772 |
STRINGi | 9606.ENSP00000009041 |
PTM databases
iPTMneti | O95772 |
PhosphoSitePlusi | O95772 |
SwissPalmi | O95772 |
Polymorphism and mutation databases
BioMutai | STARD3NL |
Proteomic databases
EPDi | O95772 |
jPOSTi | O95772 |
MaxQBi | O95772 |
PaxDbi | O95772 |
PeptideAtlasi | O95772 |
PRIDEi | O95772 |
ProteomicsDBi | 51038 51039 [O95772-2] |
Protocols and materials databases
DNASUi | 83930 |
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000009041; ENSP00000009041; ENSG00000010270 [O95772-1] ENST00000396013; ENSP00000379334; ENSG00000010270 [O95772-1] |
GeneIDi | 83930 |
KEGGi | hsa:83930 |
UCSCi | uc003tfr.4 human [O95772-1] |
Organism-specific databases
CTDi | 83930 |
DisGeNETi | 83930 |
EuPathDBi | HostDB:ENSG00000010270.13 |
GeneCardsi | STARD3NL |
HGNCi | HGNC:19169 STARD3NL |
HPAi | HPA019204 |
MIMi | 611759 gene |
neXtProti | NX_O95772 |
OpenTargetsi | ENSG00000010270 |
PharmGKBi | PA134990065 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410IPP0 Eukaryota ENOG4110JA9 LUCA |
GeneTreei | ENSGT00940000155476 |
HOGENOMi | HOG000252985 |
HOVERGENi | HBG052455 |
InParanoidi | O95772 |
OMAi | WWAIAFT |
OrthoDBi | 1437203at2759 |
PhylomeDBi | O95772 |
TreeFami | TF313869 |
Enzyme and pathway databases
Reactomei | R-HSA-196108 Pregnenolone biosynthesis |
Miscellaneous databases
ChiTaRSi | STARD3NL human |
GeneWikii | STARD3NL |
GenomeRNAii | 83930 |
PROi | PR:O95772 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000010270 Expressed in 194 organ(s), highest expression level in secondary oocyte |
ExpressionAtlasi | O95772 baseline and differential |
Genevisiblei | O95772 HS |
Family and domain databases
InterProi | View protein in InterPro IPR019498 MENTAL |
Pfami | View protein in Pfam PF10457 MENTAL, 1 hit |
PROSITEi | View protein in PROSITE PS51439 MENTAL, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | STR3N_HUMAN | |
Accessioni | O95772Primary (citable) accession number: O95772 Secondary accession number(s): A4D1X0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 15, 2002 |
Last sequence update: | May 1, 1999 | |
Last modified: | February 13, 2019 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot