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UniProtKB - O95760 (IL33_HUMAN)

Entry version 158 (23 Feb 2022)
Sequence version 1 (01 May 1999)
Previous versions | rss
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Protein

Interleukin-33

Gene

IL33

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016).

Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528).

3 Publications

In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (PubMed:21734074).

This form is rapidely lost upon angiogenic or proinflammatory activation (PubMed:18787100).

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine
Biological processTranscription

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O95760

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1257604, PIP3 activates AKT signaling
R-HSA-5689880, Ub-specific processing proteases
R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-9014843, Interleukin-33 signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O95760

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-33
Short name:
IL-33
Alternative name(s):
Interleukin-1 family member 11
Short name:
IL-1F11
Nuclear factor from high endothelial venules
Short name:
NF-HEV
Cleaved into the following 3 chains:
Interleukin-33 (95-270)
Interleukin-33 (99-270)
Interleukin-33 (109-270)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IL33Imported
Synonyms:C9orf26, IL1F11, NFHEV
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:16028, IL33

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608678, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O95760

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000137033

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Cytoplasm, Cytoplasmic vesicle, Nucleus, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi144E → K: Decreases affinity for IL1RL1. 1 Publication1
Mutagenesisi148E → K: 7-fold decrease in affinity for IL1RL1. 1 Publication1
Mutagenesisi149D → K: Almost abolishes binding to IL1RL1. 1 Publication1
Mutagenesisi165E → K: 8-fold decrease in affinity for IL1RL1. 1 Publication1
Mutagenesisi244D → K: Decreases affinity for IL1RL1. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		90865

Open Targets

More...OpenTargetsi		ENSG00000137033

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162392005

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O95760, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4630890

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		IL33

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000967901 – 270Interleukin-33Add BLAST270
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00004300831 – 941 PublicationAdd BLAST94
ChainiPRO_000043008495 – 270Interleukin-33 (95-270)Add BLAST176
ChainiPRO_000043008599 – 270Interleukin-33 (99-270)Add BLAST172
ChainiPRO_0000430086109 – 270Interleukin-33 (109-270)Add BLAST162

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The full-length protein can be released from cells and is able to signal via the IL1RL1/ST2 receptor. However, proteolytic processing by CSTG/cathepsin G and ELANE/neutrophil elastase produces C-terminal peptides that are more active than the unprocessed full length protein. May also be proteolytically processed by calpains (PubMed:19596270). Proteolytic cleavage mediated by apoptotic caspases including CASP3 and CASP7 results in IL33 inactivation (PubMed:19559631). In vitro proteolytic cleavage by CASP1 was reported (PubMed:16286016) but could not be confirmed in vivo (PubMed:19465481) suggesting that IL33 is probably not a direct substrate for that caspase.6 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei94 – 95Cleavage; by CTSG1 Publication2
Sitei98 – 99Cleavage; by ELANE1 Publication2
Sitei108 – 109Cleavage; by CTSG1 Publication2

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O95760

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O95760

PeptideAtlas

More...PeptideAtlasi		O95760

PRoteomics IDEntifications database

More...PRIDEi		O95760

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		4342
51036 [O95760-1]
51037 [O95760-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O95760

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O95760

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By infection with the parasite H.polygyrus.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000137033, Expressed in left coronary artery and 204 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O95760, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000137033, Tissue enhanced (urinary)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a 1:1:1 heterotrimeric complex with its primary high-affinity receptor IL1RL1 and the coreceptor IL1RAP.

Interacts with cargo receptor TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion (PubMed:32272059).

3 Publications

(Microbial infection) Interacts (in reduced form) with H.polygyrus ARI.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		124776, 8 interactors

Database of interacting proteins

More...DIPi		DIP-37862N

Protein interaction database and analysis system

More...IntActi		O95760, 6 interactors

Molecular INTeraction database

More...MINTi		O95760

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000370842

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O95760, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1270
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		O95760

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O95760

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O95760

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 65Homeodomain-like HTH domainAdd BLAST65
Regioni66 – 111Interaction with RELABy similarityAdd BLAST46

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The homeodomain-like HTH domain mediates nuclear localization and heterochromatin association.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IL-1 family. Highly divergent.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RW83, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000005185

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_1795771_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O95760

Identification of Orthologs from Complete Genome Data

More...OMAi		HRKSSKC

Database of Orthologous Groups

More...OrthoDBi		1062809at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O95760

TreeFam database of animal gene trees

More...TreeFami		TF338120

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026145, IL-33

The PANTHER Classification System

More...PANTHERi		PTHR21114, PTHR21114, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15095, IL33, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O95760-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKPKMKYSTN KISTAKWKNT ASKALCFKLG KSQQKAKEVC PMYFMKLRSG 
        60         70         80         90        100
LMIKKEACYF RRETTKRPSL KTGRKHKRHL VLAACQQQST VECFAFGISG 
       110        120        130        140        150
VQKYTRALHD SSITGISPIT EYLASLSTYN DQSITFALED ESYEIYVEDL 
       160        170        180        190        200
KKDEKKDKVL LSYYESQHPS NESGDGVDGK MLMVTLSPTK DFWLHANNKE 
       210        220        230        240        250
HSVELHKCEK PLPDQAFFVL HNMHSNCVSF ECKTDPGVFI GVKDNHLALI 
       260        270
KVDSSENLCT ENILFKLSET
Length:270
Mass (Da):30,759
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7C158069196EF636
GO
Isoform 2 (identifier: O95760-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     115-156: Missing.

Show »
Length:228
Mass (Da):25,930
Checksum:iD48B2E3078CFA6C8
GO
Isoform 3 (identifier: O95760-3) [UniParc]FASTAAdd to basket
Also known as: spIL-33

The sequence of this isoform differs from the canonical sequence as follows:
     72-113: Missing.

Note: Constitutively active.Curated
Show »
Length:228
Mass (Da):26,104
Checksum:iA982BD564D8FEC0E
GO
Isoform 4 (identifier: O95760-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-157: KSQQKAKEVC...EDLKKDEKKD → N

Show »
Length:144
Mass (Da):16,250
Checksum:i1B73431981DFFF46
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti139E → G in BAG36208 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049576263I → M. Corresponds to variant dbSNP:rs16924241EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04544031 – 157KSQQK…DEKKD → N in isoform 4. 1 PublicationAdd BLAST127
Alternative sequenceiVSP_04494872 – 113Missing in isoform 3. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_042728115 – 156Missing in isoform 2. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB024518 mRNA Translation: BAA75892.1
AY905581 mRNA Translation: AAX86998.1
HQ641439 mRNA Translation: ADR77828.1
AK295908 mRNA Translation: BAG58697.1
AK303943 mRNA Translation: BAG64871.1
AK313414 mRNA Translation: BAG36208.1
CR407619 mRNA Translation: CAG28547.1
AL353741 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58748.1
CH471071 Genomic DNA Translation: EAW58750.1
CH471071 Genomic DNA Translation: EAW58751.1
BC047085 mRNA Translation: AAH47085.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS56563.1 [O95760-2]
CCDS56564.1 [O95760-4]
CCDS6468.1 [O95760-1]
CCDS83341.1 [O95760-3]

NCBI Reference Sequences

More...RefSeqi		NP_001186569.1, NM_001199640.1 [O95760-2]
NP_001186570.1, NM_001199641.1 [O95760-4]
NP_001300973.1, NM_001314044.1 [O95760-1]
NP_001300974.1, NM_001314045.1 [O95760-1]
NP_001300975.1, NM_001314046.1
NP_001300976.1, NM_001314047.1
NP_001300977.1, NM_001314048.1 [O95760-3]
NP_254274.1, NM_033439.3 [O95760-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000381434; ENSP00000370842; ENSG00000137033
ENST00000417746; ENSP00000394039; ENSG00000137033 [O95760-4]
ENST00000456383; ENSP00000414238; ENSG00000137033 [O95760-2]
ENST00000611532; ENSP00000478858; ENSG00000137033 [O95760-3]
ENST00000682010; ENSP00000507310; ENSG00000137033

Database of genes from NCBI RefSeq genomes

More...GeneIDi		90865

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:90865

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000682010.1; ENSP00000507310.1; NM_033439.4; NP_254274.1

UCSC genome browser

More...UCSCi		uc011lmh.3, human [O95760-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024518 mRNA Translation: BAA75892.1
AY905581 mRNA Translation: AAX86998.1
HQ641439 mRNA Translation: ADR77828.1
AK295908 mRNA Translation: BAG58697.1
AK303943 mRNA Translation: BAG64871.1
AK313414 mRNA Translation: BAG36208.1
CR407619 mRNA Translation: CAG28547.1
AL353741 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58748.1
CH471071 Genomic DNA Translation: EAW58750.1
CH471071 Genomic DNA Translation: EAW58751.1
BC047085 mRNA Translation: AAH47085.1
CCDSiCCDS56563.1 [O95760-2]
CCDS56564.1 [O95760-4]
CCDS6468.1 [O95760-1]
CCDS83341.1 [O95760-3]
RefSeqiNP_001186569.1, NM_001199640.1 [O95760-2]
NP_001186570.1, NM_001199641.1 [O95760-4]
NP_001300973.1, NM_001314044.1 [O95760-1]
NP_001300974.1, NM_001314045.1 [O95760-1]
NP_001300975.1, NM_001314046.1
NP_001300976.1, NM_001314047.1
NP_001300977.1, NM_001314048.1 [O95760-3]
NP_254274.1, NM_033439.3 [O95760-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KLLNMR-A111-270[»]
4KC3X-ray3.27A112-270[»]
BMRBiO95760
SMRiO95760
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi124776, 8 interactors
DIPiDIP-37862N
IntActiO95760, 6 interactors
MINTiO95760
STRINGi9606.ENSP00000370842

Chemistry databases

ChEMBLiCHEMBL4630890

PTM databases

iPTMnetiO95760
PhosphoSitePlusiO95760

Genetic variation databases

BioMutaiIL33

Proteomic databases

MassIVEiO95760
PaxDbiO95760
PeptideAtlasiO95760
PRIDEiO95760
ProteomicsDBi4342
51036 [O95760-1]
51037 [O95760-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		O95760, 7 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3362, 1385 antibodies from 44 providers

The DNASU plasmid repository

More...DNASUi		90865

Genome annotation databases

EnsembliENST00000381434; ENSP00000370842; ENSG00000137033
ENST00000417746; ENSP00000394039; ENSG00000137033 [O95760-4]
ENST00000456383; ENSP00000414238; ENSG00000137033 [O95760-2]
ENST00000611532; ENSP00000478858; ENSG00000137033 [O95760-3]
ENST00000682010; ENSP00000507310; ENSG00000137033
GeneIDi90865
KEGGihsa:90865
MANE-SelectiENST00000682010.1; ENSP00000507310.1; NM_033439.4; NP_254274.1
UCSCiuc011lmh.3, human [O95760-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		90865
DisGeNETi90865

GeneCards: human genes, protein and diseases

More...GeneCardsi		IL33
HGNCiHGNC:16028, IL33
HPAiENSG00000137033, Tissue enhanced (urinary)
MIMi608678, gene
neXtProtiNX_O95760
OpenTargetsiENSG00000137033
PharmGKBiPA162392005
VEuPathDBiHostDB:ENSG00000137033

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RW83, Eukaryota
GeneTreeiENSGT00390000005185
HOGENOMiCLU_1795771_0_0_1
InParanoidiO95760
OMAiHRKSSKC
OrthoDBi1062809at2759
PhylomeDBiO95760
TreeFamiTF338120

Enzyme and pathway databases

PathwayCommonsiO95760
ReactomeiR-HSA-1257604, PIP3 activates AKT signaling
R-HSA-5689880, Ub-specific processing proteases
R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-9014843, Interleukin-33 signaling
SignaLinkiO95760

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		90865, 4 hits in 1033 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		IL33, human
EvolutionaryTraceiO95760

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		90865
PharosiO95760, Tbio

Protein Ontology

More...PROi		PR:O95760
RNActiO95760, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000137033, Expressed in left coronary artery and 204 other tissues
GenevisibleiO95760, HS

Family and domain databases

InterProiView protein in InterPro
IPR026145, IL-33
PANTHERiPTHR21114, PTHR21114, 1 hit
PfamiView protein in Pfam
PF15095, IL33, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIL33_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95760
Secondary accession number(s): B2R8L1
, B4DJ35, B4E1Q9, D3DRI5, E7EAX4, Q2YEJ5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: May 1, 1999
Last modified: February 23, 2022
This is version 158 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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