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Protein

Interleukin-33

Gene

IL33

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528).3 Publications
In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (PubMed:21734074). This form is rapidely lost upon angiogenic or proinflammatory activation (PubMed:18787100).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cytokine activity Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine
Biological processTranscription

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-5689880 Ub-specific processing proteases
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-9014843 Interleukin-33 signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-33
Short name:
IL-33
Alternative name(s):
Interleukin-1 family member 11
Short name:
IL-1F11
Nuclear factor from high endothelial venules
Short name:
NF-HEV
Cleaved into the following 3 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IL33
Synonyms:C9orf26, IL1F11, NFHEV
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000137033.11

Human Gene Nomenclature Database

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HGNCi
HGNC:16028 IL33

Online Mendelian Inheritance in Man (OMIM)

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MIMi
608678 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95760

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasmic vesicle, Nucleus, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi144E → K: Decreases affinity for IL1RL1. 1 Publication1
Mutagenesisi148E → K: 7-fold decrease in affinity for IL1RL1. 1 Publication1
Mutagenesisi149D → K: Almost abolishes binding to IL1RL1. 1 Publication1
Mutagenesisi165E → K: 8-fold decrease in affinity for IL1RL1. 1 Publication1
Mutagenesisi244D → K: Decreases affinity for IL1RL1. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
90865

Open Targets

More...
OpenTargetsi
ENSG00000137033

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162392005

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IL33

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000967901 – 270Interleukin-33Add BLAST270
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00004300831 – 941 PublicationAdd BLAST94
ChainiPRO_000043008495 – 270Interleukin-33 (95-270)Add BLAST176
ChainiPRO_000043008599 – 270Interleukin-33 (99-270)Add BLAST172
ChainiPRO_0000430086109 – 270Interleukin-33 (109-270)Add BLAST162

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The full-length protein can be released from cells and is able to signal via the IL1RL1/ST2 receptor. However, proteolytic processing by CSTG/cathepsin G and ELANE/neutrophil elastase produces C-terminal peptides that are more active than the unprocessed full length protein. May also be proteolytically processed by calpains (PubMed:19596270). Proteolytic cleavage mediated by apoptotic caspases including CASP3 and CASP7 results in IL33 inactivation (PubMed:19559631). In vitro proteolytic cleavage by CASP1 was reported (PubMed:16286016) but could not be confirmed in vivo (PubMed:19465481) suggesting that IL33 is probably not a direct substrate for that caspase.6 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei94 – 95Cleavage; by CTSG1 Publication2
Sitei98 – 99Cleavage; by ELANE1 Publication2
Sitei108 – 109Cleavage; by CTSG1 Publication2

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O95760

PeptideAtlas

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PeptideAtlasi
O95760

PRoteomics IDEntifications database

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PRIDEi
O95760

ProteomicsDB human proteome resource

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ProteomicsDBi
51036
51037 [O95760-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O95760

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O95760

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000137033 Expressed in 193 organ(s), highest expression level in left coronary artery

CleanEx database of gene expression profiles

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CleanExi
HS_IL33

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O95760 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB007057
HPA024426

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a 1:1:1 heterotrimeric complex with its primary high-affinity receptor IL1RL1 and the coreceptor IL1RAP.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
124776, 7 interactors

Database of interacting proteins

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DIPi
DIP-37862N

Protein interaction database and analysis system

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IntActi
O95760, 6 interactors

Molecular INTeraction database

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MINTi
O95760

STRING: functional protein association networks

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STRINGi
9606.ENSP00000370842

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1270
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KLLNMR-A111-270[»]
4KC3X-ray3.27A112-270[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O95760

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O95760

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O95760

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 65Homeodomain-like HTH domainAdd BLAST65
Regioni66 – 111Interaction with RELABy similarityAdd BLAST46

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The homeodomain-like HTH domain mediates nuclear localization and heterochromatin association.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IL-1 family. Highly divergent.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410J11H Eukaryota
ENOG41118MB LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000005185

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000070215

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG081791

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O95760

KEGG Orthology (KO)

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KOi
K12967

Identification of Orthologs from Complete Genome Data

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OMAi
KCVSFEC

Database of Orthologous Groups

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OrthoDBi
1062809at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O95760

TreeFam database of animal gene trees

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TreeFami
TF338120

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR026145 IL-33

The PANTHER Classification System

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PANTHERi
PTHR21114 PTHR21114, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF15095 IL33, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O95760-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKPKMKYSTN KISTAKWKNT ASKALCFKLG KSQQKAKEVC PMYFMKLRSG
60 70 80 90 100
LMIKKEACYF RRETTKRPSL KTGRKHKRHL VLAACQQQST VECFAFGISG
110 120 130 140 150
VQKYTRALHD SSITGISPIT EYLASLSTYN DQSITFALED ESYEIYVEDL
160 170 180 190 200
KKDEKKDKVL LSYYESQHPS NESGDGVDGK MLMVTLSPTK DFWLHANNKE
210 220 230 240 250
HSVELHKCEK PLPDQAFFVL HNMHSNCVSF ECKTDPGVFI GVKDNHLALI
260 270
KVDSSENLCT ENILFKLSET
Length:270
Mass (Da):30,759
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7C158069196EF636
GO
Isoform 2 (identifier: O95760-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     115-156: Missing.

Note: No experimental confirmation available.
Show »
Length:228
Mass (Da):25,930
Checksum:iD48B2E3078CFA6C8
GO
Isoform 3 (identifier: O95760-3) [UniParc]FASTAAdd to basket
Also known as: spIL-33

The sequence of this isoform differs from the canonical sequence as follows:
     72-113: Missing.

Note: Constitutively active.
Show »
Length:228
Mass (Da):26,104
Checksum:iA982BD564D8FEC0E
GO
Isoform 4 (identifier: O95760-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-157: KSQQKAKEVC...EDLKKDEKKD → N

Show »
Length:144
Mass (Da):16,250
Checksum:i1B73431981DFFF46
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti139E → G in BAG36208 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049576263I → M. Corresponds to variant dbSNP:rs16924241Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04544031 – 157KSQQK…DEKKD → N in isoform 4. 1 PublicationAdd BLAST127
Alternative sequenceiVSP_04494872 – 113Missing in isoform 3. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_042728115 – 156Missing in isoform 2. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB024518 mRNA Translation: BAA75892.1
AY905581 mRNA Translation: AAX86998.1
HQ641439 mRNA Translation: ADR77828.1
AK295908 mRNA Translation: BAG58697.1
AK303943 mRNA Translation: BAG64871.1
AK313414 mRNA Translation: BAG36208.1
CR407619 mRNA Translation: CAG28547.1
AL353741 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58748.1
CH471071 Genomic DNA Translation: EAW58750.1
CH471071 Genomic DNA Translation: EAW58751.1
BC047085 mRNA Translation: AAH47085.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS56563.1 [O95760-2]
CCDS56564.1 [O95760-4]
CCDS6468.1 [O95760-1]
CCDS83341.1 [O95760-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001186569.1, NM_001199640.1 [O95760-2]
NP_001186570.1, NM_001199641.1 [O95760-4]
NP_001300973.1, NM_001314044.1 [O95760-1]
NP_001300974.1, NM_001314045.1 [O95760-1]
NP_001300975.1, NM_001314046.1
NP_001300976.1, NM_001314047.1
NP_001300977.1, NM_001314048.1 [O95760-3]
NP_254274.1, NM_033439.3 [O95760-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.731660

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000381434; ENSP00000370842; ENSG00000137033 [O95760-1]
ENST00000417746; ENSP00000394039; ENSG00000137033 [O95760-4]
ENST00000456383; ENSP00000414238; ENSG00000137033 [O95760-2]
ENST00000611532; ENSP00000478858; ENSG00000137033 [O95760-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
90865

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:90865

UCSC genome browser

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UCSCi
uc011lmh.3 human [O95760-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024518 mRNA Translation: BAA75892.1
AY905581 mRNA Translation: AAX86998.1
HQ641439 mRNA Translation: ADR77828.1
AK295908 mRNA Translation: BAG58697.1
AK303943 mRNA Translation: BAG64871.1
AK313414 mRNA Translation: BAG36208.1
CR407619 mRNA Translation: CAG28547.1
AL353741 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58748.1
CH471071 Genomic DNA Translation: EAW58750.1
CH471071 Genomic DNA Translation: EAW58751.1
BC047085 mRNA Translation: AAH47085.1
CCDSiCCDS56563.1 [O95760-2]
CCDS56564.1 [O95760-4]
CCDS6468.1 [O95760-1]
CCDS83341.1 [O95760-3]
RefSeqiNP_001186569.1, NM_001199640.1 [O95760-2]
NP_001186570.1, NM_001199641.1 [O95760-4]
NP_001300973.1, NM_001314044.1 [O95760-1]
NP_001300974.1, NM_001314045.1 [O95760-1]
NP_001300975.1, NM_001314046.1
NP_001300976.1, NM_001314047.1
NP_001300977.1, NM_001314048.1 [O95760-3]
NP_254274.1, NM_033439.3 [O95760-1]
UniGeneiHs.731660

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KLLNMR-A111-270[»]
4KC3X-ray3.27A112-270[»]
ProteinModelPortaliO95760
SMRiO95760
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124776, 7 interactors
DIPiDIP-37862N
IntActiO95760, 6 interactors
MINTiO95760
STRINGi9606.ENSP00000370842

PTM databases

iPTMnetiO95760
PhosphoSitePlusiO95760

Polymorphism and mutation databases

BioMutaiIL33

Proteomic databases

PaxDbiO95760
PeptideAtlasiO95760
PRIDEiO95760
ProteomicsDBi51036
51037 [O95760-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381434; ENSP00000370842; ENSG00000137033 [O95760-1]
ENST00000417746; ENSP00000394039; ENSG00000137033 [O95760-4]
ENST00000456383; ENSP00000414238; ENSG00000137033 [O95760-2]
ENST00000611532; ENSP00000478858; ENSG00000137033 [O95760-3]
GeneIDi90865
KEGGihsa:90865
UCSCiuc011lmh.3 human [O95760-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
90865
DisGeNETi90865
EuPathDBiHostDB:ENSG00000137033.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IL33
HGNCiHGNC:16028 IL33
HPAiCAB007057
HPA024426
MIMi608678 gene
neXtProtiNX_O95760
OpenTargetsiENSG00000137033
PharmGKBiPA162392005

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J11H Eukaryota
ENOG41118MB LUCA
GeneTreeiENSGT00390000005185
HOGENOMiHOG000070215
HOVERGENiHBG081791
InParanoidiO95760
KOiK12967
OMAiKCVSFEC
OrthoDBi1062809at2759
PhylomeDBiO95760
TreeFamiTF338120

Enzyme and pathway databases

ReactomeiR-HSA-1257604 PIP3 activates AKT signaling
R-HSA-5689880 Ub-specific processing proteases
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-9014843 Interleukin-33 signaling

Miscellaneous databases

EvolutionaryTraceiO95760

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
90865

Protein Ontology

More...
PROi
PR:O95760

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000137033 Expressed in 193 organ(s), highest expression level in left coronary artery
CleanExiHS_IL33
GenevisibleiO95760 HS

Family and domain databases

InterProiView protein in InterPro
IPR026145 IL-33
PANTHERiPTHR21114 PTHR21114, 1 hit
PfamiView protein in Pfam
PF15095 IL33, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIL33_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95760
Secondary accession number(s): B2R8L1
, B4DJ35, B4E1Q9, D3DRI5, E7EAX4, Q2YEJ5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: May 1, 1999
Last modified: January 16, 2019
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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