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Protein

TBC1 domain family member 8

Gene

TBC1D8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as a GTPase-activating protein for Rab family protein(s).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei552Arginine fingerBy similarity1
Sitei591Glutamine fingerBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTPase activator activity Source: GO_Central
  • Rab GTPase binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TBC1 domain family member 8
Alternative name(s):
AD 3
Vascular Rab-GAP/TBC-containing protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TBC1D8
Synonyms:VRP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000204634.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17791 TBC1D8

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95759

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
11138

Open Targets

More...
OpenTargetsi
ENSG00000204634

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134885935

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TBC1D8

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002080331 – 1140TBC1 domain family member 8Add BLAST1140

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O95759

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O95759

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O95759

PeptideAtlas

More...
PeptideAtlasi
O95759

PRoteomics IDEntifications database

More...
PRIDEi
O95759

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51034
51035 [O95759-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O95759

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O95759

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000204634 Expressed in 228 organ(s), highest expression level in adenohypophysis

CleanEx database of gene expression profiles

More...
CleanExi
HS_TBC1D8

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O95759 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O95759 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB015211
HPA037496

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116311, 4 interactors

Protein interaction database and analysis system

More...
IntActi
O95759, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000366036

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O95759

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O95759

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini145 – 212GRAM 1Add BLAST68
Domaini285 – 353GRAM 2Add BLAST69
Domaini505 – 692Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST188

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4347 Eukaryota
COG5210 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158977

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000276905

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG054142

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O95759

KEGG Orthology (KO)

More...
KOi
K19951

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O95759

TreeFam database of animal gene trees

More...
TreeFami
TF313145

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13349 PH-GRAM1_TBC1D8, 1 hit
cd13353 PH-GRAM2_TBC1D8, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992 EF-hand-dom_pair
IPR004182 GRAM
IPR011993 PH-like_dom_sf
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
IPR036009 TBC1D8_PH-GRAM1
IPR036016 TBC1D8_PH-GRAM2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02893 GRAM, 2 hits
PF00566 RabGAP-TBC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00568 GRAM, 2 hits
SM00164 TBC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 1 hit
SSF47923 SSF47923, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50086 TBC_RABGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O95759-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWLKPEEVLL KNALKLWVTQ KSSCYFILQR RRGHGEGGGR LTGRLVGALD
60 70 80 90 100
AVLDSNARVA PFRILLQVPG SQVYSPIACG ATLEEINQHW DWLEQNLLHT
110 120 130 140 150
LSVFDNKDDI ASFVKGKVKA LIAEETSSRL AEQEEEPEKF REALVKFEAR
160 170 180 190 200
FNFPEAEKLV TYYSCCCWKG RVPRQGWLYL SINHLCFYSF FLGKELKLVV
210 220 230 240 250
PWVDIQKLER TSNVFLTDTI RITTQNKERD FSMFLNLDEV FKVMEQLADV
260 270 280 290 300
TLRRLLDNEV FDLDPDLQEP SQITKRDLEA RAQNEFFRAF FRLPRKEKLH
310 320 330 340 350
AVVDCSLWTP FSRCHTTGRM FASDSYICFA SREDGCCKII LPLREVVSIE
360 370 380 390 400
KMEDTSLLPH PIIVSIRSKV AFQFIELRDR DSLVEALLAR LKQVHANHPV
410 420 430 440 450
HYDTSADDDM ASLVFHSTSM CSDHRFGDLE MMSSQNSEES EKEKSPLMHP
460 470 480 490 500
DALVTAFQQS GSQSPDSRMS REQIKISLWN DHFVEYGRTV CMFRTEKIRK
510 520 530 540 550
LVAMGIPESL RGRLWLLFSD AVTDLASHPG YYGNLVEESL GKCCLVTEEI
560 570 580 590 600
ERDLHRSLPE HPAFQNETGI AALRRVLTAY AHRNPKIGYC QSMNILTSVL
610 620 630 640 650
LLYTKEEEAF WLLVAVCERM LPDYFNHRVI GAQVDQSVFE ELIKGHLPEL
660 670 680 690 700
AEHMNDLSAL ASVSLSWFLT LFLSIMPLES AVNVVDCFFY DGIKAIFQLG
710 720 730 740 750
LAVLEANAED LCSSKDDGQA LMILSRFLDH IKNEDSPGPP VGSHHAFFSD
760 770 780 790 800
DQEPYPVTDI SDLIRDSYEK FGDQSVEQIE HLRYKHRIRV LQGHEDTTKQ
810 820 830 840 850
NVLRVVIPEV SILPEDLEEL YDLFKREHMM SCYWEQPRPM ASRHDPSRPY
860 870 880 890 900
AEQYRIDARQ FAHLFQLVSP WTCGAHTEIL AERTFRLLDD NMDQLIEFKA
910 920 930 940 950
FVSCLDIMYN GEMNEKIKLL YRLHIPPALT ENDRDSQSPL RNPLLSTSRP
960 970 980 990 1000
LVFGKPNGDA VDYQKQLKQM IKDLAKEKDK TEKELPKMSQ REFIQFCKTL
1010 1020 1030 1040 1050
YSMFHEDPEE NDLYQAIATV TTLLLQIGEV GQRGSSSGSC SQECGEELRA
1060 1070 1080 1090 1100
SAPSPEDSVF ADTGKTPQDS QAFPEAAERD WTVSLEHILA SLLTEQSLVN
1110 1120 1130 1140
FFEKPLDMKS KLENAKINQY NLKTFEMSHQ SQSELKLSNL
Length:1,140
Mass (Da):130,835
Last modified:November 3, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i84A98A876F8DD108
GO
Isoform 2 (identifier: O95759-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: Missing.

Note: No experimental confirmation available.
Show »
Length:897
Mass (Da):102,741
Checksum:iD4742D7BF595CA36
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KQ40J3KQ40_HUMAN
TBC1 domain family member 8
TBC1D8
1,155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAY14824 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAF85515 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti977 – 979EKD → KKK in BAA76517 (PubMed:10373574).Curated3
Sequence conflicti1117I → T in BAF85515 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047500317T → A3 PublicationsCorresponds to variant dbSNP:rs2289953Ensembl.1
Natural variantiVAR_024654954G → R. Corresponds to variant dbSNP:rs1062062Ensembl.1
Natural variantiVAR_0605421073F → L1 PublicationCorresponds to variant dbSNP:rs1057580Ensembl.1
Natural variantiVAR_0221281079R → G1 PublicationCorresponds to variant dbSNP:rs746924Ensembl.1
Natural variantiVAR_0221291108M → V. Corresponds to variant dbSNP:rs3739011Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0383401 – 243Missing in isoform 2. 1 PublicationAdd BLAST243

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB024057 mRNA Translation: BAA75489.1
AB017114 mRNA Translation: BAA76517.1
AB449889 mRNA Translation: BAH16632.1
AC016738 Genomic DNA Translation: AAY14824.1 Sequence problems.
AC013722 Genomic DNA No translation available.
AK292826 mRNA Translation: BAF85515.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS46375.1 [O95759-1]

NCBI Reference Sequences

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RefSeqi
NP_001095896.1, NM_001102426.2 [O95759-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.442657

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000376840; ENSP00000366036; ENSG00000204634 [O95759-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
11138

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:11138

UCSC genome browser

More...
UCSCi
uc010fiv.4 human [O95759-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024057 mRNA Translation: BAA75489.1
AB017114 mRNA Translation: BAA76517.1
AB449889 mRNA Translation: BAH16632.1
AC016738 Genomic DNA Translation: AAY14824.1 Sequence problems.
AC013722 Genomic DNA No translation available.
AK292826 mRNA Translation: BAF85515.1 Different initiation.
CCDSiCCDS46375.1 [O95759-1]
RefSeqiNP_001095896.1, NM_001102426.2 [O95759-1]
UniGeneiHs.442657

3D structure databases

ProteinModelPortaliO95759
SMRiO95759
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116311, 4 interactors
IntActiO95759, 4 interactors
STRINGi9606.ENSP00000366036

PTM databases

iPTMnetiO95759
PhosphoSitePlusiO95759

Polymorphism and mutation databases

BioMutaiTBC1D8

Proteomic databases

EPDiO95759
MaxQBiO95759
PaxDbiO95759
PeptideAtlasiO95759
PRIDEiO95759
ProteomicsDBi51034
51035 [O95759-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376840; ENSP00000366036; ENSG00000204634 [O95759-1]
GeneIDi11138
KEGGihsa:11138
UCSCiuc010fiv.4 human [O95759-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11138
DisGeNETi11138
EuPathDBiHostDB:ENSG00000204634.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TBC1D8

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0002324
HIX0030106
HGNCiHGNC:17791 TBC1D8
HPAiCAB015211
HPA037496
neXtProtiNX_O95759
OpenTargetsiENSG00000204634
PharmGKBiPA134885935

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4347 Eukaryota
COG5210 LUCA
GeneTreeiENSGT00940000158977
HOGENOMiHOG000276905
HOVERGENiHBG054142
InParanoidiO95759
KOiK19951
PhylomeDBiO95759
TreeFamiTF313145

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TBC1D8 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
11138

Protein Ontology

More...
PROi
PR:O95759

Gene expression databases

BgeeiENSG00000204634 Expressed in 228 organ(s), highest expression level in adenohypophysis
CleanExiHS_TBC1D8
ExpressionAtlasiO95759 baseline and differential
GenevisibleiO95759 HS

Family and domain databases

CDDicd13349 PH-GRAM1_TBC1D8, 1 hit
cd13353 PH-GRAM2_TBC1D8, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR004182 GRAM
IPR011993 PH-like_dom_sf
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
IPR036009 TBC1D8_PH-GRAM1
IPR036016 TBC1D8_PH-GRAM2
PfamiView protein in Pfam
PF02893 GRAM, 2 hits
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00568 GRAM, 2 hits
SM00164 TBC, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50086 TBC_RABGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTBCD8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95759
Secondary accession number(s): A6NDL4
, A8K9W1, B9A6K4, Q53SQ4, Q9UQ32
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: November 3, 2009
Last modified: December 5, 2018
This is version 133 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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