Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Polypyrimidine tract-binding protein 3

Gene

PTBP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes FAS exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • anatomical structure morphogenesis Source: ProtInc
  • erythrocyte maturation Source: UniProtKB-KW
  • mRNA processing Source: UniProtKB-KW
  • negative regulation of RNA splicing Source: UniProtKB
  • regulation of cell differentiation Source: InterPro
  • RNA splicing Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor, RNA-binding
Biological processDifferentiation, Erythrocyte maturation, mRNA processing, mRNA splicing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polypyrimidine tract-binding protein 3
Alternative name(s):
Regulator of differentiation 1
Short name:
Rod1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTBP3
Synonyms:ROD1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000119314.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10253 PTBP3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607527 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95758

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9991

Open Targets

More...
OpenTargetsi
ENSG00000119314

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34625

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PTBP3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000818731 – 552Polypyrimidine tract-binding protein 3Add BLAST552

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei17PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki65Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei127PhosphotyrosineBy similarity1
Modified residuei138PhosphothreonineBy similarity1
Cross-linki216Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei423N6-acetyllysineCombined sources1
Modified residuei454PhosphoserineCombined sources1
Isoform 1 (identifier: O95758-1)
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O95758

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O95758

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O95758

PeptideAtlas

More...
PeptideAtlasi
O95758

PRoteomics IDEntifications database

More...
PRIDEi
O95758

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51028
51029 [O95758-1]
51030 [O95758-2]
51031 [O95758-4]
51032 [O95758-5]
51033 [O95758-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O95758

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O95758

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O95758

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in several hematopoietic cell lines examined.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000119314 Expressed in 220 organ(s), highest expression level in metanephros

CleanEx database of gene expression profiles

More...
CleanExi
HS_ROD1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O95758 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O95758 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA048374

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with THBS4 (via the acidic amphipathic C-terminus).1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115312, 115 interactors

Protein interaction database and analysis system

More...
IntActi
O95758, 284 interactors

Molecular INTeraction database

More...
MINTi
O95758

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000334499

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O95758

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O95758

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini59 – 143RRM 1PROSITE-ProRule annotationAdd BLAST85
Domaini182 – 258RRM 2PROSITE-ProRule annotationAdd BLAST77
Domaini358 – 432RRM 3PROSITE-ProRule annotationAdd BLAST75
Domaini475 – 550RRM 4PROSITE-ProRule annotationAdd BLAST76

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1190 Eukaryota
ENOG410XPMZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153363

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231699

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG069548

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O95758

KEGG Orthology (KO)

More...
KOi
K17844

Identification of Orthologs from Complete Genome Data

More...
OMAi
GAPTNEG

Database of Orthologous Groups

More...
OrthoDBi
1545178at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O95758

TreeFam database of animal gene trees

More...
TreeFami
TF319824

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12779 RRM1_ROD1, 1 hit
cd12693 RRM2_PTBP1_like, 1 hit
cd12703 RRM4_ROD1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006536 HnRNP-L/PTB
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR034798 PTBP1/2/3_RRM2
IPR021790 PTBP1_RRM
IPR033110 PTBP3_RRM4
IPR035979 RBD_domain_sf
IPR034326 ROD1_RRM1
IPR000504 RRM_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00076 RRM_1, 1 hit
PF11835 RRM_8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00360 RRM, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928 SSF54928, 3 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01649 hnRNP-L_PTB, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102 RRM, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 3 (identifier: O95758-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDGVVTDLIT VGLKRGSDEL LSSGIINGPF TMNSSTPSTA NGNDSKKFKR
60 70 80 90 100
DRPPCSPSRV LHLRKIPCDV TEAEIISLGL PFGKVTNLLM LKGKSQAFLE
110 120 130 140 150
MASEEAAVTM VNYYTPITPH LRSQPVYIQY SNHRELKTDN LPNQARAQAA
160 170 180 190 200
LQAVSAVQSG SLALSGGPSN EGTVLPGQSP VLRIIIENLF YPVTLEVLHQ
210 220 230 240 250
IFSKFGTVLK IITFTKNNQF QALLQYADPV NAHYAKMALD GQNIYNACCT
260 270 280 290 300
LRIDFSKLTS LNVKYNNDKS RDFTRLDLPT GDGQPSLEPP MAAAFGAPGI
310 320 330 340 350
ISSPYAGAAG FAPAIGFPQA TGLSVPAVPG ALGPLTITSS AVTGRMAIPG
360 370 380 390 400
ASGIPGNSVL LVTNLNPDLI TPHGLFILFG VYGDVHRVKI MFNKKENALV
410 420 430 440 450
QMADANQAQL AMNHLSGQRL YGKVLRATLS KHQAVQLPRE GQEDQGLTKD
460 470 480 490 500
FSNSPLHRFK KPGSKNFQNI FPPSATLHLS NIPPSVTVDD LKNLFIEAGC
510 520 530 540 550
SVKAFKFFQK DRKMALIQLG SVEEAIQALI ELHNHDLGEN HHLRVSFSKS

TI
Length:552
Mass (Da):59,690
Last modified:December 16, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6254928B781A436A
GO
Isoform 1 (identifier: O95758-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.

Show »
Length:521
Mass (Da):56,502
Checksum:iB73CC6F98200B704
GO
Isoform 2 (identifier: O95758-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.
     39-39: T → TGVY
     510-552: KDRKMALIQL...LRVSFSKSTI → GLANSWAQVI...VPTRYFWTKN

Show »
Length:547
Mass (Da):59,112
Checksum:iCA0668ECF9F04545
GO
Isoform 4 (identifier: O95758-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MDGVVTDLITVGLK → MDASPSPFSLPKKLNELSAR

Show »
Length:558
Mass (Da):60,417
Checksum:iD20E5BA201A6CA84
GO
Isoform 5 (identifier: O95758-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-39: T → TGVY

Show »
Length:555
Mass (Da):60,009
Checksum:iBD53F9AB611E8C2A
GO
Isoform 6 (identifier: O95758-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.
     39-39: T → TGVY

Show »
Length:524
Mass (Da):56,821
Checksum:iA82C6B5E094AFED0
GO
Isoform 7 (identifier: O95758-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-96: MDGVVTDLIT...NLLMLKGKSQ → M

Note: No experimental confirmation available.
Show »
Length:457
Mass (Da):49,540
Checksum:iE3C98C4381901EDE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6R242X6R242_HUMAN
Polypyrimidine tract-binding protei...
PTBP3
182Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1ALY4B1ALY4_HUMAN
Polypyrimidine tract-binding protei...
PTBP3
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH39896 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA75466 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BI463123 differs from that shown. Reason: Frameshift at position 92.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti259T → I in BAG50959 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0456081 – 96MDGVV…KGKSQ → M in isoform 7. 1 PublicationAdd BLAST96
Alternative sequenceiVSP_0359851 – 31Missing in isoform 1, isoform 2 and isoform 6. 2 PublicationsAdd BLAST31
Alternative sequenceiVSP_0359861 – 14MDGVV…TVGLK → MDASPSPFSLPKKLNELSAR in isoform 4. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_01086739T → TGVY in isoform 2, isoform 5 and isoform 6. 3 Publications1
Alternative sequenceiVSP_010868510 – 552KDRKM…SKSTI → GLANSWAQVILLLPPPHSAG ITGMSHHAWLSVLFSVSVPS VSSAYMFSILSCSFSSVPTR YFWTKN in isoform 2. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK001685 mRNA Translation: BAG50959.1
AK302558 mRNA Translation: BAG63824.1
CR749471 mRNA Translation: CAH18301.1
AL158824 Genomic DNA No translation available.
AL359073 Genomic DNA No translation available.
CH471105 Genomic DNA Translation: EAW59100.1
BC039896 mRNA Translation: AAH39896.1 Different initiation.
BC044585 mRNA Translation: AAH44585.1
BI463123 mRNA No translation available.
AB023967 mRNA Translation: BAA75466.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55332.1 [O95758-6]
CCDS55333.1 [O95758-5]
CCDS59140.1 [O95758-7]
CCDS59141.1 [O95758-4]
CCDS6784.1 [O95758-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001157260.1, NM_001163788.2 [O95758-6]
NP_001157262.1, NM_001163790.2 [O95758-5]
NP_001231825.1, NM_001244896.1 [O95758-7]
NP_001231826.1, NM_001244897.1 [O95758-2]
NP_001231827.1, NM_001244898.1 [O95758-4]
NP_005147.3, NM_005156.6 [O95758-3]
XP_006717409.1, XM_006717346.1 [O95758-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.269988

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000334318; ENSP00000334499; ENSG00000119314 [O95758-5]
ENST00000343327; ENSP00000340705; ENSG00000119314 [O95758-7]
ENST00000374255; ENSP00000363373; ENSG00000119314 [O95758-3]
ENST00000374257; ENSP00000363375; ENSG00000119314 [O95758-6]
ENST00000458258; ENSP00000414921; ENSG00000119314 [O95758-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9991

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9991

UCSC genome browser

More...
UCSCi
uc004bfv.4 human [O95758-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001685 mRNA Translation: BAG50959.1
AK302558 mRNA Translation: BAG63824.1
CR749471 mRNA Translation: CAH18301.1
AL158824 Genomic DNA No translation available.
AL359073 Genomic DNA No translation available.
CH471105 Genomic DNA Translation: EAW59100.1
BC039896 mRNA Translation: AAH39896.1 Different initiation.
BC044585 mRNA Translation: AAH44585.1
BI463123 mRNA No translation available.
AB023967 mRNA Translation: BAA75466.1 Different initiation.
CCDSiCCDS55332.1 [O95758-6]
CCDS55333.1 [O95758-5]
CCDS59140.1 [O95758-7]
CCDS59141.1 [O95758-4]
CCDS6784.1 [O95758-3]
RefSeqiNP_001157260.1, NM_001163788.2 [O95758-6]
NP_001157262.1, NM_001163790.2 [O95758-5]
NP_001231825.1, NM_001244896.1 [O95758-7]
NP_001231826.1, NM_001244897.1 [O95758-2]
NP_001231827.1, NM_001244898.1 [O95758-4]
NP_005147.3, NM_005156.6 [O95758-3]
XP_006717409.1, XM_006717346.1 [O95758-1]
UniGeneiHs.269988

3D structure databases

ProteinModelPortaliO95758
SMRiO95758
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115312, 115 interactors
IntActiO95758, 284 interactors
MINTiO95758
STRINGi9606.ENSP00000334499

PTM databases

iPTMnetiO95758
PhosphoSitePlusiO95758
SwissPalmiO95758

Polymorphism and mutation databases

BioMutaiPTBP3

Proteomic databases

EPDiO95758
jPOSTiO95758
PaxDbiO95758
PeptideAtlasiO95758
PRIDEiO95758
ProteomicsDBi51028
51029 [O95758-1]
51030 [O95758-2]
51031 [O95758-4]
51032 [O95758-5]
51033 [O95758-6]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334318; ENSP00000334499; ENSG00000119314 [O95758-5]
ENST00000343327; ENSP00000340705; ENSG00000119314 [O95758-7]
ENST00000374255; ENSP00000363373; ENSG00000119314 [O95758-3]
ENST00000374257; ENSP00000363375; ENSG00000119314 [O95758-6]
ENST00000458258; ENSP00000414921; ENSG00000119314 [O95758-4]
GeneIDi9991
KEGGihsa:9991
UCSCiuc004bfv.4 human [O95758-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9991
DisGeNETi9991
EuPathDBiHostDB:ENSG00000119314.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PTBP3

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0008290
HGNCiHGNC:10253 PTBP3
HPAiHPA048374
MIMi607527 gene
neXtProtiNX_O95758
OpenTargetsiENSG00000119314
PharmGKBiPA34625

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1190 Eukaryota
ENOG410XPMZ LUCA
GeneTreeiENSGT00940000153363
HOGENOMiHOG000231699
HOVERGENiHBG069548
InParanoidiO95758
KOiK17844
OMAiGAPTNEG
OrthoDBi1545178at2759
PhylomeDBiO95758
TreeFamiTF319824

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PTBP3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9991

Protein Ontology

More...
PROi
PR:O95758

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000119314 Expressed in 220 organ(s), highest expression level in metanephros
CleanExiHS_ROD1
ExpressionAtlasiO95758 baseline and differential
GenevisibleiO95758 HS

Family and domain databases

CDDicd12779 RRM1_ROD1, 1 hit
cd12693 RRM2_PTBP1_like, 1 hit
cd12703 RRM4_ROD1, 1 hit
Gene3Di3.30.70.330, 4 hits
InterProiView protein in InterPro
IPR006536 HnRNP-L/PTB
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR034798 PTBP1/2/3_RRM2
IPR021790 PTBP1_RRM
IPR033110 PTBP3_RRM4
IPR035979 RBD_domain_sf
IPR034326 ROD1_RRM1
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
PF11835 RRM_8, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 4 hits
SUPFAMiSSF54928 SSF54928, 3 hits
TIGRFAMsiTIGR01649 hnRNP-L_PTB, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTBP3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95758
Secondary accession number(s): B1ALY2
, B1ALY3, B1ALY5, B1ALY6, B3KME7, Q68DB9, Q86YB3, Q86YH9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 16, 2008
Last modified: January 16, 2019
This is version 158 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again